List of works - Matthew Perugini

A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway

scientific article

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

scientific article

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

scientific article published on 7 March 2012

A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.

scientific article

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

scientific article published on 21 May 2015

A new robust kinetic assay for DAP epimerase activity

scientific article published on 6 July 2013

A partially structured region of a largely unstructured protein, Plasmodium falciparum merozoite surface protein 2 (MSP2), forms amyloid-like fibrils

scientific article published in December 2007

A synthetic peptide that inhibits lipoprotein(a) assembly.

scientific article

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.

scientific article

Age-related differences in plasma proteins: how plasma proteins change from neonates to adults

scientific article

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

scientific article published on 28 December 2016

An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization

scientific article published on 10 December 2020

An optimized coupled assay for quantifying diaminopimelate decarboxylase activity

scientific article

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

scientific article published on 21 May 2009

Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology.

scientific article

Bicarbonate-mediated stimulation of RegA, the global virulence regulator from Citrobacter rodentium

scientific article published on 21 October 2009

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13

scientific article published on 01 March 2006

Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria

scientific article

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

scientific article published on 16 June 2011

Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.

scientific article published on 10 July 2009

Characterisation of the First Enzymes Committed to Lysine Biosynthesis in Arabidopsis thaliana

scientific article

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

scientific article published in March 2011

Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization

scientific article

Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum

scientific article published on 09 May 2018

Cloning to crystallization of dihydrodipicolinate synthase from the intracellular pathogen Legionella pneumophila

scientific article published on 30 September 2013

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

scientific article published on 25 December 2009

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens

scientific article published on 30 August 2012

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera

scientific article published on 25 November 2011

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica

scientific article published on 29 October 2010

Comparative structure and function analyses of native and his-tagged forms of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

scientific article published on 06 July 2012

Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae

scientific article published on 11 January 2018

Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase

scientific article

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

scientific article published in July 2001

Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis

scientific article

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

scientific article

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins.

scientific article published on 12 March 2018

Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species

scientific article

Crystal structure of theLeishmania majorMIX protein: A scaffold protein that mediates protein-protein interactions

scientific article

Crystal, Solution and In silico Structural Studies of Dihydrodipicolinate Synthase from the Common Grapevine

scientific article

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate

scientific article published on 14 February 2009

Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli

scientific article published on 25 December 2009

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae

scientific article published on 25 December 2009

Defining the interaction of perforin with calcium and the phospholipid membrane

scientific article

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.

scientific article published on 25 July 2010

Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions

scientific article published in December 2002

Dihydrodipicolinate synthase from Thermotoga maritima.

scientific article published on December 2006

Dihydrodipicolinate synthase is absent in fungi

scientific article published on 27 June 2018

Dimerization of Bacterial Diaminopimelate Decarboxylase Is Essential for Catalysis

scientific article

Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis

scientific article

Dimerization of Plant Defensin NaD1 Enhances Its Antifungal Activity

scientific article

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

scientific article

Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.

scientific article published on 13 August 2010

Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus

scientific article published on 21 November 2013

Dynamic Modelling Reveals 'Hotspots' on the Pathway to Enzyme-Substrate Complex Formation

scientific article

Electron capture dissociation of complexes of diacylglycerophosphocholine and divalent metal ions: competition between charge reduction and radical induced phospholipid fragmentation.

scientific article published on 26 March 2008

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

scientific article

Evolution of quaternary structure in a homotetrameric enzyme

scientific article

Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?

scientific article published on 15 November 2009

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate

scientific article published on 31 January 2009

Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin

scientific article published in July 2005

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

scientific article (publication date: 2013)

High density lipoproteins bind Aβ and apolipoprotein C-II amyloid fibrils

article

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

scientific article published on 01 February 2017

Identification of a dimeric KDG aldolase from Agrobacterium tumefaciens

scientific article published on 27 July 2017

Identification of the bona fide DHDPS from a common plant pathogen

scientific journal article

Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation

scientific article published on 05 August 2019

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

scientific journal article

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

scientific article published on February 2007

Inhibition of lysine biosynthesis: an evolving antibiotic strategy

scientific article

Insight into the self-association of key enzymes from pathogenic species.

scientific article

Integrated activities of two alternative sigma factors coordinate iron acquisition and uptake by Pseudomonas aeruginosa

scientific article

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues

scientific article

Letter: collision-induced dissociation of [metal(L)(2)](2+) complexes (metal = Cu, Ca and Mg) of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine allows distinction of the acyl groups at the sn1 and sn2 positions

scientific article published in January 2007

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.

scientific article published on 30 November 2016

Methods for sample labeling and meniscus determination in the fluorescence-detected analytical ultracentrifuge

scientific article

Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1

scientific article

Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens

scientific article published on 13 January 2020

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

scientific article published on 17 January 2020

Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis

scientific article published on 5 December 2017

Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme

scientific article

New method for purifying histidine-rich glycoprotein from human plasma redefines its functional properties

scientific article

Non-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils

scientific article published on 18 March 2004

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

scientific article published on 10 September 2009

Phospholipid interaction induces molecular-level polymorphism in apolipoprotein C-II amyloid fibrils via alternative assembly pathways.

scientific article published on 22 October 2007

Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP

scientific article published on 06 November 2020

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

scientific article

Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.

scientific article published on 28 June 2008

Quaternary Structure Analyses of an Essential Oligomeric Enzyme

scientific article published on 13 August 2015

Review: Amino Acid Biosynthesis as a Target for Herbicide Development

scientific article published on 07 June 2020

Ribosome-inactivating proteins: current status and biomedical applications

scientific article published on 30 March 2012

Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity

scientific article published on 6 November 2017

Self-assembly of peptides into spherical nanoparticles for delivery of hydrophilic moieties to the cytosol

scientific article published on May 2010

Self-association of Human Apolipoprotein E3 and E4 in the Presence and Absence of Phospholipid

scientific article published in Journal of Biological Chemistry

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications

Size matters! Fragmentation chemistry of [Cu(L)n]2+ complexes of diacylglycerophosphocholines as a function of coordination number (n = 2-7).

scientific article published in January 2007

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

scientific article (publication date: February 2002)

Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2.

scientific article published on 28 March 2008

Sources of artefacts in the electrospray ionization mass spectra of saturated diacylglycerophosphocholines: from condensed phase hydrolysis reactions through to gas phase intercluster reactions

scientific article published on 27 January 2006

Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis

scientific article

Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target

scientific article published on 11 July 2016

Structural and functional characterization of TesB from Yersinia pestis reveals a unique octameric arrangement of hotdog domains

scientific article

Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E

scientific article

Structural features of apolipoprotein B synthetic peptides that inhibit lipoprotein(a) assembly

scientific article published on 16 September 2004

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

scientific article published on 09 January 2019

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition

scientific article

Structure and Function of Cyanobacterial DHDPS and DHDPR

scientific article

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen

scientific article

Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms

scientific article published on 12 August 2006

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

scientific article published on 24 May 2018

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

scientific article

Targeting of a natural killer cell receptor family by a viral immunoevasin

scientific article

The 2.1A crystal structure of the far-red fluorescent protein HcRed: inherent conformational flexibility of the chromophore

scientific article published on 22 March 2005

The BECN1 N-terminal domain is intrinsically disordered

scientific article published on March 2016

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity.

scientific article published on 4 July 2018

The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping

scientific article

The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis

scientific article

The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum

scientific article (publication date: 12 September 2014)

The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)

scientific article published on 21 August 2020

The purification of the σFpvI/FpvR20 and σPvdS/FpvR20 protein complexes is facilitated at room temperature

scientific article published on 13 March 2019

The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum

scientific article published on 29 February 2008

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

scientific article published on 14 October 2010

The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4.

scientific article

The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers

scientific article

Trifluoroethanol induces the self-association of specific amphipathic peptides

article

Ultramarine, a chromoprotein acceptor for Förster resonance energy transfer

scientific article (publication date: 2012)

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

scientific article

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP

scientific article

i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.

scientific article

List of works by Matthew Perugini

A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

A new robust kinetic assay for DAP epimerase activity

A partially structured region of a largely unstructured protein, Plasmodium falciparum merozoite surface protein 2 (MSP2), forms amyloid-like fibrils

A synthetic peptide that inhibits lipoprotein(a) assembly.

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.

Age-related differences in plasma proteins: how plasma proteins change from neonates to adults

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization

An optimized coupled assay for quantifying diaminopimelate decarboxylase activity

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology.

Bicarbonate-mediated stimulation of RegA, the global virulence regulator from Citrobacter rodentium

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13

Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.

Characterisation of the First Enzymes Committed to Lysine Biosynthesis in Arabidopsis thaliana

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization

Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum

Cloning to crystallization of dihydrodipicolinate synthase from the intracellular pathogen Legionella pneumophila

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica

Comparative structure and function analyses of native and his-tagged forms of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae

Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins.

Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species

Crystal structure of theLeishmania majorMIX protein: A scaffold protein that mediates protein-protein interactions

Crystal, Solution and In silico Structural Studies of Dihydrodipicolinate Synthase from the Common Grapevine

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate

Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae

Defining the interaction of perforin with calcium and the phospholipid membrane

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.

Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions

Dihydrodipicolinate synthase from Thermotoga maritima.

Dihydrodipicolinate synthase is absent in fungi

Dimerization of Bacterial Diaminopimelate Decarboxylase Is Essential for Catalysis

Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis

Dimerization of Plant Defensin NaD1 Enhances Its Antifungal Activity

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.

Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus

Dynamic Modelling Reveals 'Hotspots' on the Pathway to Enzyme-Substrate Complex Formation

Electron capture dissociation of complexes of diacylglycerophosphocholine and divalent metal ions: competition between charge reduction and radical induced phospholipid fragmentation.

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

Evolution of quaternary structure in a homotetrameric enzyme

Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate

Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

High density lipoproteins bind Aβ and apolipoprotein C-II amyloid fibrils

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Identification of a dimeric KDG aldolase from Agrobacterium tumefaciens

Identification of the bona fide DHDPS from a common plant pathogen

Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

Inhibition of lysine biosynthesis: an evolving antibiotic strategy

Insight into the self-association of key enzymes from pathogenic species.

Integrated activities of two alternative sigma factors coordinate iron acquisition and uptake by Pseudomonas aeruginosa

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues

Letter: collision-induced dissociation of [metal(L)(2)](2+) complexes (metal = Cu, Ca and Mg) of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine allows distinction of the acyl groups at the sn1 and sn2 positions

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.

Methods for sample labeling and meniscus determination in the fluorescence-detected analytical ultracentrifuge

Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1

Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis