List of works by Michael W Parker

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

scientific article published on 01 September 2019

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

scientific article

A common channel-forming motif in evolutionarily distant porins.

scientific article

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

scientific article

A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.

scientific article published on 20 December 2016

A homology model for the human theta-class glutathione transferase T1-1.

scientific article

A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications

scientific article

A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore

article

A rivet model for channel formation by aerolysin-like pore-forming toxins

scientific article

A single amino acid substitution can restore the solubility of aggregated colicin A mutants in Escherichia coli

scientific article published on 01 December 1994

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

scientific article published on 20 June 2019

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

scientific article published on 5 May 2014

AMP and adenosine are both ligands for adenosine 2B receptor signaling.

scientific article published on 20 November 2017

AMPK beta subunit targets metabolic stress sensing to glycogen

scientific article

Ab initio calculations on hidden modulators of theta class glutathione transferase activity

scientific article published on 01 May 2000

Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N‑truncated Abeta in sporadic Alzheimer disease cases and mouse models.

scientific article published in November 2015

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

scientific article published on 28 November 2018

Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.

scientific article

Aerolysin--a paradigm for membrane insertion of beta-sheet protein toxins?

scientific article published in January 1998

Aerolysin--the ins and outs of a model channel-forming toxin.

scientific article

Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.

scientific article

Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase

scientific article published on 27 July 2011

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope

scientific article

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

scientific article published on 25 March 2021

An Activation-Specific Platelet Inhibitor That Can Be Turned On/Off by Medically Used Hypothermia

scientific article published on 09 June 2011

An Escherichia coli cell-free system for recombinant protein synthesis on a milligram scale.

scientific article

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin

scientific article published on 02 July 2019

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

scientific article

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin

scientific article

Anxiety over GABA(A) receptor structure relieved by AChBP.

scientific article

Application of molecular dynamics in the crystallographic refinement of colicin A

scientific article published on 01 July 1989

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation

scientific article

Binding and kinetic mechanisms of the Zeta class glutathione transferase

scientific article

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

scientific article published on 19 August 2019

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

scientific article published on 14 December 2015

Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1

scientific article

Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione S-transferases. Investigation of Ser-9 and Tyr-113 in a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.

scientific article published in November 1997

Characterization of pathogenic human monoclonal autoantibodies against GM-CSF.

scientific article published on 25 April 2013

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation

scientific article published on 17 June 2019

Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique

scientific article published in September 2003

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

scientific article published on 25 December 2009

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica

scientific article published on 29 October 2010

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

scientific article

Conformational States of Human Placental Glutathione Transferase as Probed by Limited Proteolysis

scientific article published on 01 July 1993

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407.

scientific article

Conversion of a transmembrane to a water-soluble protein complex by a single point mutation

scientific article published on 01 October 2002

Copper binding to the Alzheimer's disease amyloid precursor protein

scientific article

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

scientific article published in Journal of Biological Chemistry

Cryptic clues as to how water-soluble protein toxins form pores in membranes

scientific article

Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis

scientific article

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

scientific article

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

scientific article published on 26 December 2014

Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity

scientific article

Crystal structure of manganese superoxide dismutase from Bacillus stearothermophilus at 2.4 Å resolution

scientific article published on 01 February 1988

Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site

scientific article

Crystal structure of theLeishmania majorMIX protein: A scaffold protein that mediates protein-protein interactions

scientific article

Crystallization and preliminary X-ray analysis of a bacterial glutathione transferase

scientific article published in January 1996

Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin

scientific article published on 01 November 1996

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate

scientific article published on 14 February 2009

Crystallization and preliminary X-ray analysis of glutathione transferases from cyanobacteria

scientific article published on 24 April 2009

Crystallization and preliminary X-ray analysis of phosphoporin from the outer membrane of Escherichia coli

scientific article published in December 1991

Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin

scientific article published on 23 January 2004

Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2.

scientific article

Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β

scientific article

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

scientific article published on 19 February 2014

Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex

scientific article published on 5 July 2008

Crystallization and preliminary X-ray diffraction analysis of the unliganded human growth hormone receptor

scientific article published on 26 November 2004

Crystallization and preliminary X-ray diffraction studies of a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.

scientific article published in March 1994

Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease

scientific article

Crystallization and preliminary x-ray analysis of the auto-inhibited twitchin kinase

scientific article published on 01 March 1994

Crystallization of a proform of aerolysin, a hole-forming toxin from Aeromonas hydrophila

scientific article published on 01 April 1990

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae

scientific article published on 25 December 2009

Crystallization of glutathione S-transferase from human placenta

scientific article published on 01 May 1990

Crystallization of the glycogen-binding domain of the AMP-activated protein kinase beta subunit and preliminary X-ray analysis

scientific article

Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment

scientific article published on 21 March 2009

Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase

scientific article

Crystallographic phases through genetic engineering: experiences with colicin A

scientific article published on 01 March 1989

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

article

Cytokine receptor activation at the cell surface

scientific article published on 20 April 2012

Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels

scientific article published on 18 July 2005

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

scientific article

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

scientific article

Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition

scientific article

Direct involvement of the TEN domain at the active site of human telomerase

scientific article

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

scientific article

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9.

scientific article published on 28 August 2015

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

scientific article published on 17 July 2019

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

scientific article

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

scientific article published in 2021

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

scientific article published on 09 September 2019

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody

scientific article

EPO does not promote interaction between the erythropoietin and beta-common receptors

scientific article published in Scientific Reports

Elucidation of the substrate binding site of Siah ubiquitin ligase

scientific journal article

Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences

scientific article

Evaluation of the role of two conserved active-site residues in beta class glutathione S-transferases

scientific article published on October 2000

Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency

scientific article published on 7 September 2015

Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

scientific article published on 20 February 2017

Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).

scientific article published on 24 October 2007

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate

scientific article published on 31 January 2009

Federated repositories of X-ray diffraction images

scientific article

Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1

scientific article

From glutathione transferase to pore in a CLIC.

scientific article

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

scientific article (publication date: 2013)

Functional analysis of the evolutionarily conserved proline 53 residue in Proteus mirabilis glutathione transferase B1-1.

scientific article

GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme

scientific article published on 11 March 2002

GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase

scientific article (publication date: November 2001)

Glutamic acid-65 is an essential residue for catalysis in Proteus mirabilis glutathione S-transferase B1-1.

scientific article published on April 2002

Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme.

scientific article

Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme

scientific article published on November 2003

Homology model for the human GSTT2 Theta class glutathione transferase

scientific article

Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

scientific article published on 26 April 2006

Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases

scientific article published on 23 October 2000

Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases.

scientific article

Identification and Characterization of a Misfolded Monomeric Serpin Formed at Physiological Temperature ⬇️

scientific article published on September 17, 2010

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase.

scientific article published on 20 August 2008

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

scientific article

Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming ToxinClostridium perfringensPerfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy†

scientific article published on 01 October 1998

Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens

scientific article

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

scientific article published in June 2008

Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

scientific article

Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP.

scientific article published on 10 August 2007

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

scientific article published in Nature

Insights into autoregulation from the crystal structure of twitchin kinase

scientific article published in Nature

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

scientific article published in June 2005

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin

scientific article

Insights into the structural basis for zinc inhibition of the glycine receptor

scientific article published on 9 May 2003

Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel

scientific article

Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site

scientific article

Iron- and manganese-containing superoxide dismutases can be distinguished by analysis of their primary structures

article

Kinetic properties of missense mutations in patients with glutathione synthetase deficiency

scientific article published in July 2000

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis.

scientific article published on 7 June 2018

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

scientific article published on 27 July 2020

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

scientific article

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9

scientific article

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

scientific article

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

scientific article published on 20 November 2015

Membrane insertion of the pore-forming domain of colicin A. A spectroscopic study

scientific article published on 01 March 1991

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

scientific article published on 21 August 2005

Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34

scientific article published on 08 May 2013

Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies

scientific article

Molecular basis of cytokine receptor activation

scientific article published on July 2010

Molecular basis of glutathione synthetase deficiency and a rare gene permutation event

scientific article

Molecular determinants of common gating of a ClC chloride channel

scientific article published in Nature Communications

Molecular determinants of ginkgolide binding in the glycine receptor pore

scientific article published on 01 July 2006

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

scientific article published in February 2006

Molecular evolution of glutathione S-transferases in the genus Drosophila.

scientific article

Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins

scientific article

Monoubiquitination by the human Fanconi Anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

scientific article published on 13 March 2020

More than one way to make a hole

scientific article published on 01 April 1997

Movement of a Loop in Domain 3 of Aerolysin Is Required for Channel Formation†

scientific article published on 01 January 1998

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme

scientific article published on 20 May 1997

Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus

scientific article published in August 2005

Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.

scientific article

Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo

scientific article

Oncogenic protein interfaces: small molecules, big challenges.

scientific article published on 13 March 2014

Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase

scientific article published in October 2004

PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: in vitro bioactivity, stability and in vivo pharmacokinetics

scientific article published on 19 September 2012

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

scientific article

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

scientific article published on 13 July 2010

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

scientific article

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

scientific article published on 5 April 2013

Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation

scientific journal article

Pore-forming protein toxins: from structure to function

scientific article

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

scientific article

Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.

scientific article published in January 1998

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

scientific article published on 24 February 2020

Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid

scientific article

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

scientific article

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

scientific article

Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1.

scientific article

Protein crystallography in Australia.

scientific article published on December 1995

Protein structure and computational drug discovery

scientific article published on 20 September 2018

Protein structure from x-ray diffraction

scientific article

Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases

scientific article published on December 1999

Protonation of histidine-132 promotes oligomerization of the channel-forming toxin aerolysin.

scientific article

Purification, crystallisation and preliminary X-ray diffraction characterisation of methanol dehydrogenase from Methylosinus trichosporium OB3b.

scientific article

Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.

scientific article published on 28 June 2008

Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.

scientific article

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins

scientific article

Rational design of an organometallic glutathione transferase inhibitor

scientific article

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations

scientific article published on 12 November 2018

Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.

scientific article published on 24 April 2010

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

scientific article published on 9 March 2011

Repurposing of drugs as STAT3 inhibitors for cancer therapy

scientific article published on 08 November 2019

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth

scientific article published on 01 April 2019

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

scientific article published in 2021

Role of the β Common (βc) Family of Cytokines in Health and Disease

scientific article

Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae

article

Shifting Substrate Specificity of Human Glutathione Transferase (from Class Pi to Class Alpha) by a Single Point Mutation

scientific article published on 01 November 1998

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

scientific article

Signalling by the βc family of cytokines

scientific article published on 25 March 2013

Site-directed mutagenesis of theProteus mirabilisglutathione transferase B1-1 G-site

scientific article published on 01 February 1998

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

scientific article published on 19 July 2019

Small molecule proprotein convertase inhibitors for inhibition of embryo implantation

scientific article (publication date: 2013)

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

article

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

article

Solution Structure of Glutathione Bound to Human Glutathione Transferase P1-1: Comparison of NMR Measurements with the Crystal Structure†

scientific article published on 01 March 1998

Structural Basis for Antibody Discrimination between Two Hormones That Recognize the Parathyroid Hormone Receptor

scientific article

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

scientific article

Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target

scientific article published on 11 July 2016

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

scientific article published on 7 April 2018

Structural approaches to probing metal interaction with proteins

scientific article published on 03 March 2012

Structural basis for glycogen recognition by AMP-activated protein kinase

scientific article

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

scientific article published on 8 March 2016

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay

scientific article published in July 2003

Structural identity between the iron- and manganese-containing superoxide dismutases

scientific article published on 01 October 1987

Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration

scientific article

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

scientific article

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen

scientific article

Structure and function of glutathione S-transferases.

scientific article

Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution

scientific article

Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states

scientific article

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

scientific article (publication date: 9 May 2003)

Structure of the Janus protein human CLIC2

scientific article

Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity

scientific article

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

scientific article published on 3 December 2014

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins

scientific article

Structures of thermolabile mutants of human glutathione transferase P1-1

scientific article

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

scientific article published on 16 June 2011

Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering.

scientific article published in November 1999

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

scientific article published on 24 May 2018

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

scientific article

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

scientific article published on 7 February 2014

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

scientific article

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription.

scientific article published on 17 June 2013

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment.

scientific article published on 20 October 2017

Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies.

scientific article

The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements

scientific article published on 18 February 2016

The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.

scientific article

The GM-CSF receptor family: mechanism of activation and implications for disease

scientific article published on 18 January 2012

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

scientific article

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

scientific article published on 01 October 1999

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

scientific article published on 23 April 2019

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants

scientific article

The extended catalysis of glutathione transferase

scientific article published on 14 December 2010

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease

scientific article published on 09 November 2018

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes

scientific article published in December 1997

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

scientific article published on 12 May 2009

The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin

scientific article

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force

scientific article published on 03 July 2013

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

scientific article

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

scientific article published on 12 September 2018

The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.

scientific article

The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum

scientific article published on 29 February 2008

The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.

scientific article published in September 2014

The role of electrostatic charge in the membrane insertion of colicin A. Calculation and mutation.

scientific article

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

scientific article

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

scientific article published on 05 August 2019

The βc receptor family - Structural insights and their functional implications

scientific article published on 14 May 2015

Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione

scientific article

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2

scientific article

Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

article

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

scientific article published on 23 January 2017

Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition

scientific article published on December 2006

Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae.

scientific article published on May 1999

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.

scientific article

Valine 10 May Act as a Driver for Product Release from the Active Site of Human Glutathione Transferase P1-1

scientific article published on 01 December 2000

Vibrio spp. secrete proaerolysin as a folded dimer without the need for disulphide bond formation.

scientific article

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