List of works - Michele Fornaro

A Case of Treatment Resistant Depression and Alcohol Abuse in a Person with Mental Retardation: Response to Aripiprazole and Fluvoxamine Therapy upon Consideration of a Bipolar Diathesis after Repetitive Failure to Respond to Multiple Antidepressant

scientific article

A case of deep venous thrombosis following protracted catatonic immobility recovered with electroconvulsive therapy: the relevance for an early intervention

scientific article published on 19 September 2011

A case of severe oral self-injurious Tourette's syndrome alleviated by pregabalin

scientific article

A comparative meta-analysis of TEMPS scores across mood disorder patients, their first-degree relatives, healthy controls, and other psychiatric disorders

scientific article published on 12 February 2016

A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

scientific article published on 20 August 2015

A meta-analysis investigating the prevalence and moderators of migraines among people with bipolar disorder

scientific article published on 09 March 2015

A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation

scientific article

Adding 5-hydroxytryptamine receptor type 3 antagonists may reduce drug-induced nausea in poor insight obsessive-compulsive patients taking off-label doses of selective serotonin reuptake inhibitors: a 52-week follow-up case report

scientific article

Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study

scientific article

Affective temperaments are associated with specific clusters of symptoms and psychopathology: a cross-sectional study on bipolar disorder inpatients in acute manic, mixed, or depressive relapse

scientific article

Agomelatine beyond borders: current evidences of its efficacy in disorders other than major depression

scientific article

Agomelatine in the treatment of panic disorder ⬇️

scientific article published on 07 October 2010

Agomelatine reversal of escitalopram-induced apathy: a case report

scientific article published in April 2013

Agomelatine treatment of major depressive disorder in Parkinson's disease: a case series

scientific article published in January 2013

Alexithymia and its relationships with acute phase proteins and cytokine release: an updated review

scientific article published in October 2014

Alexithymia, Suicide Ideation, C-Reactive Protein, and Serum Lipid Levels Among Outpatients with Generalized Anxiety Disorder

scientific article published on 9 April 2015

Alexithymia, responsibility attitudes and suicide ideation among outpatients with obsessive-compulsive disorder: an exploratory study

scientific article published on 30 December 2014

Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug naïve patients with post-traumatic stress disorder: an exploratory study in the everyday 'real world' clinical practice

scientific article published on 12 December 2019

Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment

scientific article published in January 2009

Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway

scientific article

An open pilot study of zonisamide augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects.

scientific article published on 19 September 2011

An update of safety of clinically used atypical antipsychotics

scientific article

Are atypical depression, borderline personality disorder and bipolar II disorder overlapping manifestations of a common cyclothymic diathesis?

scientific article

Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report

scientific article published on 23 December 2008

Aripiprazole for relapse prevention and craving in alcohol use disorder: current evidence and future perspectives

scientific article

Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placebo-Controlled Clinical Trials

scientific article

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

scientific article

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

scientific article

Brexpiprazole for treatment-resistant major depressive disorder

scientific article published on 20 August 2019

Catatonia: a narrative review.

scientific article published on March 2011

Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials

scientific article

Choosing the appropriate pharmacotherapy for obsessive-compulsive disorder in adult patients with comorbid anxiety disorders: clinical and nosological considerations

scientific article published on 29 November 2018

Clinical features associated with early drop-out among outpatients with unipolar and bipolar depression

scientific article published on 22 October 2020

Clozapine-related pericarditis during titration phase in a patient with resistant schizophrenia and concomitant valproate treatment: a case report

scientific article published in October 2014

Cognitive functioning and subjective quality of life in relapsing-remitting multiple sclerosis patients before and after percutaneous transluminal angioplasty: a preliminary report

scientific article published on 11 June 2014

Cognitive tolerability following successful long term treatment of major depression and anxiety disorders with SSRi antidepressants

scientific article

Comments on: ''Socio-economic factors and suicide rates in European Union countries".

