List of works - Juan Carlos Mobarec

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

scientific article

Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors.

scientific article published on March 2008

Computational modeling, docking and molecular dynamics of the transcriptional activator ComA bound to a newly-identified functional DNA binding site.

scientific article published on 11 March 2014

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

scientific article

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

scientific article

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. ⬇️

scientific article published on 21 December 2016

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design

retracted scientific article published on 09 August 2019

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

scientific article

Life in blue: copper resistance mechanisms of bacteria and archaea used in industrial biomining of minerals.

scientific article published on 11 July 2010

Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques

scientific article

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

scientific article published on 14 October 2016

Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors

scientific article published on December 2016

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

scientific article

The mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signaling

scientific article published on 3 November 2015

The quorum-sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs

scientific article published on 17 November 2015

Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach

scientific article published on 29 May 2017

List of works by Juan Carlos Mobarec

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors.

Computational modeling, docking and molecular dynamics of the transcriptional activator ComA bound to a newly-identified functional DNA binding site.

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. ⬇️

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

Life in blue: copper resistance mechanisms of bacteria and archaea used in industrial biomining of minerals.

Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

The mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signaling

The quorum-sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs

Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach