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List of works by Carl R Walkley

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency

scientific article

ADAR1, inosine and the immune sensing system: distinguishing self from non-self

scientific article

ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity

scientific article published on 25 October 2018

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

scientific article published on 05 July 2019

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.

scientific article published on 12 April 2016

Adar3 Is Involved in Learning and Memory in Mice.

scientific article

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

scientific article published on 30 June 2016

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

scientific article published on 6 May 2015

Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation

scientific article published on April 2015

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

scientific article published on 04 December 2019

Cell division and hematopoietic stem cells: not always exhausting.

scientific article published on 7 July 2005

Cells of origin in osteosarcoma: mesenchymal stem cells or osteoblast committed cells?

scientific article published on 14 February 2014

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.

scientific article

Control of self-renewal and differentiation of hematopoietic stem cells by negative cell-cycle regulators

scientific article published on 01 April 2007

Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment

scientific article published on 14 December 2012

Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies.

scientific article

Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

scientific article

Defining the functions of adenosine-to-inosine RNA editing through hematology

scientific article published on 01 July 2019

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum.

scientific article published on June 2011

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

scientific article published on 14 November 2017

Dynamic landscape and regulation of RNA editing in mammals.

scientific article published in October 2017

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.

scientific article

Erythropoiesis, anemia and the bone marrow microenvironment.

scientific article published on 12 January 2011

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

scientific article published on 18 March 2011

Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion

scientific article published on 8 December 2011

Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms

scientific article

Generation and analysis of Siah2 mutant mice.

scientific article

Genetically engineered mouse models and human osteosarcoma

scientific article

Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells

scientific article published on 01 February 2007

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α.

scientific article published on 12 January 2015

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

scientific article published on 14 November 2011

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

scientific article published on 15 June 2020

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

scientific article published on 07 May 2019

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

scientific article published on 25 April 2016

Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation.

scientific article published on 23 October 2003

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

scientific article

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death.

scientific article published on 04 April 2016

Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo

scientific article published on 21 July 2014

Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development

scientific article published on 10 September 2016

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

scientific article published on 29 July 2004

MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity

scientific article

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

scientific article published on 26 February 2013

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

scientific article published on 06 November 2018

Murine Models of Bone Sarcomas

scientific article published on 01 January 2019

Murine models of osteosarcoma: A piece of the translational puzzle

scientific article published on 13 December 2017

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

scientific article published on 16 January 2005

Osteopenia in Siah1a mutant mice.

scientific article

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

scientific article published on 4 April 2016

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

scientific article published on October 2014

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

scientific article published on June 2007

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.

scientific article published on 5 September 2017

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

scientific article

RARγ is a negative regulator of osteoclastogenesis

scientific article published on 20 March 2015

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

scientific article

Rb and hematopoiesis: stem cells to anemia

scientific article published on 8 September 2008

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

scientific article

Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells

scholarly article

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

scientific article published on June 2007

Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis.

scientific article published on September 2002

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs

scientific article published on 30 October 2017

Role of ADARs in mouse development

scientific article published in January 2012

Rothmund-Thomson Syndrome-like RECQL4 truncating mutations cause a haploinsufficient low bone mass phenotype in mice

scientific article published on 23 December 2020

Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations.

scientific article published on 21 February 2018

Src family kinases and their role in hematological malignancies

scientific article

Srsf2P95Hinitiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells

article

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

scientific article

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

scientific article published on 10 April 2015

Taking HSCs down a Notch in leukemia.

scientific article published in June 2011

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

scientific article

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

scientific article

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation

scientific article

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

scientific article

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

scientific article published on 10 January 2014

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

scientific article published on 27 January 2016

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

scientific article

The majority of A-to-I RNA editing is not required for mammalian homeostasis

scientific article published on 09 December 2019

The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA.

scientific article published on 5 April 2016

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

scholarly article by Mannu K Walia et al published 28 August 2018 in Cell Death and Disease

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma

scientific article published on 5 January 2015

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation

scientific article published on 9 January 2017

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

scientific article published in Scientific Reports

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