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List of works by Luc Pellerin

A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism

scholarly article

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

scientific article

A novel method for in vitro production of human glial-like cells from neurosurgical resection tissue

scientific article

A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia

scientific article

A protein assay program for Lotus 1-2-3.

scientific article published on January 1990

A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression

scientific article published on 6 November 2002

AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice.

scientific article published on 20 October 2017

Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.

scientific article

Activity-dependent regulation of energy metabolism by astrocytes: an update

scientific article

Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

article

Alteration of glucose metabolism in cultured astrocytes after AQP9-small interference RNA application

scientific article published on 27 July 2012

Altered mRNA and Protein Expression of Monocarboxylate Transporter MCT1 in the Cerebral Cortex and Cerebellum of Prion Protein Knockout Mice

scientific article published in 2021

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

scientific article

Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators

scientific article published in February 2005

Arachidonic acid augments potassium currents in rat neocortical neurones.

scientific article

Arachidonic acid metabolites in the rat and human brain. New findings on the metabolism of prostaglandin D2 and lipoxygenase products

scientific article published on 01 January 1989

Astrocytes Couple Synaptic Activity to Glucose Utilization in the Brain

scientific article published in October 1999

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

scientific article published on 21 July 2016

Astrocytes as a predominant cellular site of (99m)Tc-HMPAO retention

scientific article published in April 2001

Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins

scientific article published on November 2008

Brain energetics (thought needs food).

scientific article

Brain energy consumption induced by electrical stimulation promotes systemic glucose uptake

scientific article published on 24 June 2011

Brain energy metabolism in Alzheimer’s disease: 99mTc-HMPAO SPECT imaging during verbal fluency and role of astrocytes in the cellular mechanism of 99mTc-HMPAO retention

scientific article published on 01 October 2001

Brain hepoxilins: formation and action

scientific article published in January 1989

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

scientific article

Brain-derived neurotrophic factor enhances the expression of the monocarboxylate transporter 2 through translational activation in mouse cultured cortical neurons.

scientific article

Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2.

scientific article published on 28 June 2011

Caveolin expression changes in the neurovascular unit after juvenile traumatic brain injury: signs of blood-brain barrier healing?

scientific article published on 4 November 2014

Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures

scientific article published on July 2003

Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy

scientific article published on 01 January 2000

Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia

scientific article published on 2 January 2016

Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain.

scientific article published in January 2005

Cellular bases of brain energy metabolism and their relevance to functional brain imaging: evidence for a prominent role of astrocytes.

scientific article published on January 1996

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

scientific article published on April 2014

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.

scientific article

Cellular mechanisms of brain energy metabolism. Relevance to functional brain imaging and to neurodegenerative disorders

scientific article published in January 1996

Cerebral Ketone Body Oxidation Is Facilitated by a High Fat Diet Enriched with Advanced Glycation End Products in Normal and Diabetic Rats.

scientific article

Comment on recent modeling studies of astrocyte-neuron metabolic interactions

scientific article published on 11 August 2010

Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons

scientific article published in November 1997

Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study

scientific article published in September 2006

Cortical Bilateral Adaptations in Rats Submitted to Focal Cerebral Ischemia: Emphasis on Glial Metabolism.

scientific article published on 7 March 2017

Cryopreservation of human brain tissue allowing timely production of viable adult human brain cells for autologous transplantation

scientific article published on October 2003

Current technical approaches to brain energy metabolism

scientific article published on 7 November 2017

Deep hypothermia and rewarming alters glutamate levels and glycogen content in cultured astrocytes

scientific article published in December 1999

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush.

scientific article published on 29 October 2014

Determinants of brain cell metabolic phenotypes and energy substrate utilization unraveled with a modeling approach

scientific article

Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells

scientific article published on 28 May 2003

Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain

scientific article published on 01 January 2000

Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination.

scientific article

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study

scientific article published on 18 June 2008

Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics.

scientific article published in July 2004

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

scientific article published on 12 September 2016

Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes

scientific article published in April 2004

Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons

scientific article published on 18 May 2013

Empiricism and rationalism: two paths toward the same goal

scientific article

Endothelial cell-derived nitric oxide enhances aerobic glycolysis in astrocytes via HIF-1α-mediated target gene activation

scientific article published in July 2012

Energy on demand

scientific article published in January 1999

Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.

scientific article published on 28 June 2007

Evidence for hypothalamic ketone body sensing: impact on food intake and peripheral metabolic responses in mice.

scientific article published on 3 November 2015

Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle

scientific article published in January 1998

Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase

scientific article published on 01 January 1996

Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain

scientific article

Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex

scientific article published on 3 January 2006

Feeding active neurons: (re)emergence of a nursing role for astrocytes

scientific article

Focal cerebral ischaemia induces a decrease in activity and a shift in ouabain affinity of Na+, K+-ATPase isoforms without modifications in mRNA and protein expression

scientific article

Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activity ⬇️

scientific article published on October 1, 2010

GABA uptake into astrocytes is not associated with significant metabolic cost: Implications for brain imaging of inhibitory transmission ⬇️

scientific article published on October 6, 2003

Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex

scientific article

Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes.

scientific article published in February 2004

Glutamate reduces glucose utilization while concomitantly enhancing AQP9 and MCT2 expression in cultured rat hippocampal neurons

scientific article

Glutamate uptake stimulates Na+,K+-ATPase activity in astrocytes via activation of a distinct subunit highly sensitive to ouabain.

scientific article published on November 1997

Glycogen metabolism as a marker of astrocyte differentiation

scientific article published on 7 October 2009

How astrocytes feed hungry neurons.

scientific article

How to balance the brain energy budget while spending glucose differently

scientific article published in January 2003

Hyperpalatable Diet and Physical Exercise Modulate the Expression of the Glial Monocarboxylate Transporters MCT1 and 4.

scientific article published on 22 September 2016

Hypothalamic sensing of ketone bodies after prolonged cerebral exposure leads to metabolic control dysregulation.

scientific article published on 06 October 2016

Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation

scientific article published in January 2004

Impact of MCT1 Haploinsufficiency on the Mouse Retina.

scientific article published in January 2018

Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio

scientific article published on 30 September 2015

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.

scientific article

Insights into neuronal cell metabolism using NMR spectroscopy: uridyl diphosphate N-acetyl-glucosamine as a unique metabolic marker.

scientific article

Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway

scientific article

Lactate as a pivotal element in neuron-glia metabolic cooperation.

scientific article

Lactate is a preferential oxidative energy substrate over glucose for neurons in culture

scientific article published in November 2003

Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process.

scientific article

Local injection of antisense oligonucleotides targeted to the glial glutamate transporter GLAST decreases the metabolic response to somatosensory activation.

scientific article published on April 2001

Long-Lasting Metabolic Imbalance Related to Obesity Alters Olfactory Tissue Homeostasis and Impairs Olfactory-Driven Behaviors.

scientific article published on 23 July 2015

Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus

scientific article published in July 1990

Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms

scientific article

Low plasma lactate concentration as a biomarker of an incompetent brain-pull: a risk factor for weight gain in type 2 diabetes patients

scientific article published on 17 March 2010

MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain

scientific article published in May 2002

Making sense of AMPA receptor trafficking by modeling molecular mechanisms of synaptic plasticity

scientific article published on 19 February 2008

Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval

scientific article published in April 2006

Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase

scientific article

Metabolic coupling during activation. A cellular view

scientific article published on January 1997

Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase

scientific article

Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2

scientific article published on 01 May 1995

Monocarboxylate transporters in the brain and in cancer.

scientific article published on 15 March 2016

Monocarboxylate transporters in the central nervous system: distribution, regulation and function.

scientific article

Monocarboxylate transporters: new players in body weight regulation.

scientific article

NEUROSCIENCE: Let There Be (NADH) Light

scientific article published in Science

Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate

scientific article published on 19 March 2015

Neuroenergetic response to prolonged cerebral glucose depletion after severe brain injury and the role of lactate

scientific article

Neuroenergetics: Astrocytes Have a Sweet Spot for Glucose

scientific article published on 01 November 2018

Neuroenergetics: calling upon astrocytes to satisfy hungry neurons

scientific article published on February 2004

Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintainance of monocarboxylate transporter MCT2 protein levels

article

Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells.

scientific article published on January 1993

Nitric oxide induces the expression of the monocarboxylate transporter MCT4 in cultured astrocytes by a cGMP-independent transcriptional activation

scientific article published on 7 September 2011

Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation

scientific article published on September 2003

Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway

scientific article published on 29 March 2007

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

scientific article

Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1α-mediated transcriptional regulation.

scientific article

Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain

scientific article published in October 2003

Protein targeting to glycogen mRNA expression is stimulated by noradrenaline in mouse cortical astrocytes

scientific article published on 01 June 2000

Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle

scientific article published in July 2004

Regulation by neurotransmitters of glial energy metabolism.

scientific article published on January 1997

Regulation of Astrocyte Energy Metabolism by Neurotransmitters

scientific article published on 01 May 1994

Regulation of the intracellular distribution, cell surface expression, and protein levels of AMPA receptor GluR2 subunits by the monocarboxylate transporter MCT2 in neuronal cells.

scientific article

Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus

scientific article

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice

scientific journal article

Rise in plasma lactate concentrations with psychosocial stress: a possible sign of cerebral energy demand

scientific article

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

scientific article published on 2 March 2017

Role of neuron-glia interaction in the regulation of brain glucose utilization.

scientific article

Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain

scientific article

Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking

scientific article

Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex

scientific journal article

Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetate

scientific article published on 20 August 2008

Sweet Sixteen for ANLS ⬇️

scientific article published on October 26, 2011

Synthesis and functions of cyclooxygenase and lipoxygenase products in brain: new findings and an appraisal

scientific article published on January 1989

Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.

scientific article published on 23 May 2011

The Hepatic Monocarboxylate Transporter 1 (MCT1) Contributes to the Regulation of Food Anticipation in Mice

scientific article published on 14 April 2021

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

scientific article

The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression

scientific article published on 29 March 2010

The astrocyte-mediated coupling between synaptic activity and energy metabolism operates through volume transmission.

scientific article

Trans-inhibition of glutamate transport prevents excitatory amino acid-induced glycolysis in astrocytes

scientific article published on 01 December 1999

Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity.

scientific article published in September 2005

Unraveling the complex metabolic nature of astrocytes

scientific article

Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures

scientific article published in January 2005

What you see is what you think--or is it?

scientific article published in February 2001

[18F]FDG PET signal is driven by astroglial glutamate transport

scientific article

[Functional brain imaging: role metabolic coupling between astrocytes and neurons]

scientific article published in September 2000

[Is lactate a major energy substrate for neurons?]

scientific article published on 01 April 2006

beta-Adrenergic stimulation promotes homocysteic acid release from astrocyte cultures: evidence for a role of astrocytes in the modulation of synaptic transmission.

scientific article published in June 1997

β-Hydroxybutyrate supports synaptic vesicle cycling but reduces endocytosis and exocytosis in rat brain synaptosomes.

scientific article published on 31 December 2015

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