scientific article published on 18 June 2012

Comparison of familial and non-familial suicidal behaviors among people with major depressive disorder: Testing the discriminative predicting role of high-yield clinical variables

scientific article published on 23 February 2018

Corrigendum to “Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and “therapeutic sensation seeking” in response towards subjective intolerance to pain” [J. A

scholarly article published in Journal of Affective Disorders

Cotard's Syndrome after breast surgery successfully treated with aripiprazole augmentation of escitalopram: a case report

scientific article published in March 2015

Could the underestimation of bipolarity obstruct the search for novel antidepressant drugs?

scientific article published on December 2011

Current Nosology of Treatment Resistant Depression: A Controversy Resistant to Revision

Current nosology of treatment resistant depression: a controversy resistant to revision

scientific article

Diagnosis of co-morbid axis-I psychiatric disorders among women with newly diagnosed, untreated endocrine disorders

scientific article published on 22 June 2010

Different measures of impulsivity in patients with anxiety disorders: a case control study.

scientific article published on 21 February 2012

Differentiating between bipolar and unipolar depression in functional and structural MRI studies

scientific article published on 27 March 2018

Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients

scientific article published on 7 August 2012

Does Screening for Bipolar Disorders Identify a “Dysregulation of Mood, Energy, and Social Rhythms Syndrome” (DYMERS)? A Heuristic Working Hypothesis

scientific article published in 2023

Duloxetine-bupropion combination for treatment-resistant atypical depression: a double-blind, randomized, placebo-controlled trial

scientific article

Effect of agomelatine treatment on C-reactive protein levels in patients with major depressive disorder: an exploratory study in "real-world," everyday clinical practice.

scientific article published on 5 October 2016

Efficacy and safety of long acting injectable atypical antipsychotics: a review

scientific article published on August 2013

Efficacy, safety and tolerability of aripiprazole in bipolar disorder: An updated systematic review and meta-analysis of randomized controlled trials.

scientific article published on 23 June 2017

Electroretinographic assessment in major depressed patients receiving duloxetine: might differences between responders and non-responders indicate a differential biological background?

scientific article published on 4 August 2011

Electroretinographic modifications induced by agomelatine: a novel avenue to the understanding of the claimed antidepressant effect of the drug?

scientific article

Emerging mania following escitalopram withdrawal in a patient with unipolar depression managed with its reintroduction

scientific article

Emotional Dysregulation in Adolescents: Implications for the Development of Severe Psychiatric Disorders, Substance Abuse, and Suicidal Ideation and Behaviors

scientific article published on 26 August 2020

Epileptic seizures but not pseudoseizures are associated with decreased density of the serotonin transporter in blood platelet membranes

scientific article published on 22 April 2008

Factor structure and reliability of the Arabic adaptation of the Hypomania Check List-32, second revision (HCL-32-R2).

scientific article

Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2).

scientific article published on 10 March 2015

How can we improve antidepressant adherence in the management of depression? A targeted review and 10 clinical recommendations

scientific article published on 01 June 2020

How common is bipolar disorder in general primary care attendees? A systematic review and meta-analysis investigating prevalence determined according to structured clinical assessments

scientific article

Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance

scientific article

Impulsivity in anxiety disorder patients: is it related to comorbid cyclothymia?

scientific article published on 12 June 2011

Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression: a systematic review and meta-analysis

scientific article published on 14 February 2018

Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019

scientific article published in 2023

Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation

scientific article

Inflammatory markers and suicidal attempts in depressed patients: A review

scientific article published on 4 January 2016

Is there cardiac risk in panic disorder? An updated systematic review

scientific article

Lifetime co-morbidity with different subtypes of eating disorders in 148 females with bipolar disorders

scientific article published on 26 June 2009

Lisdexamfetamine in the treatment of moderate-to-severe binge eating disorder in adults: systematic review and exploratory meta-analysis of publicly available placebo-controlled, randomized clinical trials

scientific article

Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews

scientific article

Medicine and psychiatry in Western culture: Ancient Greek myths and modern prejudices

scientific article (publication date: 7 October 2009)

Mediterranean Diet and its Benefits on Health and Mental Health: A Literature Review

scientific article published on 30 July 2020

Might different cytokine trends in depressed patients receiving duloxetine indicate differential biological backgrounds.

