List of works - Stefano Ricagno

A covalent homodimer probing early oligomers along amyloid aggregation

scientific article

A recurrent D-strand association interface is observed in β-2 microglobulin oligomers

scientific article

An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.

scientific article published in March 2017

Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity

scientific article published on 28 August 2019

Characterization of β2-microglobulin conformational intermediates associated to different fibrillation conditions

article published in 2011

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

scientific article

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

scientific article published in December 2017

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

scientific article

Corrigendum to “The crystal structure of FdxA, a 7Fe ferredoxin from Mycobacterium smegmatis” [Biochem. Biophys. Res. Commun. 360 (2007) 97–102]

scholarly article published in Biochemical and Biophysical Research Communications

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

scientific article published on 20 March 2019

Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

scholarly article

Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution

scientific article published in April 2004

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer

scientific article

Crystal structure of the receptor-binding protein head domain from Lactococcus lactis phage bIL170.

scientific article published on September 2006

Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid

scientific article (publication date: May 2003)

Crystallization and preliminary X-ray diffraction analysis of Nsp15 from SARS coronavirus

scientific article

Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase fromOxalobacter formigenes

scientific article published on 27 June 2003

CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization

scientific article

D-strand perturbation and amyloid propensity in beta-2 microglobulin

scientific article

DE loop mutations affect beta2-microglobulin stability and amyloid aggregation

scientific article

DE-loop mutations affect beta2 microglobulin stability, oligomerization, and the low-pH unfolded form

scientific article published on July 2010

DcE2F, a functional plant E2F-like transcriptional activator from Daucus carota

scientific article published in June 2000

De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase

scientific article (publication date: August 2007)

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis

scientific article published in December 2015

Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes

scientific article

Edge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphatase

scientific article

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

scientific article published on 11 July 2020

Embelin binds to human neuroserpin and impairs its polymerisation.

scientific article

FRET studies of various conformational states adopted by transthyretin.

scientific article published on 6 May 2017

Fibrillar vs Crystalline Full-Length β-2-Microglobulin Studied by High-Resolution Solid-State NMR Spectroscopy

scientific article published in 2010

Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer

scientific article

Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics

scientific article

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties

scientific article published on 03 May 2020

Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis

scientific article published in 2024

Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin

scientific article

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation

scientific article

Human neuroserpin: structure and time-dependent inhibition

scientific article

Identification of variable sites in Sars-CoV-2 and their abundance profiles in time

scientific article published on 01 May 2020

Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State

scientific article published on 18 January 2019

Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes

scientific article

Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis:insights into the timing of proteolysis

scientific article published on 20 September 2020

Molecular bases of neuroserpin function and pathology.

scientific article published in August 2010

Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant

scientific article

On the molecular structure of human neuroserpin polymers

scientific article published on 9 November 2011

Rapid proton-detected NMR assignment for proteins with fast magic angle spinning

scientific article

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

scientific article published on 6 May 2016

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus

scientific article

Structure, stability, and aggregation of β-2 microglobulin mutants: insights from a Fourier transform infrared study in solution and in the crystalline state

scientific article published on 3 April 2012

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties

scientific article

The crystal structure of FdxA, a 7Fe ferredoxin from Mycobacterium smegmatis

scientific article

The effects of an ideal beta-turn on beta-2 microglobulin fold stability.

scientific article

The enzymes of oxalate metabolism: unexpected structures and mechanisms

scientific article

The tempered polymerization of human neuroserpin

scientific article

The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

scientific article

Tools for the rational design of bivalent microtubule-targeting drugs.

scientific article published on 6 September 2016

Two latent and two hyperstable polymeric forms of human neuroserpin

scientific article

Wild type beta-2 microglobulin and DE loop mutants display a common fibrillar architecture

scientific article published on 24 March 2015

l- to d-Amino Acid Substitution in the Immunodominant LCMV-Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics

scientific article published on 07 March 2022

List of works by Stefano Ricagno

A covalent homodimer probing early oligomers along amyloid aggregation

A recurrent D-strand association interface is observed in β-2 microglobulin oligomers

An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.

Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity

Characterization of β2-microglobulin conformational intermediates associated to different fibrillation conditions

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

Corrigendum to “The crystal structure of FdxA, a 7Fe ferredoxin from Mycobacterium smegmatis” [Biochem. Biophys. Res. Commun. 360 (2007) 97–102]

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer

Crystal structure of the receptor-binding protein head domain from Lactococcus lactis phage bIL170.

Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid

Crystallization and preliminary X-ray diffraction analysis of Nsp15 from SARS coronavirus

Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase fromOxalobacter formigenes

CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization

D-strand perturbation and amyloid propensity in beta-2 microglobulin

DE loop mutations affect beta2-microglobulin stability and amyloid aggregation

DE-loop mutations affect beta2 microglobulin stability, oligomerization, and the low-pH unfolded form

DcE2F, a functional plant E2F-like transcriptional activator from Daucus carota

De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis

Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes

Edge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphatase

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

Embelin binds to human neuroserpin and impairs its polymerisation.

FRET studies of various conformational states adopted by transthyretin.

Fibrillar vs Crystalline Full-Length β-2-Microglobulin Studied by High-Resolution Solid-State NMR Spectroscopy

Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer

Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties

Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis

Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation

Human neuroserpin: structure and time-dependent inhibition

Identification of variable sites in Sars-CoV-2 and their abundance profiles in time

Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State

Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes

Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis:insights into the timing of proteolysis

Molecular bases of neuroserpin function and pathology.

Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant

On the molecular structure of human neuroserpin polymers

Rapid proton-detected NMR assignment for proteins with fast magic angle spinning

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus

Structure, stability, and aggregation of β-2 microglobulin mutants: insights from a Fourier transform infrared study in solution and in the crystalline state

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties

The crystal structure of FdxA, a 7Fe ferredoxin from Mycobacterium smegmatis

The effects of an ideal beta-turn on beta-2 microglobulin fold stability.

The enzymes of oxalate metabolism: unexpected structures and mechanisms

The tempered polymerization of human neuroserpin

The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

Tools for the rational design of bivalent microtubule-targeting drugs.

Two latent and two hyperstable polymeric forms of human neuroserpin

Wild type beta-2 microglobulin and DE loop mutants display a common fibrillar architecture

l- to d-Amino Acid Substitution in the Immunodominant LCMV-Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics