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Authors whose works are in public domain in at least one jurisdiction

List of works by Melissa Little

(Re)Building a Kidney.

scientific article published on 17 January 2017

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

scientific article published in Nature Communications

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

scientific article published on 03 August 2016

A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids

scientific article published on 06 September 2019

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract

scientific article

A high-resolution anatomical ontology of the developing murine genitourinary tract.

scientific article

A protocol for the identification and validation of novel genetic causes of kidney disease

scientific article published on 15 September 2015

A side order of stem cells: the SP phenotype

scientific article published in January 2006

A spatially-averaged mathematical model of kidney branching morphogenesis.

scientific article published on 24 April 2015

A strategy for generating kidney organoids: Recapitulating the development in human pluripotent stem cells.

scientific article published on 23 August 2016

Access and use of the GUDMAP database of genitourinary development

scientific article

Advances in our understanding of genetic kidney disease using kidney organoids

scientific article published on 7 May 2019

Advances in predictive in vitro models of drug-induced nephrotoxicity

scientific article published on 6 April 2018

Allelic imbalance at chromosome 1q21 in Wilms tumor

scientific article published on 01 August 1997

An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development

scientific article published on 10 November 2020

An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling.

scientific article published in March 1996

An illustrated anatomical ontology of the developing mouse lower urogenital tract.

scientific article published on 12 May 2015

An integrated pipeline for the multidimensional analysis of branching morphogenesis

scientific article published on 20 November 2014

Analysed cap mesenchyme track data from live imaging of mouse kidney development.

scientific article

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment

scientific article published on 6 June 2009

Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa

scientific journal article

Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1.

scientific article published on April 2004

Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice

scientific article

Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution

article

Atlas of gene expression in the developing kidney at microanatomic resolution

scientific article

Author Correction: Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

scientific article published on 09 March 2020

Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis

Banked Cord Blood Is a Potential Source of Cells for Deriving Induced Pluripotent Stem Cell Lines Suitable for Cellular Therapy

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis

scientific article published in February 2018

Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

scientific article published on 31 July 2018

CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface.

scientific article

CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis

scientific article

Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.

scientific article published on 23 June 2016

Cell-cell interactions driving kidney morphogenesis

scientific article

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

scientific article published on 23 November 2020

Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter

scientific article published on 25 May 2007

Choosing an easier path or following your passion

scientific article published on 01 September 2018

Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine

scientific article

Closing the circle: from organoids back to development

scientific article published in March 2016

Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord

scientific article published in June 2002

Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity

scientific article

Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses

scientific article

Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation

scientific article

Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities

article

Conserved modularity and potential for alternate splicing in mouse and human Slit genes

scientific article (publication date: 2002)

Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673)

scientific article published on 11 July 2019

Corrigendum to “A high-resolution anatomical ontology of the developing murine genitourinary tract” [Gene Expression Patterns 7 (2007) 680–699]

article

Corrigendum to “Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities” [Stem Cell. 8 (2012) 58–73]

scholarly article published in Stem Cell Research

Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta.

scientific article published on 5 January 2012

Crim1 has cell-autonomous and paracrine roles during embryonic heart development

scientific article published on 29 January 2016

Crim1 is required for maintenance of the ocular lens epithelium

scientific article published on 16 February 2018

Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems

scientific article

Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development

scientific article published on 25 April 2007

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

scientific article published on 05 December 2018

DNA binding capacity of the WT1 protein is abolished by Denys—Drash syndrome WT1 point mutations

scientific article published on 01 March 1995

Defining and redefining the nephron progenitor population

scientific article

Defining kidney biology to understand renal disease

scientific article published on 26 December 2013

Defining the molecular character of the developing and adult kidney podocyte

scientific article

Definition and spatial annotation of the dynamic secretome during early kidney development

scientific article published on June 2006

Delivering on the promise of human stem-cell research. What are the real barriers?

scientific article published on December 2006

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants.

scientific article published on 20 December 2017

Differential gene expression in the developing mouse ureter

scientific article published on 3 February 2006

Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1

scientific article published on 28 February 2019

Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors

scientific article

Direct transcriptional reprogramming to nephron progenitors

scientific article published on 10 July 2015

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

scientific article published on 15 December 2013

Dissociation of embryonic kidney followed by re-aggregation as a method for chimeric analysis

scientific article published on January 2012

Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins

scientific article

Enhanced expression of insulin-like growth factor II is not a necessary event in Wilms' tumour progression

scientific article published in June 1987

Erratum to: Access and Use of the GUDMAP Database of Genitourinary Development

article

Erratum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

scientific article published in Nature

Establishment of Metanephros Transplantation in Mice Highlights Contributions by Both Nephrectomy and Pregnancy to Developmental Progression

scientific article published on 30 August 2005

Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells

scientific article published on 15 May 2015

Evaluation of variability in human kidney organoids

scientific article published on 20 December 2018

Evidence that WT1 mutations in Denys — Drash syndrome patients may act in a dominant-negative fashion

scientific article published on 01 March 1993

Exogenous Slit2 does not affect ureteric branching or nephron formation during kidney development

scientific article published in January 2002

Expression and functional analysis of Dkk1 during early gonadal development.

scientific article

Expression of Crim1 during murine ocular development

scientific article published in June 2000

Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules

scientific article published on 12 April 2011

Expression of the vertebrate Slit gene family and their putative receptors, the Robo genes, in the developing murine kidney

scientific article published in June 2000

GUDMAP – An Online GenitoUrinary Resource

GUDMAP – An Online GenitoUrinary Resource

GUDMAP: the genitourinary developmental molecular anatomy project

scientific article published on 20 February 2008

Generating Kidney Organoids from Human Pluripotent Stem Cells Using Defined Conditions

scientific article published on 01 January 2020

Generating Kidney from Stem Cells

scientific article published on 01 February 2019

Generating a self-organizing kidney from pluripotent cells

scientific article published on April 2015

Generation of homozygosity at the c-Ha-ras-1 locus on chromosome 11p in an adrenal adenoma from an adult with Wiedemann—Beckwith syndrome

scientific article published on 01 January 1988

Generation of kidney organoids from human pluripotent stem cells

scientific article published on 18 August 2016

Global quantification of tissue dynamics in the developing mouse kidney

scientific article

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor

scientific article published on 21 May 2018

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number

scientific article published on 4 December 2017

High-Throughput Paraffin Section In Situ Hybridization and Dual Immunohistochemistry on Mouse Tissues: Figure 1 ⬇️

scientific article published on 01 July 2008

Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways

scientific article

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney ⬇️

scientific article

Identification of novel markers of mouse fetal ovary development

scientific article

Identifying the Molecular Phenotype of Renal Progenitor Cells

scientific article published on 01 September 2004

Improving our resolution of kidney morphogenesis across time and space

scientific article published on 25 March 2015

In ovo electroporation ofCrim1 in the developing chick spinal cord

scientific article published on 01 January 2003

Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish

scientific article published in April 2004

Is there such a thing as a renal stem cell?

scientific article published on 27 August 2009

Isolation of clonogenic, long-term self renewing embryonic renal stem cells

scientific article published on 27 March 2010

Kidney Side Population Reveals Multilineage Potential and Renal Functional Capacity but also Cellular Heterogeneity

scientific article published on 17 May 2006

Kidney development: two tales of tubulogenesis

scientific article published on January 2010

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells

article

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

scientific article

Kidney organoids: accurate models or fortunate accidents

scientific article published on 01 October 2019

Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development

scientific article published on 9 March 2006

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

scientific article published in Nature Communications

Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour

scientific article published on 01 January 1998

Loss of alleles on the short arm of chromosome 11 in a hepatoblastoma from a child with Beckwith-Wiedemann syndrome.

scientific article

Loss of renal microvascular integrity in postnatal Crim1 hypomorphic transgenic mice

scientific article published on 23 September 2009

Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud

scientific article

M2 macrophage polarisation is associated with alveolar formation during postnatal lung development

scientific article published on 5 April 2013

Macrophages in renal development, injury, and repair

scientific article published on May 2010

Making a Kidney Organoid Using the Directed Differentiation of Human Pluripotent Stem Cells

scientific article published in January 2017

Mammalian kidney development: principles, progress, and projections ⬇️

scientific article published in May 2012

Methylation and p16: suppressing the suppressor

scientific article

Mice null for Crim1 display altered BMP/TGFβ signaling, defects in multiple organ systems and die in utero with severe cardiovascular defects

MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis

scientific article published on 6 June 2013

Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner.

scientific article published on 6 May 2014

Modelling cell turnover in a complex tissue during development.

scientific article published on 7 September 2013

Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript

scientific article published in Science

Molecular anatomy of the kidney: what have we learned from gene expression and functional genomics?

