List of works - Francesc Posas

3D-printing of transparent bio-microfluidic devices in PEG-DA

scientific article published on 24 May 2016

A Synthetic Multicellular Memory Device.

scientific article published on 21 July 2016

A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress

scientific article published on 23 August 2012

A novel role for lncRNAs in cell cycle control during stress adaptation

scientific article published on 28 September 2014

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.

scientific article published on 17 January 2018

An RB insensitive to CDK regulation.

scientific article published on 14 December 2016

Biochemical characterization of recombinant yeast PPZ1, a protein phosphatase involved in salt tolerance.

scientific article

Biophysical properties of Saccharomyces cerevisiae and their relationship with HOG pathway activation

scientific article

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

scientific article

Control of Cdc28 CDK1 by a stress-induced lncRNA

scientific article

Control of cell cycle in response to osmostress: lessons from yeast.

scientific article published on January 2007

Control of cell cycle progression by the stress-activated Hog1 MAPK

scientific article published on 03 January 2005

Controlling gene expression in response to stress.

scientific article

Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae

scientific article

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

scientific article

Dealing with osmostress through MAP kinase activation.

scientific article

Dealing with transcriptional outbursts during S phase to protect genomic integrity.

scientific article published on 07 September 2013

Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases

scientific article

Distributed biological computation with multicellular engineered networks

scientific article

Elongating under Stress.

scientific article published on 7 September 2011

Evolution of protein phosphorylation across 18 fungal species.

scientific article published in October 2016

Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways

scientific article published on 10 March 2004

Gene expression profiling of yeasts overexpressing wild type or misfolded Pma1 variants reveals activation of the Hog1 MAPK pathway

scientific article published on 12 January 2011

H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes

scientific article published on 26 March 2015

Hog1 activation delays mitotic exit via phosphorylation of Net1

scientific article published on 07 April 2020

Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling

scientific article

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.

scientific article

Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress.

scientific article

Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia

scientific article published in February 2016

Initiation of the transcriptional response to hyperosmotic shock correlates with the potential for volume recovery

scientific article published on 5 July 2013

Interaction Dynamics Determine Signaling and Output Pathway Responses.

scientific article

Mucins, osmosensors in eukaryotic cells?

scientific article published on 05 November 2007

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

scientific article published on 25 January 2018

Nucleotide sequence of a rat heart cDNA encoding the isotype alpha of the catalytic subunit of protein phosphatase 2A.

scientific article published on October 1989

Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription

scientific article

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

scientific article

Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade

scientific article published on April 2015

Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity

scientific article

Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses.

scientific article published on 27 March 2018

Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress

scientific article

Regulation of transcription elongation in response to osmostress.

scientific article published on 20 November 2017

Response to hyperosmotic stress

scientific article published on October 2012

Role of protein phosphatase 2A in the control of glycogen metabolism in yeast.

scientific article published in April 1995

Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast Kluyveromyces lactis.

scientific article published on 13 March 2017

Saccharomyces cerevisiaegene SIT4 is involved in the control of glycogen metabolism ⬇️

scientific article published on February 25, 1991

Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins

scientific article published on 18 September 2011

Signal transduction by MAP kinase cascades in budding yeast

scientific article

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

scientific article

Sir2 plays a key role in cell fate determination upon SAPK activation.

scientific article

Synthetic biology: insights into biological computation.

scientific article

The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms

scientific article published on 5 September 2012

The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress

scientific article

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation

scientific article published on 11 October 2017

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.

scientific article

The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.

scientific article

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.

scientific article published on 14 September 2016

The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells.

scientific article

The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells

scientific article published on 01 March 1993

The Stress-Activated Hog1 Kinase Is a Selective Transcriptional Elongation Factor for Genes Responding to Osmotic Stress

article

The gene DIS2S1 is essential in Saccharomyces cerevisiae and is involved in glycogen phosphorylase activation

scientific article published on 01 May 1991

The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.

scientific article

The p38 Pathway: From Biology to Cancer Therapy

scientific article published on 11 March 2020

The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis

scientific article published on 14 August 2020

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress

scientific article published on 28 May 2009

The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase.

scientific article

Time-dependent quantitative multicomponent control of the G₁-S network by the stress-activated protein kinase Hog1 upon osmostress

scientific article published in September 2011

Timing of gene expression in a cell-fate decision system

scientific article published on 25 April 2018

Transient activation of the HOG MAPK pathway regulates bimodal gene expression.

scientific article

Untargeted metabolomics unravels functionalities of phosphorylation sites in Saccharomyces cerevisiae

scientific article

Validation of regulated protein phosphorylation events in yeast by quantitative mass spectrometry analysis of purified proteins

scientific article published on 19 September 2012

Whole genome analysis of p38 SAPK-mediated gene expression upon stress.

scientific article

Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.

scientific article

Yeast Cip1 is activated by environmental stress to inhibit Cdk1-G1 cyclins via Mcm1 and Msn2/4.

scientific article

Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.

scientific article

List of works by Francesc Posas

3D-printing of transparent bio-microfluidic devices in PEG-DA

A Synthetic Multicellular Memory Device.

A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress

A novel role for lncRNAs in cell cycle control during stress adaptation

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.

An RB insensitive to CDK regulation.

Biochemical characterization of recombinant yeast PPZ1, a protein phosphatase involved in salt tolerance.

Biophysical properties of Saccharomyces cerevisiae and their relationship with HOG pathway activation

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

Control of Cdc28 CDK1 by a stress-induced lncRNA

Control of cell cycle in response to osmostress: lessons from yeast.

Control of cell cycle progression by the stress-activated Hog1 MAPK

Controlling gene expression in response to stress.

Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

Dealing with osmostress through MAP kinase activation.

Dealing with transcriptional outbursts during S phase to protect genomic integrity.

Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases

Distributed biological computation with multicellular engineered networks

Elongating under Stress.

Evolution of protein phosphorylation across 18 fungal species.

Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways

Gene expression profiling of yeasts overexpressing wild type or misfolded Pma1 variants reveals activation of the Hog1 MAPK pathway

H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes

Hog1 activation delays mitotic exit via phosphorylation of Net1

Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.

Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress.

Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia

Initiation of the transcriptional response to hyperosmotic shock correlates with the potential for volume recovery

Interaction Dynamics Determine Signaling and Output Pathway Responses.

Mucins, osmosensors in eukaryotic cells?

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

Nucleotide sequence of a rat heart cDNA encoding the isotype alpha of the catalytic subunit of protein phosphatase 2A.

Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade

Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity

Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses.

Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress

Regulation of transcription elongation in response to osmostress.

Response to hyperosmotic stress

Role of protein phosphatase 2A in the control of glycogen metabolism in yeast.

Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast Kluyveromyces lactis.

Saccharomyces cerevisiaegene SIT4 is involved in the control of glycogen metabolism ⬇️

Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins

Signal transduction by MAP kinase cascades in budding yeast

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

Sir2 plays a key role in cell fate determination upon SAPK activation.

Synthetic biology: insights into biological computation.

The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms

The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.

The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.

The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells.

The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells

The Stress-Activated Hog1 Kinase Is a Selective Transcriptional Elongation Factor for Genes Responding to Osmotic Stress

The gene DIS2S1 is essential in Saccharomyces cerevisiae and is involved in glycogen phosphorylase activation

The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.

The p38 Pathway: From Biology to Cancer Therapy

The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress

The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase.

Time-dependent quantitative multicomponent control of the G₁-S network by the stress-activated protein kinase Hog1 upon osmostress

Timing of gene expression in a cell-fate decision system

Transient activation of the HOG MAPK pathway regulates bimodal gene expression.

Untargeted metabolomics unravels functionalities of phosphorylation sites in Saccharomyces cerevisiae

Validation of regulated protein phosphorylation events in yeast by quantitative mass spectrometry analysis of purified proteins

Whole genome analysis of p38 SAPK-mediated gene expression upon stress.

Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.

Yeast Cip1 is activated by environmental stress to inhibit Cdk1-G1 cyclins via Mcm1 and Msn2/4.

Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.