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List of works by Vicente Felipo

3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis

scientific article published on 12 April 2011

5'-adenosine monophosphate inhibits ternary complex formation by rat liver eIF-2

scientific article published on 01 August 1987

A Multiomics Study To Unravel the Effects of Developmental Exposure to Endosulfan in Rats: Molecular Explanation for Sex-Dependent Effects

scientific article published on 10 September 2019

A protein-free diet changes synaptosomal membrane fluidity and tyrosine and glutamate transport

scientific article published in May 1989

A rare and revealing glimpse of the cerebrospinal fluid of patients with hepatic encephalopathy

scientific article published on 24 September 2016

A rat liver cell-free system for the synthesis of proteins and their transport into mitochondria

scientific article published on 01 January 1986

A simple animal model of hyperammonemia

scientific article

A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A.

scientific article published in January 2007

A specific inhibitor of protein kinase C induces differentiation of neuroblastoma cells

scientific article

Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells

scientific article published on 01 March 1991

Activation of N-methyl-D-aspartate receptors in rat brain in vivo following acute ammonia intoxication: characterization by in vivo brain microdialysis

scientific article published on 01 March 2000

Activation of NMDA receptor mediates the toxicity of ammonia and the effects of ammonia on the microtubule-associated protein MAP-2.

scientific article published on January 1993

Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death

scientific article published on 5 July 2005

Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients.

scientific article published on 10 January 2007

Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane

scientific article published on 13 October 2006

Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons

scientific article published in May 1997

Acute ammonia intoxication induces an NMDA receptor-mediated increase in poly(ADP-ribose) polymerase level and NAD metabolism in nuclei of rat brain cells

scientific article

Acute ammonia neurotoxicity in vivo involves increase in cytoplasmic protein P53 without alterations in other markers of apoptosis

scientific article

Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors

scientific article published on January 1992

Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain.

scientific article published on 3 July 2008

Adenosine 5'-triphosphate stimulates the release of polypeptides from mitochondria

scientific article published on 01 April 1985

Alcohol exposure during brain development reduces 3H-MK-801 binding and enhances metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis in rat hippocampus

scientific article published on 01 March 1995

Alteration of mitochondrial calcium homeostasis by ammonia-induced activation of NMDA receptors in rat brain in vivo

scientific article published on 01 October 2000

Alterations in adipocytokines and cGMP homeostasis in morbid obesity patients reverse after bariatric surgery

scientific article published on 01 February 2013

Alterations in soluble guanylate cyclase content and modulation by nitric oxide in liver disease.

scientific article published in November 2004

Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis

scientific article published in January 2001

Altered modulation of soluble guanylate cyclase by nitric oxide in patients with liver disease.

scientific article

Altered modulation of soluble guanylate cyclase in lymphocytes from patients with liver disease.

scientific article

Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits.

scientific article

Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo: molecular mechanisms and implications for neuropathology.

scientific article

Ammonia prevents activation of NMDA receptors by glutamate in rat cerebellar neuronal cultures

scientific article published on 01 December 1995

Ammonia prevents glutamate-induced but not low K(+)-induced apoptosis in cerebellar neurons in culture

scientific article published in January 2003

Ammonium ingestion prevents depletion of hepatic energy metabolites induced by acute ammonium intoxication

scientific article published on 01 November 1991

Ammonium injection induces an N-methyl-D-aspartate receptor-mediated proteolysis of the microtubule-associated protein MAP-2.

scientific article

Amyloid-β impairs, and ibuprofen restores, the cGMP pathway, synaptic expression of AMPA receptors and long-term potentiation in the hippocampus

scientific article published on January 2010

An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain

scientific article published on 05 March 2012

Assembly and disassembly of brain tubulin is affected by high ammonia levels

scientific article published on 01 March 1989

Beta-amyloid-induced activation of caspase-3 in primary cultures of rat neurons

scientific article published on 01 October 2000

Bile duct ligation plus hyperammonemia in rats reproduces the alterations in the modulation of soluble guanylate cyclase by nitric oxide in brain of cirrhotic patients

scientific article published in January 2005

Blocking NMDA receptors delays death in rats with acute liver failure by dual protective mechanisms in kidney and brain.

scientific article

Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication

scientific article

Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and Na+,K(+)-ATPase

scientific article published on 01 December 1994

Brain cholinergic impairment in liver failure.

scientific article published on 04 September 2008

Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis.

scientific article published in June 2006

Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats.

scientific article published on 25 October 2010

Brain regional alterations in the modulation of the glutamate-nitric oxide-cGMP pathway in liver cirrhosis. Role of hyperammonemia and cell types involved.

scientific article

Carbachol-induced hydrolysis of phospholipids in hippocampal slices may be mediated in part by subsequent activation of metabotropic glutamate receptors

scientific article published in June 1998

Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons

scientific article published on 01 October 1996

Carnitine inhibits hydrolysis of inositol phospholipids induced by activation of metabotropic receptors

scientific article published in December 1998

Carnitine prevents NMDA receptor-mediated activation of MAP-kinase and phosphorylation of microtubule-associated protein 2 in cerebellar neurons in culture

scientific article published in August 2002

Cell-free synthesis and processing of a large precursor of glutamate dehydrogenase of rat liver

scientific article published on 01 August 1982

Cerebellum proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138.

scientific article published on 14 June 2011

Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy.

scientific article

Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation

scientific article published in March 2006

Chronic exposure to 2,5-hexanedione impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in rat brain in vivo.

scientific article published in June 2003

Chronic exposure to aluminium impairs the glutamate-nitric oxide-cyclic GMP pathway in the rat in vivo.

scientific article published in March 1999

Chronic exposure to aluminum impairs neuronal glutamate-nitric oxide-cyclic GMP pathway

scientific article published on 01 April 1998

Chronic exposure to ammonia alters basal and NMDA-induced phosphorylation of NMDA receptor-subunit NR1.

scientific article

Chronic exposure to ammonia alters pathways modulating phosphorylation of microtubule-associated protein 2 in cerebellar neurons in culture

scientific article published on December 1999

Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture

scientific article published on January 2005

Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture.

scientific article published in January 2005

Chronic hyperammonemia alters extracellular glutamate, glutamine and GABA and membrane expression of their transporters in rat cerebellum. Modulation by extracellular cGMP

scientific article published on 11 January 2019

Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo.

scientific article published in December 2003

Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats.

scientific article published in May 2010

Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo

scientific article published in October 1998

Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes: a putative peripheral marker for neurological alterations.

scientific article published in April 1999

Chronic hyperammonemia in vivo impairs long-term potentiation in hippocampus by altering activation of cyclic GMP-dependent-protein kinase and of phosphodiesterase 5.

scientific article published in August 2005

Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum

scientific article published on 30 November 2009

Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxication

scientific article published in January 1993

Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium-calmodulin kinase II.

scientific article published on 21 May 2008

Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations.

scientific article

Chronic liver failure in rats impairs glutamatergic synaptic transmission and long-term potentiation in hippocampus and learning ability

scientific article published in April 2007

Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats

scientific article published on 01 February 2000

Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy.

scientific article published on December 2006

Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy

scientific article published on 10 November 2011

Control of brain glutamine synthesis by NMDA receptors.

scientific article published on January 2007

Control of urea synthesis and ammonia detoxification.

scientific article published on January 1993

Control of urea synthesis and ammonia utilization in protein deprivation and refeeding

scientific article published on 01 March 1991

Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis.

scientific article published on August 2005

Current state of knowledge of hepatic encephalopathy (part II): changes in brain white matter tracts integrity are associated with cognitive deficits in minimal hepatic encephalopathy

scientific article published on 20 September 2016

Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications.

scientific article published on 02 March 2010

Determination of intracellular ATP in primary cultures of neurons

scientific article published on 01 February 1997

Developmental exposure to polychlorinated biphenyls 52, 138 or 180 affects differentially learning or motor coordination in adult rats. Mechanisms involved

scientific article published on 9 March 2010

Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats.

scientific article

Developmental exposure to polychlorinated biphenyls or methylmercury, but not to its combination, impairs the glutamate-nitric oxide-cyclic GMP pathway and learning in 3-month-old rats.

scientific article published on 20 May 2008

Diet induced hyperammonemia decreases neuronal nuclear size in rat entorhinal cortex

scientific article published in August 1997

Differential effects of chronic hyperammonemia on modulation of the glutamate-nitric oxide-cGMP pathway by metabotropic glutamate receptor 5 and low and high affinity AMPA receptors in cerebellum in vivo.

scientific article published on 11 April 2012

Differential effects of the protein kinase C inhibitors H7 and calphostin C on the cell cycle of neuroblastoma cells

scientific article published in November 1992

Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved.

scientific article published on 5 November 2010

Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo

scientific article published on 12 June 2011

Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying.

scientific article published in December 2002

Early spatial memory deficit induced by 2,5-hexanedione in the rat.

scientific article published in March 2002

Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment.

scientific article published in March 2007

Effect of L-carnitine on postischemic inhibition of protein synthesis in the rat brain

scientific article published in September 2009

Effect of a prolonged protein-free diet on cell size, protein synthesis and degradation of rat liver

scientific article published in January 1989

Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria

scientific article

Effects of hyperammonemia on brain protein kinase C substrates

scientific article published on September 1996

Encapsulation of glutamine synthetase in mouse erythrocytes: a new procedure for ammonia detoxification

scientific article

Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points.

scientific article published on 2 November 2017

Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia

scientific article published in 2022

Exit of proteins and fragments thereof from mitochondria is accelerated by the import of cytosolic synthesized proteins

scientific article published on 01 May 1983

Experimental models of hepatic encephalopathy: ISHEN guidelines.

scientific article published on July 2009

Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models

scientific article published on 15 November 2011

Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging

scientific article

Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved.

scientific article published on 15 December 2017

Extracellular Protein Kinase A Modulates Intracellular Calcium/Calmodulin-Dependent Protein Kinase II, Nitric Oxide Synthase, and the Glutamate-Nitric Oxide-cGMP Pathway in Cerebellum. Differential Effects in Hyperammonemia.

scientific article

Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats

scientific article published on 28 February 2020

Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway

scientific article

Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms

scientific article published on 17 October 2018

Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy.

scientific article published on 21 March 2012

GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

scientific article published on 2 July 2015

Gender differences in spatial learning, synaptic activity, and long-term potentiation in the hippocampus in rats: molecular mechanisms

scientific article published on 22 June 2015

Gender differential effects of developmental exposure to methyl-mercury, polychlorinated biphenyls 126 or 153, or its combinations on motor activity and coordination

scientific article

Glutamate and muscarinic receptors in the molecular mechanisms of acute ammonia toxicity and of its prevention.

scientific article published on January 1997

Glutamate induces a calcineurin-mediated dephosphorylation of Na+,K(+)-ATPase that results in its activation in cerebellar neurons in culture

scientific article published on 01 January 1996

Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure

scientific article published on 5 February 2007

Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide ⬇️

scientific article published on September 1, 2003

H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells

scientific article published on 01 May 1992

H7, an inhibitor of protein kinase C, inhibits tumour cell division in mice bearing ascitic Ehrlich's carcinoma

scientific article published on 01 January 1994

H7, an inhibitor of protein kinase C, prevents serum-induced phosphorylation of Raf and MAP kinase in neuroblastoma cells

scientific article published on 01 August 1996

Haemodynamic effects of long-term administration of sildenafil in normotensive pregnant and non-pregnant rats.

scientific article published on 18 January 2011

Hepatic encephalopathy: effects of liver failure on brain function.

scientific article published on 23 October 2013

High ammonia levels decrease brain acetylcholinesterase activity both in vivo and in vitro

scientific article published on 01 August 1994

High ammonia levels in brain induce tubulin in cerebrum but not in cerebellum

scientific article published on 01 December 1988

Hippocampal long-term potentiation is reduced in mature compared to young male rats but not in female rats

scientific article published on 29 March 2007

Hyperammonaemia alters the mechanisms by which metabotropic glutamate receptors in nucleus accumbens modulate motor function.

scientific article published on 22 June 2007

Hyperammonemia alters glycinergic neurotransmission and modulation of the glutamate-nitric oxide-cGMP pathway by extracellular glycine in cerebellum in vivo.

scientific article

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms

scientific article published on 8 February 2018

Hyperammonemia alters the modulation by different neurosteroids of the glutamate-nitric oxide-cyclic GMP pathway through NMDA- GABAA - or sigma receptors in cerebellum in vivo.

scientific article

Hyperammonemia decreases body fat content in rat

scientific article published on 01 June 1989

Hyperammonemia decreases protein-kinase-C-dependent phosphorylation of microtubule-associated protein 2 and increases its binding to tubulin

scientific article published in May 1993

Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro

scientific article published in April 2000

Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G.

scientific article published in February 2004

Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex

scientific article published on 31 December 2008

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

scientific article published on 16 February 2016

Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy

scientific article published on 18 March 2010

Hyperammonemia induces polymerization of brain tubulin

scientific article published in September 1990

Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices.

scientific article

Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra

scientific article published on 10 August 2006

IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy

scientific article published on 01 March 2009

Impaired release of corticosterone from adrenals contributes to impairment of circadian rhythms of activity in hyperammonemic rats.

scientific article published in February 2013

In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats

scientific article published on 14 May 2016

In vivo exposure to carbon monoxide causes delayed impairment of activation of soluble guanylate cyclase by nitric oxide in rat brain cortex and cerebellum.

scientific article

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats.

scientific article published on 27 December 2017

Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task

scientific article

Induction of rat brain tubulin following ammonium ingestion

scientific article published on 01 October 1988

Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts.

scientific article published in August 2007

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.

scientific article published on 13 September 2016

Inherited neuromuscular diseases. Translation from pathomechanisms to therapies

scientific article published on 01 January 2009

Inhibition of protein kinase C arrests proliferation of human tumors

scientific article published in June 1991

Inhibition of protein kinase C induces differentiation in Neuro-2a cells ⬇️

scientific article published on June 1, 1990

Inhibition of protein kinase C induces differentiation of neuroblastoma cells

scientific article published on 01 September 1989

Inhibition of protein kinase C restores Na+,K(+)-ATPase activity in sciatic nerve of diabetic mice

scientific article published on 01 April 1992

Inhibitors of phospholipase C prevent glutamate neurotoxicity in primary cultures of cerebellar neurons

scientific article published on 01 March 2000

Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures

scientific article published in February 1993

Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls

scientific article published on 24 February 2012

Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy.

scientific article

Is cognitive impairment in cirrhotic patients due to increased peroxynitrite and oxidative stress?

scientific article published on 12 February 2015

L-carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity

scientific article

Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum

scientific article published on 01 October 1995

Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus.

scientific article

Long-term ingestion of ammonium increases acetylglutamate and urea levels without affecting the amount of carbamoyl-phosphate synthase

scientific article published on 01 October 1988

Long-term ingestion of ammonium inhibits lysosomal proteolysis in rat liver

scientific article published on 01 July 1988

Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase, alterations in hyperammonemia

scientific article published on 16 June 2005

Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase, and cGMP-degrading phosphodiesterase.

scientific article published in December 2002

Lymphocyte cytochrome c oxidase, cyclic GMP and cholinergic muscarinic receptors as peripheral indicators of carbon monoxide neurotoxicity after acute and repeated exposure in the rat.

scientific article published on 8 November 2005

Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors

scientific article published on 28 August 2007

Mass spectrometrical analysis of galectin proteins in primary rat cerebellar astrocytes

scientific article

Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: therapeutical implications.

scientific article published on 6 February 2009

Metabolism of cyclic GMP in non-alcoholic fatty liver disease in morbid obesity.

scientific article published in August 2011

Metabotropic glutamate receptor 5 modulates the nitric oxide-cGMP pathway in cerebellum in vivo through activation of AMPA receptors

scientific article published on 12 February 2011

Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase

scientific article published on 4 January 2010

Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons.

scientific article

Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28-, Th22 and Tfh and B lymphocytes

scientific article published on 27 July 2017

Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy.

scientific article published on 22 August 2015

Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture.

scientific article published in November 2004

Modulation of NMDA receptors by AKT kinase.

scientific article

Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function.

scientific article

Modulation of glutamine synthesis in cultured astrocytes by nitric oxide.

scientific article published in August 1997

Molecular mechanisms of the alterations in NMDA receptor-dependent long-term potentiation in hyperammonemia.

scientific article

Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats.

scientific article

Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy

scientific article published on 08 July 2020

Mutagenicity of nitric oxide-releasing compounds in Escherichia coli: effect of superoxide generation and evidence for two mutagenic mechanisms

scientific article published in October 2001

NMDA receptor antagonists prevent acute ammonia toxicity in mice

scientific article published on 01 October 1996

NMDA receptors in hyperammonemia and hepatic encephalopathy.

scientific article published on December 2007

NMDA-induced phosphorylation of the microtubule-associated protein MAP-2 is mediated by activation of nitric oxide synthase and MAP kinase

scientific article

Neurobiology of ammonia.

scientific article

Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity

scientific article published in May 2009

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

scientific article published on 18 April 2016

Neuronal and inducible nitric oxide synthase expression in the rat cerebellum following portacaval anastomosis

scientific article published on 01 June 2005

Neurons exposed to ammonia reproduce the differential alteration in nitric oxide modulation of guanylate cyclase in the cerebellum and cortex of patients with liver cirrhosis

scientific article

Neurotoxicity of ammonia and glutamate: molecular mechanisms and prevention.

scientific article published in August 1998

Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons

scientific article published on July 1998

Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication

scientific article published in March 1998

Nitroarginine, an inhibitor of nitric oxide synthetase, attenuates ammonia toxicity and ammonia-induced alterations in brain metabolism

scientific article published on 01 April 1995

Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests

scientific article

Normality tables in the Spanish population for psychometric tests used in the diagnosis of minimal hepatic encephalopathy

scientific article published in July 2006

Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts

scientific article published in February 2005

Paradoxical protection of both protein-free and high protein diets against acute ammonium intoxication

scientific article published on 01 October 1988

Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests

scientific article published on 01 February 2012

Perinatal exposure to purity-controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months.

scientific article published on 08 July 2013

Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications

scientific article published on 22 March 2019

Pharmacological manipulation of cyclic GMP levels in brain restores learning ability in animal models of hepatic encephalopathy: therapeutic implications.

scientific article published on March 2006

Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis

scientific article published on April 2006

Polychlorinated biphenyls PCB 153 and PCB 126 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.

scientific article published on 29 April 2009

Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms

scientific article

Precursors of mitochondrial proteins are degraded in the cytosol at different rates

scientific article published on 01 December 1986

Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats

scientific article published on 26 November 2013

Prenatal exposure of rats to ammonia impairs NMDA receptor function and affords delayed protection against ammonia toxicity and glutamate neurotoxicity

scientific article published on 01 September 1995

Prenatal exposure to aluminum reduces expression of neuronal nitric oxide synthase and of soluble guanylate cyclase and impairs glutamatergic neurotransmission in rat cerebellum

scientific article

Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons

scientific article published in January 2007

Preparation and handling of brain mitochondria useful to study uptake and release of calcium

scientific article published in July 2001

Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors.

scientific article

Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide

scientific article published on 01 July 1999

Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.

scientific article

Prevention of the acute neurotoxic effects of phenytoin on rat peripheral nerve by H7, an inhibitor of protein kinase C

scientific article published on 01 November 1992

Progressive reduction of sleep time and quality in rats with hepatic encephalopathy caused by portacaval shunts.

scientific article published on 12 November 2011

Protective effect of long term ammonium ingestion against acute ammonium intoxication

scientific article published on 01 June 1988

Protein kinase C inhibitors, H7 and calphostin C, inhibit induction of DNA synthesis by cytosolic extracts of exponentially growing neuroblastoma cells in isolated nuclei

scientific article published on 01 December 1994

Protein kinase C isoforms and cell proliferation in neuroblastoma cells

scientific article

Proteome analysis of primary neurons and astrocytes from rat cerebellum

scientific article published in May 2005

Rats that consume caffeine show decreased brain protein synthesis.

