List of works - Amy E. Chadwick

Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity

scientific article published on 06 May 2019

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation

scientific article

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers

scientific article published in 2021

Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention

scientific article

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program

scientific article published on 01 April 2019

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

scientific article published on 23 February 2010

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

scientific article published on 06 July 2019

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

scientific article published in Journal of Biological Chemistry

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials

scientific article

Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo

scientific article published on 15 February 2017

Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells.

scientific article

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

scientific article published on 20 November 2019

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.

scientific article published on 2 April 2016

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism

scientific article published on 19 April 2019

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture

scientific article published in PLoS ONE

Safety perspectives on presently considered drugs for the treatment of COVID-19

scientific article published on 17 July 2020

The mitochondrial paradox

scientific article published on 25 June 2020

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death

scientific article published on 5 March 2015

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity

scientific article published on 07 August 2018

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine

scientific article published on 28 July 2020

List of works by Amy E. Chadwick

Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers

Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials

Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo

Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture

Safety perspectives on presently considered drugs for the treatment of COVID-19

The mitochondrial paradox

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine