List of works by Ludmil B. Alexandrov

A mutational signature in gastric cancer suggests therapeutic strategies

scientific article published on 29 October 2015

A nonlinear dynamic model of DNA with a sequence-dependent stacking term

scientific article published on 05 March 2009

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

scientific article

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa

scientific article published on 01 August 2018

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.

scientific article published on 4 February 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

scientific article

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma

scientific article

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

scientific article

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

Binding of nucleoid-associated protein fis to DNA is regulated by DNA breathing dynamics

scientific article

C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

scientific article

Clock-like mutational processes in human somatic cells

scientific article published on 9 November 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

scientific article

Computer modeling describes gravity-related adaptation in cell cultures

scientific article

Correction: DNA Dynamics Is Likely to Be a Factor in the Genomic Nucleotide Repeats Expansions Related to Diseases.

scientific article

DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases

scientific article

DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation

scientific article

Deciphering signatures of mutational processes operative in human cancer

scientific article

Evaluating the role of coherent delocalized phonon-like modes in DNA cyclization

scientific article

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

scientific article

Fast randomization of large genomic datasets while preserving alteration counts

scientific article published on September 2014

Generating realistic null hypothesis of cancer mutational landscapes using SigProfilerSimulator

scientific article published on 07 October 2020

Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

scientific article published in February 2012

Genome sequencing of normal cells reveals developmental lineages and mutational processes

scientific article published on 29 June 2014

Genomic and evolutionary classification of lung cancer in never smokers

scientific article published on 06 September 2021

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

scientific article published on 06 January 2020

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

scientific article published on January 2014

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

scientific article published on 31 December 2019

Inactivating CUX1 mutations promote tumorigenesis

scientific article

Integrative genomic analysis of mouse and human hepatocellular carcinoma

article published in the Proceedings of the National Academy of Sciences of the United States of America

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

scientific article published on 13 March 2018

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

scientific article published on 23 July 2021

Mammalian stem cells reprogramming in response to terahertz radiation

scientific article

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Modelling the magnetic signature of neuronal tissue

scientific article

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

scientific article published on 24 February 2016

Mutational processes molding the genomes of 21 breast cancers

scientific article

Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.

scientific article

Mutational signatures associated with tobacco smoking in human cancer

scientific article (publication date: 3 November 2016)

Mutational signatures associated with tobacco smoking in human cancer

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice

scientific article published on 20 January 2020

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

scientific article

Non-thermal effects of terahertz radiation on gene expression in mouse stem cells

scientific article

Nonnegative/Binary matrix factorization with a D-Wave quantum annealer

scientific article published in PLoS ONE

Precancer Atlas to Drive Precision Prevention Trials.

scientific article

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

scientific article

Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors

scientific article published in Science

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

scientific article

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events

scientific article published on 30 August 2019

Somatic evolution and global expansion of an ancient transmissible cancer lineage

scientific article

Specificity and heterogeneity of terahertz radiation effect on gene expression in mouse mesenchymal stem cells

scientific article

St. Jude Cloud-a Pediatric Cancer Genomic Data Sharing Ecosystem

scientific article published on 06 January 2021

Strength of immune selection in tumors varies with sex and age

scientific article published on 17 August 2020

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

scientific article published on 22 June 2015

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

scientific article published on 05 December 2019

The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment

scientific article published on 16 January 2019

The Life History of 21 Breast Cancers

The Repertoire of Mutational Signatures in Human Cancer

The driver landscape of sporadic chordoma

scientific article published on 12 October 2017

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

scientific article published on 18 June 2020

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

scientific article published in Nature Communications

The mutational signature profile of known and suspected human carcinogens in mice

scientific article published on 28 September 2020

The repertoire of mutational signatures in human cancer

scientific article published on 05 February 2020

The role of structural parameters in DNA cyclization

scientific article published on 4 February 2016

The topography of mutational processes in breast cancer genomes

scientific article published on 02 May 2016

Timing the initiation of multiple myeloma

scientific article published on 21 April 2020

Timing, rates and spectra of human germline mutation

scientific article published on 14 December 2015

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

scientific article

Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage

scientific article

Understanding mutagenesis through delineation of mutational signatures in human cancer

scientific article published on 4 May 2016

Understanding the origins of human cancer

scientific article

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.

scientific article

Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy

scientific article published on 17 October 2019

Paulina is supported by:

About Paulina

Help