scientific article published in January 1986

Rats with mild bile duct ligation show hepatic encephalopathy with cognitive and motor impairment in the absence of cirrhosis: effects of alcohol ingestion.

scientific article published on 18 May 2014

Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition.

scientific article published on 4 December 2013

Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations.

scientific article published on 23 July 2015

Real-time cytometric assay of nitric oxide and superoxide interaction in peripheral blood monocytes: A no-wash, no-lyse kinetic method.

scientific article published on 11 March 2015

Reduced white matter microstructural integrity correlates with cognitive deficits in minimal hepatic encephalopathy.

scientific article published on 11 November 2013

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy ⬇️

scientific article published on 2 November 2016

Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients.

scientific article published in November 2002

Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat.

scientific article

Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain

scientific article

Retention of actin synthesis in liver under conditions that inhibit synthesis of almost all other proteins

scientific article published on 01 January 1987

Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage

scientific article published in 2021

Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications.

scientific article published on 22 January 2009

Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons

article

Role of nitric oxide and cyclic GMP in glutamate-induced neuronal death

scientific article

Roles of the NMDA Receptor and EAAC1 Transporter in the Modulation of Extracellular Glutamate by Low and High Affinity AMPA Receptors in the Cerebellum in Vivo: Differential Alteration in Chronic Hyperammonemia

scientific article published on 2 October 2015

Selective regional alterations in the content or distribution of neuronal and glial cytoskeletal proteins in brain of rats chronically exposed to 2,5-hexanedione

scientific article published in August 2002

Selective regional distribution of tubulin induced in cerebrum by hyperammonemia

scientific article published on 01 December 1989

Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms.

scientific article published in July 2005

Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance

scientific article published on October 2010

Serum nitrotyrosine and psychometric tests as indicators of impaired fitness to drive in cirrhotic patients with minimal hepatic encephalopathy

scientific article published on 29 May 2013

Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus

scientific article published on 28 November 2016

Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts.

scientific article published on 20 June 2016

Sildenafil citrate improves perinatal outcome in fetuses from pre-eclamptic rats.

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Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms.

scientific article published on 29 October 2015

Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy

scientific article published on 11 March 2017

Sources of oxygen radicals in brain in acute ammonia intoxication in vivo

scientific article published in August 2003

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

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Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway

scientific article published on 22 February 2020

Sustained recovery of Na(+)-K(+)-ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC

scientific article published on 01 February 1993

Synthesis and transport of the precursor for the beta-subunit of rat liver F1-ATPase

scientific article published on 01 January 1984

Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity

scientific article (publication date: August 2004)

Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction

scientific article published on 19 November 2019

The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons.

scientific article published on 14 February 2018

The effects of hyperammonemia in learning and brain metabolic activity.

scientific article published on 12 January 2014

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

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The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy

scientific article published in December 2006

The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats.

scientific article

The precursor of rat liver mitochondrial glutamate dehydrogenase has enzymatic activity

scientific article published on 01 July 1983

The susceptibility of MAP-2 to proteolytic degradation increases when bound to tubulin

scientific article published in October 1992

Transport and regulation of polypeptide precursors of mature mitochondrial proteins.

scientific article published on January 1984

Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy.

scientific article

Transport of the precursor for rat liver glutamate dehydrogenase into mitochondria "in vitro".

scientific article

Treatment of hyperammonemia with carbamylglutamate in rats

scientific article published on 01 March 1992

Treatment with sildenafil prevents impairment of learning in rats born to pre-eclamptic mothers.

scientific article published on 9 September 2010

Trialkylglycines: a new family of compounds with in vivo neuroprotective activity.

scientific article

Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging

scientific article published in June 2011

Value of the critical flicker frequency in patients with minimal hepatic encephalopathy

scientific article published on 01 April 2007

cGMP modulates stem cells differentiation to neurons in brain in vivo

scientific article published in December 2009

cGMP modulates stem cells differentiation to neurons in brain in vivo pathological implications.

scientific article published in August 2011

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts.

scientific article published on 2 June 2011

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