scientific article published on 14 September 2012

NGF serum levels variations in major depressed patients receiving duloxetine

scientific article published on 16 March 2013

New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine.

scientific article

Obsessive-compulsive aspects and pathological gambling in an Italian sample

scientific article

Obsessive-compulsive disorder and related disorders: a comprehensive survey

scientific article

Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine

scientific article published on 29 October 2010

Overcoming the Use of Mechanical Restraints in Psychiatry: A New Challenge in the Everyday Clinical Practice at the Time of COVID-19

scientific article published on 23 November 2020

Pharmacological management of depression in patients with multiple sclerosis

scientific article published on 12 September 2018

Preclinical Considerations about Affective Disorders and Pain: A Broadly Intertwined, yet Often Under-Explored, Relationship Having Major Clinical Implications

scientific article published on 25 September 2020

Prevalence and clinical features associated to bipolar disorder-migraine comorbidity: a systematic review

scientific article

Prevalence and clinical features associated with bipolar disorder polypharmacy: a systematic review

scientific article

Prevalence and correlates of major depressive disorder, bipolar disorder and schizophrenia among nursing home residents without dementia: systematic review and meta-analysis

scientific article published on 13 March 2019

Prevalence and diagnostic distribution of medically unexplained painful somatic symptoms across 571 major depressed outpatients

scientific article

Progress in bipolar disorder drug design toward the development of novel therapeutic targets: a clinician's perspective

scientific article published on 22 January 2018

Prominent autistic traits and subthreshold bipolar/mixed features of depression in severe anorexia nervosa

scientific article published on 04 November 2019

Psychopathological aspects of kidney transplantation: Efficacy of a multidisciplinary team

scientific article

Religious Coping, Hopelessness, and Suicide Ideation in Subjects with First-Episode Major Depression: An Exploratory Study in the Real World Clinical Practice

scientific article published on 27 November 2020

Reply to Dr. Gentili’ “Analysis of tolerance to antidepressant drugs in FDA Adverse Event Reporting System”

scientific article published on 15 December 2018

Reply to Dr. Sharma’ “Understanding antidepressant tachyphylaxis”

scientific article published on 22 November 2018

Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review

scientific article

Sensation seeking in major depressive patients: relationship to sub-threshold bipolarity and cyclothymic temperament

scientific article

Somatopsychic correlates and quality of life of the dialyzed patient: a cross-sectional study.

scientific article published in September 2014

Successful use of agomelatine in the treatment of major depression in a woman taking tamoxifen: a case report

scientific article published in January 2014

Successful ziprasidone monotherapy in a case of delusional parasitosis: a one-year followup

scientific article published on 16 May 2013

Suicide during Perinatal Period: Epidemiology, Risk Factors, and Clinical Correlates

scientific article

Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series ⬇️

scientific article published on February 28, 2011

Targeting the Noradrenergic System in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of Prazosin Trials.

scientific article published on 06 May 2015

The 'dead man walking' disorder: an update on Cotard's syndrome

scientific article published on 05 June 2020

The Interface between Neuroscience and Neuro-Psychoanalysis: Focus on Brain Connectivity

scientific article

The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia

scientific article published in 2023

The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. ⬇️

scientific article published on 5 April 2019

The Relationships between Cholesterol and Suicide: An Update

scientific article published on 23 December 2012

The Role of Agomelatine in the Treatment of Anxiety Disorders

The argument of antidepressant drugs in the treatment of bipolar depression: mixed evidence or mixed states?

scientific article published on 04 September 2012

The burden of mood-disorder/cerebrovascular disease comorbidity: essential neurobiology, psychopharmacology, and physical activity interventions

scientific article published on 6 July 2017

The emergence of loss of efficacy during antidepressant drug treatment for major depressive disorder: An integrative review of evidence, mechanisms, and clinical implications

scholarly article by Michele Fornaro et al published 29 October 2018 in Pharmacological Research

The identification of biomarkers predicting acute and maintenance lithium treatment response in bipolar disorder: A plea for further research attention

