List of works - Steffen Sinning

A Photoswitchable Inhibitor of the Human Serotonin Transporter

scientific article published on 10 April 2020

A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state

scientific article

A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

scientific article published on 12 January 2018

A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin

scientific article published on 22 January 2015

An extended study of dimeric phenyl tropanes.

scientific article published on 10 June 2009

Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.

scientific article

Binding of mazindol and analogs to the human serotonin and dopamine transporters

scientific article

Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation.

scientific article

Cholesterol binding to a conserved site modulates conformation, pharmacology and transport kinetics of the human serotonin transporter.

scientific article published on 19 January 2018

Combinatorial synthesis of benztropine libraries and their evaluation as monoamine transporter inhibitors.

scientific article

Comparative modeling of the human monoamine transporters: similarities in substrate binding.

scientific article published on 8 November 2012

High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors

scientific article published on 22 August 2007

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

scientific article published on 22 April 2015

P25α / TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity

scientific article published on 23 December 2010

QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter

scientific article published on 10 May 2007

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

scientific article published on 04 September 2018

Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies

scientific article published on 23 February 2019

Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter

scientific article published on 21 April 2016

Synthesis of 3,7-disubstituted imipramines by palladium-catalysed amination/cyclisation and evaluation of their inhibition of monoamine transporters

scientific article published on 18 August 2011

Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters

scientific article published on 30 March 2007

Two- and three dimensional combinatorial chemistry from multicomponent Grignard reagents

scientific article published in July 2004

Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release

scientific article

List of works by Steffen Sinning

A Photoswitchable Inhibitor of the Human Serotonin Transporter

A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state

A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin

An extended study of dimeric phenyl tropanes.

Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.

Binding of mazindol and analogs to the human serotonin and dopamine transporters

Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation.

Cholesterol binding to a conserved site modulates conformation, pharmacology and transport kinetics of the human serotonin transporter.

Combinatorial synthesis of benztropine libraries and their evaluation as monoamine transporter inhibitors.

Comparative modeling of the human monoamine transporters: similarities in substrate binding.

High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

P25α / TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity

QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies

Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter

Synthesis of 3,7-disubstituted imipramines by palladium-catalysed amination/cyclisation and evaluation of their inhibition of monoamine transporters

Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters

Two- and three dimensional combinatorial chemistry from multicomponent Grignard reagents

Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release