List of works - Louise Serpell

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer's disease.

scientific article published on 18 December 2013

A cluster of familial Creutzfeldt-Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry?

scientific article published in December 2002

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

scientific article published on 22 July 2016

A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone

scientific article published on May 2007

A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation

scientific article

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking.

scientific article published on 15 September 2017

Alzheimer's amyloid fibrils: structure and assembly

scientific article

Amyloid fibrils: abnormal protein assembly

scientific article published on 20 July 2008

Amyloid structure

scientific article published in 2014

Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42

scientific article published on 10 February 2017

Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention.

scientific article

Atomic models of de novo designed cc beta-Met amyloid-like fibrils

scientific article published on 5 December 2007

Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes

scientific article published in October 2011

Cathepsin K as a novel amyloid fibril protein in humans

scientific article published on 9 May 2017

Characterization of Amyloid Cores in Prion Domains

scientific article published on 30 September 2016

Characterizing the assembly of the Sup35 yeast prion fragment, GNNQQNY: structural changes accompany a fiber-to-crystal switch.

scientific article published on January 2010

Chemically and thermally stable silica nanowires with a β-sheet peptide core for bionanotechnology

scientific article (publication date: December 2016)

Chemically programmed self-sorting of gelator networks

scientific article

Computational de novo design of a self-assembling peptide with predefined structure.

scientific article

Controlling the network type in self-assembled dipeptide hydrogels

scientific article published on 10 February 2017

Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements

scientific article published in April 2009

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

scientific article

De novo design of a biologically active amyloid. ⬇️

scientific article

Dehydration stability of amyloid fibrils studied by AFM

scientific article published on 14 August 2009

Dementia of the eye: the role of amyloid beta in retinal degeneration

scientific article

Diffraction to study protein and peptide assemblies

scientific article published on 23 August 2006

Direct visualisation of the beta-sheet structure of synthetic Alzheimer's amyloid

scientific article published on May 2000

Distinct tau prion strains propagate in cells and mice and define different tauopathies

scientific article published on 22 May 2014

Effect of molecular structure on the properties of naphthalene-dipeptide hydrogelators

scientific article

Effects of Aβ exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network

scientific article published on 29 May 2015

Engineering nanoscale order into a designed protein fiber

scholarly article

Erratum: Corrigendum: Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

scholarly article published in Nature Methods

Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation

scientific article

Examination of the Structure of the Transthyretin Amyloid Fibril by Image Reconstruction from Electron Micrographs

scientific article published on 01 November 1995

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

scientific article published on 14 February 2010

Exploring the sequence-structure relationship for amyloid peptides

scientific article published on March 2013

Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein

scientific article published on 4 April 2006

Flow linear dichroism of some prototypical proteins.

scientific article published in September 2009

From natural to designer self-assembling biopolymers, the structural characterisation of fibrous proteins & peptides using fibre diffraction

scientific article published on 29 July 2010

Glucagon fibril polymorphism reflects differences in protofilament backbone structure

scientific article published on 12 February 2010

Half a century of amyloids: past, present and future

scientific article published on 07 July 2020

Human beta-synuclein rendered fibrillogenic by designed mutations

scientific article published on 10 September 2010

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

scientific article published on 22 February 2011

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

scientific article published in May 2001

Identifying the Coiled-Coil Triple Helix Structure of β-Peptide Nanofibers at Atomic Resolution

scientific article published on 31 August 2018

Inflammation protein SAA2.2 spontaneously forms marginally stable amyloid fibrils at physiological temperature

scientific article published on 5 October 2011

Insights into the architecture of the Ure2p yeast protein assemblies from helical twisted fibrils

scientific article

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

scientific article

Kinetically Controlled Coassembly of Multichromophoric Peptide Hydrogelators and the Impacts on Energy Transport

scientific article published on 5 June 2017

Low molecular weight gelator-dextran composites

scientific article published on 18 August 2010

Membrane and surface interactions of Alzheimer’s Aβ peptide – insights into the mechanism of cytotoxicity ⬇️

scientific article published on July 26, 2011

Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

scientific article published on 06 September 2020

Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway

scientific article published on 05 February 2020

Modular Design of Self-Assembling Peptide-Based Nanotubes

scientific article published on 28 July 2015

Molecular basis for amyloid fibril formation and stability

scientific article

Molecular organization of fibroin heavy chain and mechanism of fibre formation in Bombyx mori

scientific article published on 29 June 2024

Molecular structure of a fibrillar Alzheimer's A beta fragment

scientific article published in October 2000

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

scientific article

Nuclear Tau and Its Potential Role in Alzheimer's Disease

scientific article

Nucleation of alpha 1-antichymotrypsin polymerization

scientific article published in March 2003

Nucleation-dependent aggregation kinetics of Yeast Sup35 fragment GNNQQNY

scientific article published on 03 December 2020

On crystal versus fiber formation in dipeptide hydrogelator systems

scientific article

Physical Methods for Studies of Fiber Formation and Structure

Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy

scientific article

Polymerization of human angiotensinogen: insights into its structural mechanism and functional significance

scientific article published on November 2006

Presenilin structure, function and role in Alzheimer disease.

scientific article published in July 2000

Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors.

scientific article published on 7 June 2017

Proteasomal degradation of tau protein

scientific article published in October 2002

Protein fiber linear dichroism for structure determination and kinetics in a low-volume, low-wavelength couette flow cell

scientific article

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

scientific article

Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science

scientific article

Rational Design of Helical Nanotubes from Self-Assembly of Coiled-Coil Lock Washers

scientific article published on 03 October 2013

Rational design and application of responsive alpha-helical peptide hydrogels

scientific article published on July 2009

Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy

scientific article published on 12 August 2008

Salt-induced hydrogelation of functionalised-dipeptides at high pH

scientific article published on 17 October 2011

Self-assembly mechanism for a naphthalene-dipeptide leading to hydrogelation.

scientific article published in April 2010

Self-assembly of phenylalanine oligopeptides: insights from experiments and simulations

scientific article published on June 2009

Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein

scientific article published on 20 September 2007

Silica Nanowires Templated by Amyloid-like Fibrils

scientific article published on 5 October 2015

Silica Nanowires Templated by Amyloid-like Fibrils

scientific article

Silk Road Revealed: Mechanism of silk fibre formation in Bombyx mori

scientific article published on 3 June 2023

Spider silk and amyloid fibrils: a structural comparison

scientific article published in February 2007

Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP).

scientific article published on 14 December 2015

Structural Analysis of Proteinaceous Components in Byssal Threads of the MusselMytilus galloprovincialis

article

Structural analyses of fibrinogen amyloid fibrils

scientific article published on 01 September 2007

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

scientific article published on 8 December 2011

Structural characterisation of islet amyloid polypeptide fibrils

scientific article published on January 2004

Structural determinants in a library of low molecular weight gelators

scientific article published on February 2015

Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction

scientific article

Structural integrity of beta-sheet assembly

scientific article published on August 2009

Structure and morphology of the Alzheimer's amyloid fibril

scientific article

Structure and texture of fibrous crystals formed by Alzheimer's abeta(11-25) peptide fragment

scientific article published in August 2003

Structure-dependent effects of amyloid-β on long-term memory in Lymnaea stagnalis

scientific article published on 24 March 2017

Structures for amyloid fibrils

scientific article

Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix

scientific article published on 01 August 1996

Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterization

scientific article published in February 2006

Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure

scientific article

The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation

scientific article published on 28 February 2019

The Effect of Alzheimer’s Aβ Aggregation State on the Permeation of Biomimetic Lipid Vesicles

scientific article published on 05 October 2010

The amyloid architecture provides a scaffold for enzyme-like catalysts.

scientific article published on 19 July 2017

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

scientific article

The common architecture of cross-beta amyloid

article by Thomas R Jahn et al published 29 January 2010 in Journal of Molecular Biology

The diversity and utility of amyloid fibrils formed by short amyloidogenic peptides

scientific article published on 20 October 2017

The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels

scientific article published in November 2014

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease

scientific article published on 16 December 2016

The involvement of tau in nucleolar transcription and the stress response

scientific article published on 31 July 2018

The molecular basis of amyloidosis.

scientific article published on December 1997

The protofilament substructure of amyloid fibrils11Edited by F. E. Cohen

scientific article published on 01 July 2000

The relationship between amyloid structure and cytotoxicity

scientific article

The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1.

scientific article published on 10 January 2013

Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes

scientific article published on 21 July 2015

Using chirality to influence supramolecular gelation

scientific article published on 03 July 2019

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

scientific article published on January 2012

WALTZ-DB: a benchmark database of amyloidogenic hexapeptides

scientific article

X-ray diffraction studies of amyloid structure

scientific article published on 01 January 2005

X-ray fibre diffraction studies of amyloid fibrils

scientific article published in January 2012

Zinc-dysprosium functionalized amyloid fibrils

scientific article published on 01 October 2019

[34] X-Ray fiber diffraction of amyloid fibrils

scientific article published on 01 January 1999

List of works by Louise Serpell

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer's disease.

