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List of works by Michael Kyba

A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.

scientific article

A Role for Thrombopoietin in Hemangioblast Development ⬇️

scientific article published on January 1, 2003

A conserved role for Hox paralog group 4 in regulation of hematopoietic progenitors

scientific article published on June 2009

A critical role for endoglin in the emergence of blood during embryonic development.

scientific article

A focal domain of extreme demethylation within D4Z4 in FSHD2.

scientific article published on 2 January 2013

A moderate oestradiol level enhances neutrophil number and activity in muscle after traumatic injury but strength recovery is accelerated

scientific article published on 24 August 2018

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

scientific article published on 11 September 2019

Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor

scientific journal article

Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes

scientific article

An ES cell-derived immune system

scientific article published on 01 March 2008

An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells ⬇️

scientific article published on January 1, 2013

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

scientific article published on 2 October 2008

Assessment of the myogenic stem cell compartment following transplantation of Pax3/Pax7-induced embryonic stem cell-derived progenitors

scientific article published in May 2011

Author Correction: Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model

scientific article published on 22 February 2018

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets ⬇️

scientific article published on November 18, 2012

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.

scientific article

Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.

scientific article published on 30 August 2006

Caspase activity mediates the differentiation of embryonic stem cells.

scientific article published on June 2008

Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

scientific article

Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

scientific article published on 01 February 2017

Characterization of an in vitro differentiation assay for pancreatic-like cell development from murine embryonic stem cells: detailed gene expression analysis.

scientific article

Comment on structural basis of DUX4/IGH-driven transactivation

scientific article published on 27 July 2018

Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages

scientific article

Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy

scientific article

Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA

scientific article published on 01 December 2018

DNA-binding sequence specificity of DUX4.

scientific article published on January 2015

DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells.

scientific article published on 12 July 2018

DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.

scientific article published on 06 March 2016

DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation

scientific article

Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.

scientific article

Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast

scientific article

Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm

scientific article published on January 2016

Development of hematopoietic repopulating cells from embryonic stem cells

scientific article published on January 2003

Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.

scientific article

Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene

scientific article

Drosophila Cyclin G and epigenetic maintenance of gene expression during development

scientific article published on 7 May 2015

ER71 directs mesodermal fate decisions during embryogenesis

scientific article

Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems

scientific article published in May 2002

Engraftment of embryonic stem cell-derived myogenic progenitors in a dominant model of muscular dystrophy

scientific article published on 13 August 2009

Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery

scientific article

Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5.

scientific article

Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin

scientific article published on April 2012

Estrogen Regulates the Satellite Cell Compartment in Females

Estrogen Regulates the Satellite Cell Compartment in Females

Estrogen Regulates the Satellite Cell Compartment in Females

scientific article published on 01 July 2019

Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression

scientific article published on August 2012

Evolutionarily conserved - pathway orchestrates cardiopulmonary development

article published in the Proceedings of the National Academy of Sciences of the United States of America

Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors

scientific article

Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis.

scientific article published on September 2013

Expression of the human FSHD-linked DUX4 gene induces neurogenesis during differentiation of murine embryonic stem cells

scientific article published on 9 May 2013

Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene

scientific article

Flow Cytometry and Transplantation-Based Quantitative Assays for Satellite Cell Self-Renewal and Differentiation

scientific article published on January 2016

Freeze Injury of the Tibialis Anterior Muscle

scientific article

Functional myogenic engraftment from mouse iPS cells.

scientific article published on November 2011

Functional skeletal muscle regeneration from differentiating embryonic stem cells

scientific article published on 20 January 2008

GATA2 functions at multiple steps in hemangioblast development and differentiation

scientific article published on 13 December 2006

GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.

scientific article published on 16 October 2015

Gene therapy by allele selection in a mouse model of beta-thalassemia.

scientific article

Generation of functional thyroid from embryonic stem cells

scientific article published on 10 October 2012

Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells

scientific article published on 22 February 2011

Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.

