List of works - Michael Koval

A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential.

scientific article

A scalable workflow to characterize the human exposome

scientific article published on 22 September 2021

Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.

scientific article published on 07 June 2013

Asymmetric distribution of dynamin-2 and β-catenin relative to tight junction spikes in alveolar epithelial cells

scientific article published on 10 June 2021

Autologous apoptotic cell engulfment stimulates chemokine secretion by vascular smooth muscle cells.

scientific article published on August 2005

Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats

scientific journal article

Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats

scientific article published on 13 May 2011

Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis

scientific article

Claudin heterogeneity and control of lung tight junctions.

scientific article published on 15 October 2012

Claudins--key pieces in the tight junction puzzle

scientific article

Claudins: Gatekeepers of lung epithelial function

scientific article

Claudins: control of barrier function and regulation in response to oxidant stress.

scientific article

Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells

scientific article

Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells

scientific article published on 19 April 2001

Connexins, pannexins and innexins: protein cousins with overlapping functions

scientific article

Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.

scientific article published on 26 April 2018

Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins

scientific article

Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin.

scientific article published on 08 October 2009

Cross-talk between pulmonary injury, oxidant stress, and gap junctional communication.

scientific article

Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization

scientific article

Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum

scientific journal article

Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).

scientific article published on March 2015

Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism

scientific article published on 2 April 2008

Desmosome assembly and disassembly are membrane raft-dependent

scientific article (publication date: 2014)

Detrimental effects of flame retardant, PBB153, exposure on sperm and future generations

scientific article published on 22 May 2020

Developmental regulation of claudin localization by fetal alveolar epithelial cells

scientific article published on 3 September 2004

Drowning out communication. Focus on "The human Cx26-D50A and Cx26-A88V mutations causing keratitis-ichthyosis-deafness syndrome display increased hemichannel activity".

scientific article published on 10 April 2013

Effects of different routes of endotoxin injury on barrier function in alcoholic lung syndrome

scientific article published on 22 August 2018

Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium

scientific article published on 20 April 2020

Endothelial endocytic pathways: gates for vascular drug delivery

scientific article published on 01 July 2004

Extracellular matrix influences alveolar epithelial claudin expression and barrier function

scientific article published on 7 May 2009

Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells

scientific article published on 3 February 2004

HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation

scientific article

Heterogeneity of claudin expression by alveolar epithelial cells

scientific article published on 23 January 2003

Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes

scientific article published on 04 October 2013

Hyperoxia induces paracellular leak and alters claudin expression by neonatal alveolar epithelial cells

scientific article published on 23 November 2017

ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs.

scientific article published on 14 September 2004

Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3

scientific journal article

Identification of rab20 as a potential regulator of connexin 43 trafficking

scientific article

Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner

scientific article published on 17 February 2017

Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.

scientific article

Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line ⬇️

scientific article published on October 15, 2010

Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts

scientific article published on June 1989

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

scientific article

Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.

scientific article published on June 2006

Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues

scientific article published on 20 February 2014

Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis

scientific article published on 07 June 2017

Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O⁻₂ signaling

scientific article published on 9 December 2011

Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography.

scientific article published on 24 December 2012

Nanotopography facilitates in vivo transdermal delivery of high molecular weight therapeutics through an integrin-dependent mechanism

scientific article published on 27 March 2015

Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation

scientific article published on 20 May 2005

Pathways and control of connexin oligomerization.

scientific article

Peroxisome proliferator-activated receptor-γ agonists attenuate biofilm formation by Pseudomonas aeruginosa.

scientific article published on 25 April 2017

Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins

scientific article

Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction

scientific article published on 15 August 2019

Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

scientific article

Regulation of connexin43 oligomerization is saturable

scientific article published in July 2005

Regulation of gap junction proteins by alveolar epithelial cells in response to injury

scientific article published on 01 July 1999

Regulation of heterotypic claudin compatibility

scientific article published on 14 August 2007

RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1.

scientific article published on 8 January 2008

Roles for claudins in alveolar epithelial barrier function.

scientific article

Sharing signals: connecting lung epithelial cells with gap junction channels.

scientific article

Size of IgG-opsonized particles determines macrophage response during internalization

scientific article published in July 1998

Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells

scientific article published in February 2002

Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress

scientific article published on 23 July 2003

Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts

scientific article published on August 1990

Sphingomyelin synthesis in endosomal compartments?

scientific article published on 01 April 1995

Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR‐mediated apical conductance

scientific article published in 2021

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43

scientific article

Systems Proteomics View of the Endogenous Human Claudin Protein Family

scientific article

Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization

scientific article

The Effects of Endogenous Cannabinoids on the Mammalian Respiratory System: A Scoping Review of Cyclooxygenase-Dependent Pathways

The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels.

scientific article published on 5 October 2015

The contribution of epithelial sodium channels to alveolar function in health and disease.

scientific article published on January 2009

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

scientific article published on 17 April 2015

Tight junctions, but not too tight: fine control of lung permeability by claudins

scientific article published on 12 June 2009

Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43 ⬇️

scientific article published on August 1, 1995

Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform

scientific article published on 26 April 2017

Ubiquitin-independent Proteasomal Degradation of Endoplasmic Reticulum-localized Connexin43 Mediated by CIP75 ⬇️

scientific article published on October 12, 2010

tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre

scientific article

List of works by Michael Koval

A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential.

A scalable workflow to characterize the human exposome

Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.

Asymmetric distribution of dynamin-2 and β-catenin relative to tight junction spikes in alveolar epithelial cells

Autologous apoptotic cell engulfment stimulates chemokine secretion by vascular smooth muscle cells.

Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats

Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats

Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis

Claudin heterogeneity and control of lung tight junctions.

Claudins--key pieces in the tight junction puzzle

Claudins: Gatekeepers of lung epithelial function

Claudins: control of barrier function and regulation in response to oxidant stress.

Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells

Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells

Connexins, pannexins and innexins: protein cousins with overlapping functions

Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.

Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins

Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin.

Cross-talk between pulmonary injury, oxidant stress, and gap junctional communication.

Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization

Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum

Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).

Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism

Desmosome assembly and disassembly are membrane raft-dependent

Detrimental effects of flame retardant, PBB153, exposure on sperm and future generations

Developmental regulation of claudin localization by fetal alveolar epithelial cells

Drowning out communication. Focus on "The human Cx26-D50A and Cx26-A88V mutations causing keratitis-ichthyosis-deafness syndrome display increased hemichannel activity".

Effects of different routes of endotoxin injury on barrier function in alcoholic lung syndrome

Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium

Endothelial endocytic pathways: gates for vascular drug delivery

Extracellular matrix influences alveolar epithelial claudin expression and barrier function

Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells

HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation

Heterogeneity of claudin expression by alveolar epithelial cells

Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes

Hyperoxia induces paracellular leak and alters claudin expression by neonatal alveolar epithelial cells

ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs.

Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3

Identification of rab20 as a potential regulator of connexin 43 trafficking

Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner

Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.

Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line ⬇️

Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.

Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues

Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis

Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O⁻₂ signaling

Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography.

Nanotopography facilitates in vivo transdermal delivery of high molecular weight therapeutics through an integrin-dependent mechanism

Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation

Pathways and control of connexin oligomerization.

Peroxisome proliferator-activated receptor-γ agonists attenuate biofilm formation by Pseudomonas aeruginosa.

Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins

Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction

Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

Regulation of connexin43 oligomerization is saturable

Regulation of gap junction proteins by alveolar epithelial cells in response to injury

Regulation of heterotypic claudin compatibility

RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1.

Roles for claudins in alveolar epithelial barrier function.

Sharing signals: connecting lung epithelial cells with gap junction channels.

Size of IgG-opsonized particles determines macrophage response during internalization

Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells

Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress

Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts

Sphingomyelin synthesis in endosomal compartments?

Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR‐mediated apical conductance

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43

Systems Proteomics View of the Endogenous Human Claudin Protein Family

Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization

The Effects of Endogenous Cannabinoids on the Mammalian Respiratory System: A Scoping Review of Cyclooxygenase-Dependent Pathways

The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels.

The contribution of epithelial sodium channels to alveolar function in health and disease.

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

Tight junctions, but not too tight: fine control of lung permeability by claudins

Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43 ⬇️

Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform

Ubiquitin-independent Proteasomal Degradation of Endoplasmic Reticulum-localized Connexin43 Mediated by CIP75 ⬇️