scientific article

Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor

article

Movement through Slits: cellular migration via the Slit family

scientific article

Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development

scientific article published on 08 January 2020

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

scientific article

N-terminal Slit2 promotes survival and neurite extension in cultured peripheral neurons

scientific article published on 01 December 2002

Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis

scientific article published on 22 December 2004

Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation

scientific article

Nephron formation adopts a novel spatial topology at cessation of nephrogenesis

scientific article published on 21 September 2011

Nephron progenitor cells: shifting the balance of self-renewal and differentiation

scientific article published on January 2014

Nephron progenitor commitment is a stochastic process influenced by cell migration

scholarly article by Kynan T Lawlor et al published 24 January 2019 in eLife

Novel WT1 exon 9 mutation (D396Y) in a patient with early onset Denys Drash syndrome

scientific article published in April 2000

Organoids: a Special Issue.

scientific article published in March 2017

Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish.

scientific article

PAX2 activates WNT4 expression during mammalian kidney development

scientific article

Parietal Epithelial Cells Regenerate Podocytes

scientific article published on 28 January 2009

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

scientific article published on 21 December 2020

PlexinA4 is necessary as a downstream target of Islet2 to mediate Slit signaling for promotion of sensory axon branching

scientific article

Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures

scientific article published on 21 October 2013

Production and metabolic clearance of angiotensinogen in conscious rats as measured by steady-state isotope dilution.

scientific article published on March 1987

Production of a mouse line with a conditional Crim1 mutant allele

scientific article

Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring.

scientific article published on 20 April 2018

Proximal tubule overexpression of a locally acting IGF isoform, Igf-1Ea, increases inflammation after ischemic injury

scientific article published on 24 December 2011

RNA binding by the Wilms tumor suppressor zinc finger proteins.

scientific article published on July 1996

ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation

scientific article

Recapitulating kidney development: Progress and challenges

scientific article published on 20 September 2018

Recreating kidney progenitors from pluripotent cells

scientific article published on 13 September 2013

Recreating, expanding and using nephron progenitor populations

scientific article published on 01 February 2020

Redirection of renal mesenchyme to stromal and chondrocytic fates in the presence of TGF-beta2.

scientific article

Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling

scientific article

Regrow or repair: potential regenerative therapies for the kidney

scientific article published on 26 July 2006

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo.

scientific article published on 28 February 2018

Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling

scientific article published on 14 January 2015

Renal organogenesis: what can it tell us about renal repair and regeneration?

scientific article published on October 2011

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

scientific article

Report on the first Asia-Pacific Kidney Development Workshop

scientific article

Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation

scientific article published on 11 March 2019

Reprogramming somatic cells to a kidney fate

scientific article published on 13 June 2014

Reprogramming the kidney: a novel approach for regeneration

scientific article published on 21 March 2012

Review article: Potential cellular therapies for renal disease: can we translate results from animal studies to the human condition?

scientific article published on September 2009

Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells.

scientific article published on 7 February 2017

Shining a Light on Alport Syndrome

scientific article published on 01 May 2018

Simultaneous reprogramming and gene editing of human fibroblasts

scientific article published on 5 April 2018

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk

scientific article published on 12 June 2019

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

scholarly article by Alexander N Combes et al published 23 January 2019 in Genome Medicine

Spatial gene expression in the T-stage mouse metanephros

scientific journal article

Stem cell options for kidney disease.

scientific article published on January 2009

Stromal cells in tissue homeostasis: balancing regeneration and fibrosis

scientific article

Stromal protein Ecm1 regulates ureteric bud patterning and branching

scientific article

Subfractionation of differentiating human embryonic stem cell populations allows the isolation of a mesodermal population enriched for intermediate mesoderm and putative renal progenitors

scientific article

The GUDMAP database--an online resource for genitourinary research

scientific article

The Life Cycle of the Nephron Progenitor

scientific article published in October 2015

The Renal Papilla: An Enigma in Damage and Repair

scientific article published on 03 November 2011

The Wilms’ tumour suppressor protein, WT1, undergoes CRM1‐independent nucleocytoplasmic shuttling ⬇️

scientific article published on November 6, 2003

The kidney research national dialogue: gearing up to move forward

scientific article

The origin of the mammalian kidney: implications for recreating the kidney in vitro

scientific article

The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development

scientific article

Three non-overlapping regions of chromosome arm 11p allele loss identified in infantile tumors of adrenal and liver

scientific article published on 01 October 1993

Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development

scientific article

Tracing the Life of the Kidney Tubule— Re-Establishing Dogma and Redirecting the Options

scientific article published on 01 March 2008

Understanding kidney morphogenesis to guide renal tissue regeneration.

scientific article

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

scientific journal article

Use of in situ hybridization to examine gene expression in the embryonic, neonatal, and adult urogenital system

scientific article published in January 2012

Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell–derived endothelium

scientific article published on 10 January 2019

WT1: what has the last decade told us?

scientific article published on 29 March 1999

Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.

scientific article published on May 2002

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

scientific article published on 05 December 2018

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