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List of works by Brenda Schulman

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

scientific article

A role of autophagy in spinocerebellar ataxia-Rare exception or general principle?

scientific article published on 22 April 2016

A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

scientific article published on 09 August 2019

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

scientific article published on 24 September 2012

Allosteric regulation through a switch element in the autophagy E2, Atg3

scientific article published on 09 November 2019

Atomistic autophagy: the structures of cellular self-digestion

scientific article

Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.

scientific article published on December 2013

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

scientific article

Building and remodelling Cullin-RING E3 ubiquitin ligases

scientific article

CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

scientific article published on 13 September 2021

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

scientific article published on 20 September 2018

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

scientific article

Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation

scientific article published on 01 June 2022

Crystallographic Characterization of ATG Proteins and Their Interacting Partners

scientific article published on 9 November 2016

DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift

scientific article published on 07 December 2020

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

scientific article published on 11 January 2021

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.

scientific article published on 12 May 2015

Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

scientific article published on 26 March 2018

Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE

scientific article published in 2024

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

scientific article

Dual-color pulse-chase ubiquitination assays to simultaneously monitor substrate priming and extension

scientific article published on 11 February 2019

Identification and characterization of the first small molecule inhibitor of MDMX

scientific article

Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4.

scientific article

Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis

scientific article published on 01 December 2020

Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler

scientific article published on 07 December 2020

Mechanism of APC/CCDC20 activation by mitotic phosphorylation

scientific article published on 25 April 2016

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

scientific article published on 9 October 2014

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

scientific article

Molecular glue concept solidifies

scientific article published on 01 January 2020

Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.

scientific article published on 26 January 2016

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures ⬇️

scientific article published on November 11, 2012

Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex

scientific article published in 2024

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

scientific article published on 29 July 2020

Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20

scientific article published on 09 March 2020

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

scientific article published on 26 March 2018

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

scientific article published on 25 October 2018

Production of Human ATG Proteins for Lipidation Assays.

scientific article published on 11 November 2016

Protein neddylation: beyond cullin-RING ligases

scientific article

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

scientific article (publication date: September 2015)

Quantifying the heterogeneity of macromolecular machines by mass photometry

scientific article published on 14 April 2020

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

scientific article

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

scientific article published on 30 March 2015

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer

scientific article

Structural Basis for a Reciprocal Regulation between SCF and CSN ⬇️

scientific article published on 06 September 2012

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.

scientific article

Structural biology: A protein engagement RING.

scientific article published in September 2012

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism ⬇️

scientific article published on May 23, 2013

Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface

scientific article

Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8

scientific article

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome

scientific article published on 6 December 2014

Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1 ⬇️

scientific article published on February 6, 2013

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

scientific article

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

scientific article

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains

scientific article published on 12 February 2021

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

scientific journal article

Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly

scientific article published on 03 February 2021

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

scientific article published on 25 April 2016

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