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List of works by Henrik J. Ditzel

A cell-penetrating peptide from a novel pVII-pIX phage-displayed random peptide library.

scientific article published in December 2002

A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide.

scientific article

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

scientific article published on 06 November 2019

A human single-chain antibody specific for integrin alpha3beta1 capable of cell internalization and delivery of antitumor agents.

scientific article

A method for blocking antigen-independent binding of human IgM to frozen tissue sections when screening human hybridoma antibodies

scientific article published on 01 October 1990

ARAP1 is an independent prognostic biomarker in older women with ovarian high-grade serous adenocarcinoma receiving first-line platinum-based antineoplastic therapy

scientific article published on 03 September 2019

Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways

scientific article

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells.

scientific article published on 6 March 2018

Advantages of multiple clinical tests for determining the optimum treatment strategy for ER-positive breast cancer

scientific article published on 27 May 2008

Affinity isolation of antigen-specific circulating B cells for generation of phage display-derived human monoclonal antibodies

scientific article published in January 2009

Alterations in circulating miRNA levels following early-stage estrogen receptor-positive breast cancer resection in post-menopausal women.

scientific article

Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma

scientific article

Analytical variables influencing the performance of a miRNA based laboratory assay for prediction of relapse in stage I non-small cell lung cancer (NSCLC).

scientific article

Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells

scientific article published on 16 September 2013

Antibodies in human infectious disease.

scientific article

Antigens recognized by two human monoclonal IgM anticolon cancer antibodies, 16.88 and C-OU1 (B9165)

scientific article published on 01 October 1991

Application of proteomics in the study of rodent models of cancer.

scientific article published on 25 June 2014

Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis

scientific article published in February 2004

Association of tissue inhibitor of metalloproteinases-1 and Ki67 in estrogen receptor positive breast cancer

scientific article published on 4 December 2012

Autoantibodies against C1q in systemic lupus erythematosus are antigen-driven

scientific article

Autoantibodies to GPI are predominantly present in extra-articular complications of human rheumatoid arthritis

scholarly article by FA van Gaalen et al published 24 February 2003 in Arthritis Research and Therapy

Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease

scientific article published in August 2001

CYP19A1 polymorphisms and clinical outcomes in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial

scientific article published on 3 May 2015

CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial

scientific article published on 6 March 2012

CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients

scientific article published on 07 November 2018

Cancer-associated cleavage of cytokeratin 8/18 heterotypic complexes exposes a neoepitope in human adenocarcinomas

scientific article

Characterization of a human-human hybridoma antibody, C-OU1, directed against a colon tumor-associated antigen

scientific article published on April 1992

Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence.

scientific article

Cloning and expression of a novel human antibody-antigen pair associated with Felty's syndrome.

scientific article published on August 2000

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.

scientific article

Combined FGFR and Akt pathway inhibition abrogates growth of FGFR1 overexpressing EGFR-TKI-resistant NSCLC cells

scientific article published on 15 July 2021

Concise review: Signaling pathways essential for triple-negative breast cancer stem-like cells

scientific article published on 19 November 2020

Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer

scientific article published on 4 September 2017

Correlation between circulating cell-free PIK3CA tumor DNA levels and treatment response in patients with PIK3CA-mutated metastatic breast cancer.

scientific article published on 4 May 2018

Corrigendum: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.

scientific article

De novo pathway-based biomarker identification.

scientific article published in September 2017

Decorin is down-regulated in multiple myeloma and MGUS bone marrow plasma and inhibits HGF-induced myeloma plasma cell viability and migration

scientific article published on 7 July 2013

Detecting Plasma Tumor DNA in Early-Stage Breast Cancer--Letter

scientific article published on 01 August 2015

Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection.

scientific article published on July 1996

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

scientific article published on 27 February 2016

Discriminating isogenic cancer cells and identifying altered unsaturated fatty acid content as associated with metastasis status, using k-means clustering and partial least squares-discriminant analysis of Raman maps

scientific article

Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display

scientific article

Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation.

scientific article published on 8 July 2008

Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors.

scientific article

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

scientific article published on 18 November 2020

Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability.

scientific article

Efficient isolation and quantitative proteomic analysis of cancer cell plasma membrane proteins for identification of metastasis-associated cell surface markers.

scientific article published on June 2009

Elucidation of Altered Pathways in Tumor-Initiating Cells of Triple-Negative Breast Cancer: A Useful Cell Model System for Drug Screening

scientific article published on 10 June 2017

Elucidation of epithelial-mesenchymal transition-related pathways in a triple-negative breast cancer cell line model by multi-omics interactome analysis.

scientific article published on November 2014

Epigenetic Reprogramming of Pericentromeric Satellite DNA in Premalignant and Malignant Lesions.

scientific article published on 12 January 2018

Epigenetic modulation of cancer-germline antigen gene expression in tumorigenic human mesenchymal stem cells: implications for cancer therapy

scientific article published on 4 June 2009

Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.

scientific article published in June 2019

Evaluation of procedures for the fixation and processing of human tissue for immunohistochemical analysis of human monoclonal antibodies

scientific article published on 01 July 1991

Evaluation of the ability of adjuvant tamoxifen-benefit gene signatures to predict outcome of hormone-naive estrogen receptor-positive breast cancer patients treated with tamoxifen in the advanced setting.

scientific article published on 10 July 2014

Exome sequencing identifies somatic point mutations associated with acquired endocrine resistance in breast cancer cell lines

scientific article

Expression of osteoblast and osteoclast regulatory genes in the bone marrow microenvironment in multiple myeloma: only up-regulation of Wnt inhibitors SFRP3 and DKK1 is associated with lytic bone disease.

scientific article published on 5 August 2013

Expression, purification and characterization of the cancer-germline antigen GAGE12I: a candidate for cancer immunotherapy

scientific article published on 27 May 2010

Functional Heterogeneity within the CD44 High Human Breast Cancer Stem Cell-Like Compartment Reveals a Gene Signature Predictive of Distant Metastasis ⬇️

scientific article published on September 25, 2012

Fyn is an important molecule in cancer pathogenesis and drug resistance.

scientific article published on 21 August 2015

GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL).

scientific article

Gene expression alterations associated with outcome in aromatase inhibitor-treated ER+ early-stage breast cancer patients

scientific article published on 19 November 2015

Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy.

scientific article

Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study

scientific article

Global microRNA expression profiling of high-risk ER+ breast cancers from patients receiving adjuvant tamoxifen mono-therapy: a DBCG study

scientific article (publication date: 2012)

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.

scientific article published on 03 February 2016

Hepatocyte growth factor pathway upregulation in the bone marrow microenvironment in multiple myeloma is associated with lytic bone disease.

scientific article published on 22 February 2013

High CDK6 Protects Cells from Fulvestrant-Mediated Apoptosis and is a Predictor of Resistance to Fulvestrant in Estrogen Receptor-Positive Metastatic Breast Cancer

scientific article

Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery

scientific article published on 29 June 2017

Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers

scientific article published in PLoS ONE

Human antibodies in cancer and autoimmune disease.

scientific article

Human monoclonal Fab fragments specific for viral antigens from combinatorial IgA libraries ⬇️

scientific article published on May 1, 1995

Human-human hybridoma producing monoclonal antibodies against colorectal cancer-associated antigens

scientific article published on 01 August 1990

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.

scientific article

Identification of genes for normalization of real-time RT-PCR data in breast carcinomas

scientific article

Identification of genes with altered expression in medullary breast cancer vs. ductal breast cancer and normal breast epithelia.

scientific article published on June 2006

Identification of talin head domain as an immunodominant epitope of the antiplatelet antibody response in patients with HIV-1-associated thrombocytopenia.

scientific article published on 17 August 2004

Identification of the specificity of isolated phage display single-chain antibodies using yeast two-hybrid screens

scientific article published in January 2009

Immunohistochemical analysis of the binding of human IgM to secretory component present in normal adult colon epithelia, but not in colon cancer and fetal colon epithelia

scientific article published on 01 January 1990

Immunoscintigraphy of colon cancers with the human monoclonal antibody COU-1.

scientific article published on February 1994

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

scientific article published on 01 June 2019

Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties

scientific article

Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer

scientific article (publication date: 30 August 2016)

Intratumor genetic heterogeneity of breast carcinomas as determined by fine needle aspiration and TaqMan low density array.

scientific article

KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer

scientific article published on 28 September 2018

Keratin 34betaE12/keratin7 expression is a prognostic factor of cancer-specific and overall survival in patients with early stage non-small cell lung cancer

scientific article published on 9 June 2015

KeyPathwayMiner 4.0: condition-specific pathway analysis by combining multiple omics studies and networks with Cytoscape.

scientific article

KeyPathwayMinerWeb: online multi-omics network enrichment.

scientific article published on 5 May 2016

Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.

scientific article published on 7 August 2015

Limited SP17 expression within tumors diminishes its therapeutic potential ⬇️

scientific article published on 01 December 2012

Lipids, curvature stress, and the action of lipid prodrugs: free fatty acids and lysolipid enhancement of drug transport across liposomal membranes

scientific article published on 03 August 2011

MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development

scientific article published on 5 January 2007

MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

scientific article published on 04 January 2021

Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry.

scientific article published on 24 March 2009

Modified cytokeratins expressed on the surface of carcinoma cells undergo endocytosis upon binding of human monoclonal antibody and its recombinant Fab fragment.

scientific article

Molecular analysis of the human autoantibody response to alpha-fodrin in Sjögren's syndrome reveals novel apoptosis-induced specificity.

scientific article

Molecular characterization of the circulating anti-HIV-1 gp120-specific B cell repertoire using antibody phage display libraries generated from pre-selected HIV-1 gp120 binding PBLs.

scientific article

Myeloma plasma cell expression of osteoblast regulatory genes: overexpression of SFRP3 correlates with clinical bone involvement at diagnosis

scientific article published on 7 August 2012

NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer

scientific article

Neutralization of Human Immunodeficiency Virus Type 1 by Antibody to gp120 Is Determined Primarily by Occupancy of Sites on the Virion Irrespective of Epitope Specificity ⬇️

scientific article published on May 1, 1998

Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure.

scientific article published on January 1995

Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: a case control study.

scientific article

On the performance of de novo pathway enrichment.

scientific article

Oncogenic cancer/testis antigens: prime candidates for immunotherapy.

scientific article published on June 2015

One-step FPLC-size-exclusion chromatography procedure for purification of rDMBT1 6 kb with increased biological activity

scientific article published on 20 November 2017

Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness

scientific article published on 14 March 2020

Patients with inflammatory arthritic diseases harbor elevated serum and synovial fluid levels of free and immune-complexed glucose-6-phosphate isomerase (G6PI)

scientific article published on 24 August 2006

Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78.

scientific article

Pilot scale purification of human monoclonal IgM (COU-1) for clinical trials

scientific article published on 01 June 1997

Preparation of antigen-binding monomeric and half-monomeric fragments from human monoclonal IgM antibodies against colorectal cancer-associated antigens

scientific article published on 01 April 1993

Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography.

scientific article

Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site.

scientific article published on June 1995

Quantitative proteomics reveals novel proteins and central pathways associated with endocrine resistance in breast cancer.

scientific article published on 16 November 2011

Raised levels of anti-glucose-6-phosphate isomerase IgG in serum and synovial fluid from patients with inflammatory arthritis.

scientific article published on 30 September 2004

Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins

scientific article published on 01 July 2019

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

scientific article published on 07 February 2020

Robust de novo pathway enrichment with KeyPathwayMiner 5.

scientific article published on 28 June 2016

S100A14 is a novel independent prognostic biomarker in the triple-negative breast cancer subtype.

scientific article published on 24 April 2015

SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer.

scientific article published on 19 June 2018

SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression.

scientific article published on 23 September 2014

SSX2-4 expression in early-stage non-small cell lung cancer

scientific article published on 20 March 2014

Scanning the cell surface proteome of cancer cells and identification of metastasis-associated proteins using a subtractive immunization strategy.

scientific article published on November 2009

Selection of LNA-containing DNA aptamers against recombinant human CD73.

scientific article published on May 2015

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Simian Immunodeficiency Virus (SIV) Envelope-Specific Fabs with High-Level Homologous Neutralizing Activity: Recovery from a Long-Term-Nonprogressor SIV-Infected Macaque ⬇️

scientific article published on January 1, 1998

Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non–Small Cell Lung Cancer

scientific article published on 13 February 2015

Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes

scientific article published on 16 July 2021

TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression.

scientific article

The Genomic Grade Assay Compared With Ki67 to Determine Risk of Distant Breast Cancer Recurrence

scientific article published on 03 December 2015

The K/BxN mouse: a model of human inflammatory arthritis.

scientific article published on January 2004

The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2.

scientific article published on January 1999

The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer

scientific article published on 16 November 2011

The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.

scientific article published in July 2012

The potential of Src inhibitors

scientific article published on 2 October 2015

The role of GAGE cancer/testis antigen in metastasis: the jury is still out

scientific article published on 8 January 2016

The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells.

scientific article

The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells.

scientific article

Tissue microarrays in non-small-cell lung cancer: reliability of immunohistochemically-determined biomarkers

scientific article published on 21 November 2013

Translocation of an intracellular antigen to the surface of medullary breast cancer cells early in apoptosis allows for an antigen-driven antibody response elicited by tumor-infiltrating B cells

article

Tumor detection with 131I-labeled human monoclonal antibody COU-1 in patients with suspected colorectal carcinoma

scientific article published on 01 December 1993

Tumor-selective replication herpes simplex virus-based technology significantly improves clinical detection and prognostication of viable circulating tumor cells.

scientific article published on 18 May 2016

Tumour localization and pharmacokinetics of iodine-125 human monoclonal IgM antibody (COU-1) and its monomeric and half-monomeric fragments analysed in nude mice grafted with human tumour

scientific article published on 01 January 1992

[99mTc anti-carcinoembryonic antigen in colorectal cancer]

scientific article published on 01 March 1994

[Eosinophilic gastroenteritis with liver involvement and ascites]

scientific article published on 01 June 1988

miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations.

scientific article published on 10 August 2015

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