List of works by Amélia M. Silva

(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

scientific article published on 20 February 2020

3D printing in the design of pharmaceutical dosage forms

scientific article published on 25 June 2019

Anti-inflammatory and anti-cancer activity of citral: Optimization of citral-loaded solid lipid nanoparticles (SLN) using experimental factorial design and LUMiSizer®

scientific article published on 29 October 2018

Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo, in vitro and ex vivo studies

scientific article published on 24 February 2016

Bursting electrical activity in pancreatic ?-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels

scientific article published on 01 September 1993

Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications

scientific article published on 06 November 2019

Cationic solid lipid nanoparticles interfere with the activity of antioxidant enzymes in hepatocellular carcinoma cells

scientific article published on 13 May 2014

Chemical Characterization and Bioactivity of Extracts from Thymus mastichina: A Thymus with a Distinct Salvianolic Acid Composition

scientific article published on 31 December 2019

Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of Candida Skin Infections.

scientific article published on 13 May 2019

Comet assay reveals no genotoxicity risk of cationic solid lipid nanoparticles.

scientific article

Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines

scientific article published on 11 September 2019

Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics

scientific article published on 01 July 1998

Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53.

scientific article

Current nanotechnology approaches for the treatment and management of diabetic retinopathy.

scientific article published on December 2014

Design of cationic lipid nanoparticles for ocular delivery: development, characterization and cytotoxicity

scientific article published on 23 November 2013

Development and Optimization of Alpha-Pinene-Loaded Solid Lipid Nanoparticles (SLN) Using Experimental Factorial Design and Dispersion Analysis

scientific article published on 24 July 2019

Development and characterization of a cationic lipid nanocarrier as non-viral vector for gene therapy.

scientific article published on 19 October 2014

Ecotoxicity to Freshwater Organisms and Cytotoxicity of Nanomaterials: Are We Generating Sufficient Data for Their Risk Assessment?

scientific article published on 30 December 2020

Effect of mucoadhesive polymers on the in vitro performance of insulin-loaded silica nanoparticles: Interactions with mucin and biomembrane models.

scientific article published on 3 April 2015

Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes.

scientific article published on 5 June 2015

Efficient chemo-enzymatic gluten detoxification: reducing toxic epitopes for celiac patients improving functional properties.

scientific article

Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic beta cells.

scientific article

Endopolysaccharides from Ganoderma resinaceum, Phlebia rufa, and Trametes versicolor Affect Differently the Proliferation Rate of HepG2 Cells

scientific article published on 25 January 2013

Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxidative DNA Damage

scientific article published on 29 November 2019

Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines.

scientific article published on 26 September 2017

High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic beta-cells during blockade of K(ATP) channels

scientific article published in September 1992

High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus.

scientific article

How can age and lifestyle variables affect DNA damage, repair capacity and endogenous biomarkers of oxidative stress?

scholarly article by Jorge Pinto Soares published in February 2015

Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs.

scientific article published on 11 July 2017

In Vitro Cytotoxicity of Oleanolic/Ursolic Acids-Loaded in PLGA Nanoparticles in Different Cell Lines

scientific article published on 24 July 2019

In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment.

scientific article published on 24 December 2013

In vitro, ex vivo and in vivo characterization of PLGA nanoparticles loading pranoprofen for ocular administration

scientific article published on 29 July 2016

Key production parameters for the development of solid lipid nanoparticles by high shear homogenization

scientific article published on 08 August 2019

Linalool bioactive properties and potential applicability in drug delivery systems

scientific article published on 03 August 2018

Lipid nanoparticles as carriers for the treatment of neurodegeneration associated with Alzheimer's disease and glaucoma: present and future challenges

scientific article published on 17 February 2020

Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles

scientific article published on 30 June 2018

Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness

scientific article published on 23 September 2019

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization.

scientific article

Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma

scientific article published on 20 November 2017

Membrane lipid profile alterations are associated with the metabolic adaptation of the Caco-2 cells to aglycemic nutritional condition

scientific article published in February 2014

Microemulsion and Microemulsion-Based Gels for Topical Antifungal Therapy with Phytochemicals.

scientific article published on 2 June 2016

Modified Rose Bengal assay for surface hydrophobicity evaluation of cationic solid lipid nanoparticles (cSLN)

scientific article published on 10 January 2012

Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities

scientific article published in 2022

Multiple Cell Signalling Pathways of Human Proinsulin C-Peptide in Vasculopathy Protection

scientific article published on 18 January 2020

Nanoemulsions for delivery of flavonoids: formulation andin vitrorelease of rutin as model drug

scientific article published on 12 August 2013

Nanoencapsulation of polyphenols for protective effect against colon-rectal cancer.

scientific article published on 23 August 2012

Nanoparticle Delivery Systems in the Treatment of Diabetes Complications

scientific article published on 20 November 2019

Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers - a systematic review of in vitro data

scientific article

New grape stems' isolated phenolic compounds modulate reactive oxygen species, glutathione, and lipid peroxidation in vitro: Combined formulations with vitamins C and E.

scientific article

Ocular Cell Lines and Genotoxicity Assessment

scientific article published on 19 March 2020

Ocular Drug Delivery - New Strategies for Targeting Anterior and Posterior Segments of the Eye.

scientific article published on 16 December 2015

Optimization of linalool-loaded solid lipid nanoparticles using experimental factorial design and long-term stability studies with a new centrifugal sedimentation method

Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line

scientific article published on 04 January 2019

Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders

scientific article published on 3 January 2018

Oxidative stress prevention and anti-apoptosis activity of grape (Vitis vinifera L.) stems in human keratinocytes

scientific article published on 04 July 2016

PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterization.

scientific article published on 3 May 2016

Perillaldehyde 1,2-epoxide Loaded SLN-Tailored mAb: Production, Physicochemical Characterization and In Vitro Cytotoxicity Profile in MCF-7 Cell Lines

scientific article published on 16 February 2020

Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation

scientific article published on 28 September 2014

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

scientific article published on 15 August 2020

Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species

scientific article published on 17 June 2020

Preparation and characterization of PEG-coated silica nanoparticles for oral insulin delivery

scientific article published on 30 July 2014

Prunus lusitanica L. Fruits: A Promising Underexploited Source of Nutrients with Potential Economic Value

scientific article published in 2023

Quinoline‑ and Benzoselenazole-Derived Unsymmetrical Squaraine Cyanine Dyes: Design, Synthesis, Photophysicochemical Features and Light-Triggerable Antiproliferative Effects against Breast Cancer Cell Lines

scientific article published on 10 June 2020

Real Time Electrochemical Detection of 5-HT/Insulin Secretion from Single Pancreatic Islets: Effect of Glucose and K+Depolarization

scientific article published on 01 November 1996

Red and Near-Infrared Absorbing DicyanomethyleneSquaraine Cyanine Dyes: PhotophysicochemicalProperties and Anti-Tumor Photosensitizing Effects

scientific article published on 01 May 2020

Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in absence of functional K(ATP) channels

scientific article published on 21 May 2008

Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy

scientific article published on 17 April 2018

Serum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep

scientific article published in June 2014

Silica-based matrices: State of the art and new perspectives for therapeutic drug delivery

scientific article

Solid lipid nanoparticles affect microbial colonization and enzymatic activity throughout the decomposition of alder leaves in freshwater microcosms.

scientific article published on 21 October 2016

Solid lipid nanoparticles for hydrophilic biotech drugs: Optimization and cell viability studies (Caco-2 & HEPG-2 cell lines)

scientific article published on 02 May 2014

Sucupira Oil-Loaded Nanostructured Lipid Carriers (NLC): Lipid Screening, Factorial Design, Release Profile, and Cytotoxicity

scientific article published on 06 February 2020

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Review of Classical and New Compounds: Part-I

scientific article published on 10 October 2019

Surface engineering of silica nanoparticles for oral insulin delivery: Characterization and cell toxicity studies

article

Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells

scientific article published on 22 November 2018

Synthesis and factorial design applied to a novel chitosan/sodium polyphosphate nanoparticles via ionotropic gelation as an RGD delivery system

scientific article published on 21 November 2016

Synthesis, spectroscopic characterization and biological evaluation of unsymmetrical aminosquarylium cyanine dyes

scientific article published on 11 May 2017

Targeting dendritic cells for the treatment of autoimmune disorders

scientific article

The Influence of Polysaccharide Coating on the Physicochemical Parameters and Cytotoxicity of Silica Nanoparticles for Hydrophilic Biomolecules Delivery

scientific article published on 27 July 2019

The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements

scientific article published on 01 May 2020

Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems

scientific article published on 01 August 2019

Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds

scientific article published on 01 July 2018

Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities

scientific article published on 03 June 2020

Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts)

scientific article published on 04 May 2018

Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying

scientific article published on 07 October 2013

Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems

scientific article published on 12 November 2019

Two- and Three-Dimensional Spectrofluorimetric Qualitative Analysis of Selected Vegetable Oils for Biomedical Applications

scientific article published on 28 November 2020

Uveal melanoma: physiopathology and new in situ-specific therapies

scientific article published on 11 May 2019

Validation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate

scientific article published on 28 August 2014

Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents

scientific article published on 01 January 2018

alpha-Latrotoxin increases spontaneous and depolarization-evoked exocytosis from pancreatic islet beta-cells

scientific article published on 10 March 2005

d-α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity

scientific article published on 22 June 2016

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