List of works by Qihua Tan

A case-only approach for assessing gene by sex interaction in human longevity

scientific article published on 01 April 2002

A case-only genome-wide association study on gene-sex interaction in allergic rhinitis

article

A centenarian-only approach for assessing gene-gene interaction in human longevity

scientific article published on 01 February 2002

A combinatory approach for selecting prognostic genes in microarray studies of tumour survivals

scientific article published on 30 July 2009

A cross-sectional analysis of age and sex patterns in grip strength, tooth loss, near vision and hearing levels in Chinese aged 50-74 years

scientific article

A genome-wide association study of cognitive function in Chinese adult twins.

scientific article published on 14 August 2017

A growth curve model with fractional polynomials for analysing incomplete time-course data in microarray gene expression studies.

scientific article

A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family

scientific article published on 15 May 2013

AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians

scientific article published on 29 August 2012

Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles.

scientific article published on 21 February 2018

Age-dependent DNA methylation patterns on the Y chromosome in elderly males

scientific article published on 21 February 2019

Altered fate of tendon-derived stem cells isolated from a failed tendon-healing animal model of tendinopathy.

scientific article published on 16 December 2012

Analyzing age-specific genetic effects on human extreme age survival in cohort-based longitudinal studies

scientific article published on 15 August 2012

Anti-inflammatory heat shock protein 70 genes are positively associated with human survival

scientific article published on January 2010

Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models.

scientific article published in January 2004

Arrayed primer extension in the "array of arrays" format: a rational approach for microarray-based SNP genotyping.

scientific article published in January 2007

Assessing genetic association with human survival at multi-allelic loci.

scientific article published in January 2004

Association between the surfactant protein D (SFTPD) gene and subclinical carotid artery atherosclerosis.

scientific article published on 29 December 2015

Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts

scientific article published in PLoS ONE

Association of miR-548c-5p, miR-7-5p, miR-210-3p, miR-128-3p with recurrence in systemically untreated breast cancer.

scientific article

Association of polycystic ovary syndrome susceptibility single nucleotide polymorphism rs2479106 and PCOS in Caucasian patients with PCOS or hirsutism as referral diagnosis

scientific article published on 13 April 2012

Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50-74 years

scientific article published on 22 November 2012

Atopic dermatitis -- a total genome-scan for susceptibility genes

scientific article published on 01 January 2004

Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals.

scientific article

Blood DNA methylation age is not associated with cognitive functioning in middle-aged monozygotic twins

scientific article published on 04 November 2016

Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population

scientific article published on 27 June 2006

Candidate region linkage analysis in twins discordant or concordant for depression symptomatology

scientific article published on June 2009

Change in Depression Symptomatology and Cognitive Function in Twins: A 10-Year Follow-Up Study

scientific article

Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study

scientific article published on 02 May 2018

Circulating surfactant protein D is associated to mortality in elderly women: a twin study

scientific article published on 20 August 2012

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

scientific article published on 01 January 2018

Classification of breast cancer subtypes by combining gene expression and DNA methylation data.

scientific article

Classifications within molecular subtypes enables identification of BRCA1/BRCA2 mutation carriers by RNA tumor profiling

scientific article

Cohort difference in the risk of selected candidate genes on all-cause mortality at advanced ages

scientific article published on 23 January 2020

Combined experimental and statistical strategy for mass spectrometry based serum protein profiling for diagnosis of breast cancer: a case-control study

scientific article

Comparison of gene sets for expression profiling: prediction of metastasis from low-malignant breast cancer

scientific article published on 01 September 2007

Comprehensive analysis of high-throughput screens with HiTSeekR

scientific article

Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway

scientific article

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

scientific article

Correspondence analysis of microarray time-course data in case-control design

scientific article

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

scientific article published on 13 November 2015

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins

scientific article published on 8 February 2018

DNA methylation age and perceived age in elderly Danish twins.

scientific article published on 28 September 2017

DNA methylation age is associated with mortality in a longitudinal Danish twin study.

scientific article

DNA methylome profiling in identical twin pairs discordant for body mass index

scientific article published on 31 May 2019

DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

scientific article published on 08 February 2019

Deciphering the DNA Methylome of Polycystic Ovary Syndrome

scientific article published on 15 April 2020

Design and analysis in genetic studies of human ageing and longevity.

scientific article

DiMmer: Discovery of Differentially Methylated Regions in Epigenome-Wide Association Study (EWAS) Data

scientific article published on 01 January 2018

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

scientific article

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

scientific article

Differential and correlation analyses of microarray gene expression data in the CEPH Utah families

scientific article

Differential effect of surgical manipulation on gene expression in normal breast tissue and breast tumor tissue

article

Differential long noncoding RNA profiling of BMI in twins

scientific article published on 09 September 2020

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study.

scientific article

Differentially Methylated Genomic Regions in Birth-Weight Discordant Twin Pairs.

scientific article published on February 2016

Disease-Concordant Twins Empower Genetic Association Studies

scientific article published on 23 December 2016

Dissecting complex phenotypes using the genomics of twins

scientific article published on 10 February 2010

Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

scientific article

EWASex: an efficient R-package to predict sex in epigenome-wide association studies

scientific article published on 11 December 2020

Early life affects late-life health through determining DNA methylation across the lifespan: A twin study

scientific article published on 14 March 2022

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts

scientific article published in October 2017

Effects of FOXO genotypes on longevity: a biodemographic analysis.

scientific article

Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.

scientific article published on 9 October 2012

Efficacy of repetitive transcranial magnetic stimulation in the prevention of relapse of depression: study protocol for a randomized controlled trial

scientific article published on 17 October 2013

Efficient Management of High-Throughput Screening Libraries with SAVANAH

Efficient detection of differentially methylated regions using DiMmeR.

scientific article

Efficient sample tracking with OpenLabFramework

scientific article

Enriched power of disease-concordant twin-case-only design in detecting interactions in genome-wide association studies

scientific article published on 18 January 2019

Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS)

scientific article published on 19 February 2019

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.

scientific article published on 6 August 2016

Epigenetic signature of birth weight discordance in adult twins

scientific article

Epigenetic signature of preterm birth in adult twins.

scientific article published on 27 June 2018

Epigenome-Wide Association Study of Cognitive Functioning in Middle-Aged Monozygotic Twins.

scientific article published on 12 December 2017

Epigenome-wide association study of depression symptomatology in elderly monozygotic twins

scientific article published on 02 September 2019

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength

scientific article published on 28 June 2019

Estimating haplotype relative risks on human survival in population-based association studies

scientific article published on 18 April 2005

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

scientific article published on 12 January 2012

Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples

scientific article published on 28 April 2020

Extraction of high-quality epidermal RNA after ammonium thiocyanate-induced dermo-epidermal separation of 4 mm human skin biopsies.

scientific article published on 23 July 2009

Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer

scientific article published on 24 January 2017

Feature selection for predicting tumor metastases in microarray experiments using paired design.

scientific article published on 20 March 2007

Gender-specific patterns in age-related decline in general health among Danish and Chinese: a cross-national comparative study

scientific article published on 23 December 2011

Gene Expression Meta-Analysis Identifies Cytokine Pathways and 5q Aberrations Involved in Metastasis of ERBB2 Amplified and Basal Breast Cancer.

scientific article

Gene expression in epithelial ovarian cancer: a study of intratumor heterogeneity

scientific article published on 15 March 2007

Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis

scientific article published on 22 February 2008

Gene expression meta-analysis identifies chromosomal regions involved in ovarian cancer survival

scientific article

Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer

scientific article

Gene expression profiles as prognostic markers in women with ovarian cancer

scientific article

Gene expression profiles for predicting metastasis in breast cancer: a cross-study comparison of classification methods

scientific article published on 28 November 2012

Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study

scientific article

Gene, environment and cognitive function: a Chinese twin ageing study.

scientific article published on April 2015

Generalized Correlation Coefficient for Non-Parametric Analysis of Microarray Time-Course Data.

scientific article

Genes and longevity: lessons from studies of centenarians

scientific article published on 01 July 2000

Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity

scientific article

Genetic alterations within the DENND1A gene in patients with polycystic ovary syndrome (PCOS)

scientific article (publication date: 2013)

Genetic and Environmental Basis in Phenotype Correlation Between Physical Function and Cognition in Aging Chinese Twins.

scientific article published on February 2017

Genetic and Environmental Influences on Correlations Between Hearing and Cognitive Functions in Middle and Older Chinese Twins.

scientific article published on 14 August 2017

Genetic and Environmental Influences on Pulmonary Function and Muscle Strength: The Chinese Twin Study of Aging

scientific article published on February 2017

Genetic and Environmental Regulation on Longitudinal Change of Metabolic Phenotypes in Danish and Chinese Adult Twins.

scientific article published on 10 February 2016

Genetic and environmental dissections of sub-phenotypes of metabolic syndrome in the Chinese population: a twin-based heritability study.

scientific article published on 7 April 2011

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.

scientific article published on 14 December 2016

Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study

scientific article published on 30 August 2017

Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

scientific article published on 29 July 2020

Genetic association analysis of human longevity in cohort studies of elderly subjects: an example of the PON1 gene in the Danish 1905 birth cohort.

scientific article

Genetic interplay between human longevity and metabolic pathways - a large-scale eQTL study

scientific article published on 19 April 2017

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland.

scientific article

Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.

scientific article published on 28 December 2011

Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.

scientific article published on 16 May 2018

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide expression analysis of human in vivo irritated epidermis: differential profiles induced by sodium lauryl sulfate and nonanoic acid

scientific article published on 29 April 2010

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Genome-wide linkage and association scans for pulse pressure in Chinese twins

article

Global Gene Expression Profiling and Transcription Factor Network Analysis of Cognitive Aging in Monozygotic Twins

scientific article published on 14 June 2021

Global expression profiling of cognitive level and decline in middle-aged monozygotic twins

scientific article published on 26 August 2019

Global gene expression profiling of telangiectasial tissue from patients with hereditary hemorrhagic telangiectasia

scientific article published on 16 April 2015

Global microRNA profiling of metastatic conjunctival melanoma

scientific article published on 01 October 2019

GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China

scientific article published on 3 June 2014

Handling blood cell composition in epigenetic studies on ageing.

scientific article published on 3 June 2017

Haplotype Effects on Human Survival: Logistic Regression Models Applied to Unphased Genotype Data

Haplotype association analysis of human disease traits using genotype data of unrelated individuals

article

Harnessing the power of twins in epigenetic association studies: causal inference and more

scientific article published on 13 December 2019

Heat-shock protein 70 genes and human longevity: a view from Denmark

scientific article published in May 2006

Heritability analysis on serum lipids of adult twins in Qingdao City

scientific article published on May 2010

Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins.

scientific article published on 6 March 2018

Heritability and Whole Genome Linkage of Pulse Pressure in Chinese Twin Pairs

article

Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese: A Population-Based Twin Study

article

Heritability of eleven metabolic phenotypes in Danish and Chinese twins: a cross-population comparison.

scientific article published on 19 May 2013

Hierarchical linear modeling of longitudinal pedigree data for genetic association analysis

scientific article

High-Resolution Genome-Wide Linkage Mapping Identifies Susceptibility Loci for BMI in the Chinese Population

article

Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis

scientific article

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies

scientific article

Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

scientific article

Impact of obesity and physical inactivity on the long-term change in grip strength among middle-aged and older European adults

scientific article published on 08 March 2019

Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages

scientific article published on 28 September 2015

Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China.

scientific article

Jllumina - A comprehensive Java-based API for statistical Illumina Infinium HumanMethylation450 and MethylationEPIC data processing

scientific article

Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity.

scientific article published in November 2003

Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer

scientific article published on 21 November 2013

Long non-coding RNA expression profiles in hereditary haemorrhagic telangiectasia

scientific article

Long non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers

scientific article published on 11 April 2015

Longitudinal Investigation into Genetics in the Conservation of Metabolic Phenotypes in Danish and Chinese Twins

scientific article

Longitudinal analysis of sibling correlation on blood pressure using mixed modeling

scientific article published on 27 February 2019

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts

scientific article published on 28 January 2019

Lung function discordance in monozygotic twins and associated differences in blood DNA methylation

scientific article published on 21 December 2017

Measuring the genetic influence in modulating the human life span: gene-environment interaction and the sex-specific genetic effect

scientific article published on 01 January 2001

MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study

scientific article published on 01 August 2018

Microarray R-based analysis of complex lysate experiments with MIRACLE.

scientific article published on September 2014

Microarray-based RNA profiling of breast cancer: batch effect removal improves cross-platform consistency.

scientific article

Mining gene networks with application to GAW15 Problem 1.

scientific article

Multivariate modeling of body mass index, pulse pressure, systolic and diastolic blood pressure in Chinese twins

scientific article published on 22 December 2014

Multivariate modelling of endophenotypes associated with the metabolic syndrome in Chinese twins

scientific article published on 29 September 2010

NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36.