A cluster of familial Creutzfeldt-Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry?

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone

A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking.

Alzheimer's amyloid fibrils: structure and assembly

Amyloid fibrils: abnormal protein assembly

Amyloid structure

Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42

Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention.

Atomic models of de novo designed cc beta-Met amyloid-like fibrils

Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes

Cathepsin K as a novel amyloid fibril protein in humans

Characterization of Amyloid Cores in Prion Domains

Characterizing the assembly of the Sup35 yeast prion fragment, GNNQQNY: structural changes accompany a fiber-to-crystal switch.

Chemically and thermally stable silica nanowires with a β-sheet peptide core for bionanotechnology

Chemically programmed self-sorting of gelator networks

Computational de novo design of a self-assembling peptide with predefined structure.

Controlling the network type in self-assembled dipeptide hydrogels

Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

De novo design of a biologically active amyloid. ⬇️

Dehydration stability of amyloid fibrils studied by AFM

Dementia of the eye: the role of amyloid beta in retinal degeneration

Diffraction to study protein and peptide assemblies

Direct visualisation of the beta-sheet structure of synthetic Alzheimer's amyloid

Distinct tau prion strains propagate in cells and mice and define different tauopathies

Effect of molecular structure on the properties of naphthalene-dipeptide hydrogelators

Effects of Aβ exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network

Engineering nanoscale order into a designed protein fiber

Erratum: Corrigendum: Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation

Examination of the Structure of the Transthyretin Amyloid Fibril by Image Reconstruction from Electron Micrographs

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

Exploring the sequence-structure relationship for amyloid peptides

Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein

Flow linear dichroism of some prototypical proteins.

From natural to designer self-assembling biopolymers, the structural characterisation of fibrous proteins & peptides using fibre diffraction

Glucagon fibril polymorphism reflects differences in protofilament backbone structure

Half a century of amyloids: past, present and future

Human beta-synuclein rendered fibrillogenic by designed mutations

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

Identifying the Coiled-Coil Triple Helix Structure of β-Peptide Nanofibers at Atomic Resolution

Inflammation protein SAA2.2 spontaneously forms marginally stable amyloid fibrils at physiological temperature

Insights into the architecture of the Ure2p yeast protein assemblies from helical twisted fibrils

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

Kinetically Controlled Coassembly of Multichromophoric Peptide Hydrogelators and the Impacts on Energy Transport

Low molecular weight gelator-dextran composites

Membrane and surface interactions of Alzheimer’s Aβ peptide – insights into the mechanism of cytotoxicity ⬇️

Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway

Modular Design of Self-Assembling Peptide-Based Nanotubes

Molecular basis for amyloid fibril formation and stability

Molecular organization of fibroin heavy chain and mechanism of fibre formation in Bombyx mori

Molecular structure of a fibrillar Alzheimer's A beta fragment

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

Nuclear Tau and Its Potential Role in Alzheimer's Disease

Nucleation of alpha 1-antichymotrypsin polymerization

Nucleation-dependent aggregation kinetics of Yeast Sup35 fragment GNNQQNY

On crystal versus fiber formation in dipeptide hydrogelator systems

Physical Methods for Studies of Fiber Formation and Structure

Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy

Polymerization of human angiotensinogen: insights into its structural mechanism and functional significance

Presenilin structure, function and role in Alzheimer disease.

Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors.

Proteasomal degradation of tau protein

Protein fiber linear dichroism for structure determination and kinetics in a low-volume, low-wavelength couette flow cell

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science

Rational Design of Helical Nanotubes from Self-Assembly of Coiled-Coil Lock Washers

Rational design and application of responsive alpha-helical peptide hydrogels

Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy

Salt-induced hydrogelation of functionalised-dipeptides at high pH

Self-assembly mechanism for a naphthalene-dipeptide leading to hydrogelation.

Self-assembly of phenylalanine oligopeptides: insights from experiments and simulations

Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein

Silica Nanowires Templated by Amyloid-like Fibrils