scientific article published on 14 January 2016

Hematopoiesis from embryonic stem cells: lessons from and for ontogeny

scientific article published on November 2003

Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)

scientific article

Hemogenic endothelium in a dish ⬇️

scientific article published on January 17, 2013

Heterogeneity of Mesp1+ mesoderm revealed by single-cell RNA-seq.

scientific article

High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice

scientific article

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

scientific article published on February 2014

HoxA3 is an apical regulator of haemogenic endothelium

scientific article

HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors

scientific article published in April 2002

Human ES- and iPS-derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice.

scientific article

Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma

scientific article published on 12 October 2021

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells

scientific article

Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells

scientific article

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors

scientific article published on 10 February 2016

Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression

scientific article published in Scientific Reports

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome.

scientific article published on 23 June 2016

Meeting report: the 2020 FSHD International Research Congress

scientific article published on 08 December 2020

Mesoderm, Cooked Up Fast and Served to Order

scientific article published on 01 August 2016

Mesodermal patterning activity of SCL.

scientific article published on 21 September 2008

Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs

scientific article published on July 2008

Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner.

scientific article published on May 2013

Modulating the malignancy of Hox proteins

scientific article published on January 2017

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis

scientific article

Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells

scientific article published in December 2013

Mouse models of two missense mutations in actin binding domain 1 of dystrophin associated with Duchenne or Becker muscular dystrophy

scientific article published on 28 November 2017

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model

scientific article published on 15 September 2017

NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation

scientific article published on 18 September 2013

Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10.

scientific article published on 09 April 2013

Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis.

scientific article published on 4 April 2011

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo.

scholarly article

Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation

scientific article published on 26 October 2017

Nuclear transplantation, embryonic stem cells and the potential for cell therapy

scientific article published on January 2004

OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.

scientific article

Pax7 remodels the chromatin landscape in skeletal muscle stem cells

scientific article published on 25 April 2017

Pluripotent Stem Cell-Based Therapeutics for Muscular Dystrophies

scientific article published on 01 September 2019

Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment

scientific article published on 13 February 2019

Prospective isolation of skeletal muscle stem cells with a Pax7 reporter

scientific article

Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate.

scientific article published on October 2010

RAE28, BMI1, and M33 Are Members of Heterogeneous Multimeric Mammalian Polycomb Group Complexes ⬇️

scientific article published on April 17, 1998

Rapid genetic modification of mouse embryonic stem cells by Inducible Cassette Exchange recombination.

scientific article published on January 2014

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.

scientific article published on February 2014

Replication of bone-marrow pathophysiology

scientific article published on 01 April 2020

Satellite cell heterogeneity revealed by G-Tool, an open algorithm to quantify myogenesis through colony-forming assays ⬇️

scientific article published on June 15, 2012

Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity

scientific article published on 01 July 2018

Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs

scientific article

TBX3 Directs Cell-Fate Decision toward Mesendoderm

scientific article published on 29 August 2013

TBX3 Directs Cell-Fate Decision toward Mesendoderm.

scientific article published on 8 May 2014

Tantalus, a novel ASX-interacting protein with tissue-specific functions.

scientific article published in June 2001

The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.

scientific article

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

scientific article

The SAM domain of polyhomeotic, RAE28, and scm mediates specific interactions through conserved residues

scientific article published in January 1998

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

scientific journal article

The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells

scientific article

The polyhomeotic locus of Drosophila melanogaster is transcriptionally and post-transcriptionally regulated during embryogenesis

scientific article published in August 1997

The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development

scientific article published on September 2010

Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen

scientific article

Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells

scientific article

Twist of fate for skeletal muscle mesenchymal cells.

scientific article published in March 2017

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.

scientific article published on 9 January 2018

White fat progenitor cells reside in the adipose vasculature.

scientific article

Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain

scientific article published on 5 December 2011

miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism

scientific article published on 4 January 2017

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells

scientific article

p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.

scientific article

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