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List of works by Jon S Thorson

'Sweetening' natural products via glycorandomization

scientific article published on 13 October 2005

A Methodological Comparison: The Advantage of Phosphorimidates in Expanding the Sugar Nucleotide Repertoire

scientific article published on 01 October 1998

A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay

scientific article published on 15 March 2008

A comprehensive review of glycosylated bacterial natural products.

scientific article

A continuous assay for DNA cleavage using molecular break lights

scientific article published on January 2006

A continuous assay for DNA cleavage: the application of "break lights" to enediynes, iron-dependent agents, and nucleases

scientific article published on December 2000

A diastereoselective oxa-Pictet-Spengler-based strategy for (+)-frenolicin B and epi-(+)-frenolicin B synthesis

scientific article published on 23 October 2013

A divergent enantioselective strategy for the synthesis of griseusins

scientific article

A general NMR-based strategy for the in situ characterization of sugar-nucleotide-dependent biosynthetic pathways

scientific article

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

scientific article published on 21 January 2003

A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution

scientific article

A simple strategy for glycosyltransferase-catalyzed aminosugar nucleotide synthesis.

scientific article

AdoMet analog synthesis and utilization: current state of the art.

scientific article

Antibacterial Activity of Endophytic Actinomycetes Isolated from the Medicinal Plant Vochysia divergens (Pantanal, Brazil).

scientific article published on 6 September 2017

Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471. ⬇️

scientific article published on 19 March 2018

Antibacterial and Cytotoxic Actinomycins Y6-Y9 and Zp from Streptomyces sp. Strain Gö-GS12. ⬇️

scientific article published on 13 October 2016

Antibiotic optimization via in vitro glycorandomization ⬇️

scientific article published on November 9, 2003

Application of the nucleotidylyltransferase Ep toward the chemoenzymatic synthesis of dTDP-desosamine analogues

scientific article published in May 2003

Assessment of Chemoselective Neoglycosylation Methods Using Chlorambucil as a Model ⬇️

scientific article published on October 25, 2010

Asymmetric enzymatic glycosylation of mitoxantrone

scientific article

Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces ⬇️

scientific article published on 22 May 2019

Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2. ⬇️

scientific article published on 30 March 2017

Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds.

scientific article published in March 2018

Biosynthetic and Synthetic Strategies for Assembling Capuramycin-Type Antituberculosis Antibiotics

scientific article published on 25 January 2019

Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis

scientific article published on 22 April 2013

Characterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formation

scientific article published on December 2008

Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.

scientific article

Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.

scientific article

Chemoenzymatic synthesis of the Salmonella group E1 core trisaccharide using a recombinant beta-(1-->4)-mannosyltransferase.

scientific article

Cofactor characterization and mechanistic studies of CDP-6-deoxy-delta 3,4-glucoseen reductase: exploration into a novel enzymatic C-O bond cleavage event

scientific article published on November 1993

Colchicine glycorandomization influences cytotoxicity and mechanism of action

scientific article

Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity

scientific article

Correction to "Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8"

scientific article published on 12 October 2015

Creation of the first anomeric d / l -sugar kinase by means of directed evolution ⬇️

scientific article published on November 11, 2003

Crystal structure of SsfS6, the putativeC-glycosyltransferase involved in SF2575 biosynthesis

scientific article

Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691 ⬇️

scientific article published on 19 June 2015

Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.

scientific article

Development of a universal glycosyltransferase assay amenable to high-throughput formats

scientific article

Dihydroisocoumarins produced by Diaporthe cf. heveae LGMF1631 inhibiting citrus pathogens

scientific article published on 10 August 2019

Diversifying vancomycin via chemoenzymatic strategies.

scientific article

Enhancement of cyclopamine via conjugation with nonmetabolic sugars

scientific article

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

scientific article

Enhancing the divergent activities of betulinic acid via neoglycosylation

scientific article

Enhancing the latent nucleotide triphosphate flexibility of the glucose-1-phosphate thymidylyltransferase RmlA.

scientific article published on 12 April 2007

Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics

scientific article published on 24 May 2018

Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules ⬇️

scientific article (publication date: October 2011)

Enzymatic tools for engineering natural product glycosylation.

scientific article

Enzyme-mediated bioorthogonal technologies: catalysts, chemoselective reactions and recent methyltransferase applications

scientific article published in 2021

Expanding nature's chemical repertoire through metabolic engineering and biocatalysis

scientific article published on 28 March 2012

Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution

scientific article

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

scientific article

Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins

scientific article

Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues

scientific article (publication date: 7 April 2014)

Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects

scientific article published on 17 January 2019

Frenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15 ⬇️

scientific article

Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways

scientific article published on 28 June 2016

Glycosyloxyamine neoglycosylation: a model study using calicheamicin.

scientific article

Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation

scientific article (publication date: December 2011)

HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration

scientific article published on 01 May 2019

High-throughput colorimetric assays for nucleotide sugar formation and glycosyl transfer.

scientific article published in January 2012

Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning

scientific article

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

scientific article

Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteria

scientific article published on 18 April 2008

Influence of Sugar Amine Regiochemistry on Digitoxigenin Neoglycoside Anticancer Activity

scientific article

Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics

scientific article published on 13 February 2018

Loop dynamics of thymidine diphosphate-rhamnose 3'-O-methyltransferase (CalS11), an enzyme in calicheamicin biosynthesis

scientific article published on January 2016

Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe. ⬇️

scientific article published on 31 January 2017

Mechanistic implications of Escherichia coli galactokinase structure-based engineering

scientific article published in July 2004

Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes

scientific article published on 03 March 2020

Microbispora sp. LGMB259 endophytic actinomycete isolated from Vochysia divergens (Pantanal, Brazil) producing β-carbolines and indoles with biological activity.

scientific article

Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy

scientific article published on 16 November 2020

Model for antibiotic optimization via neoglycosylation: synthesis of liponeoglycopeptides active against VRE

scientific article published on 12 June 2007

Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46. ⬇️

scientific article published on 9 April 2014

Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation

scientific article

Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine.

scientific article

Natural product glycorandomization.

scientific article published on April 2004

Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification

scientific article

Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads

scientific article

Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells

scientific article published in April 1995

OleD Loki as a Catalyst for Hydroxamate Glycosylation

scientific article published on 26 November 2019

OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation

scientific article published on 9 January 2017

Phaeophleospora vochysiae Savi & Glienke sp. nov. Isolated from Vochysia divergens Found in the Pantanal, Brazil, Produces Bioactive Secondary Metabolites.

scientific article published on 15 February 2018

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

scientific article

Probing the coenzyme and substrate binding events of CDP-D-glucose 4,6-dehydratase: mechanistic implications

scientific article published on April 1996

Probing the regiospecificity of enzyme-catalyzed steroid glycosylation.

scientific article

Puromycins B-E, Naturally Occurring Amino-Nucleosides Produced by the Himalayan Isolate Streptomyces sp. PU-14G ⬇️

scientific article published on 12 November 2018

Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model

scientific article

Recombinant E. coli prototype strains for in vivo glycorandomization.

scientific article

Resistance to enediyne antitumor antibiotics by CalC self-sacrifice

scientific article (publication date: 12 September 2003)

Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15. ⬇️

scientific article

Secondary metabolites produced by Microbacterium sp. LGMB471 with antifungal activity against the phytopathogen Phyllosticta citricarpa

scientific article published on 18 December 2018

Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa ⬇️

scientific article published on 21 February 2019

Selective detection of sugar phosphates by capillary electrophoresis/mass spectrometry and its application to an engineered E. coli host

scientific article published in July 2007

Self-Resistance During Muraymycin Biosynthesis: A Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.

scientific article published on 7 May 2018

Spore forming Actinobacterial diversity of Cholistan Desert Pakistan: Polyphasic taxonomy, antimicrobial potential and chemical profiling

scientific article published on 22 February 2019

Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6. ⬇️

scientific article

Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases

scientific article

Structural Characterization of CalS8, a TDP-α-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis

scientific article

Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis

scientific article

Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway

scientific article

Structural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway

scientific article

Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis

scientific article published on 21 September 2021

Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2

scientific article published on 7 January 2015

Structural characterization of the mitomycin 7-O-methyltransferase

scientific article

Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.

scientific article published on 29 April 2016

Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces

scientific article published on 13 December 2019

Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM

scientific article

Structure and specificity of a permissive bacterial C-prenyltransferase

scientific article published on 6 February 2017

Structure, activity, synthesis and biosynthesis of aryl-C-glycosides.

scientific article

Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization

scientific article

Structure-based engineering of E. coli galactokinase as a first step toward in vivo glycorandomization

scientific article published in June 2005

Structure-based enhancement of the first anomeric glucokinase

scientific article published in July 2004

Structure-based enzyme engineering and its impact on in vitro glycorandomization.

scientific article published on January 2004

Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization

scientific article published on 01 March 2003

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses

scientific article published on 01 April 2006

Synthesis and antibacterial activity of doxycycline neoglycosides.

scientific article published on 29 August 2013

Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly

scientific article published on April 2008

Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8 ⬇️

scientific article

The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.

scientific article published on 8 April 2015

The biosynthesis of indolocarbazoles in a heterologous E. coli host.

scientific article

The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710 ⬇️

scientific article

The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers

scientific article

The hedamycin locus implicates a novel aromatic PKS priming mechanism

scientific article

The identification of perillyl alcohol glycosides with improved antiproliferative activity

scientific article

The impact of enzyme engineering upon natural product glycodiversification

scientific article

The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility

scientific article

The native production of the sesquiterpene isopterocarpolone by Streptomyces sp. RM-14-6 ⬇️

scientific article

The structural biology of enzymes involved in natural product glycosylation

scientific article

Total synthesis of griseusins and elucidation of the griseusin mechanism of action

scientific article published on 27 June 2019

Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

scientific article

Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT fromSulfolobus solfataricus

scientific article

Using Ambystoma mexicanum (Mexican axolotl) embryos, chemical genetics, and microarray analysis to identify signaling pathways associated with tissue regeneration

scientific article

Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions

scientific article (publication date: 21 August 2011)

Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2. ⬇️

scientific article

Vochysiamides A and B: Two new bioactive carboxamides produced by the new species Diaporthe vochysiae

scientific article published on 22 July 2019

Warfarin glycosylation invokes a switch from anticoagulant to anticancer activity.

scientific article published on 28 June 2011

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