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List of works by Jan Brezovský

Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity.

scientific article published on 17 April 2017

Are time-dependent fluorescence shifts at the tunnel mouth of haloalkane dehalogenase enzymes dependent on the choice of the chromophore?

scientific article published on 20 June 2013

CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures

scientific article

CAVER Analyst 1.0: graphic tool for interactive visualization and analysis of tunnels and channels in protein structures.

scientific article

CAVER Analyst 2.0: analysis and visualization of channels and tunnels in protein structures and molecular dynamics trajectories

scientific article published on 01 October 2018

CAVER: Algorithms for Analyzing Dynamics of Tunnels in Macromolecules

scientific article

Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling

scientific article published on 11 July 2017

Computational tools for designing and engineering biocatalysts

scientific article

Computational tools for designing smart libraries.

scientific article

Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2.

scientific article published on 26 December 2017

Computer-assisted engineering of the synthetic pathway for biodegradation of a toxic persistent pollutant.

scientific article published on 17 December 2013

Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17

scientific article published on 28 October 2019

Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear β-Haloalkanes: Open-Solvated versus Occluded-Desolvated Active Sites.

scientific article published on 23 March 2017

Discovery of Novel Haloalkane Dehalogenase Inhibitors.

scientific article published on 15 January 2016

Dynamics, a Powerful Component of Current and Future in Silico Approaches for Protein Design and Engineering

scientific article published on 14 April 2020

Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel

scientific article

Enzyme Tunnels and Gates As Relevant Targets in Drug Design.

scientific article

Expansion of access tunnels and active-site cavities influence activity of haloalkane dehalogenases in organic cosolvents

scientific article

FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

scientific article published on 3 November 2015

FireProt: web server for automated design of thermostable proteins

scientific article published on 26 April 2017

Fructose 1-phosphate is the one and only physiological effector of the Cra (FruR) regulator of Pseudomonas putida.

scientific article published on 4 April 2014

HotSpot Wizard 2.0: automated design of site-specific mutations and smart libraries in protein engineering

scientific article

Impact of the access tunnel engineering on catalysis is strictly ligand-specific

scientific article published on 25 February 2018

Interaction of organic solvents with protein structures at protein-solvent interface

scientific article published on 4 July 2012

Maximizing the efficiency of multienzyme process by stoichiometry optimization.

scientific article published on 5 August 2014

Mechanism-based discovery of novel substrates of haloalkane dehalogenases using in silico screening

scientific article published on 30 December 2014

Molecular Gating of an Engineered Enzyme Captured in Real Time

scientific article published on 3 December 2018

PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.

scientific article

PredictSNP: robust and accurate consensus classifier for prediction of disease-related mutations

scientific article published on 16 January 2014

Site-Specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence

scientific article published on 09 April 2015

Software tools for identification, visualization and analysis of protein tunnels and channels.

scientific article published on 10 February 2012

Structural and functional analysis of a novel haloalkane dehalogenase with two halide-binding sites

scientific article

Substrate specificity of haloalkane dehalogenases.

scientific article

The effect of a unique halide-stabilizing residue on the catalytic properties of haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58.

scientific article

Tools and data services registry: a community effort to document bioinformatics resources

scientific article

Toxic effects of nine polycyclic aromatic compounds on Enchytraeus crypticus in artificial soil in relation to their properties.

scientific article published on 29 April 2011

Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling.

scientific article published on 28 April 2015

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