List of works - Nicole Schmitt

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation

scientific article published on 29 January 2020

A common structural component for β-subunit mediated modulation of slow inactivation in different KV channels

scientific article published on 26 June 2013

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

scientific article published on 11 February 2013

A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias

scientific article

A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly

scientific article published on February 2000

Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells

scientific article

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels

scientific article

Brugada syndrome risk loci seem protective against atrial fibrillation

scientific article

Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations.

scientific article published on 23 March 2006

Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

scientific article published on April 2014

Characterization and mechanisms of action of novel NaV1.5 channel mutations associated with Brugada syndrome

scientific article published in February 2013

Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

scientific article

Contribution of Kv7 channels to basal coronary flow and active response to ischemia.

scientific article published on 30 September 2013

Differential effects of ICA-27243 on cloned K(V)7 channels

scientific article published on 17 August 2010

Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders

scientific article published on 16 April 2013

Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2.

scientific article

Fast detection of extrasynaptic GABA with a whole-cell sniffer

scientific article

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group

scientific article (publication date: 2014)

Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome

scientific article published in November 2005

Functional phenotype variations of two novel KV 7.1 mutations identified in patients with Long QT syndrome

scientific article published on 11 January 2020

Functional properties of human neuronal Kv11 channels

scientific article published on 25 March 2009

Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation

scientific article (publication date: 2014)

Genetic modifier of the QTc interval associated with early-onset atrial fibrillation

scientific article published in October 2013

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

scientific article

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

scientific article published on 27 December 2013

Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans

scientific article (publication date: 2013)

High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance

scientific article

High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation

scientific article published on 8 June 2012

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation

scientific journal article

In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of -Adrenergic Receptor Signaling

scientific article (publication date: 4 June 2013)

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis ⬇️

scientific article

Investigating gene-microRNA networks in atrial fibrillation patients with mitral valve regurgitation

scientific article published on 11 May 2020

Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada syndrome mutant.

scientific article published on 21 February 2014

KCNE1 Modulates the Sensitivity of Kv7.1 to Polyunsaturated Fatty Acids

KCNE3 mutation V17M identified in a patient with lone atrial fibrillation

scientific article published on 16 January 2008

KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

scientific article

KCNQ1 channels sense small changes in cell volume

scientific article published on 17 April 2003

KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval

scientific article

Letter by Olesen et al Regarding Article, “MOG1: A New Susceptibility Gene for Brugada Syndrome”

Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656.

scientific article published in July 2005

Long QT 1 mutation KCNQ1A344V increases local anesthetic sensitivity of the slowly activating delayed rectifier potassium current

scientific article published in September 2006

Modulation of ERG channels by XE991.

scientific article published on May 2007

Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A

scientific article

Multiple genetic variations in sodium channel subunits in a case of sudden infant death syndrome

scientific article published on 25 April 2018

Mutation in Nav1.5 Associated with Brugada Syndrome - a Mutational Hotspot?

Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation

scientific article

Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients

scientific article

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

scientific article

Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning

scientific article

Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2

scientific article published in December 2010

Phosphorylation of connexin43 on serine 306 regulates electrical coupling

scientific article

Polyunsaturated Fatty acids as Kv7 Channel Modulators

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel

scientific article published on 21 April 2015

Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes

scientific article

Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking

scientific article

Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment

scientific article published on 20 February 2007

SUMO co-expression modifies KV 11.1 channel activity

scientific article published on 9 September 2017

Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons

scientific article

Structural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complex

scientific article published on 24 December 2009

The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels

scientific article published on 10 August 2006

The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes

scientific article

The anticonvulsant retigabine suppresses neuronal KV2-mediated currents

scientific article published on 13 October 2016

The novel C-terminal KCNQ1 mutation M520R alters protein trafficking.

scientific article published on 27 April 2007

Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway.

scientific article published on 17 October 2017

Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization

scientific article published on 13 February 2013

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation

scientific article published on 18 October 2013

List of works by Nicole Schmitt

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation

A common structural component for β-subunit mediated modulation of slow inactivation in different KV channels

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias

A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly

Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels

Brugada syndrome risk loci seem protective against atrial fibrillation

Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations.

Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

Characterization and mechanisms of action of novel NaV1.5 channel mutations associated with Brugada syndrome

Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

Contribution of Kv7 channels to basal coronary flow and active response to ischemia.

Differential effects of ICA-27243 on cloned K(V)7 channels

Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders

Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2.

Fast detection of extrasynaptic GABA with a whole-cell sniffer

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group

Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome

Functional phenotype variations of two novel KV 7.1 mutations identified in patients with Long QT syndrome

Functional properties of human neuronal Kv11 channels

Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation

Genetic modifier of the QTc interval associated with early-onset atrial fibrillation

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans

High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance

High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation

In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of -Adrenergic Receptor Signaling

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis ⬇️

Investigating gene-microRNA networks in atrial fibrillation patients with mitral valve regurgitation

Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada syndrome mutant.

KCNE1 Modulates the Sensitivity of Kv7.1 to Polyunsaturated Fatty Acids

KCNE3 mutation V17M identified in a patient with lone atrial fibrillation

KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

KCNQ1 channels sense small changes in cell volume

KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval

Letter by Olesen et al Regarding Article, “MOG1: A New Susceptibility Gene for Brugada Syndrome”

Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656.

Long QT 1 mutation KCNQ1A344V increases local anesthetic sensitivity of the slowly activating delayed rectifier potassium current

Modulation of ERG channels by XE991.

Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A

Multiple genetic variations in sodium channel subunits in a case of sudden infant death syndrome

Mutation in Nav1.5 Associated with Brugada Syndrome - a Mutational Hotspot?

Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation

Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning

Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2

Phosphorylation of connexin43 on serine 306 regulates electrical coupling

Polyunsaturated Fatty acids as Kv7 Channel Modulators

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel

Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes

Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking

Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment

SUMO co-expression modifies KV 11.1 channel activity

Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons

Structural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complex

The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels

The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes

The anticonvulsant retigabine suppresses neuronal KV2-mediated currents

The novel C-terminal KCNQ1 mutation M520R alters protein trafficking.

Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway.

Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation