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List of works by Michele Mishto

A large fraction of HLA class I ligands are proteasome-generated spliced peptides.

scientific article published on 20 October 2016

A mathematical model of protein degradation by the proteasome

scientific article published on 21 January 2005

A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms

scientific article published in April 2006

Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells

scientific article published in January 2002

An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

scientific article published on 3 November 2017

An in silico-in vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients

scientific article published on 15 November 2019

Association of p53 polymorphisms and colorectal cancer: modulation of risk and progression.

scientific article published on 12 May 2008

Author Correction: NMDA-receptor inhibition and oxidative stress during hippocampal maturation differentially alter parvalbumin expression and gamma-band activity

scientific article published in Scientific Reports

CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products

scientific article

Current understanding on the role of standard and immunoproteasomes in inflammatory/immunological pathways of multiple sclerosis

scientific article published on 02 January 2014

Driving forces of proteasome-catalyzed peptide splicing in yeast and humans

scientific article

ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope

scientific article published on 27 November 2019

Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study

scientific article published in February 2010

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease

scientific article

Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis

scientific article published on 09 March 2017

Genes, ageing and longevity in humans: problems, advantages and perspectives.

scientific article published on December 2006

Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides

scientific article published on 01 July 2021

Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population

scientific article

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

scientific article

Immunoproteasome expression is induced in mesial temporal lobe epilepsy

scientific article published on 30 March 2011

Immunoproteasome in Macaca fascicularis: no age-dependent modification of abundance and activity in the brain and insight into an in silico structural model

scientific article published in February 2008

Immunoproteasome in cancer and neuropathologies: a new therapeutic target?

scientific article published on January 2013

Immunoproteasomes and immunosenescence

scientific article published on October 2003

Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes

scientific article published on 15 May 2020

Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver

scientific article

Mapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells

scientific article published on 13 November 2018

Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics

scientific article published on 8 February 2008

Modelling proteasome and proteasome regulator activities.

scientific article

Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities

scientific article published on 22 May 2013

Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection

scientific article

NMDA-receptor inhibition and oxidative stress during hippocampal maturation differentially alter parvalbumin expression and gamma-band activity.

scientific article published on 22 June 2018

Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system

scientific article

Neuroinflammatory targets and treatments for epilepsy validated in experimental models.

scientific article

Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain

scientific article

Post-Translational Peptide Splicing and T Cell Responses

scientific article published on 19 August 2017

Proteasome Modulation in Brain: A New Target for Anti-Aging Drugs?

Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation

scientific article published on 20 November 2014

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes

scientific article published on 6 April 2016

Proteolytic dynamics of human 20S thymoproteasome

scientific article published on 26 March 2019

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

scientific article

Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing

scientific article published on September 2016

Studies on immunoproteasome in human liver. Part I: absence in fetuses, presence in normal subjects, and increased levels in chronic active hepatitis and cirrhosis

scientific article published on 26 May 2010

Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies.

scientific article published on January 2010

The 20S proteasome splicing activity discovered by SpliceMet

scientific article

The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing

scientific article

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.

scientific article

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy.

scientific article

Towards a liquid self: how time, geography, and life experiences reshape the biological identity

scientific article published on 09 April 2014

Untangling Extracellular Proteasome-Osteopontin Circuit Dynamics in Multiple Sclerosis

scientific article published on 20 March 2019

Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?

scientific article published on 01 June 2018

inSPIRE: An open-source tool for increased mass spectrometry identification rates using Prosit spectral prediction

scientific article published in 2022

p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes

scientific article published in December 2002

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