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List of works by Giovanni Lentini

A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues

scientific article published on 01 January 2018

A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma.

scientific article published on 31 May 2017

A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells ⬇️

scientific article published on July 4, 2013

An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite

scientific article published on 01 June 2012

Antimicrobial and Antibiofilm Activities of Citrus Water-Extracts Obtained by Microwave-Assisted and Conventional Methods

scientific article published on 17 June 2018

Biostimulant Formulations and Moringa oleifera Extracts to Improve Yield, Quality, and Storability of Hydroponic Lettuce

scientific article published on 2 January 2023

COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

scientific article published on 16 April 2020

Camel (Camelus spp.) Urine Bioactivity and Metabolome: A Systematic Review of Knowledge Gaps, Advances, and Directions for Future Research

scientific article published in 2022

Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity

scientific article published in May 2010

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

scientific article published on January 2013

Crystal structure of N-(2-{[(2E)-3-(4-chlorophenyl)-2-propenyl]- (methyl)ammonio}methylphenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide dihydrogen phosphate — methanol (1:1), [C26H30ClN2SO4][H2PO4] · CH4O

Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors

scientific article published on 3 July 2010

Did Ebola survivors use plant medicines, and if so, which ones?

scientific article published on 14 January 2015

Discovery of a new mexiletine-derived agonist of the hERG K+ channel.

scientific article published on 19 June 2017

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

scientific article published in January 2017

Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity

scientific article published on 09 January 2015

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

scientific article

Facile entry to (-)-(R)- and (+)-(S)-mexiletine

scientific article published on 01 March 2000

Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones

article published in 2010

Facile, alternative route to lubeluzole, its enantiomer, and the racemate

scientific article published in May 2006

First synthesis and full characterization of mexiletine N-carbonyloxy β-d-glucuronide

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

scientific article published on 22 July 2020

Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

scientific article

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

scientific article

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX

scientific article published on November 1999

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

scientific article

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine.

scientific article published on 31 July 2015

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

scientific article published on 25 January 2003

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

scientific article published on 24 July 2015

Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective

scientific article published on 17 August 2017

Microchip capillary electrophoresis-electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: an intriguing case

scientific article

Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization

scientific article published in 2022

Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II

Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.

scientific article

Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.

scientific article published on 15 February 2012

N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II.

scientific article

New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase

scientific article

New doxorubicin nanocarriers based on cyclodextrins

scientific article published on 4 April 2017

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

scientific article

Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition.

scientific article published on 27 July 2017

Old Drug Scaffold, New Activity: Thalidomide-Correlated Compounds Exert Different Effects on Breast Cancer Cell Growth and Progression

scientific article published on 18 January 2017

One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

scientific article published in November 2003

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

scientific article published in October 2003

Optimization of Microwave-Assisted Extraction of Antioxidants from Bamboo Shoots of Phyllostachys pubescens

scientific article published on 05 January 2020

Phytochemical, antioxidant and anti-α-glucosidase activity evaluations of Bergenia cordifolia

scientific article published on 22 November 2011

Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin

scientific article published on 26 March 2018

Recent trends and future prospects in computational GPCR drug discovery: from virtual screening to polypharmacology.

scientific article published on January 2013

Repurposing therapeutic agents and herbal medicines to defeat viral nemesis

scientific article published on 30 March 2020

Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers

scientific article

Shouldn't enantiomeric purity be included in the 'minimum information about a bioactive entity'? ⬇️

scientific article published on 01 September 2012

Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules.

scientific article published on 10 November 2015

Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

scientific article published on 01 December 1995

Stereoselectivity in central analgesic action of tocainide and its analogs.

scientific article published in January 1993

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

scientific article

Stereospecific synthesis of m-Hydroxymexiletine enantiomers

scientific article published on 01 September 2012

Synthesis and Biological Evaluation of Chiral α-Aminoanilides with Central Antinociceptive Activity

scientific article published on 21 March 2007

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

scientific article published in March 2010

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

scientific article

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

scientific article

Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues

scientific article

Targeting <i>Penicillium expansum</i> GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

scientific article published on 31 December 2020

The Chemistry and Pharmacology of Citrus Limonoids

scientific article

The effects of tocainide and its chiral analogs on sodium channels of human muscle

scientific article published in September 1990

The therapeutic power of green

scientific article published on 05 July 2019

The trivial names of citrus limonoids

scientific article published on 22 January 2017

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