List of works - Lee Bardwell

A combination of multisite phosphorylation and substrate sequestration produces switchlike responses

scientific article

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission

scientific article

A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.

scientific article

A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates

scientific article (publication date: 29 August 2003)

A scalable and integrative system for pathway bioinformatics and systems biology

scientific article

A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast

scientific article

A theoretical framework for specificity in cell signaling

scientific article

A walk-through of the yeast mating pheromone response pathway

scientific article

A walk-through of the yeast mating pheromone response pathway

scientific article published in September 2004

Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates

scientific article

Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs

scientific article published in March 2004

BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages

scientific article published on August 2011

CK2 activates kinesin via induction of a conformational change

scientific article

Casein kinase 2 reverses tail-independent inactivation of kinesin-1.

scientific article

Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation

scientific article

Characterization of the RAD10 gene of Saccharomyces cerevisiae and purification of Rad10 protein

scientific article

Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate

scientific article

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors

scientific article

Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells

scientific article

Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.

scientific article

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

scientific article

G-protein signaling: a new branch in an old pathway

scientific article published on October 2006

High frequency of large spontaneous deletions of DNA in tumor-derived CHEF cells

scientific article

Inhibition of Rad3 DNA helicase activity by DNA adducts and abasic sites: implications for the role of a DNA helicase in damage-specific incision of DNA

scientific article published on 01 January 1993

Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway

scientific article

Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases

scientific article

Mathematical models of specificity in cell signaling

scientific article published on 26 February 2007

Mechanisms of MAPK signalling specificity

scientific article

Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo

scientific article

Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae

scientific article

Noise filtering tradeoffs in spatial gradient sensing and cell polarization response

scientific article

Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis

scientific article published on 30 October 2008

Plant Signalling Pathways: A Comparative Evolutionary Overview

article

Protein scaffolds can enhance the bistability of multisite phosphorylation systems

scientific article

Pseudokinases: Flipping the ATP for AMPylation

scientific article published on 01 January 2019

Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK

scientific article

Selectivity of docking sites in MAPK kinases

scientific article

Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae

scientific article published on December 1994

Signal transduction: turning a switch into a rheostat

scientific article published on October 2008

Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.

scientific article

Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease

scientific article

Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation

scientific article

Stable and specific association between the yeast recombination and DNA repair proteins RAD1 and RAD10 in vitro

scientific article published on July 1992

Substrate specificity of the Rad3 ATPase/DNA helicase of Saccharomyces cerevisiae and binding of Rad3 protein to nucleic acids.

scientific article

Synthetic biology: modulating the MAP kinase module.

scientific article published in April 2011

The DNA helicase and adenosine triphosphatase activities of yeast Rad3 protein are inhibited by DNA damage. A potential mechanism for damage-specific recognition

scientific article published on 01 January 1992

The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.

scientific article published on 10 April 2017

The mutagenic and carcinogenic effects of gene transfer.

scientific article

Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions

scientific article

Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae

scientific article

Ultrasensitive responses and specificity in cell signaling

scientific article

Yeast DNA recombination and repair proteins Rad1 and Rad10 constitute a complex in vivo mediated by localized hydrophobic domains

scientific article

Yeast RAD3 protein binds directly to both SSL2 and SSL1 proteins: implications for the structure and function of transcription/repair factor b.

scientific article

List of works by Lee Bardwell

A combination of multisite phosphorylation and substrate sequestration produces switchlike responses

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission

A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.

A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates

A scalable and integrative system for pathway bioinformatics and systems biology

A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast

A theoretical framework for specificity in cell signaling

A walk-through of the yeast mating pheromone response pathway

A walk-through of the yeast mating pheromone response pathway

Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates

Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs

BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages

CK2 activates kinesin via induction of a conformational change

Casein kinase 2 reverses tail-independent inactivation of kinesin-1.

Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation

Characterization of the RAD10 gene of Saccharomyces cerevisiae and purification of Rad10 protein

Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors

Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells

Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

G-protein signaling: a new branch in an old pathway

High frequency of large spontaneous deletions of DNA in tumor-derived CHEF cells

Inhibition of Rad3 DNA helicase activity by DNA adducts and abasic sites: implications for the role of a DNA helicase in damage-specific incision of DNA

Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway

Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases

Mathematical models of specificity in cell signaling

Mechanisms of MAPK signalling specificity

Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo

Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae

Noise filtering tradeoffs in spatial gradient sensing and cell polarization response

Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis

Plant Signalling Pathways: A Comparative Evolutionary Overview

Protein scaffolds can enhance the bistability of multisite phosphorylation systems

Pseudokinases: Flipping the ATP for AMPylation

Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK

Selectivity of docking sites in MAPK kinases

Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae

Signal transduction: turning a switch into a rheostat

Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.

Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease

Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation

Stable and specific association between the yeast recombination and DNA repair proteins RAD1 and RAD10 in vitro

Substrate specificity of the Rad3 ATPase/DNA helicase of Saccharomyces cerevisiae and binding of Rad3 protein to nucleic acids.

Synthetic biology: modulating the MAP kinase module.

The DNA helicase and adenosine triphosphatase activities of yeast Rad3 protein are inhibited by DNA damage. A potential mechanism for damage-specific recognition

The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.

The mutagenic and carcinogenic effects of gene transfer.

Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions

Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae

Ultrasensitive responses and specificity in cell signaling

Yeast DNA recombination and repair proteins Rad1 and Rad10 constitute a complex in vivo mediated by localized hydrophobic domains

Yeast RAD3 protein binds directly to both SSL2 and SSL1 proteins: implications for the structure and function of transcription/repair factor b.