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List of works by Jason W. Locasale

A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect

scientific article published on September 2016

A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues

scientific article published in September 2010

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.

scientific article published on 8 September 2017

A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis

scientific article

A metabolic signature of colon cancer initiating cells

A metabolic signature of colon cancer initiating cells.

scientific article

A reactive metabolite as an immune suppressant

scientific article published on 01 May 2020

A roadmap for interpreting (13)C metabolite labeling patterns from cells

scientific article

A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data ⬇️

scientific article

A spoonful of DHAP keeps mTORC1 running on sugars

scientific article published on 27 July 2020

A strategy for sensitive, large scale quantitative metabolomics

scientific article

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

scientific article published on April 2016

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

scientific article published on 10 July 2015

Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding.

scientific article published in March 2008

Altered metabolism in cancer

scientific article

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

scientific article published in June 2012

Antigen receptor control of methionine metabolism in T cells

scientific article published on 27 March 2019

Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

scientific article published on 01 November 2019

Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics

scientific article published on 25 September 2020

Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide

scientific article

Biochemistry: A toxin that fuels metabolism

scientific article published in Nature

Cancer Cell Metabolism

scientific article published on 10 August 2011

Cancer's insatiable appetite

scientific article published on October 2009

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

scientific article published on 16 April 2018

Characterization of the usage of the serine metabolic network in human cancer

scientific article

Computational approaches for understanding energy metabolism

scientific article

Context dependent utilization of serine in cancer.

scientific article published on 30 January 2015

Cooperative virus propagation underlies COVID-19 transmission dynamics

scientific article published on 08 May 2020

Correction to: ‘The Warburg Effect: How Does it Benefit Cancer Cells?’

scientific article published on 11 February 2016

Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life

scientific article published on 09 October 2019

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Development and quantitative evaluation of a high-resolution metabolomics technology

scientific article published on 28 January 2014

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

scientific article published on 05 October 2020

Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo

scientific article published on 20 October 2015

Dysregulated metabolism contributes to oncogenesis

scientific article

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

scientific article published on 30 March 2016

Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice

scientific article published on January 2016

Environmental factors shape methionine metabolism in p16/MTAP deleted cells

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer

scientific article published on 16 June 2020

Epigenetics and cancer metabolism

scientific article published on 11 October 2013

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

scientific article published on 16 January 2017

Estimating relative changes of metabolic fluxes

scientific article

Evaluating bioactive food components in obesity and cancer prevention

scientific article

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

scientific article

Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases

scientific article

Extraction parameters for metabolomics from cultured cells

scientific article

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

scientific article published on 3 October 2016

Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain

scientific article

Genetic selection for enhanced serine metabolism in cancer development

scientific article published on 15 November 2011

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.

scientific article published on 16 October 2014

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.

scientific article published on 6 November 2014

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

scientific article published on March 2017

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

scientific article published on 05 August 2019

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

scientific article published on 07 August 2020

Heterogeneity of glycolysis in cancers and therapeutic opportunities

scientific article

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

scientific article published on 21 April 2013

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

scientific article published on 20 March 2015

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

scientific article

Human pluripotent stem cells decouple respiration from energy production

scientific article

IDH3α regulates one-carbon metabolism in glioblastoma

scientific article published on 02 January 2019

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.

scientific article published on August 2016

IL-6 and Ovarian Cancer--Letter

scientific article published on 6 December 2011

Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

scientific article published on 20 July 2020

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells

scientific article published on 01 January 2019

Influence of threonine metabolism on S-adenosylmethionine and histone methylation

scientific article published on November 2012

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

scientific article

Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism

scientific article published on 14 December 2016

Interactions between epigenetics and metabolism in cancers ⬇️

scientific article published on November 15, 2012

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

scientific article published in Nature Communications

Maximizing the efficacy of angiogenesis inhibitors

scientific article published on 5 December 2011

Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data

scientific article

Metabolic interactions with cancer epigenetics

scientific article published on 9 September 2016

Metabolic landscape of the tumor microenvironment at single cell resolution

scientific article published on 21 August 2019

Metabolic pathway alterations that support cell proliferation.

scientific article published on January 2011

Metabolic pattern formation in the tumor microenvironment.

scientific article published on 9 February 2017

Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment.

scientific article

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

scientific article

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival

scientific article

Metabolic rewiring drives resistance to targeted cancer therapy ⬇️

scientific article published on July 17, 2012

Metabolism in the tumor microenvironment: insights from single-cell analysis

scientific article published on 09 February 2020

Metabolism: A new layer of glycolysis

scientific article

Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma

scientific article

Metabolomics reveals intratumor heterogeneity - Implications for precision medicine

scientific article published on 24 April 2017

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

scientific article published on 5 April 2016

Metabolomics: A Primer

scientific article published on 11 February 2017

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

scientific article published on 12 October 2016

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

scientific article published on 12 September 2019

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.

scientific article published on 16 May 2018

Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width

article

Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development

scientific article

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

scientific article published on 18 February 2019

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

scientific article

Molecular features that predict the response to antimetabolite chemotherapies

scientific article published on 3 October 2017

Myeloid -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

scientific article published on 18 January 2019

Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.

scientific article published on 26 June 2019

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

scientific article

One-carbon metabolism and epigenetics: understanding the specificity

scientific article

Organization of enzyme concentration across the metabolic network in cancer cells

scientific article

PHGDH amplification and altered glucose metabolism in human melanoma

scientific article published on 28 October 2011

Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases

scientific article published on 30 May 2018

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

scientific article

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

scientific article

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

scientific article published on 15 November 2019

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

scientific article

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.

scientific article published on 27 March 2017

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.

scientific article

RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards

scientific article

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.

scientific article published on 20 December 2016

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.

scientific article published on 12 September 2016

Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins

scientific article

Rewiring of glycolysis in cancer cell metabolism

scientific article published on 7 November 2010

SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

scientific article published on 17 January 2019

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

scientific article published on 23 November 2020

Scaffold proteins confer diverse regulatory properties to protein kinase cascades.

scholarly article

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

scientific article published on 22 January 2014

Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape

scientific article published in December 2016

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

scientific article published in Nature Communications

Serine, glycine and one-carbon units: cancer metabolism in full circle

scientific article

Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord

scientific article published on 22 June 2017

Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

scientific article published on 6 December 2016

Signal duration and the time scale dependence of signal integration in biochemical pathways

scientific article

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

scientific article published on 25 November 2012

T cell stemness and dysfunction in tumors are triggered by a common mechanism

scientific article

Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation

scientific article published on 08 February 2021

Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow

scientific article published on 31 May 2016

Teleological Role of L-2-Hydroxyglutarate Dehydrogenase in the Kidney

scientific article published on 14 September 2020

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

scientific article

The Warburg Effect: How Does it Benefit Cancer Cells?

scientific article

The consequences of enhanced cell-autonomous glucose metabolism

scientific article

The evolving metabolic landscape of chromatin biology and epigenetics

scientific article published on 09 September 2020

The impact of cellular metabolism on chromatin dynamics and epigenetics

scientific article

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

scientific article published on 23 May 2016

The rate of glycolysis quantitatively mediates specific histone acetylation sites

scientific article

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

scientific article published on 8 March 2007

Thermodynamic constraints on the regulation of metabolic fluxes

scientific article published in Journal of Biological Chemistry

Thermodynamic constraints on the regulation of metabolic fluxes

scientific article published on 7 June 2018

Three-state kinetic mechanism for scaffold-mediated signal transduction

scientific article published on 21 November 2008

Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

scientific article published on 06 March 2020

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

scientific article published on 8 March 2011

Understanding metabolism with flux analysis: From theory to application

scientific article published on 22 September 2016

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

scientific article published on 16 March 2020

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.

scientific article

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

scientific article published on 7 September 2016

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