The impact of premenstrual dysphoric disorder among 92 bipolar patients

scientific article published on 7 July 2010

The influence of affective temperaments and psychopathological traits on the definition of bipolar disorder subtypes: a study on bipolar I Italian national sample

scientific article published on 2 February 2010

The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice

scientific article published on 13 June 2013

The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis

scientific article published on 5 February 2016

The prevalence and predictors of obstructive sleep apnea in major depressive disorder, bipolar disorder and schizophrenia: A systematic review and meta-analysis

scientific article published on 09 March 2016

The relationship between drive to thinness, conscientiousness and bulimic traits during adolescence: a comparison between younger and older cases in 608 healthy volunteers

scientific article published on 31 October 2013

The relationship between the dietary inflammatory index (DII®) and incident depressive symptoms: A longitudinal cohort study

scientific article published on 04 April 2018

The role of intranasal oxytocin in the treatment of patients with schizophrenia: a systematic review

scientific article published on March 2013

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management

scientific article

Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: relationship with cyclothymic temperament and "therapeutic sensation seeking" in response towards subjective intolerance to pain

scientific article published on 30 July 2013

Treatment of antipsychotic-induced hyperprolactinemia: an update on the role of the dopaminergic receptors D2 partial agonist aripiprazole

scientific article published on January 2014

Unexplained somatic symptoms during major depression: prevalence and clinical impact in a national sample of Italian psychiatric outpatients

scientific article published on 12 January 2011

Update on novel antipsychotics and pharmacological strategies for treatment-resistant schizophrenia

scientific article published in 2022

Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease

scientific article published in January 2010

VEGF plasma level variations in duloxetine-treated patients with major depression

scientific article

β-amyloid 1-42 induces physiological transcriptional regulation of BACE1.

scientific article

List of works by Michele Fornaro

A Case of Treatment Resistant Depression and Alcohol Abuse in a Person with Mental Retardation: Response to Aripiprazole and Fluvoxamine Therapy upon Consideration of a Bipolar Diathesis after Repetitive Failure to Respond to Multiple Antidepressant

A case of deep venous thrombosis following protracted catatonic immobility recovered with electroconvulsive therapy: the relevance for an early intervention

A case of severe oral self-injurious Tourette's syndrome alleviated by pregabalin

A comparative meta-analysis of TEMPS scores across mood disorder patients, their first-degree relatives, healthy controls, and other psychiatric disorders

A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

A meta-analysis investigating the prevalence and moderators of migraines among people with bipolar disorder

A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation

Adding 5-hydroxytryptamine receptor type 3 antagonists may reduce drug-induced nausea in poor insight obsessive-compulsive patients taking off-label doses of selective serotonin reuptake inhibitors: a 52-week follow-up case report

Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study

Affective temperaments are associated with specific clusters of symptoms and psychopathology: a cross-sectional study on bipolar disorder inpatients in acute manic, mixed, or depressive relapse

Agomelatine beyond borders: current evidences of its efficacy in disorders other than major depression

Agomelatine in the treatment of panic disorder ⬇️

Agomelatine reversal of escitalopram-induced apathy: a case report

Agomelatine treatment of major depressive disorder in Parkinson's disease: a case series

Alexithymia and its relationships with acute phase proteins and cytokine release: an updated review

Alexithymia, Suicide Ideation, C-Reactive Protein, and Serum Lipid Levels Among Outpatients with Generalized Anxiety Disorder

Alexithymia, responsibility attitudes and suicide ideation among outpatients with obsessive-compulsive disorder: an exploratory study

Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug naïve patients with post-traumatic stress disorder: an exploratory study in the everyday 'real world' clinical practice

Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment

Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway

An open pilot study of zonisamide augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects.

An update of safety of clinically used atypical antipsychotics

Are atypical depression, borderline personality disorder and bipolar II disorder overlapping manifestations of a common cyclothymic diathesis?

Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report

Aripiprazole for relapse prevention and craving in alcohol use disorder: current evidence and future perspectives

Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placebo-Controlled Clinical Trials

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

Brexpiprazole for treatment-resistant major depressive disorder

Catatonia: a narrative review.

Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials

Choosing the appropriate pharmacotherapy for obsessive-compulsive disorder in adult patients with comorbid anxiety disorders: clinical and nosological considerations

Clinical features associated with early drop-out among outpatients with unipolar and bipolar depression

Clozapine-related pericarditis during titration phase in a patient with resistant schizophrenia and concomitant valproate treatment: a case report

Cognitive functioning and subjective quality of life in relapsing-remitting multiple sclerosis patients before and after percutaneous transluminal angioplasty: a preliminary report

Cognitive tolerability following successful long term treatment of major depression and anxiety disorders with SSRi antidepressants

Comments on: ''Socio-economic factors and suicide rates in European Union countries".

Comparison of familial and non-familial suicidal behaviors among people with major depressive disorder: Testing the discriminative predicting role of high-yield clinical variables

Corrigendum to “Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and “therapeutic sensation seeking” in response towards subjective intolerance to pain” [J. A

Cotard's Syndrome after breast surgery successfully treated with aripiprazole augmentation of escitalopram: a case report

Could the underestimation of bipolarity obstruct the search for novel antidepressant drugs?

Current Nosology of Treatment Resistant Depression: A Controversy Resistant to Revision

Current nosology of treatment resistant depression: a controversy resistant to revision

Diagnosis of co-morbid axis-I psychiatric disorders among women with newly diagnosed, untreated endocrine disorders

Different measures of impulsivity in patients with anxiety disorders: a case control study.

Differentiating between bipolar and unipolar depression in functional and structural MRI studies

Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients

Does Screening for Bipolar Disorders Identify a “Dysregulation of Mood, Energy, and Social Rhythms Syndrome” (DYMERS)? A Heuristic Working Hypothesis

Duloxetine-bupropion combination for treatment-resistant atypical depression: a double-blind, randomized, placebo-controlled trial

Effect of agomelatine treatment on C-reactive protein levels in patients with major depressive disorder: an exploratory study in "real-world," everyday clinical practice.

Efficacy and safety of long acting injectable atypical antipsychotics: a review

Efficacy, safety and tolerability of aripiprazole in bipolar disorder: An updated systematic review and meta-analysis of randomized controlled trials.

Electroretinographic assessment in major depressed patients receiving duloxetine: might differences between responders and non-responders indicate a differential biological background?

Electroretinographic modifications induced by agomelatine: a novel avenue to the understanding of the claimed antidepressant effect of the drug?

Emerging mania following escitalopram withdrawal in a patient with unipolar depression managed with its reintroduction

Emotional Dysregulation in Adolescents: Implications for the Development of Severe Psychiatric Disorders, Substance Abuse, and Suicidal Ideation and Behaviors

Epileptic seizures but not pseudoseizures are associated with decreased density of the serotonin transporter in blood platelet membranes

Factor structure and reliability of the Arabic adaptation of the Hypomania Check List-32, second revision (HCL-32-R2).

Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2).

How can we improve antidepressant adherence in the management of depression? A targeted review and 10 clinical recommendations

How common is bipolar disorder in general primary care attendees? A systematic review and meta-analysis investigating prevalence determined according to structured clinical assessments

Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance

Impulsivity in anxiety disorder patients: is it related to comorbid cyclothymia?

Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression: a systematic review and meta-analysis

Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019

Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation

Inflammatory markers and suicidal attempts in depressed patients: A review

Is there cardiac risk in panic disorder? An updated systematic review

Lifetime co-morbidity with different subtypes of eating disorders in 148 females with bipolar disorders

Lisdexamfetamine in the treatment of moderate-to-severe binge eating disorder in adults: systematic review and exploratory meta-analysis of publicly available placebo-controlled, randomized clinical trials

Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews

Medicine and psychiatry in Western culture: Ancient Greek myths and modern prejudices

Mediterranean Diet and its Benefits on Health and Mental Health: A Literature Review

Might different cytokine trends in depressed patients receiving duloxetine indicate differential biological backgrounds.

NGF serum levels variations in major depressed patients receiving duloxetine

New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine.

Obsessive-compulsive aspects and pathological gambling in an Italian sample

Obsessive-compulsive disorder and related disorders: a comprehensive survey

Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine