List of works - Joseph A. Marsh

A Graph-Based Approach for Detecting Sequence Homology in Highly Diverged Repeat Protein Families

scientific article published on 01 January 2019

A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect

scientific article published on 21 April 2016

Alpha Helices Are More Robust to Mutations than Beta Strands

scientific article

Biallelic variants in DNA2 cause microcephalic primordial dwarfism

scientific article published on 23 June 2019

Buried and accessible surface area control intrinsic protein flexibility

scientific article

Calculation of residual dipolar couplings from disordered state ensembles using local alignment

scientific article published on 31 May 2008

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodeling

scientific article published on 12 January 2018

Characterization of disordered proteins with ENSEMBLE.

scientific article

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

scientific article published on 25 April 2024

Co-translational assembly of protein complexes

scientific article

Computational Modelling of Protein Complex Structure and Assembly

scientific article published in January 2018

Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

scientific article published on 12 February 2018

ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity

scientific article published on 10 August 2017

Editorial overview: Sequences and topology: Dynamic sequences and topologies of proteins

scientific article published on 01 June 2018

Ensemble modeling of protein disordered states: Experimental restraint contributions and validation ⬇️

scientific article published on November 17, 2011

Evolution of condensin and cohesin complexes driven by replacement of Kite by Hawk proteins

scientific article published on January 2017

Evolution of protein interfaces in multimers and fibrils.

scientific article published in June 2019

Experimental Characterization of Protein Complex Structure, Dynamics, and Assembly

scientific article published in January 2018

Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

scientific article

Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data

scientific article published on 10 October 2019

Functional determinants of protein assembly into homomeric complexes

scientific article published on 10 July 2017

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

scientific article published on 26 November 2018

How do proteins gain new domains?

scientific article published on 15 July 2010

Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

scientific article

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

article published in 2018

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

scientific article published on 01 April 2019

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

scientific article published on 06 October 2016

Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology

scientific article published in March 2018

Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes

scientific article published on 12 July 2019

Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes

scientific article published on 01 August 2019

Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective

scientific article published on 25 June 2019

Mouse mutations cause retinal degeneration and reduced mitochondrial function

scientific article published on 18 December 2018

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

scientific article published on 01 November 2020

Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration

scientific article published on 22 September 2017

Operon Gene Order Is Optimized for Ordered Protein Complex Assembly

scientific article

Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain

scientific article

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.

scientific article

Principles of assembly reveal a periodic table of protein complexes

scientific article

Probing the diverse landscape of protein flexibility and binding ⬇️

scientific article published on September 20, 2012

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

scientific article published on 13 June 2019

Protein complexes are under evolutionary selection to assemble via ordered pathways

scientific article

Protein flexibility facilitates quaternary structure assembly and evolution

scientific article

Proteome-scale prediction of molecular mechanisms underlying dominant genetic diseases

scientific article published in 2024

Recurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA-protein interaction

scientific article published on 08 November 2019

Regulation, evolution and consequences of cotranslational protein complex assembly

scientific article

Relative solvent accessible surface area predicts protein conformational changes upon binding

scientific article published on June 2011

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

scientific article

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

scientific article

Signalling assemblies: the odds of symmetry

scientific article

Structural Determinants of Sleeping Beauty Transposase Activity

scientific article published on 12 July 2016

Structural and evolutionary versatility in protein complexes with uneven stoichiometry

scientific article

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

scientific article

Structural signature of the MYPT1-PP1 interaction.

scientific article published on 10 December 2010

Structure and disorder in an unfolded state under nondenaturing conditions from ensemble models consistent with a large number of experimental restraints

scientific article

Structure, dynamics, assembly, and evolution of protein complexes

scientific article published on 08 December 2014

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

scientific article

Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs

scientific article published on January 2007

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture

scientific article published in June 2012

The genetic basis and evolution of red blood cell sickling in deer.

scientific article published on 18 December 2017

The properties of human disease mutations at protein interfaces

scientific article published on 04 February 2022

The role of protein complexes in human genetic disease

scientific article published on 01 July 2019

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.

scientific article

Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR.

scientific article

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

scientific article published in 2022

Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations

scientific article published on 01 July 2020

Whole genome sequencing reveals novel mutations causing autosomal dominant inherited macular degeneration

scientific article published on 19 November 2018

List of works by Joseph A. Marsh

A Graph-Based Approach for Detecting Sequence Homology in Highly Diverged Repeat Protein Families

A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect

Alpha Helices Are More Robust to Mutations than Beta Strands

Biallelic variants in DNA2 cause microcephalic primordial dwarfism

Buried and accessible surface area control intrinsic protein flexibility

Calculation of residual dipolar couplings from disordered state ensembles using local alignment

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodeling

Characterization of disordered proteins with ENSEMBLE.

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

Co-translational assembly of protein complexes

Computational Modelling of Protein Complex Structure and Assembly

Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity

Editorial overview: Sequences and topology: Dynamic sequences and topologies of proteins

Ensemble modeling of protein disordered states: Experimental restraint contributions and validation ⬇️

Evolution of condensin and cohesin complexes driven by replacement of Kite by Hawk proteins

Evolution of protein interfaces in multimers and fibrils.

Experimental Characterization of Protein Complex Structure, Dynamics, and Assembly

Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data

Functional determinants of protein assembly into homomeric complexes

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

How do proteins gain new domains?

Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology

Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes

Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes

Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective

Mouse mutations cause retinal degeneration and reduced mitochondrial function

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration

Operon Gene Order Is Optimized for Ordered Protein Complex Assembly

Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.

Principles of assembly reveal a periodic table of protein complexes

Probing the diverse landscape of protein flexibility and binding ⬇️

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

Protein complexes are under evolutionary selection to assemble via ordered pathways

Protein flexibility facilitates quaternary structure assembly and evolution

Proteome-scale prediction of molecular mechanisms underlying dominant genetic diseases

Recurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA-protein interaction

Regulation, evolution and consequences of cotranslational protein complex assembly

Relative solvent accessible surface area predicts protein conformational changes upon binding

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

Signalling assemblies: the odds of symmetry

Structural Determinants of Sleeping Beauty Transposase Activity

Structural and evolutionary versatility in protein complexes with uneven stoichiometry

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

Structural signature of the MYPT1-PP1 interaction.

Structure and disorder in an unfolded state under nondenaturing conditions from ensemble models consistent with a large number of experimental restraints

Structure, dynamics, assembly, and evolution of protein complexes

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture

The genetic basis and evolution of red blood cell sickling in deer.

The properties of human disease mutations at protein interfaces

The role of protein complexes in human genetic disease

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.

Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR.

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations

Whole genome sequencing reveals novel mutations causing autosomal dominant inherited macular degeneration