List of works - Michael Mildner

2,3,7,8-tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model

scientific article published in January 2005

A preclinical model for studying herpes simplex virus infection

scientific article published on 08 November 2018

Abstract: 10.40 Paracrine Factors From Human Peripheral Blood Mononuclear Cells Improve Wound Healing, Scar Quality, And Angiogenesis In A Porcine Burn Model.

scientific article published on 20 January 2017

Age-related changes in expression and function of Toll-like receptors in human skin

scientific article published on 3 October 2012

Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes

scientific article published on 13 August 2010

Analysis of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells: Impact of Released Proteins and Exosomes for Tissue Regeneration.

scientific article

Anti-acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent.

scientific article published on 23 June 2009

Anti-thymocyte globulin induces neoangiogenesis and preserves cardiac function after experimental myocardial infarction.

scientific article

Antimicrobial peptides are highly abundant and active in postoperative pleural drainage fluids

scientific article published on 16 July 2014

Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model

scientific article

Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes

scientific article published on 22 January 2013

Bioinformatics approach for choosing the correct reference genes when studying gene expression in human keratinocytes

scientific article published on 15 May 2015

Butyrate Decreases ICAM-1 Expression in Human Oral Squamous Cell Carcinoma Cells

scientific article published on 29 February 2020

CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin

scientific article published on 4 May 2015

CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma

scientific article published on May 1996

Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science.

scientific article published on April 2017

Characterization of a cDNA clone, encoding a 70 kDa heat shock protein from the dermatophyte pathogen Trichophyton rubrum.

scientific article

Clinical-radiological, histological and genetic analyses in a lung transplant recipient with Mounier-Kuhn syndrome and end-stage chronic obstructive pulmonary disease

scientific article published on 21 May 2014

DNase 2 is the main DNA-degrading enzyme of the stratum corneum

scientific article

DNase1L2 degrades nuclear DNA during corneocyte formation

scientific article

Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7.

scientific article published on 5 March 2009

Development of Blood and Lymphatic Endothelial Cells in Embryonic and Fetal Human Skin

scientific article published on 15 July 2015

Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions

scientific article published in Scientific Reports

Dying blood mononuclear cell secretome exerts antimicrobial activity.

scientific article published on 11 August 2016

EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary Hypertension

scientific article published on 28 April 2022

ELMO3 predicts poor outcome in T1 laryngeal cancer.

scientific article

Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination

scientific article published on 29 March 2011

Epidermal CCL27 expression is regulated during skin development and keratinocyte differentiation

scientific article published on 13 September 2013

Escherichia coli ghosts promote innate immune responses in human keratinocytes

article

Establishment of keratinocyte cell lines from human hair follicles

scientific article published in Scientific Reports

Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome.

scientific article published on August 2017

Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology.

scientific article

Expression of inducible nitric oxide synthase in human breast cancer depends on tumor grade

scientific article published on 01 July 1999

Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells.

scientific article

Fetal human keratinocytes produce large amounts of antimicrobial peptides: involvement of histone-methylation processes

scientific article published on 2 April 2014

Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function

scientific article

Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli

scientific article

Gene silencing in a human organotypic skin model

article

Hepatocyte Growth Factor Establishes Autocrine and Paracrine Feedback Loops for the Protection of Skin Cells after UV Irradiation

Hepatocyte growth factor/scatter factor inhibits UVB induced apoptosis of human keratinocytes via the PI-3-kinase pathway

scientific article published on 01 December 1999

Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway

scientific article published on 30 January 2002

High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells

scientific article

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

scientific article published on 15 November 2012

Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid

scientific article

Human embryonic epidermis contains a diverse Langerhans cell precursor pool

scientific article published on February 2014

Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture.

scientific article published on March 1995

Identification of a human cDNA encoding a novel Bcl-x isoform.

scientific article published on July 1998

Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

scientific article published in 2006

Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function

scientific journal article

Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma.

scientific article published on March 1999

Induction of inducible nitric oxide synthase expression in human secretory endometrium

scientific article published on 01 February 1998

Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction ⬇️

scientific article published on March 17, 2011

Ionizing radiation regulates long non-coding RNAs in human peripheral blood mononuclear cells

scientific article published on 14 December 2016

Irradiated cultured apoptotic peripheral blood mononuclear cells regenerate infarcted myocardium.

scientific article

Keratinocytes express the CD146 (Muc18/S-endo) antigen in tissue culture and during inflammatory skin diseases

scientific article

Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model

scientific article published on 6 May 2010

Local and systemic RAGE axis changes in pulmonary hypertension: CTEPH and iPAH

scientific article

Long-acting beneficial effect of percutaneously intramyocardially delivered secretome of apoptotic peripheral blood cells on porcine chronic ischemic left ventricular dysfunction.

scientific article

Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.

scientific article published on 3 August 2017

Matriptase-1 expression is lost in psoriatic skin lesions and is downregulated by TNFα in vitro

article published in 2015

Mononuclear cell secretome protects from experimental autoimmune myocarditis

scientific article

Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine

scholarly article by Oliver Brandt et al published May 2012 in Nanomedicine: Nanotechnology, Biology and Medicine

Nitric oxide synthases in Kaposi's sarcoma are expressed predominantly by vessels and tissue macrophages

scientific article published on 01 August 1998

Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis

scientific article

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging

scientific article published on 06 March 2020

Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation

scientific article published on 23 February 2015

Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model

scientific article (publication date: 2016)

Peripheral blood mononuclear cell secretome for tissue repair

scientific article

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

scientific article published in Journal of Biological Chemistry

Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes

scientific article

Primary sources and immunological prerequisites for sST2 secretion in humans

scholarly article by Michael Mildner et al published 2 April 2010 in Cardiovascular Research

Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

scientific article

Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract

scientific article

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

scientific article published on 08 January 2020

Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids

scientific article published in September 2004

Role for Lipids Secreted by Irradiated Peripheral Blood Mononuclear Cells in Inflammatory Resolution in Vitro ⬇️

scientific article published on 30 June 2020

Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I).

scientific article

Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation

scientific article

Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study.

scientific article published on 28 September 2011

Secretome of peripheral blood mononuclear cells enhances wound healing

scientific article published in 2013

Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia.

scientific article

Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases

scientific article

Suppression of autophagy dysregulates the antioxidant response and causes premature senescence of melanocytes

scientific article published on 7 October 2014

TGF-β in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis

scientific article published on 13 November 2020

Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia.

scientific article published on 2 December 2012

The antimicrobial heterodimer S100A8/S100A9 (calprotectin) is upregulated by bacterial flagellin in human epidermal keratinocytes

scientific article published on 17 June 2010

The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus

scientific article published in May 2017

The hsp27kD heat shock protein and p38-MAPK signaling are required for regular epidermal differentiation.

scientific article

The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa

scientific article published on 11 August 2016

The secretome of apoptotic human peripheral blood mononuclear cells attenuates secondary damage following spinal cord injury in rats.

scientific article published on 19 March 2015

The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation

scientific article published on 29 October 2021

Tissue-regenerative potential of the secretome of γ-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis

scientific article published on 30 September 2019

Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease

scientific article published on 03 April 2019

Transcription of the caspase-14 gene in human epidermal keratinocytes requires AP-1 and NFkappaB.

scientific article published on 18 April 2008

Vascular endothelial growth factor is constitutively expressed in normal human salivary glands and is secreted in the saliva of healthy individuals.

scientific article

[The role of nitric oxide in reproduction]

scientific article published on 01 January 1998

miR-155 Contributes to Normal Keratinocyte Differentiation and Is Upregulated in the Epidermis of Psoriatic Skin Lesions

scientific article published on 05 December 2020

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

scientific article

List of works by Michael Mildner

2,3,7,8-tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model

A preclinical model for studying herpes simplex virus infection

Abstract: 10.40 Paracrine Factors From Human Peripheral Blood Mononuclear Cells Improve Wound Healing, Scar Quality, And Angiogenesis In A Porcine Burn Model.

