List of works - Richard Bayliss

7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent

scientific article published on 6 August 2015

A Large Domain Swap in the VirB11 ATPase of Brucella suis Leaves the Hexameric Assembly Intact

A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation

scientific article

A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ⬇️

scientific article

A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2

scientific article

A closed conformation of the Caenorhabditis elegans separase-securin complex ⬇️

scientific article published on 13 April 2016

A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms

scientific article published on 2 July 2013

A moving target: structure and disorder in pursuit of Myc inhibitors ⬇️

scientific article

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase ⬇️

scientific article (publication date: 7 November 2016)

Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic ⬇️

scientific article published on November 16, 2011

Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis

scientific article

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain ⬇️

scientific article published on July 2016

Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization

scientific article

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

scientific article

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle. ⬇️

scientific article published in December 2017

Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells

scientific article

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

scientific article

Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship

scientific article

Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease

scientific article published on 05 March 2019

Cell cycle regulation by the NEK family of protein kinases ⬇️

scientific article published on October 1, 2012

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches ⬇️

scientific article

Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding

scientific article

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

scientific article

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

scientific article

Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation

scientific article

Crystallization and Initial X-Ray Diffraction Characterization of Complexes of FxFG Nucleoporin Repeats with Nuclear Transport Factors

Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization

scientific article published on 30 December 2020

Density functional theory studies of MTSL nitroxide side chain conformations attached to an activation loop ⬇️

scientific article published on 23 March 2016

Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity

scientific article

Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy ⬇️

scientific article

Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer ⬇️

scientific article published on 29 December 2016

Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity

scholarly article

Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification

scientific article

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

scientific article published in 2021

EML proteins in microtubule regulation and human disease ⬇️

scientific article

EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7

scientific article published on 17 March 2020

EML4-ALK Variants: Biological and Molecular Properties, and the Implications for Patients ⬇️

scientific article published on 5 September 2017

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

scientific article

Erratum: The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase.

scientific article published on 3 February 2016

Exploring the Conformational Landscape and Stability of Aurora A Using Ion-Mobility Mass Spectrometry and Molecular Modeling

scientific article published on 31 January 2022

Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Porein Vivo

scientific article published in Journal of Biological Chemistry

Functional Tat transport of unstructured, small, hydrophilic proteins

scientific article published on 11 September 2007

GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta

scientific article

Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells ⬇️

scientific article published on 18 July 2017

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

scientific article published on 4 May 2015

Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase

scientific article

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

scientific article

Insights into Aurora-A Kinase Activation Using Unnatural Amino Acids Incorporated by Chemical Modification

scientific article

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

scientific article

Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP

scientific article

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

scientific article published on 2 November 2015

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

scientific article

Mitotic Regulation by NEK Kinase Networks ⬇️

scientific article published in December 2017

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

scientific article published on 13 August 2019

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release ⬇️

scientific article published on 14 August 2018

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix ⬇️

scientific article published on 6 March 2018

Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import.

scientific article published in June 2001

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs ⬇️

scientific article

NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system

scientific article

Neurodevelopmental protein Musashi 1 interacts with the Zika genome and promotes viral replication ⬇️

scientific article

New tools for evaluating protein tyrosine sulfation and carbohydrate sulfation ⬇️

scientific article published on 5 October 2018

On the molecular mechanisms of mitotic kinase activation

scientific article

Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

scientific article

Resonance Assignments of the Complex between TraN and the C-terminal Domain of TraO from the Conjugative Plasmid pKM101

scientific article published on 01 January 2006

Solution NMR assignment of the C-terminal domain of human chTOG. ⬇️

scientific article published on 26 March 2018

Solution NMR assignment of the cryptic sixth TOG domain of mini spindles

scientific article published on 14 May 2015

Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains

scientific article published on 29 October 2015

Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats

scientific article

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

scientific article

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors ⬇️

scientific article

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

scientific article

Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES ⬇️

scientific article published on 26 May 2016

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

scientific article

Structure-guided design of purine-based probes for selective Nek2 inhibition ⬇️

scientific article

Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori

scientific article

Switching Aurora-A kinase on and off at an allosteric site ⬇️

scientific article published on 25 March 2017

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. ⬇️

scientific article

TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation

scientific article

Targeting cancer stem-like cells using dietary-derived agents - Where are we now?

scientific article published on 6 April 2016

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis

scientific article

The Ys and wherefores of protein kinase autoinhibition

scientific article published on 30 April 2015

The primary cilium: guardian of organ development and homeostasis

scientific article published on January 2014

The structural mechanisms that underpin mitotic kinase activation

scientific article published on August 2013

The structure of C290A:C393A Aurora A provides structural insights into kinase regulation

scientific article published on 19 February 2015

The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase

scientific article

Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases ⬇️

scientific article published on 09 October 2018

List of works by Richard Bayliss

7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent

A Large Domain Swap in the VirB11 ATPase of Brucella suis Leaves the Hexameric Assembly Intact

A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation

A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ⬇️

A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2

A closed conformation of the Caenorhabditis elegans separase-securin complex ⬇️

A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms

A moving target: structure and disorder in pursuit of Myc inhibitors ⬇️

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase ⬇️

Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic ⬇️

Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain ⬇️

Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle. ⬇️

Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship

Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease

Cell cycle regulation by the NEK family of protein kinases ⬇️

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches ⬇️

Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation

Crystallization and Initial X-Ray Diffraction Characterization of Complexes of FxFG Nucleoporin Repeats with Nuclear Transport Factors

Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization

Density functional theory studies of MTSL nitroxide side chain conformations attached to an activation loop ⬇️

Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity

Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy ⬇️

Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer ⬇️

Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity

Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

EML proteins in microtubule regulation and human disease ⬇️

EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7

EML4-ALK Variants: Biological and Molecular Properties, and the Implications for Patients ⬇️

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

Erratum: The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase.

Exploring the Conformational Landscape and Stability of Aurora A Using Ion-Mobility Mass Spectrometry and Molecular Modeling

Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Porein Vivo

Functional Tat transport of unstructured, small, hydrophilic proteins

GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta

Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells ⬇️

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

Insights into Aurora-A Kinase Activation Using Unnatural Amino Acids Incorporated by Chemical Modification

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

Mitotic Regulation by NEK Kinase Networks ⬇️

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release ⬇️

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix ⬇️

Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import.

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs ⬇️

NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system

Neurodevelopmental protein Musashi 1 interacts with the Zika genome and promotes viral replication ⬇️

New tools for evaluating protein tyrosine sulfation and carbohydrate sulfation ⬇️

On the molecular mechanisms of mitotic kinase activation

Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Resonance Assignments of the Complex between TraN and the C-terminal Domain of TraO from the Conjugative Plasmid pKM101

Solution NMR assignment of the C-terminal domain of human chTOG. ⬇️

Solution NMR assignment of the cryptic sixth TOG domain of mini spindles

Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains

Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors ⬇️

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES ⬇️

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

Structure-guided design of purine-based probes for selective Nek2 inhibition ⬇️

Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori

Switching Aurora-A kinase on and off at an allosteric site ⬇️

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. ⬇️

TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation

Targeting cancer stem-like cells using dietary-derived agents - Where are we now?