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List of works by Frances J. Sharom

15N,(1)H Heteronuclear correlation NMR of gramicidin A in DMPC-d(67).

scientific article published in September 2002

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro.

scientific article published on 11 August 2013

ABC efflux pump-based resistance to chemotherapy drugs.

scientific article published on July 2009

ABC multidrug transporters: structure, function and role in chemoresistance.

scientific article

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

scientific article published on 01 August 1992

Biochemical changes in the equine capsule following prostaglandin-induced pregnancy failure

scientific article published on 01 March 1997

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

scientific article published on October 2004

Characterization and functional reconstitution of the multidrug transporter ⬇️

scientific article published on February 1, 1995

Characterization of fluorescent sterol binding to purified human NPC1.

scientific article published on 24 November 2008

Characterization of the proto-oncogenic and mutant forms of the transmembrane region of Neu in micelles

scientific article published on 29 March 2004

Combined chemical and enzymatic stable isotope labeling for quantitative profiling of detergent-insoluble membrane proteins isolated using Triton X-100 and Brij-96.

scientific article published on February 2006

Comparison of proto-oncogenic and mutant forms of the transmembrane region of the Neu receptor in TFE.

scientific article

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

scientific article published on 03 March 2014

Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter.

scientific article

Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers

scientific article published on 26 February 2012

Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents

scientific article published on December 2010

Direct modification of the glycocalyx of a cultured muscle cell line by incorporation of foreign gangliosides and an integral membrane glycoprotein

scientific article published in January 1978

Drug transport by reconstituted P-glycoprotein in proteoliposomes. Effect of substrates and modulators, and dependence on bilayer phase state

scientific article published in March 2001

Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.

scientific article

Effects of polychlorinated biphenyls on biological membranes: physical toxicity and molar volume relationships

scientific article published on 01 December 1980

Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools.

scientific article

FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

scientific article

Flipping and flopping-lipids on the move ⬇️

scientific article published on July 26, 2011

Fluorescence studies of drug binding and translocation by membrane transporters

scientific article published in January 2010

Fluorescence studies on the nucleotide binding domains of the P-glycoprotein multidrug transporter

scientific article published on 01 March 1997

Fluorescent probe partitioning in GUVs of binary phospholipid mixtures: implications for interpreting phase behavior

scientific article published on 16 September 2011

Fluorescent probe partitioning in giant unilamellar vesicles of 'lipid raft' mixtures

scientific article published on September 2010

Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates

scientific article

Glycophorin and the concanavalin A receptor of human erythrocytes: their receptor function in lipid bilayers ⬇️

scientific article

Glycosylphosphatidylinositol-anchored proteins: structure, function, and cleavage by phosphatidylinositol-specific phospholipase C.

scientific article

Immunosuppression by YAC-1 lymphoma: role of shed gangliosides.

scientific article published on October 1996

Inhibition of mouse lymphocyte 5'-nucleotidase by cannabinoids: a physical toxicity effect

scientific article published on 01 May 1984

Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs

scientific article published in October 2005

Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site.

scientific article

Interaction of LDS-751 with the drug-binding site of P-glycoprotein: a Trp fluorescence steady-state and lifetime study

scientific article published on 8 October 2009

Interaction of P-glycoprotein with defined phospholipid bilayers: a differential scanning calorimetric study

scientific article published on 01 August 1997

Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter ⬇️

scientific article published on June 15, 1997

Interaction of concanavalin A and a divalent derivative with lymphocytes and reconstituted lymphocyte membrane glycoproteins

scientific article published on 01 January 1989

Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function

scientific article published on 5 April 2007

Interaction of multidrug-resistant Chinese hamster ovary cells with the peptide ionophore gramicidin D

scientific article published on 01 February 1994

Interaction of the P-Glycoprotein Multidrug Transporter with Sterols

scientific article

Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport

scientific article published on December 2008

Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells

scientific article published in August 1999

Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores

scientific article published on 01 April 1995

Isolation and characterization of lipid rafts with different properties from RBL-2H3 (rat basophilic leukaemia) cells

scientific article

Isolation and incorporation into lipid vesicles of a concanavalin A receptor from human erythrocytes

scientific article published in March 1977

Kinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.

scientific article

Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates.

scientific article

Lipid-protein interactions of the human erythrocyte concanavalin A receptor in phospholipid bilayers

scientific article published on 01 July 1984

Membrane gangliosides modulate interleukin-2-stimulated T-lymphocyte proliferation

scientific article published on August 1991

New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter.

scientific article

Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regions.

scientific article published on September 2003

Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.

scientific article published on May 2007

Overexpression, purification, and structural analysis of the hydrophobic E5 protein from human papillomavirus type 16

scientific article published on 01 July 2003

P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors

scientific article published in December 2006

PI-specific phospholipase C cleavage of a reconstituted GPI-anchored protein: modulation by the lipid bilayer

scientific article published in January 2002

Phenotypic variability in hyperphosphatasia with seizures and neurologic deficit (Mabry syndrome).

scientific article published on 7 February 2012

Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter

scientific article

Proteins that bind and move lipids: MsbA and NPC1.

scientific article

Proximity of the nucleotide binding domains of the P-glycoprotein multidrug transporter to the membrane surface: a resonance energy transfer study

scientific article

Proximity of the protein moiety of a GPI-anchored protein to the membrane surface: a FRET study.

scientific article

Quantitative characterization of coexisting phases in DOPC/DPPC/cholesterol mixtures: comparing confocal fluorescence microscopy and deuterium nuclear magnetic resonance

scientific article published on 23 October 2009

Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier.

scientific article published on 07 February 2014

Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).

scientific article published in December 2006

Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains

scientific article published in September 1996

Spectroscopic and biophysical approaches for studying the structure and function of the P-glycoprotein multidrug transporter.

scientific article

Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

scientific article

Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication

scientific article published on 21 December 2013

The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites

scientific article

The P-Glycoprotein Efflux Pump: How Does it Transport Drugs? ⬇️

scientific article published on December 1, 1997

The P-glycoprotein multidrug transporter.

scientific article published on September 2011

The effects of lipids and detergents on ATPase-active P-glycoprotein

scientific article published on February 1993

The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter

scientific article published in May 1999

The reconstituted Escherichia coli MsbA protein displays lipid flippase activity

scientific article published on July 2010

The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

scientific article published on July 2005

The transmembrane domain of Neu in a lipid bilayer: molecular dynamics simulations

scientific article

Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer

scientific article

Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.

scientific article published in February 2003

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

scientific article published on August 1992

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