List of works by Carlo Franchini

1-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-pyrrolidine-2-carboxamide: investigation of structural variations.

scientific article published on 28 June 2011

2-Aminobenzothiazole derivatives: search for new antifungal agents

scientific article published on 9 April 2013

AT1 Receptor Ligands: Virtual-Screening-Based Design with TOPP Descriptors, Synthesis, and Biological Evaluation of Pyrrolidine Derivatives

scientific article published on 01 September 2007

Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites

scientific article published on 01 March 2013

Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity

scientific article published in May 2010

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

scientific article published on January 2013

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

scientific article

Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors

scientific article published on 3 July 2010

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

scientific article

Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones

article published in 2010

First synthesis and full characterization of mexiletine N-carbonyloxy β-d-glucuronide

Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

scientific article

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

scientific article

In vitro effectiveness of anidulafungin against Candida sp. biofilms

scientific article published on 11 September 2013

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

scientific article

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

scientific article published on 25 January 2003

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

scientific article published on 24 July 2015

Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II

Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.

scientific article published on 15 February 2012

N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II.

scientific article

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

scientific article

New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase

scientific article

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

scientific article

One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

scientific article published in November 2003

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

scientific article published in October 2003

Optimization of Microwave-Assisted Extraction of Antioxidants from Bamboo Shoots of Phyllostachys pubescens

scientific article published on 05 January 2020

Polyphenols and obesity prevention: critical insights on molecular regulation, bioavailability and dose in preclinical and clinical settings

scientific article published on 21 May 2020

Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers

scientific article

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

scientific article

Stereoselective interaction of tocainide and its chiral analogs with the sodium channels in human myoballs.

scientific article published in April 1991

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

scientific article

Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity

scientific article published in October 2009

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

scientific article published in March 2010

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

scientific article

Synthesis of functionalized arylaziridines as potential antimicrobial agents.

scientific article published on 4 August 2014

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

scientific article

Tocainide analogues binding to human serum albumin: a HPLAC and circular dichroism study

scientific article published on 7 March 2010

Voltage Gated Sodium Channel Blockers: Synthesis of Mexiletine Analogues and Homologues

scientific article published on 03 May 2020

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