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List of works by Rosario Rizzuto

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

scientific article

A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion

scientific article published on 8 June 2005

A role for calcium in Bcl-2 action?

scientific article

Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter

scientific article

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

scientific article published on 22 August 2008

Altered dopamine homeostasis differentially affects mitochondrial voltage-dependent anion channels turnover

scientific article published on 3 July 2014

Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth

scientific article

Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region

scientific article published on 12 October 2004

Bcl-2 and Bax modulate adenine nucleotide translocase activity.

scientific article published in January 2003

Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle

scientific article published on 15 February 2012

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

scholarly article

Biological markers of oxidative stress in mitochondrial myopathies with progressive external ophthalmoplegia ⬇️

scientific article published on September 1, 1991

Biosensors for the detection of calcium and pH.

scientific article published on January 2007

Breast Tissue Engineering: Decellularized Scaffolds Derived from Porcine Mammary Glands

scientific article published in October 2015

Ca(2+) transfer from the ER to mitochondria: when, how and why

scientific article

Ca2+ on the move: ways and means to translate a multifarious signal

scientific article published in August 2002

Ca2+ signaling, mitochondria and cell death

scientific article published on March 2008

Calcium and apoptosis: facts and hypotheses

scientific article published on November 2003

Calcium and mitochondria: mechanisms and functions of a troubled relationship

scientific article

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

scientific article

Calcium dynamics in catecholamine-containing secretory vesicles

scientific article published on 8 April 2005

Calcium mobilization from mitochondria in synaptic transmitter release ⬇️

scientific article published on November 10, 2003

Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein.

scientific article published on 10 June 2003

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

scientific article

Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission

scientific article published on 01 December 2004

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

scientific article

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca 2+ Responses ⬇️

scientific article (publication date: 12 June 1998)

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

scientific article published on January 2007

Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling

scientific article published on 12 March 2009

Copper and bezafibrate cooperate to rescue cytochrome c oxidase deficiency in cells of patients with SCO2 mutations

scientific article

Crosstalk between Calcium and ROS in Pathophysiological Conditions

scientific article published on 24 April 2019

Crosstalk between Mitochondrial Ca2+ Uptake and Autophagy in Skeletal Muscle

scientific article published on 08 September 2019

Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA.

scientific article

Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells

scientific article published on 11 March 2009

Differential recruitment of PKC isoforms in HeLa cells during redox stress

scientific article

Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25

scientific article published on 13 December 2012

Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis

scientific article

Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells

scientific article

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

article

Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis

scientific article published on 22 June 2007

Endoplasmic reticulum/mitochondria calcium cross-talk.

scientific article published on January 2007

Enjoy the Trip: Calcium in Mitochondria Back and Forth

scientific article published on 4 May 2016

Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).

scientific article

Erratum to "Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock" [Mol Metab 3 (2014) 29-41].

scientific article published on 16 September 2014

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells

scientific article published on February 2003

Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis

scientific article

Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.

scientific article

Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells

scientific journal article

FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria

scientific article published on 11 July 2016

Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells

scientific article published on 14 November 2012

Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation

scientific article published on 24 November 2009

Gene expression changes of single skeletal muscle fibers in response to modulation of the mitochondrial calcium uniporter (MCU).

scientific article

Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion

scientific article

High glucose induces adipogenic differentiation of muscle-derived stem cells

scholarly article

Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter

scientific article published on 01 June 2021

Imaging calcium dynamics using targeted recombinant aequorins

scientific article published on 01 August 2008

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

scientific article published on 08 January 2007

Inhibitory interaction of the 14-3-3{epsilon} protein with isoform 4 of the plasma membrane Ca(2+)-ATPase pump

scientific article published on 26 August 2005

Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins

scientific journal article

Innovation: Looking forward to seeing calcium

scientific article (publication date: July 2003)

Intracellular evaluation of ER targeting elucidates a mild form of inherited coagulation deficiency

scientific article

Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

scientific article published on 21 July 2009

Kαλóς και Aγαθóς: how mitochondrial beauty translates into biological virtue

scientific article published on 14 May 2013

Long-term modulation of mitochondrial Ca2+ signals by protein kinase C isozymes

scientific article published on 19 April 2004

Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization

scientific article published on 26 June 2008

Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signalling

scientific article published on 8 July 2016

MAM: more than just a housekeeper

scientific article

MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity

scientific article

Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation

scientific article published on 26 November 2007

Measuring baseline Ca(2+) levels in subcellular compartments using genetically engineered fluorescent indicators

scientific article published on January 2014

Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism

scientific article published in April 2005

Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

scientific article

Mitochondria as sensors and regulators of calcium signalling

scientific article published on August 2012

Mitochondria, calcium and cell death: a deadly triad in neurodegeneration

scientific article

Mitochondria: from basic biology to cardiovascular disease

scientific article published on 14 March 2009

Mitochondrial 'flashes': a radical concept repHined.

scientific article published on 20 August 2012

Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes

scientific article

Mitochondrial Ca2+ uptake requires sustained Ca2+ release from the endoplasmic reticulum

scientific article published on 13 February 2003

Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.

scientific article published on 28 April 2016

Mitochondrial calcium signalling in cell death

scientific article published in August 2005

Mitochondrial longevity pathways.

scientific article

Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics

scientific article published on September 2012

Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195.

scientific article published on 4 October 2008

Molecular control of mitochondrial calcium uptake

scientific article published on 30 April 2014

Molecular diversity and pleiotropic role of the mitochondrial calcium uniporter

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter

scientific article published on 8 March 2016

Molecules and roles of mitochondrial calcium signaling

scientific article published on May 2011

NF-kappaB activation is required for apoptosis in fibrocystin/polyductin-depleted kidney epithelial cells

scientific article

Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction

scientific article

Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death

scientific article published on 16 October 2019

Overexpression of adenine nucleotide translocase reduces Ca2+ signal transmission between the ER and mitochondria.

scientific article published on 25 July 2006

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

scientific journal article

Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?

scientific article published on June 2004

Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake

scientific article published on 01 May 2021

Peroxisomes as novel players in cell calcium homeostasis

scientific article

Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

scientific article published on June 2012

Polycystin-1 promotes PKCalpha-mediated NF-kappaB activation in kidney cells

scientific article published on 18 September 2006

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

scientific article published on 01 February 2007

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

scientific article published on July 23, 1992

Recent advances in the molecular mechanism of mitochondrial calcium uptake

scientific article published on 28 November 2018

Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells

scientific article

Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

scientific journal article

Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase.

scientific article

Regulation of autophagy by cytoplasmic p53

scientific article

Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation

scientific article

Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress

scientific article

Signaling pathways in mitochondrial dysfunction and aging

scientific article

Sphingosine 1-phosphate receptors modulate intracellular Ca2+ homeostasis

scientific article published on 11 December 2006

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

scientific article published on 21 April 2009

Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.

scientific article

The Golgi Ca2+-ATPase KlPmr1p function is required for oxidative stress response by controlling the expression of the heat-shock element HSP60 in Kluyveromyces lactis

scientific article

The collagen-mitochondria connection

scientific article

The contribution of the SPCA1 Ca2+ pump to the Ca2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference

scientific article

The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis.

scientific article published on 19 February 2004

The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca(2+)-dependent pathway(s).

scientific article published on 15 December 2004

The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms

scientific article published on 04 September 2007

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

scientific journal article

The mitochondrial Ca2+ uniporter ⬇️

scientific article published on 04 June 2012

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells

scientific article

The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2+) load upon cell stimulation by inhibiting Ca(2+) efflux from the organelle

scientific article published on December 2008

The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles

scientific article published on 11 February 2013

The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo

scientific article

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

scientific journal article

The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.

scientific article published on 2 May 2016

The origin of intermuscular adipose tissue and its pathophysiological implications

scientific article published on 08 September 2009

The p13 protein of human T cell leukemia virus type 1 (HTLV-1) modulates mitochondrial membrane potential and calcium uptake

scientific article published on 25 February 2010

The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells

scientific article published on March 2012

The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death

scientific article published on July 2008

Toll-like receptors hit calcium

scientific article published on April 2014

Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure

scientific article

Treatment by Therapeutic Magnetic Resonance (TMR™) increases fibroblastic activity and keratinocyte differentiation in an in vitro model of 3D artificial skin

scientific article published on 05 June 2015

When calcium goes wrong: genetic alterations of a ubiquitous signaling route

scientific article

Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β)

scientific article published on October 2012

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

scientific article

p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria

scientific article

pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant

scientific article

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