Age-related changes in expression and function of Toll-like receptors in human skin

Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes

Analysis of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells: Impact of Released Proteins and Exosomes for Tissue Regeneration.

Anti-acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent.

Anti-thymocyte globulin induces neoangiogenesis and preserves cardiac function after experimental myocardial infarction.

Antimicrobial peptides are highly abundant and active in postoperative pleural drainage fluids

Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model

Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes

Bioinformatics approach for choosing the correct reference genes when studying gene expression in human keratinocytes

Butyrate Decreases ICAM-1 Expression in Human Oral Squamous Cell Carcinoma Cells

CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin

CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma

Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science.

Characterization of a cDNA clone, encoding a 70 kDa heat shock protein from the dermatophyte pathogen Trichophyton rubrum.

Clinical-radiological, histological and genetic analyses in a lung transplant recipient with Mounier-Kuhn syndrome and end-stage chronic obstructive pulmonary disease

DNase 2 is the main DNA-degrading enzyme of the stratum corneum

DNase1L2 degrades nuclear DNA during corneocyte formation

Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7.

Development of Blood and Lymphatic Endothelial Cells in Embryonic and Fetal Human Skin

Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions

Dying blood mononuclear cell secretome exerts antimicrobial activity.

EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary Hypertension

ELMO3 predicts poor outcome in T1 laryngeal cancer.

Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination

Epidermal CCL27 expression is regulated during skin development and keratinocyte differentiation

Escherichia coli ghosts promote innate immune responses in human keratinocytes

Establishment of keratinocyte cell lines from human hair follicles

Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome.

Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology.

Expression of inducible nitric oxide synthase in human breast cancer depends on tumor grade

Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells.

Fetal human keratinocytes produce large amounts of antimicrobial peptides: involvement of histone-methylation processes

Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function

Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli

Gene silencing in a human organotypic skin model

Hepatocyte Growth Factor Establishes Autocrine and Paracrine Feedback Loops for the Protection of Skin Cells after UV Irradiation

Hepatocyte growth factor/scatter factor inhibits UVB induced apoptosis of human keratinocytes via the PI-3-kinase pathway

Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway

High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid

Human embryonic epidermis contains a diverse Langerhans cell precursor pool

Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture.

Identification of a human cDNA encoding a novel Bcl-x isoform.

Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function

Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma.

Induction of inducible nitric oxide synthase expression in human secretory endometrium

Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction ⬇️

Ionizing radiation regulates long non-coding RNAs in human peripheral blood mononuclear cells

Irradiated cultured apoptotic peripheral blood mononuclear cells regenerate infarcted myocardium.

Keratinocytes express the CD146 (Muc18/S-endo) antigen in tissue culture and during inflammatory skin diseases

Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model

Local and systemic RAGE axis changes in pulmonary hypertension: CTEPH and iPAH

Long-acting beneficial effect of percutaneously intramyocardially delivered secretome of apoptotic peripheral blood cells on porcine chronic ischemic left ventricular dysfunction.

Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.

Matriptase-1 expression is lost in psoriatic skin lesions and is downregulated by TNFα in vitro

Mononuclear cell secretome protects from experimental autoimmune myocarditis

Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine

Nitric oxide synthases in Kaposi's sarcoma are expressed predominantly by vessels and tissue macrophages

Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging

Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation

Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model

Peripheral blood mononuclear cell secretome for tissue repair

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes

Primary sources and immunological prerequisites for sST2 secretion in humans

Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids

Role for Lipids Secreted by Irradiated Peripheral Blood Mononuclear Cells in Inflammatory Resolution in Vitro ⬇️

Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I﻿).

Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation

Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study.

Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I).