List of works - Thomas Stockner

'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function

scientific article published on 15 December 2014

A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1)

scientific article published on 26 February 2015

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.

scientific article

A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues

scientific article published on 14 February 2015

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter

scientific article published on 13 April 2015

A salt-bridge motif involved in ligand binding and large-scale domain motions of the maltose-binding protein.

scientific article

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters

scientific article published on December 2013

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

scientific article published on 24 June 2013

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API

scientific article published on 16 September 2021

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters

scientific article

Both reentrant loops of the sodium-coupled glutamate transporters contain molecular determinants of cation selectivity

scientific article published on 19 July 2018

Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer

scientific article

Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting.

scientific article published in April 2012

Computational models for prediction of interactions with ABC-transporters

scientific article published on 14 March 2008

Computer modeling of polyleucine-based coiled coil dimers in a realistic membrane environment: insight into helix-helix interactions in membrane proteins

scientific article published in July 2004

Conversion of chemical to mechanical energy by the nucleotide binding domains of ABCB1

scientific article published on 13 February 2020

Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

scientific article

Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters

scientific article

Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol 4,5-bisphosphate-independent manner

scientific article published on 31 January 2019

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.

scientific article published on 6 June 2018

Enantioselectivity of epoxide hydrolase catalysed oxirane ring opening: a 3D QSAR study.

scientific article published in January 2003

Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates

scientific article

Functional Impact of the G279S Substitution in the Adenosine A1-Receptor (A1R-G279S7.44), a Mutation Associated with Parkinson's Disease

scientific article published on 01 September 2020

Functional impact of the G279S substitution in the adenosine A1-receptor (A1R-G279S), a mutation associated with Parkinson's disease

scientific article published on 08 July 2020

Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients.

scientific article

Insights into the molecular evolution of oxytocin receptor ligand binding

scientific article

Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications

scientific article

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction

scientific article

Membrane-mediated effect on ion channels induced by the anesthetic drug ketamine

scientific article published in June 2010

Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein.

scientific article

Molecular dynamics simulations of the Apo-, Holo-, and acyl-forms of Escherichia coli acyl carrier protein

scientific article published on 22 September 2008

Molecular dynamics studies of a molecular switch in the glucocorticoid receptor

scientific article published in April 2003

Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model

scientific article

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites

scientific article published on 22 December 2015

Pharmacological correction of misfolding of ABC proteins

scientific article

Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.

scientific article published on 23 December 2013

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site

scientific article published on 20 October 2015

Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain

scientific article published on 3 July 2012

SLC6 transporter oligomerization

scientific article published on 07 August 2020

Solution Structure and Membrane Binding of the Toxin Fst of the par Addiction Module

scientific article

Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2

scientific article

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

scientific article published on 12 February 2019

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.

scientific article

Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C

scientific article published on 3 January 2013

Symmetric allosteric mechanism of hexameric Escherichia coli arginine repressor exploits competition between L-arginine ligands and resident arginine residues.

scientific article

Synergy of Molecular Dynamics and Isothermal Titration Calorimetry in Studies of Allostery

article

The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

scientific article published on 28 November 2019

The Amino Terminus of LeuT Changes Conformation in an Environment Sensitive Manner

scientific article published on 19 December 2019

The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters

scientific article

Thermal Unfolding of the Human Serotonin Transporter: Differential Effect by Stabilizing and Destabilizing Mutations and Cholesterol on Thermodynamic and Kinetic Stability

scholarly article

Unifying concept of serotonin transporter-associated currents

scientific article published on 9 November 2011

What can naturally occurring mutations tell us about Cav1.x channel function? ⬇️

scientific article published on 04 December 2012

List of works by Thomas Stockner

'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function

A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1)

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.

A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter

A salt-bridge motif involved in ligand binding and large-scale domain motions of the maltose-binding protein.

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters

Both reentrant loops of the sodium-coupled glutamate transporters contain molecular determinants of cation selectivity

Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer

Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting.

Computational models for prediction of interactions with ABC-transporters

Computer modeling of polyleucine-based coiled coil dimers in a realistic membrane environment: insight into helix-helix interactions in membrane proteins

Conversion of chemical to mechanical energy by the nucleotide binding domains of ABCB1

Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters

Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol 4,5-bisphosphate-independent manner

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.

Enantioselectivity of epoxide hydrolase catalysed oxirane ring opening: a 3D QSAR study.

Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates

Functional Impact of the G279S Substitution in the Adenosine A1-Receptor (A1R-G279S7.44), a Mutation Associated with Parkinson's Disease

Functional impact of the G279S substitution in the adenosine A1-receptor (A1R-G279S), a mutation associated with Parkinson's disease

Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients.

Insights into the molecular evolution of oxytocin receptor ligand binding

Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction

Membrane-mediated effect on ion channels induced by the anesthetic drug ketamine

Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein.

Molecular dynamics simulations of the Apo-, Holo-, and acyl-forms of Escherichia coli acyl carrier protein

Molecular dynamics studies of a molecular switch in the glucocorticoid receptor

Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites

Pharmacological correction of misfolding of ABC proteins

Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site

Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain

SLC6 transporter oligomerization

Solution Structure and Membrane Binding of the Toxin Fst of the par Addiction Module

Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.

Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C

Symmetric allosteric mechanism of hexameric Escherichia coli arginine repressor exploits competition between L-arginine ligands and resident arginine residues.

Synergy of Molecular Dynamics and Isothermal Titration Calorimetry in Studies of Allostery

The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

The Amino Terminus of LeuT Changes Conformation in an Environment Sensitive Manner

The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters

Thermal Unfolding of the Human Serotonin Transporter: Differential Effect by Stabilizing and Destabilizing Mutations and Cholesterol on Thermodynamic and Kinetic Stability

Unifying concept of serotonin transporter-associated currents

What can naturally occurring mutations tell us about Cav1.x channel function? ⬇️