List of works - Samuel Singer

13C- and 31P-NMR studies of human colon cancer in-vitro and in-vivo

scientific article published on January 1993

A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas

scientific article

A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.

scientific article published on 29 February 2008

A differentiation-based phylogeny of cancer subtypes

scientific article

A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations

scientific article

A tribute to Murray F. Brennan, MD.

scientific article published in March 2008

Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation

scientific article published in June 2005

Activity of Sorafenib against desmoid tumor/deep fibromatosis

scientific article

Adult rhabdomyosarcoma survival improved with treatment on multimodality protocols.

scientific article published on 13 February 2013

Adults with Ewing's sarcoma/primitive neuroectodermal tumor: adverse effect of older age and primary extraosseous disease on outcome

scientific article published on 01 July 1999

Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival

scientific article

Advances in sarcoma genomics and new therapeutic targets

scientific article

Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression.

scientific article published on October 2006

Atypical lipomatous tumor/well-differentiated liposarcoma of the extremity and trunk wall: importance of histological subtype with treatment recommendations.

scientific article published on January 2004

Biochemical analysis using high-resolution magic angle spinning NMR spectroscopy distinguishes lipoma-like well-differentiated liposarcoma from normal fat.

scientific article

Blood neutrophil-to-lymphocyte ratio is prognostic in gastrointestinal stromal tumor.

scientific article published on 02 October 2012

Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma

scientific article published on 01 August 2004

Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma.

scientific article

Comparison of Perioperative Radiation Therapy and Surgery Versus Surgery Alone in 204 Patients With Primary Retroperitoneal Sarcoma: A Retrospective 2-Institution Study

scientific article published on July 2015

Comparison of local recurrence with conventional and intensity-modulated radiation therapy for primary soft-tissue sarcomas of the extremity

scientific article

Consistent MYC and FLT4 gene amplification in radiation‐induced angiosarcoma but not in other radiation‐associated atypical vascular lesions ⬇️

scientific article published on January 1, 2011

Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material

scientific article

Copy number losses define subgroups of dedifferentiated liposarcoma with poor prognosis and genomic instability.

scientific article published on 12 January 2012

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

scientific article

Diagnosis and management of lipomatous tumors.

scientific article

Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications

scientific article published on June 2015

Differentiation and reversal of malignant changes in colon cancer through PPARgamma

scientific article published on 01 September 1998

Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation

scientific article published on 01 July 2005

Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets.

scientific article published on 24 September 2013

Effectiveness of palliative procedures for intra-abdominal sarcomas.

scientific article

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

scientific article (publication date: 15 August 2002)

Empirical insights into the stochasticity of small RNA sequencing

scientific article published on 7 April 2016

Evaluation of a Clinically Applicable Post-Surgical Classification System for Primary Retroperitoneal Soft-Tissue Sarcoma

scientific article published on 12 April 2004

Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.

scientific article

Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology

scientific article

Fat-free MRI based on magnetization exchange

scientific article

Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.

scientific article published on June 2006

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas

scientific article published on December 2011

Functional copy-number alterations in cancer

scientific article

Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma.

scientific article

Gradient, high-resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells

scientific article

Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue

scientific article published on 01 September 1997

High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas.

scientific article published on 10 November 2011

High-resolution MAS NMR spectroscopy detection of the spin magnetization exchange by cross-relaxation and chemical exchange in intact cell lines and human tissue specimens

scientific article

High-risk features in radiation-associated breast angiosarcomas

scientific article published on 08 October 2013

Histology-based Classification Predicts Pattern of Recurrence and Improves Risk Stratification in Primary Retroperitoneal Sarcoma

scientific article

IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting

scientific article

Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data

scientific article

Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing

scientific article

Impact of Intensity-Modulated Radiation Therapy on Local Control in Primary Soft-Tissue Sarcoma of the Extremity

article

Influence of site on the therapeutic ratio of adjuvant radiotherapy in soft-tissue sarcoma of the extremity.

scientific article published in September 2005

Intensity Modulated Radiation Therapy for Primary Soft Tissue Sarcoma of the Extremity: Preliminary Results

scientific article published on 23 March 2007

Isotropic susceptibility shift under MAS: the origin of the split water resonances in 1H MAS NMR spectra of cell suspensions.

scientific article

KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors

scientific article

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

scientific article

Lessons learned from the study of 10,000 patients with soft tissue sarcoma.

scientific article

Liposarcoma subtypes: identification with computed tomography and ultrasound-guided percutaneous needle biopsy

scientific article published on 6 October 2004

Local control comparison of adjuvant brachytherapy to intensity-modulated radiotherapy in primary high-grade sarcoma of the extremity

scientific article published on 24 January 2011

Long-term outcomes in extremity soft tissue sarcoma after a pathologically negative re-resection and without radiotherapy

scientific article published on June 2008

Long-term salvageability for patients with locally recurrent soft-tissue sarcomas

scientific article published on 01 May 1992

Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

scientific article published in May 2004

Multiple primary soft tissue sarcomas

scientific article published on 01 December 2004

Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis

scientific article

Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma

scientific article published in November 2004

Novel MIR143-NOTCH fusions in benign and malignant glomus tumors

scientific article published on 2 September 2013

Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors--molecular characterization shows genetic overlap with endometrial stromal sarcoma.

scientific article

Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing.

scientific article published on 27 November 2014

Oncologic outcomes of sporadic, neurofibromatosis-associated, and radiation-induced malignant peripheral nerve sheath tumors

scientific article published on 10 August 2012

Optimal Percent Myxoid Component to Predict Outcome in High-Grade Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.

scientific article published on 12 January 2016

Outcome of Metastatic GIST in the Era before Tyrosine Kinase Inhibitors

article

PDGFRA activating mutations in gastrointestinal stromal tumors.

scientific article

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.

scientific article published on 21 September 2014

Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors

scientific article published on 01 January 2007

Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours.

scientific article published on 4 July 2012

Pediatric and adolescent synovial sarcoma: multivariate analysis of prognostic factors and survival outcomes.

scientific article published on 10 August 2012

Perioperative chemotherapy in patients undergoing pulmonary resection for metastatic soft-tissue sarcoma of the extremity : a retrospective analysis.

scientific article published in November 2007

Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma.

scientific article

Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS.

scientific article

Predicting outcome by growth rate of locally recurrent retroperitoneal liposarcoma: the one centimeter per month rule.

scientific article

Predictors of survival and recurrence in primary leiomyosarcoma.

scientific article published on 25 January 2013

Prognostic Factors for Survival in Patients With Locally Recurrent Extremity Soft Tissue Sarcomas

scientific article published on 03 March 2005

Prognostic factors and survival in pediatric and adolescent liposarcoma

scientific article

Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors

scientific article published on 01 September 2002

Reconstruction after soft tissue sarcoma resection in the setting of brachytherapy: a 10-year experience

scientific article published on 01 May 2004

Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations.

scientific article published on 5 January 2016

Resolution of creatine and phosphocreatine 1H signals in isolated human skeletal muscle using HR-MAS 1H NMR.

scientific article published on June 2008

Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor

article

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

scientific article

Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread.

scientific article published on 26 January 2007

Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma

scientific article

Soft tissue sarcoma diagnosed subsequent to lymphoma is associated with prior radiotherapy and decreased survival

scientific article published on 04 April 2011

Soft tissue sarcoma of the head & neck: nomogram validation and analysis of staging systems.

scientific article

Sorafenib Inhibits the Imatinib-Resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor

scientific article published on 01 August 2007

Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells

scientific article

Spindle cell rhabdomyosarcoma (so-called) in adults: report of two cases with emphasis on differential diagnosis

scientific article published on 01 April 1998

Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk

scientific article published in September 2006

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

scientific article

Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging.

scientific article published on January 2015

Targeted exome sequencing profiles genetic alterations in leiomyosarcoma

scientific article

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.

scientific article

The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial

scientific article

The impact of chemotherapy on the survival of patients with high-grade primary extremity liposarcoma.

scientific article published in October 2004

The landscape of somatic copy-number alteration across human cancers

scientific article

The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

scientific article

Translocation t(8;13)(p11;q11-12) in stem cell leukemia/lymphoma of T-cell and myeloid lineages

scientific article published on 01 February 1995

Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST).

scientific article published in February 2008

Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma.

scientific article published in September 2003

Validation of the postoperative nomogram for 12-year sarcoma-specific mortality

scientific article published in November 2004

Water suppression without signal loss in HR-MAS 1H NMR of cells and tissues.

scientific article

Why do patients with low-grade soft tissue sarcoma die?

scientific article published on October 2008

List of works by Samuel Singer

13C- and 31P-NMR studies of human colon cancer in-vitro and in-vivo

A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas

A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.

A differentiation-based phylogeny of cancer subtypes

A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations

A tribute to Murray F. Brennan, MD.

Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation

Activity of Sorafenib against desmoid tumor/deep fibromatosis

Adult rhabdomyosarcoma survival improved with treatment on multimodality protocols.

Adults with Ewing's sarcoma/primitive neuroectodermal tumor: adverse effect of older age and primary extraosseous disease on outcome

Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival

Advances in sarcoma genomics and new therapeutic targets

Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression.

Atypical lipomatous tumor/well-differentiated liposarcoma of the extremity and trunk wall: importance of histological subtype with treatment recommendations.

Biochemical analysis using high-resolution magic angle spinning NMR spectroscopy distinguishes lipoma-like well-differentiated liposarcoma from normal fat.

Blood neutrophil-to-lymphocyte ratio is prognostic in gastrointestinal stromal tumor.

Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma

Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma.

Comparison of Perioperative Radiation Therapy and Surgery Versus Surgery Alone in 204 Patients With Primary Retroperitoneal Sarcoma: A Retrospective 2-Institution Study

Comparison of local recurrence with conventional and intensity-modulated radiation therapy for primary soft-tissue sarcomas of the extremity

Consistent MYC and FLT4 gene amplification in radiation‐induced angiosarcoma but not in other radiation‐associated atypical vascular lesions ⬇️

Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material

Copy number losses define subgroups of dedifferentiated liposarcoma with poor prognosis and genomic instability.

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

Diagnosis and management of lipomatous tumors.

Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications

Differentiation and reversal of malignant changes in colon cancer through PPARgamma

Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation

Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets.

Effectiveness of palliative procedures for intra-abdominal sarcomas.

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

Empirical insights into the stochasticity of small RNA sequencing

Evaluation of a Clinically Applicable Post-Surgical Classification System for Primary Retroperitoneal Soft-Tissue Sarcoma

Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.

Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology

Fat-free MRI based on magnetization exchange

Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas

Functional copy-number alterations in cancer

Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma.

Gradient, high-resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells

Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue

High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas.

High-resolution MAS NMR spectroscopy detection of the spin magnetization exchange by cross-relaxation and chemical exchange in intact cell lines and human tissue specimens

High-risk features in radiation-associated breast angiosarcomas

Histology-based Classification Predicts Pattern of Recurrence and Improves Risk Stratification in Primary Retroperitoneal Sarcoma

IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting

Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data

Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing

Impact of Intensity-Modulated Radiation Therapy on Local Control in Primary Soft-Tissue Sarcoma of the Extremity

Influence of site on the therapeutic ratio of adjuvant radiotherapy in soft-tissue sarcoma of the extremity.

Intensity Modulated Radiation Therapy for Primary Soft Tissue Sarcoma of the Extremity: Preliminary Results

Isotropic susceptibility shift under MAS: the origin of the split water resonances in 1H MAS NMR spectra of cell suspensions.

KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

Lessons learned from the study of 10,000 patients with soft tissue sarcoma.

Liposarcoma subtypes: identification with computed tomography and ultrasound-guided percutaneous needle biopsy

Local control comparison of adjuvant brachytherapy to intensity-modulated radiotherapy in primary high-grade sarcoma of the extremity

Long-term outcomes in extremity soft tissue sarcoma after a pathologically negative re-resection and without radiotherapy

Long-term salvageability for patients with locally recurrent soft-tissue sarcomas

Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

Multiple primary soft tissue sarcomas

Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis

Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma

Novel MIR143-NOTCH fusions in benign and malignant glomus tumors

Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors--molecular characterization shows genetic overlap with endometrial stromal sarcoma.

Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing.

Oncologic outcomes of sporadic, neurofibromatosis-associated, and radiation-induced malignant peripheral nerve sheath tumors

Optimal Percent Myxoid Component to Predict Outcome in High-Grade Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.

Outcome of Metastatic GIST in the Era before Tyrosine Kinase Inhibitors

PDGFRA activating mutations in gastrointestinal stromal tumors.

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.

Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors

Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours.

Pediatric and adolescent synovial sarcoma: multivariate analysis of prognostic factors and survival outcomes.

Perioperative chemotherapy in patients undergoing pulmonary resection for metastatic soft-tissue sarcoma of the extremity : a retrospective analysis.

Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma.

Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS.

Predicting outcome by growth rate of locally recurrent retroperitoneal liposarcoma: the one centimeter per month rule.