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List of works by Andrei Chabes

A common telomeric gene silencing assay is affected by nucleotide metabolism

scientific article published on April 2011

A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.

scientific article published on 16 August 2018

A top-down view on DNA replication and recombination from 9,000 feet above sea level

scientific article published on 27 April 2011

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.

scientific article published on 23 January 2018

Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis

scientific article published on 17 April 2017

Break-induced replication is highly inaccurate

scientific article

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress

scientific article published on 10 October 2017

Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

scientific article

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

scientific article published on 31 March 2015

Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.

scholarly article

Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

scientific article published on June 2000

Corrigendum: Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.

scientific article published on 7 April 2017

DNA building blocks at the foundation of better survival.

scientific article

Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection.

scientific article

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria

scientific article published on 03 October 2019

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants

scientific article

Elimination of rNMPs from mitochondrial DNA has no effect on its stability

scientific article published on 08 June 2020

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

scientific article published on 10 January 2012

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.

scientific article published on 4 September 2008

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

scientific article published on 9 March 2015

Genome instability due to ribonucleotide incorporation into DNA.

scientific article

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.

scientific article published on 24 November 2015

H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly

scientific article

Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

scientific article published on 11 April 2016

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

scientific article published on 9 March 2010

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase

scientific article

Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity

scientific article (publication date: December 2014)

Lesion bypass by S. cerevisiae Pol ζ alone.

scientific article

Molecular basis of the essential s phase function of the rad53 checkpoint kinase

scientific article published on 10 June 2013

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage

scholarly article by Julien Bacal published in November 2018

Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality

scientific article

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer.

scientific article published on May 2015

Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.

scientific article

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance

scientific article published on 17 September 2013

Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

scientific article published on 10 August 2020

Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant

scientific article published on 27 August 2012

Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired.

scientific article published on 6 November 2017

Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.

scientific article

Rnr4p, a novel ribonucleotide reductase small-subunit protein

scientific article

Rtt105 functions as a chaperone for replication protein A to preserve genome stability

scientific article published on 31 July 2018

S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.

scientific article published on 24 November 2015

SAMHD1 acts at stalled replication forks to prevent interferon induction

scientific article published in Nature

Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.

scientific article published on 12 June 2017

Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall

scientific article published on 23 October 2014

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

scientific article

Telomere length homeostasis responds to changes in intracellular dNTP pools

scientific article published on 18 January 2013

Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups

scientific article published on 11 April 2014

The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast

scientific article

The mutation spectrum in genomic late replication domains shapes mammalian GC content

scientific article

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage

scientific article

Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA

scientific article published on 31 January 2013

Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness

scientific article

Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in

scholarly article by Paula M van Mourik published in July 2018

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

scientific article

Yeast Sml1, a protein inhibitor of ribonucleotide reductase.

scientific article

Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit

scientific article

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

scientific article published on 31 March 2015

dNTP pools determine fork progression and origin usage under replication stress

scientific article published on 10 January 2012

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