List of works - Deborah V Novack

A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells.

scientific article published on 21 May 2015

A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function

scientific article

A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy

scientific article

Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure

article

Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice

scientific article published on 18 March 2008

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms

scientific article published on 20 June 2015

Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation

scientific article published on 26 December 2012

Antagonizing Integrin β3 Increases Immunosuppression in Cancer

scientific article published on 23 May 2016

Are we overtreating papillomas diagnosed on core needle biopsy?

scientific article

Bcl-2 gene family and the regulation of programmed cell death

scientific article

Bcl-2 protein expression during murine development

scientific journal article

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

scientific journal article

Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice

scientific article published on 8 March 2004

Bisphosphonate-associated femoral fracture: implications for management in patients with malignancies

scientific article published on 11 August 2009

Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases

scientific article published in October 2008

Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis

scientific article

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

scientific article published on 26 July 2017

Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series.

scientific article published on 23 June 2009

Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases

scientific article published on 30 August 2017

Breast cancer–derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment

scientific article published in 2021

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption

scientific article

Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9.

scientific article published on 30 December 2015

Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice

scientific article

Creation and preliminary characterization of a leptin knockout rat.

scientific article

Critical role of beta3 integrin in experimental postmenopausal osteoporosis

scientific article published on 25 July 2005

Damaging fatigue loading stimulates increases in periosteal vascularity at sites of bone formation in the rat ulna

scientific article published on 06 June 2007

Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.

scientific article

Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA

scientific article published on 29 August 2019

Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts

scientific article

Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.

scientific article published on 14 October 2013

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin

scientific article

Dysosteosclerosis presents as an "osteoclast-poor" form of osteopetrosis: comprehensive investigation of a 3-year-old girl and literature review.

scientific article

Editorial: Inflammatory Osteoclasts: A Different Breed of Bone Eaters?

scientific article

Estrogen and bone: osteoclasts take center stage.

scientific article

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha

scientific article

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

scientific article

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy

scientific article

Germinal center B-cells resist transformation by Kras independently of tumor suppressor Arf

scientific article

Hypermineralized whale rostrum as the exemplar for bone mineral

scientific article (publication date: 2013)

Idiopathic Acquired Osteosclerosis in a Middle-Aged Woman With Systemic Lupus Erythematosus

scientific article

Immunohistochemistry of Skeletal Tissues

scientific article published on 01 January 2015

Inflammasomes in Bone Diseases

scientific article published on 01 January 2018

Inflammatory osteolysis: a conspiracy against bone

scientific article published on June 2017

Inhibition of CaMKK2 reverses age-associated decline in bone mass

scientific article published on 25 February 2015

Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation

scientific article published on July 2013

Juvenile Paget's disease with heterozygous duplication within TNFRSF11A encoding RANK

scientific article

M-CSF mediates TNF-induced inflammatory osteolysis

scientific article

Manifestations in a family with autosomal dominant bone fragility and limb-girdle myopathy.

scientific article

Mapping autosomal dominant progressive limb-girdle myopathy with bone fragility to chromosome 9p21-p22: a novel locus for a musculoskeletal syndrome.

scientific article published on 22 October 2005

Marrow Stromal Cells and Osteoclast Precursors Differentially Contribute to TNF- -Induced Osteoclastogenesis In Vivo

scientific article published on 01 October 2004

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

scientific article

Multitasking by the OC Lineage during Bone Infection: Bone Resorption, Immune Modulation, and Microbial Niche

scientific article published on 24 September 2020

NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

scientific article

NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.

scientific article

NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis

scientific article

NLRP12 provides a critical checkpoint for osteoclast differentiation

scientific article

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms

scientific article

Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65).

scientific article published on 14 July 2015

Novel ERα positive breast cancer model with estrogen independent growth in the bone microenvironment.

scientific article published on 06 July 2016

Osteoclast motility: putting the brakes on bone resorption.

scientific article

Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption.

scientific article published on 20 June 2016

Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice.

scientific article published on 10 June 2013

Osteoclasts-Key Players in Skeletal Health and Disease

scientific article published on June 2016

Ovariectomy Activates Chronic Low-Grade Inflammation Mediated by Memory T Cells, Which Promotes Osteoporosis in Mice

scientific article published on 29 January 2020

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

scientific article published on 19 October 2006

Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts

scientific article published on 9 August 2007

Photoacoustic microscopy enables multilayered histological imaging of human breast cancer without staining

scientific article published on 19 February 2018

Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts

scientific article

Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells

scientific article published on 06 August 2020

Rapid skeletal turnover in a radiographic mimic of osteopetrosis.

scientific article

Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family

scientific article

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

scientific article published on June 2008

RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation

scholarly article

Reply: Response to: Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis Might Be Secondary to Systemic Mastocytosis

scientific article published on 10 June 2015

Response to: A Rapid Skeletal Turnover in Radiographic Mimic of Osteopetrosis Might Be Secondary to Systemic Mastocytosis

article

Role of NF-κB in the skeleton ⬇️

scientific article published on November 16, 2010

Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner.

scientific article

Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly

scientific article published on 15 October 2019

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

scientific article

Suppressed Bone Turnover during Alendronate Therapy for High-Turnover Osteoporosis

scientific article published on 01 November 2006

TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling

scientific article published on 8 February 2018

TSH, The Bone Suppressing Hormone

scientific article published on 01 October 2003

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling

scientific article

The FOX(O1) blasts off.

scientific article published in March 2010

The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis

scientific article

The osteoclast: friend or foe?

scientific article published on January 2008

The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+-NFATC1 axis

scientific article published on 12 March 2020

Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts

scientific article

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass

scientific journal article

Unique personalities within the NF-κB family: distinct functions for p65 and RelB in the osteoclast.

scientific article published in January 2011

p38MAPK plays a crucial role in stromal-mediated tumorigenesis

scientific article

List of works by Deborah V Novack

A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells.

A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function

A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy

Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure

Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms

Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation

Antagonizing Integrin β3 Increases Immunosuppression in Cancer

Are we overtreating papillomas diagnosed on core needle biopsy?

Bcl-2 gene family and the regulation of programmed cell death

Bcl-2 protein expression during murine development

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice

Bisphosphonate-associated femoral fracture: implications for management in patients with malignancies

Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases

Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series.

Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases

Breast cancer–derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption

Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9.

Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice

Creation and preliminary characterization of a leptin knockout rat.

Critical role of beta3 integrin in experimental postmenopausal osteoporosis

Damaging fatigue loading stimulates increases in periosteal vascularity at sites of bone formation in the rat ulna

Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.

Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA

Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts

Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin

Dysosteosclerosis presents as an "osteoclast-poor" form of osteopetrosis: comprehensive investigation of a 3-year-old girl and literature review.

Editorial: Inflammatory Osteoclasts: A Different Breed of Bone Eaters?

Estrogen and bone: osteoclasts take center stage.

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy

Germinal center B-cells resist transformation by Kras independently of tumor suppressor Arf

Hypermineralized whale rostrum as the exemplar for bone mineral

Idiopathic Acquired Osteosclerosis in a Middle-Aged Woman With Systemic Lupus Erythematosus

Immunohistochemistry of Skeletal Tissues

Inflammasomes in Bone Diseases

Inflammatory osteolysis: a conspiracy against bone

Inhibition of CaMKK2 reverses age-associated decline in bone mass

Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation

Juvenile Paget's disease with heterozygous duplication within TNFRSF11A encoding RANK

M-CSF mediates TNF-induced inflammatory osteolysis

Manifestations in a family with autosomal dominant bone fragility and limb-girdle myopathy.

Mapping autosomal dominant progressive limb-girdle myopathy with bone fragility to chromosome 9p21-p22: a novel locus for a musculoskeletal syndrome.

Marrow Stromal Cells and Osteoclast Precursors Differentially Contribute to TNF- -Induced Osteoclastogenesis In Vivo

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

Multitasking by the OC Lineage during Bone Infection: Bone Resorption, Immune Modulation, and Microbial Niche

NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.

NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis

NLRP12 provides a critical checkpoint for osteoclast differentiation

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms

Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65).

Novel ERα positive breast cancer model with estrogen independent growth in the bone microenvironment.

Osteoclast motility: putting the brakes on bone resorption.

Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption.

Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice.

Osteoclasts-Key Players in Skeletal Health and Disease

Ovariectomy Activates Chronic Low-Grade Inflammation Mediated by Memory T Cells, Which Promotes Osteoporosis in Mice

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts

Photoacoustic microscopy enables multilayered histological imaging of human breast cancer without staining

Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts

Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells

Rapid skeletal turnover in a radiographic mimic of osteopetrosis.

Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation

Reply: Response to: Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis Might Be Secondary to Systemic Mastocytosis

Response to: A Rapid Skeletal Turnover in Radiographic Mimic of Osteopetrosis Might Be Secondary to Systemic Mastocytosis

Role of NF-κB in the skeleton ⬇️

Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner.

Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.