List of works - Jorg Tost

A DEMETER-like DNA demethylase governs tomato fruit ripening

scientific article

A General Framework for Interrogation of mRNA Stability Programs Identifies RNA-Binding Proteins that Govern Cancer Transcriptomes ⬇️

scientific article published on 01 May 2018

A novel tumor suppressor function of Kindlin-3 in solid cancer.

scientific article

A polymorphism in the TH 2 locus control region is associated with changes in DNA methylation and gene expression

scientific article published on 14 July 2014

A translational perspective on epigenetics in allergic diseases

scientific article published on 01 September 2018

Accurate CpG and non-CpG cytosine methylation analysis by high-throughput locus-specific pyrosequencing in plants.

scientific article

Altered gene expression in human placentas after IVF/ICSI

scientific article (publication date: 14 October 2014)

Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.

scientific article

Analysis and annotation of genome-wide DNA methylation patterns in two nonhuman primate species using the Infinium Human Methylation 450K and EPIC BeadChips

scientific article published on 11 May 2020

Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing

scientific article (publication date: July 2003)

Analysis of gene-specific DNA methylation patterns by pyrosequencing technology.

scientific article

BRAF(V600) mutation levels predict response to vemurafenib in metastatic melanoma

scientific article published in August 2014

C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.

scientific article

COLD-PCR Technologies in the Area of Personalized Medicine: Methodology and Applications.

scientific article published on 18 January 2017

Clinical value of early detection of circulating tumour DNA-BRAFV600mut in patients with metastatic melanoma treated with a BRAF inhibitor.

scientific article published on 21 June 2017

Clonogenic cell subpopulations maintain congenital melanocytic nevi

scientific article

Combination of promoter hypomethylation and PDX1 overexpression leads to TBX15 decrease in vascular IUGR placentas.

scientific article published on February 2011

Comparison of the quantification of KRAS mutations by digital PCR and E-ice-COLD-PCR in circulating-cell-free DNA from metastatic colorectal cancer patients.

scientific article

Complete pipeline for Infinium(®) Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation.

scientific article

Comprehensive evaluation of methods to isolate, quantify, and characterize circulating cell-free DNA from small volumes of plasma.

scientific article

Consequences of VHL Loss on Global DNA Methylome

scientific article published on 20 February 2018

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells

scientific article

Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions

scientific article published on 17 June 2020

DNA Methylation Analysis of ChIP Products at Single Nucleotide Resolution by Pyrosequencing®.

scientific article

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

scientific article published on 30 March 2016

DNA methylation analysis by pyrosequencing

scientific article published on 01 January 2007

DNA methylation and gene expression patterns in breast cancer progression from in situ carcinoma to invasive carcinoma.

scientific article

DNA methylation associated with polycomb repression in retinoic acid receptor β silencing.

scientific article

DNA methylation at enhancers identifies distinct breast cancer lineages

scientific article published on 9 November 2017

DNA methylation profiles distinguish different subtypes of gastroenteropancreatic neuroendocrine tumors.

scientific article published on 11 September 2015

DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

scientific article

DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project

scientific article

DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival

scientific article

DNA methylation signatures in circulating cell-free DNA for the monitoring of at-risk populations progressing to lung cancer

scientific article

DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.

scientific article published on 7 October 2014

DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker.

scientific article published on January 2009

DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker.

scientific article published on January 2010

DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1.

scientific article

De novo quantitative bisulfite sequencing using the pyrosequencing technology.

scientific article published in October 2004

Deregulation of microRNA expression in monocytes and CD4 T lymphocytes from patients with axial spondyloarthritis

scientific article published on 12 February 2019

Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sjögren's syndrome.

scientific article published on 15 September 2017

Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma

scientific article published on 05 June 2019

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

scientific article published on 21 August 2020

Differences in transcription patterns between induced pluripotent stem cells produced from the same germ layer are erased upon differentiation.

scientific article

Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy

scientific article

Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib

scientific article published on 14 October 2015

Dynamic changes of DNA methylation and lung disease in cystic fibrosis: lessons from a monogenic disease

scientific article published on 27 July 2018

Epigenetic Changes in Inflammatory and Autoimmune Diseases ⬇️

scientific article published on January 1, 2013

Epigenetic mechanisms and the relationship to childhood asthma

scientific article published on October 2010

Epigenetic plasticity of eosinophils and other immune cell subsets in childhood asthma

scientific article published on 26 February 2018

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes

scientific article published on 15 June 2011

Epigenetics

scientific article published on 11 September 2012

Epigenetics and allergy: from basic mechanisms to clinical applications.

scientific article published on 21 March 2017

Epigenetics of the immune system and alterations in inflammation and autoimmunity.

scientific article published in April 2017

Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

scientific article published in Nature Communications

Exhaustive methylation analysis revealed uneven profiles of methylation at IGF2/ICR1/H19 11p15 loci in Russell Silver syndrome.

scientific article published on 13 November 2014

Expression of miRNAs from the Imprinted DLK1/DIO3 Locus Signals the Osteogenic Potential of Human Pluripotent Stem Cells

scientific article published on 26 November 2019

Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia

scientific article published on 6 November 2006

Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

scientific article

Follow the trace of death: methylation analysis of cell-free DNA for clinical applications in non-cancerous diseases

scientific article published on 16 August 2016

Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer

scientific article

GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer

scientific article

GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas.

scientific article published on July 2008

Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut-sensitized mice

scientific article published on 08 October 2018

Gene expression profiling in insulinomas of Men1 beta-cell mutant mice reveals early genetic and epigenetic events involved in pancreatic beta-cell tumorigenesis.

scientific article published in December 2006

Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis

scientific article published on 6 November 2015

Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis

scientific article

Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II.

scientific article published on 21 July 2013

Genotyping single nucleotide polymorphisms by MALDI mass spectrometry in clinical applications.

scientific article

Genotyping single nucleotide polymorphisms by mass spectrometry.

scientific article

Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome

scientific article published on 24 October 2013

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression

scientific article published on 05 June 2009

Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2.

scientific article published on 26 August 2016

IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance.

scientific article

Identification and quantification of differentially methylated loci by the pyrosequencing technology

scientific article published on 01 January 2009

Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide association study

scientific article published on 4 February 2015

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

scientific article

Improved reproducibility in genome-wide DNA methylation analysis for PAXgene-fixed samples compared with restored formalin-fixed and paraffin-embedded DNA.

scientific article

Improving breast cancer survival analysis through competition-based multidimensional modeling

scientific article

In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation

scientific article published on 01 May 2014

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood

scientific article

Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors

scientific article

Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients

scientific article

Introducing the research article reporting checklist for bioinformatic and data re-analysis studies

scientific article published in 2022

Involvement of Tumor Necrosis Factor Receptor Type II in FoxP3 Stability and as a Marker of Treg Cells Specifically Expanded by Anti-Tumor Necrosis Factor Treatments in Rheumatoid Arthritis

scientific article published on 20 February 2020

Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.

scientific article

MeQA: a pipeline for MeDIP-seq data quality assessment and analysis

scientific article

Methylation of imprinted IGF2 regions is associated with total, visceral, and hepatic adiposity in postmenopausal women

scientific article published on 02 October 2018

Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines

scientific article published on 01 August 2011

Methylation profile of the promoter region of IRF5 in primary Sjögren's syndrome

scientific article published on 01 October 2012

Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer

scientific article

Modulation of imprinted gene network in placenta results in normal development of in vitro manipulated mouse embryos.

scientific article published on 11 February 2010

Molecular haplotyping at high throughput.

scientific article

Multiplexing of E-ice-COLD-PCR Assays for Mutation Detection and Identification

scientific article published on 22 June 2016

NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi.

scientific article

NSD1 Inactivation and SETD2 Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas

scientific article published on 28 July 2017

New technologies for DNA analysis--a review of the READNA Project

scientific article

Non-random, individual-specific methylation profiles are present at the sixth CTCF binding site in the human H19/IGF2 imprinting control region

scientific article published in 2007

Parental vitamin D deficiency during pregnancy is associated with increased blood pressure in offspring via Panx1 hypermethylation.

scientific article published on 21 October 2016

Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome

scientific article published on 13 June 2011

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

scientific article published on 24 August 2021

Placentas from pregnancies conceived by IVF/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions

scientific article published on 22 January 2013

Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome

scientific article published on 21 August 2014

Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation

scientific article published on 21 June 2018

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension

scientific article published on 19 May 2017

Pyrosequencing Technology. Preface

scientific article published in January 2015

Pyrosequencing®-Based Identification of Low-Frequency Mutations Enriched Through Enhanced-ice-COLD-PCR.

scientific article

Quality control and single nucleotide resolution analysis of methylated DNA immunoprecipitation products

scientific article published on 23 July 2010

Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

scientific article

Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors

scientific article published on January 2009

Rapid identification of promoter hypermethylation in hepatocellular carcinoma by pyrosequencing of etiologically homogeneous sample pools

scientific article

Recurrent NRAS mutations in pulmonary Langerhans cell histiocytosis.

scientific article

SNP-Based Quantification of Allele-Specific DNA Methylation Patterns by Pyrosequencing®.

scientific article

Serial pyrosequencing for quantitative DNA methylation analysis

scientific article published on 01 June 2006

Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet

scientific article (publication date: 21 December 2010)

Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer.

scientific article

Sustained response to salvage therapy for dabrafenib-resistant metastatic Langerhans cell sarcoma

scientific article published on 8 August 2016

Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers

scientific article

Systemic epigenetic response to recombinant lentiviral vectors independent of proviral integration

scientific article published on 11 July 2016

The epigenetics of breast cancer

scientific article published on 29 April 2010

Twin DNA methylation profiling reveals flare-dependent interferon signature and B-cell promoter hypermethylation in systemic lupus erythematosus.

scientific article published on 23 January 2018

Ultrasensitive detection and identification of BRAF V600 mutations in fresh frozen, FFPE, and plasma samples of melanoma patients by E-ice-COLD-PCR.

scientific article

Upregulation of membrane-bound CD40L on CD4+ T cells in women with primary Sjögren's syndrome.

scientific article published in January 2014

Variation in genomic landscape of clear cell renal cell carcinoma across Europe

scientific article published on 29 October 2014

Welcome to Epigenomics

scientific article published on 01 October 2009

Whole-Genome Bisulfite Sequencing for the Analysis of Genome-Wide DNA Methylation and Hydroxymethylation Patterns at Single-Nucleotide Resolution

scientific article published on 01 January 2018

aCNViewer: Comprehensive genome-wide visualization of absolute copy number and copy neutral variations.

scientific article published on 19 December 2017

miRNA profiling identifies deregulated miRNAs associated with osteosarcoma development and time to metastasis in two large cohorts.

scientific article published on 9 November 2017

List of works by Jorg Tost

A DEMETER-like DNA demethylase governs tomato fruit ripening

A General Framework for Interrogation of mRNA Stability Programs Identifies RNA-Binding Proteins that Govern Cancer Transcriptomes ⬇️

A novel tumor suppressor function of Kindlin-3 in solid cancer.

A polymorphism in the TH 2 locus control region is associated with changes in DNA methylation and gene expression

A translational perspective on epigenetics in allergic diseases

Accurate CpG and non-CpG cytosine methylation analysis by high-throughput locus-specific pyrosequencing in plants.

Altered gene expression in human placentas after IVF/ICSI

Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.

Analysis and annotation of genome-wide DNA methylation patterns in two nonhuman primate species using the Infinium Human Methylation 450K and EPIC BeadChips

Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing

Analysis of gene-specific DNA methylation patterns by pyrosequencing technology.

BRAF(V600) mutation levels predict response to vemurafenib in metastatic melanoma

C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.

COLD-PCR Technologies in the Area of Personalized Medicine: Methodology and Applications.

Clinical value of early detection of circulating tumour DNA-BRAFV600mut in patients with metastatic melanoma treated with a BRAF inhibitor.

Clonogenic cell subpopulations maintain congenital melanocytic nevi

Combination of promoter hypomethylation and PDX1 overexpression leads to TBX15 decrease in vascular IUGR placentas.

Comparison of the quantification of KRAS mutations by digital PCR and E-ice-COLD-PCR in circulating-cell-free DNA from metastatic colorectal cancer patients.

Complete pipeline for Infinium(®) Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation.

Comprehensive evaluation of methods to isolate, quantify, and characterize circulating cell-free DNA from small volumes of plasma.

Consequences of VHL Loss on Global DNA Methylome

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells

Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions

DNA Methylation Analysis of ChIP Products at Single Nucleotide Resolution by Pyrosequencing®.

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

DNA methylation analysis by pyrosequencing

DNA methylation and gene expression patterns in breast cancer progression from in situ carcinoma to invasive carcinoma.

DNA methylation associated with polycomb repression in retinoic acid receptor β silencing.

DNA methylation at enhancers identifies distinct breast cancer lineages

DNA methylation profiles distinguish different subtypes of gastroenteropancreatic neuroendocrine tumors.

DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project

DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival

DNA methylation signatures in circulating cell-free DNA for the monitoring of at-risk populations progressing to lung cancer

DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.

DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker.

DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker.

DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1.

De novo quantitative bisulfite sequencing using the pyrosequencing technology.

Deregulation of microRNA expression in monocytes and CD4 T lymphocytes from patients with axial spondyloarthritis

Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sjögren's syndrome.

Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Differences in transcription patterns between induced pluripotent stem cells produced from the same germ layer are erased upon differentiation.

Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy

Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib

Dynamic changes of DNA methylation and lung disease in cystic fibrosis: lessons from a monogenic disease

Epigenetic Changes in Inflammatory and Autoimmune Diseases ⬇️

Epigenetic mechanisms and the relationship to childhood asthma

Epigenetic plasticity of eosinophils and other immune cell subsets in childhood asthma

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes

Epigenetics

Epigenetics and allergy: from basic mechanisms to clinical applications.

Epigenetics of the immune system and alterations in inflammation and autoimmunity.

Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

Exhaustive methylation analysis revealed uneven profiles of methylation at IGF2/ICR1/H19 11p15 loci in Russell Silver syndrome.

Expression of miRNAs from the Imprinted DLK1/DIO3 Locus Signals the Osteogenic Potential of Human Pluripotent Stem Cells

Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia

Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

Follow the trace of death: methylation analysis of cell-free DNA for clinical applications in non-cancerous diseases

Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer

GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer

GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas.

Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut-sensitized mice

Gene expression profiling in insulinomas of Men1 beta-cell mutant mice reveals early genetic and epigenetic events involved in pancreatic beta-cell tumorigenesis.

Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis

Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis

Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II.

Genotyping single nucleotide polymorphisms by MALDI mass spectrometry in clinical applications.

Genotyping single nucleotide polymorphisms by mass spectrometry.

Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression

Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2.

IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance.

Identification and quantification of differentially methylated loci by the pyrosequencing technology

Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide association study

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

Improved reproducibility in genome-wide DNA methylation analysis for PAXgene-fixed samples compared with restored formalin-fixed and paraffin-embedded DNA.

Improving breast cancer survival analysis through competition-based multidimensional modeling