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List of works by Ivan Votruba

3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic

scientific article published on 21 October 2010

6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents

scientific article

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

scientific article

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

scientific article published on 23 May 2011

Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro

scientific article

Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants ⬇️

scientific article published on August 26, 2011

CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases

scientific article

Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides

scientific article published on September 2005

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.

scientific article published on 22 June 2010

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis

scientific article

Evaluation of the impact of S‐adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome ⬇️

scientific article published on March 15, 1998

Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines

scientific article published on April 2004

Genotoxicity of purine acyclic nucleotide analogs

scientific article published on January 1, 1997

In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl- 2,5-dihydrofuran-2-ones against common and emerging yeasts and molds

scientific article published on March 2004

Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues

scientific article

Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes

scientific article

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

scientific article published on 19 August 2008

Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates

scientific article published on February 1, 2012

Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).

scientific article published in August 2009

Mechanism of inhibitory effects of 2,3-dihydro-1,3-6h-oxazine-2,6-dione (3-oxauracil). Biosynthesis of 3-oxauridine phosphates in intact cells and cell-free extracts of Escherichia coli

scientific article

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

scientific article published on May 2013

PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.

scientific article published on November 2003

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase

scientific article

Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells

scientific article published on July 1, 2010

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma

scientific article published on January 2007

Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds

scientific article published on June 2004

Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7.

scientific article

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines

scientific article published on 11 July 2011

Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations

scientific article

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides

scientific article published on 29 November 2007

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides

scientific article published on 23 October 2007

Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*

scientific journal article

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization

scientific article

Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated ⬇️

scientific article published on January 1, 1995

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