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List of works by Berthold Gottgens

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site

scientific article

A HaemAtlas: characterizing gene expression in differentiated human blood cells

scientific article

A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis

scientific article

A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms

scientific article

A graphical model approach visualizes regulatory relationships between genome-wide transcription factor binding profiles

scientific article

A new RNASeq-based reference transcriptome for sugar beet and its application in transcriptome-scale analysis of vernalization and gibberellin responses.

scientific article

A novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity

scientific article (publication date: September 2008)

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients ⬇️

scientific article published on August 2, 2010

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

scientific article published on 27 March 2018

A single-cell molecular map of mouse gastrulation and early organogenesis

scientific article published on 20 February 2019

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

scientific article published on 30 June 2016

A tripartite transcription factor network regulates primordial germ cell specification in mice

scientific article

Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).

scientific article

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

scientific article published on 17 January 2013

Advancing Stem Cell Research through Multimodal Single-Cell Analysis

scientific article published on 13 January 2020

Advancing haematopoietic stem and progenitor cell biology through single-cell profiling.

scientific article published on 4 June 2016

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability.

scientific article published on 22 February 2016

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

scientific article published on 04 March 2020

Analysis of multiple genomic sequence alignments: a web resource, online tools, and lessons learned from analysis of mammalian SCL loci.

scientific article

Assessing the reliability of spike-in normalization for analyses of single-cell RNA sequencing data ⬇️

scientific article published on 13 October 2017

BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

scientific article published on 9 August 2013

BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium

scientific article published on 13 December 2019

BTR: training asynchronous Boolean models using single-cell expression data

scientific article

Blood and immune development in human fetal bone marrow and Down syndrome

scientific article published on 29 September 2021

Blood: Education for stem cells

scientific article published on 17 May 2017

BloodExpress: a database of gene expression in mouse haematopoiesis

scientific article

Building an ENCODE-style data compendium on a shoestring.

scientific article

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

scientific article published on 03 September 2020

CODEX: a next-generation sequencing experiment database for the haematopoietic and embryonic stem cell communities.

scientific article

Cell-Specific Computational Modeling of the PIM Pathway in Acute Myeloid Leukemia.

scientific article published on 13 December 2016

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis

scientific article published on 24 March 2013

Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis

scientific article published on 27 January 2022

Chromatin structure and transcriptional regulation of the stem cell leukaemia (SCL) gene in mast cells.

scientific article published on May 1999

Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.

scientific article published on 25 June 2015

CoMoDis: composite motif discovery in mammalian genomes

scientific article

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

scientific article published on 01 December 2019

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

scientific article published on October 2010

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

scientific article

Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting.

scientific article

ConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sites

scientific article

Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms

scientific article

Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells

scientific article

Correction: Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits.

scientific article published on 21 July 2011

Creating cellular diversity through transcription factor competition

scientific article

Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.

scientific article published in November 2017

Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.

scientific article

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

scientific article published on 08 August 2016

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.

scientific article published on June 2016

Deciphering transcriptional control mechanisms in hematopoiesis:the impact of high-throughput sequencing technologies.

scientific article published on 23 July 2011

Decoding human fetal liver haematopoiesis

scientific article published on 09 October 2019

Decoding the regulatory network of early blood development from single-cell gene expression measurements.

scientific article

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development

article

Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.

scientific article published on 8 January 2018

Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq.

scientific article

Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages

scientific article

Delineating MEIS1 cis-regulatory elements active in hematopoietic cells

scientific article published on 7 October 2013

Demystifying blood stem cell fates

scientific article published in March 2017

Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data

scientific article

Differentiation of murine committed megakaryocytic progenitors isolated by a novel strategy reveals the complexity of GATA and Ets factor involvement in megakaryocytopoiesis and an unexpected potential role for GATA-6.

scientific article

Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis

scientific article published on 04 May 2020

Discordant regulation of SCL/TAL-1 mRNA and protein during erythroid differentiation.

scientific article published on July 1995

Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium

scientific article published on 01 December 2019

Dissecting stem cell differentiation using single cell expression profiling

scientific article published on 22 September 2016

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

scientific article published on 16 March 2020

Distinct Molecular Trajectories Converge to Induce Naive Pluripotency

scientific article published on 15 August 2019

Distinct mechanisms direct SCL/tal-1 expression in erythroid cells and CD34 positive primitive myeloid cells

scientific article published in March 1997

Diverse Routes toward Early Somites in the Mouse Embryo

scientific article published on 01 December 2020

Drug target optimization in chronic myeloid leukemia using innovative computational platform

scientific article published on 3 February 2015

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation. ⬇️

scientific article published on 18 February 2016

Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia

scientific article

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

scientific article published on 2 May 2011

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

scientific article

Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code

scientific article published on 19 September 2008

Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer

scientific article published on 16 February 2006

Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis

scientific article

Enhanced hematovascular contribution of SCL 3' enhancer expressing fetal liver cells uncovers their potential to integrate in extramedullary adult niches

scientific article published in January 2010

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.

scientific article published on 20 July 2010

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

scientific article

Erratum: Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis

article

Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal.

scientific article published in May 2013

Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal

scientific journal article

Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development

scientific article published on 14 February 2012

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.

scientific article published on June 2002

Establishment of mouse expanded potential stem cells.

scientific article

Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence

scientific article published on January 2006

Expanded potential stem cell media as a tool to study human developmental hematopoiesis in vitro

scientific article published on 18 July 2019

Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors

scientific article

Fast and sensitive multiple alignment of large genomic sequences

scientific article

Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells.

scientific article published on 30 June 2005

From genes to cells to tissues--modelling the haematopoietic system.

scientific article published on 14 July 2009

From haematopoietic stem cells to complex differentiation landscapes.

scientific article published in January 2018

Function-based identification of mammalian enhancers using site-specific integration

scientific article

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.

scientific article published on 18 June 2015

GATA transcription in a small rhodamine 123(low)CD34(+) subpopulation of a peripheral blood-derived CD34(-)CD105(+) mesenchymal cell line.

scientific article published on August 2002

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

scientific article published on 08 August 2019

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

scientific article published on 28 May 2015

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

scientific article

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

scientific article

Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development

scientific journal article

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche

scientific article published on 21 October 2019

Gene regulatory networks governing haematopoietic stem cell development and identity

scientific article published on January 2010

Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data

scientific article

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium.

scientific article

Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia

scientific article

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

scientific article published on 23 August 2013

Genome-scale technology driven advances to research into normal and malignant haematopoiesis

scientific article published on 31 December 2012

Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

scientific journal article

Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.

scientific article

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes.

scientific article published on 23 August 2013

Genome-wide analysis of transcriptional regulators in human hscs reveals a densely interconnected network of coding and non-coding genes

article

Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia

scientific article

Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development.

scientific article published on 13 January 2005

Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.

scientific article

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

scientific article

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.

scientific article published on 27 May 2013

Hard-wired heterogeneity in blood stem cells revealed using a dynamic regulatory network model

scientific article published on July 2013

How haematopoiesis research became a fertile ground for regulatory network biology as pioneered by Eric Davidson

scientific article published on 21 November 2020

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

scientific article published on July 2009

Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells

scientific article published on 15 November 2002

Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets

scientific article published on 04 November 2019

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

scientific article published on 23 August 2016

Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites

scientific article

Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression

scientific article published on 14 January 2013

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL(+) multipotent adult progenitor cell clones from peripheral blood.

scientific article

In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis.

scientific article published on 14 December 2004

Index sorting resolves heterogeneous murine hematopoietic stem cell populations

scientific article

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.

scientific article published on 26 August 2004

Inference, validation, and dynamic modeling of transcription networks in multipotent hematopoietic cells

scientific article published on 18 April 2007

Integrated analyses of chromatin accessibility and gene expression data for elucidating the transcriptional regulatory mechanisms during early hematopoietic development in mouse.

scientific article published on 18 March 2013

Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model

scientific article published on 25 January 2016

Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validation

scientific article published on 12 December 2011

Interactions between lineage-associated transcription factors govern haematopoietic progenitor states

scientific article published on 26 October 2020

Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells

scientific article published on 01 May 2020

Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation

scientific article

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

scientific article

Key regulators control distinct transcriptional programmes in blood progenitor and mast cells

scientific article

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

scientific article

Large conserved domains of low DNA methylation maintained by Dnmt3a

scientific article published on 24 November 2013

Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool

scientific article published on 12 June 2019

Lineage-restricted regulation of the murine SCL/TAL-1 promoter.

scientific article

Local and systemic responses to SARS-CoV-2 infection in children and adults

scientific article published on 22 December 2021

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

scientific article published on 11 October 2011

Machine learning predicts putative hematopoietic stem cells within large single-cell transcriptomics data sets

scientific article published on 09 September 2019

Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity

scientific article published in October 2017

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

scientific article published on 23 November 2020

Manipulation of Mouse Hematopoietic Progenitors by Specific Retroviral Infection

scientific article published on 18 August 2003

Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain

scientific article

Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits

scientific article

Maximum parsimony analysis of gene expression profiles permits the reconstruction of developmental cell lineage trees

scientific article published on 23 February 2011

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

scientific article published on 12 September 2017

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome

scientific article

Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate

scientific article

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

scientific article

Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse

scientific article published on October 2009

Multi-omics profiling of mouse gastrulation at single-cell resolution

scientific article published on 11 December 2019

Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.

scientific article published on 26 April 2017

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

scientific article published in Nature Communications

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

scientific article published on 29 March 2017

Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

scientific article published on 02 December 2019

Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells

scientific article published in Scientific Reports

New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing

scientific article published on 06 February 2019

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

scientific article published on 09 March 2020

Nuclear JAK2.

scientific article published in December 2011

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Ontogeny of haematopoiesis: recent advances and open questions

scientific article published on 22 October 2009

PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

scientific article published on 19 March 2019

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element

scientific article

Prenatal development of human immunity

scientific article published on 01 May 2020

Probabilistic PCA of censored data: accounting for uncertainties in the visualization of high-throughput single-cell qPCR data

scientific article

Processing, visualising and reconstructing network models from single-cell data.

scientific article

Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif

scientific journal article

Protocol: precision engineering of plant gene loci by homologous recombination cloning in Escherichia coli

scientific article

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

scientific article

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

scientific article

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells

scientific article published on 06 September 2018

Real-time PCR mapping of DNaseI-hypersensitive sites using a novel ligation-mediated amplification technique

scientific article

Reconstructing Gene Regulatory Networks That Control Hematopoietic Commitment

scientific article published on 01 January 2019

Reconstructing blood stem cell regulatory network models from single-cell molecular profiles

scientific article

Regulatory network control of blood stem cells

scientific article

Rescue of the lethal scl(-/-) phenotype by the human SCL locus

scientific article published in June 2002

Resolving early mesoderm diversification through single-cell expression profiling

scientific article published on 6 July 2016

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver

scientific journal article

Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration

scientific article published on 27 April 2020

SCNS: a graphical tool for reconstructing executable regulatory networks from single-cell genomic data.

scientific article

Shared transcription factors contribute to distinct cell fates

scientific article

Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis

scientific article

Single cell genomics and developmental biology: moving beyond the generation of cell type catalogues

scientific article published on 03 July 2020

Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses

scientific article published on 07 October 2013

Single-Cell Sequencing in Normal and Malignant Hematopoiesis

scientific article published on 01 March 2018

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis

scientific article

Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine

scientific article published on August 2017

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification

scientific article

Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.

scientific article published on 21 November 2017

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

scientific article published on 10 July 2018

Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis

scientific article published on 30 March 2020

Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development

scientific article published on 20 October 2020

Single-cell multi-omics analysis of the immune response in COVID-19

scientific article published on 20 April 2021

Single-cell transcriptional profiling: a window into embryonic cell-type specification.

scientific article published on 17 April 2018

Sorting apples from oranges in single-cell expression comparisons

scientific article published on 01 April 2018

Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing

scientific article published in 2023

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

scientific article published on 8 February 2013

System-wide studies of the transcriptional programming of chromatin during early hematopoietic development

scientific article published on 18 March 2013

Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells

scientific article published on 25 November 2019

T cell cytolytic capacity is independent of initial stimulation strength

scholarly article by Arianne C Richard et al published 16 July 2018 in Nature Immunology

TFBScluster web server for the identification of mammalian composite regulatory elements

scientific article published on July 2006

TFBScluster: a resource for the characterization of transcriptional regulatory networks

scientific article published on 26 April 2005

TRES predicts transcription control in embryonic stem cells.

scientific article published on 23 June 2014

Tdr2, a new zebrafish transposon of the Tc1 family

scientific article published in November 1999

Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system.

scientific article published in March 2007

The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development

scientific article published in July 2012

The Human Cell Atlas

scientific article

The Human Cell Atlas

The JAK-STAT signaling pathway is differentially activated in CALR-positive compared with JAK2V617F-positive ET patients.

scientific article published on March 2015

The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity

scientific article published on 10 July 2015

The SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins.

scientific article published on 20 August 2007

The SCL 3' enhancer responds to Hedgehog signaling during hemangioblast specification

scientific article published on 01 December 2006

The SCL gene specifies haemangioblast development from early mesoderm.

scientific article published on July 1998

The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity

scholarly article

The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors

scientific article published on 08 January 2021

The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program

article

The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres

scientific article published on 15 January 2021

The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling

scientific article

The epidermis comprises autonomous compartments maintained by distinct stem cell populations

scientific article published on 15 August 2013

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

scientific article published on 20 April 2015

The gene encoding hematopoietic cell phosphatase (SHP-1) is structurally and transcriptionally intact in polycythemia vera

article

The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.

scientific article published on 28 August 2012

The local and systemic response to SARS-CoV-2 infection in children and adults

scientific article published on 15 March 2021

The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters

scientific article published on 25 March 2009

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.

scientific article published on 19 October 2006

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates

scientific article published on 27 February 2019

The proto-oncogene ERG in megakaryoblastic leukemias

scientific article

The pufferfish SLP-1 gene, a new member of the SCL/TAL-1 family of transcription factors.

scientific article published in February 1998

The role of the stem cell leukemia (SCL) gene in hematopoietic and endothelial lineage specification

scientific article

The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1

scientific article

The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production

scientific article published on 25 November 2020

The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.

scientific article published on 15 February 2012

The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis

scientific article published on 23 November 2011

The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors

scientific article

The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.

scientific article

The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.

scientific article published on 3 April 2009

The transcriptional programme controlled by Runx1 during early embryonic blood development

scientific article published on 21 April 2012

Three distinct patterns of histone H3Y41 phosphorylation mark active genes.

scientific article

Transcription of the SCL gene in erythroid and CD34 positive primitive myeloid cells is controlled by a complex network of lineage-restricted chromatin-dependent and chromatin-independent regulatory elements.

scientific article published in November 1997

Transcriptional hierarchies regulating early blood cell development

scientific article published on 13 August 2013

Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells

scientific article

Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling

scientific article published on 28 January 2014

Transcriptional network control of normal and leukaemic haematopoiesis

scientific article

Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation

scientific article

Transcriptional regulation of haematopoietic stem cells

scientific article published on January 2013

Transcriptional regulation of haematopoietic transcription factors.

scientific article published on 10 February 2011

Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci

scientific article

Transcriptional regulation of the stem cell leukemia gene by PU.1 and Elf-1.

scientific article

Transcriptional regulatory networks in haematopoiesis

scientific article published on 07 October 2008

Transgenic analysis of the stem cell leukemia +19 stem cell enhancer in adult and embryonic hematopoietic and endothelial cells.

scientific article published on 28 July 2005

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

scientific article published on 28 October 2020

Two Classes of Homeodomain Proteins Specify the Multiple A Mating Types of the Mushroom Coprinus cinereus

scientific article published in 1994

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

scientific article

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

scientific article published on 07 May 2018

Yolk sac cell atlas reveals multiorgan functions during human early development

scientific article published on 17 August 2023

cis-Regulatory remodeling of the SCL locus during vertebrate evolution.

scientific article published on 18 October 2010

p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion

scientific article published on 2 June 2022

p57Kip2 regulates embryonic haematopoietic stem cell numbers by controlling the size of the sympathoadrenal progenitor pool

Scientific preprint posted 13 September 2021

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