scientific article

No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians

scientific article published on 01 October 2005

Novel loci and pathways significantly associated with longevity

scientific article published on 25 February 2016

On the power of epigenome-wide association studies using a disease-discordant twin design

scientific article published on 01 December 2018

Online Interactive Microbial Classification and Geospatial Distributional Analysis Using BioAtlas

scientific article published on 01 January 2018

OpenLabNotes--An Electronic Laboratory Notebook Extension for OpenLabFramework

scientific article published on 6 October 2015

Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome

scientific article

Possible gene dosage effect of glutathione-S-transferases on atopic asthma: using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers

scientific article published in September 2004

Power assessment for genetic association study of human longevity using offspring of long-lived subjects

scientific article

Power estimation for gene-longevity association analysis using concordant twins

scientific article published on 16 September 2014

Power for genetic association study of human longevity using the case-control design

scientific article published on 27 August 2008

Power of non-parametric linkage analysis in mapping genes contributing to human longevity in long-lived sib-pairs.

scientific article published in April 2004

Prediction of breast cancer metastasis by gene expression profiles: a comparison of metagenes and single genes.

scientific article

Prediction of metastasis from low-malignant breast cancer by gene expression profiling

scientific article published on 01 March 2007

Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project.

scientific article published on 28 July 2014

Probing genetic overlap in the regulation of systolic and diastolic blood pressure in Danish and Chinese twins.

scientific article published on 15 May 2014

Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation

scientific article

RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families

scientific article published on 31 January 2014

RNA quality and gene expression analysis of ovarian tumor tissue undergoing repeated thaw-freezing

scientific article published on 13 July 2006

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

article

Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus

scientific article published in July 2001

Retrospective analysis of main and interaction effects in genetic association studies of human complex traits

scientific article

Robust de novo pathway enrichment with KeyPathwayMiner 5.

scientific article published on 28 June 2016

Sex Differences in Genetic Associations With Longevity

Sex and age specific reduction in stress resistance and mitochondrial DNA copy number in Drosophila melanogaster

scientific article published on 23 August 2019

Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene.

scientific article published on 31 May 2006

Spotting and validation of a genome wide oligonucleotide chip with duplicate measurement of each gene.

scientific article published on 19 April 2006

Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage

Surfactant protein-D, a potential mediator of inflammation in axial spondyloarthritis

scientific article published on 01 October 2018

Surfactant protein-D-encoding gene variant polymorphisms are linked to respiratory outcome in premature infants.

scientific article published on 9 July 2014

Testosterone treatment increases androgen receptor and aromatase gene expression in myotubes from patients with PCOS and controls, but does not induce insulin resistance

scientific article

The 82-plex plasma protein signature that predicts increasing inflammation.

scientific article

The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

scientific article

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

scientific article published on 31 July 2019

The Danish Twin Registry: linking surveys, national registers, and biological information.

scientific article published on 19 October 2012

The Qingdao Twin Registry: a status update

scientific article published on 27 November 2012

The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity.

scientific article published on 12 December 2012

The epigenome of twins as a perfect laboratory for studying behavioural traits

scientific article published on 16 September 2019

The epigenomics of polycystic ovarian syndrome: from pathogenesis to clinical manifestations.

scientific article

The gene expression and immunohistochemical time-course of diphenylcyclopropenone-induced contact allergy in healthy humans following repeated epicutaneous challenges.

scientific article

The genetic basis for cognitive ability, memory, and depression symptomatology in middle-aged and elderly chinese twins.

scientific article published on 14 January 2015

The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach.

scientific article published in July 2002

The sex chromosomes of the aging epigenome

scientific article published on 30 August 2020

Therapeutic effects and associated adverse events of multikinase inhibitors in metastatic renal cell carcinoma: A meta-analysis

scientific article published on 15 April 2015

Twin methodology in epigenetic studies

scientific article

Twins for epigenetic studies of human aging and development

scientific article

Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity

scientific article published on 01 August 2001

Weak Grip Strength and Cognition Predict Functional Limitation in Older Europeans

scientific article published on 25 October 2018

Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI.

scientific article published on 13 November 2017

Weighted gene co-regulation network analysis (WGCNA) of promoter DNA methylation on all-cause mortality in old-aged birth cohorts finds modules of high-risk associated biomarkers

scientific article published on 10 March 2020

White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study

scientific article published on 14 October 2018

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

scientific article

[Genomic medicine and artificial intelligence] ⬇️

scientific article published on 01 April 2019

[Heritability of serum uric acid in adult twins].

scientific article published in April 2010

dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors

scientific article

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