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List of works by Stefan Michiels

A Dual Model for Prioritizing Cancer Mutations in the Non-coding Genome Based on Germline and Somatic Events

scientific article published on 20 November 2015

A Poisson approach to the validation of failure time surrogate endpoints in individual patient data meta-analyses

scientific article

A benchmark study of scoring methods for non-coding mutations.

scientific article published on 11 January 2018

A common language in neoadjuvant breast cancer clinical trials: proposals for standard definitions and endpoints

scientific article published on June 2012

A comparison between different prediction models for invasive breast cancer occurrence in the French E3N cohort

scientific article

A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences

scientific article published on 17 July 2013

A gene signature of chemo-immunization to predict outcome in patients with triple negative breast cancer treated with neoadjuvant chemotherapy

article

A gene signature to predict high tumor-infiltrating lymphocytes after neoadjuvant chemotherapy and outcome in patients with triple-negative breast cancer

scientific article published on 25 October 2017

A joint model for the dependence between clustered times to tumour progression and deaths: A meta-analysis of chemotherapy in head and neck cancer

scientific article published on 23 October 2011

A microsimulation model to assess the economic impact of immunotherapy in non-small cell lung cancer

scientific article published on 19 April 2020

A prospective examination of circulating tumor cell profiles in non-small-cell lung cancer molecular subgroups

scientific article published on 19 June 2017

Abstract S1-03: Pooled individual patient data analysis of stromal tumor infiltrating lymphocytes in primary triple negative breast cancer treated with anthracycline-based chemotherapy

Accounting for grouped predictor variables or pathways in high-dimensional penalized Cox regression models

scientific article published on 02 July 2020

Activation of the phosphatidylinositol 3'-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1.

scientific article published on November 2011

Addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: a meta-analysis of individual patient data

scientific article

Application of an acceptance sampling plan for post-production quality control of chemotherapeutic batches in an hospital pharmacy

scientific article published on 05 June 2006

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Ca

scientific article published on 2 August 2017

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in I

scientific article published in September 2017

Association between FGFR1 copy numbers, MAP3K1 mutations, and survival in axillary node-positive, hormone receptor-positive, and HER2-negative early breast cancer in the PACS04 and METABRIC studies

scientific article published on 16 October 2019

Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: a pooled in-silico analysis

scientific article

Association between the nuclear to cytoplasmic ratio of p27 and the efficacy of adjuvant polychemotherapy in early breast cancer

scientific article published on 11 January 2012

Authors' Reply to Schoenfeld: "Progression-Free Survival as a Surrogate for Overall Survival in Clinical Trials of Targeted Therapy in Advanced Solid Tumors".

scientific article published in June 2017

Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis

scientific article published on May 2010

Benefits of Adding a Drug to a Single-Agent or a 2-Agent Chemotherapy Regimen in Advanced Non–Small-Cell Lung Cancer

scientific article published on 01 July 2004

Bias and precision of methods for estimating the difference in restricted mean survival time from an individual patient data meta-analysis.

scientific article

Bias in the estimation of false discovery rate in microarray studies

scientific article published on 16 August 2005

Biomarker studies: a call for a comprehensive biomarker study registry

scientific article published on March 2011

Breast cancer molecular subclassification and estrogen receptor expression to predict efficacy of adjuvant anthracyclines-based chemotherapy: a biomarker study from two randomized trials

scientific article

CD44+ CD24-/low phenotype and resistance to trastuzumab in HER2-positive breast cancer cell lines

scientific article published in January 2011

CD4⁺ follicular helper T cell infiltration predicts breast cancer survival

scientific article published on 17 June 2013

CXCR4 expression in early breast cancer and risk of distant recurrence

scientific article published on 25 November 2009

Characterization and clinical evaluation of CD10+ stroma cells in the breast cancer microenvironment

scientific article published on 10 January 2012

Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis.

scientific article published on 12 April 2018

Clinical Usefulness of Microarrays for Cancer Prognosis in 2010--Letter

scientific article published on 01 December 2010

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

scientific article

Concordance between HER-2 status determined by qPCR in Fine Needle Aspiration Cytology (FNAC) samples compared with IHC and FISH in Core Needle Biopsy (CNB) or surgical specimens in breast cancer patients

scientific article published on 5 August 2016

Correction: Association between SPARC mRNA Expression, Prognosis and Response to Neoadjuvant Chemotherapy in Early Breast Cancer: A Pooled in-silico Analysis

scientific article published on 16 December 2013

Correction: PIK3CA Genotype and a PIK3CA Mutation-Related Gene Signature and Response to Everolimus and Letrozole in Estrogen Receptor Positive Breast Cancer

article

Corrigendum to "Precision medicine for patients with advanced biliary tract cancers: An effective strategy within the prospective MOSCATO-01 trial" [Eur J Cancer 87 (2017) 122-130].

scientific article published on 14 February 2018

Cost effectiveness of molecular profiling for adjuvant decision making in patients with node-negative breast cancer

scientific article

Cross-Validation Study for Epidermal Growth Factor Receptor and KRAS Mutation Detection in 74 Blinded Non-small Cell Lung Carcinoma Samples: A Total of 5550 Exons Sequenced by 15 Molecular French Laboratories (Evaluation of the EGFR Mutation Status f

article

Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor–Positive Metastatic Breast Cancer

scientific article published on 26 February 2019

DNA methylation profiling reveals a predominant immune component in breast cancers.

scientific article

Differential expression of biomarkers in lung adenocarcinoma: a comparative study between smokers and never-smokers

scientific article published on 11 October 2005

Disease-free survival as a surrogate for overall survival in adjuvant trials of gastric cancer: a meta-analysis

scientific article

Does triple-negative phenotype accurately identify basal-like tumour? An immunohistochemical analysis based on 143 'triple-negative' breast cancers

scientific article

Défis statistiques posés par les biopuces

scientific article published on 01 March 2008

ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors

scientific article published on 26 March 2018

Effects of Estrogen Receptor and Human Epidermal Growth Factor Receptor-2 Levels on the Efficacy of Trastuzumab: A Secondary Analysis of the HERA Trial

scientific article published on 21 April 2016

Efficacy of histology-agnostic and molecularly-driven HER2 inhibitors for refractory cancers.

scientific article published on 12 January 2018

Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling.

scientific article

Empirical extensions of the lasso penalty to reduce the false discovery rate in high-dimensional Cox regression models.

scientific article published on 10 March 2016

Erratum to: Bias and precision of methods for estimating the difference in restricted mean survival time from an individual patient data meta-analysis.

scientific article published on 15 June 2016

Establishing the Evidence Bar for Molecular Diagnostics in Personalised Cancer Care

scientific article published on 11 November 2015

Estimating causal effects of time-dependent exposures on a binary endpoint in a high-dimensional setting.

scientific article published on 3 July 2018

Evaluation of Treatment Effect with Paired Failure Times in a Single-Arm Phase II Trial in Oncology.

scientific article published on 11 January 2018

Exonic expression profiling of breast cancer and benign lesions: a retrospective analysis

scientific article published on 25 February 2009

Exploring disparities in incidence and mortality rates of breast and gynecologic cancers according to the Human Development Index in the Pan-American region.

scientific article published on 31 May 2017

Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma.

scientific article

Expression of erythropoietin and its receptor in neuroblastomas

scientific article

Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer

scientific article published on 05 September 2007

False discovery rate, sensitivity and sample size for microarray studies.

scientific article published on 19 April 2005

Fatigue and physical activity in cancer survivors: A cross-sectional population-based study.

scientific article published on 12 March 2019

Feasibility Study of EndoTAG-1, a Tumor Endothelial Targeting Agent, in Combination with Paclitaxel followed by FEC as Induction Therapy in HER2-Negative Breast Cancer

scientific article

Feasibility and first reports of the MATCH-R repeated biopsy trial at Gustave Roussy

scientific article published on 08 September 2020

Feasibility of developing reliable gene expression modules from FFPE derived RNA profiled on Affymetrix arrays

scientific article published in PLoS ONE

Five-Gene Signature in Non–Small-Cell Lung Cancer

article

Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations

scientific article

Gene expression profiling: does it add predictive accuracy to clinical characteristics in cancer prognosis?

scientific article published on 25 January 2007

Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas

scientific article

Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis.

scientific article

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk

scientific article published on 23 February 2009

Genome-wide copy number analyses of samples from LACE-Bio project identify novel prognostic and predictive markers in early stage non-small cell lung cancer

article published in 2018

Genome-wide gene expression profiling to predict resistance to anthracyclines in breast cancer patients

scientific article

Genomic Grade Index (GGI): feasibility in routine practice and impact on treatment decisions in early breast cancer

scientific article

Genomic grade adds prognostic value in invasive lobular carcinoma.

scientific article published in October 2012

Guidelines for time-to-event end point definitions in breast cancer trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials).

scientific article published on 13 October 2015

Guidelines for time-to-event end point definitions in breast cancer trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials)†

scientific article

HER2-positive circulating tumor cells in breast cancer

scientific article

HEX, PAX-8 and TTF-1 gene expression in human thyroid tissues: a comparative analysis with other genes involved in iodide metabolism

article

High-Throughput Genomics and Clinical Outcome in Hard-to-Treat Advanced Cancers: Results of the MOSCATO 01 Trial

scientific article published on 01 April 2017

Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers: Entering the back door

scientific article published on 27 January 2018

Identification of biomarker-by-treatment interactions in randomized clinical trials with survival outcomes and high-dimensional spaces.

scientific article published on 15 November 2016

Image-guided tumour biopsies in a prospective molecular triage study (MOSCATO-01): What are the real risks?

scientific article published on 14 September 2018

Immunohistochemichal expression of biomarkers: a comparative study between diagnostic bronchial biopsies and surgical specimens of non-small-cell lung cancer

scientific article published on 12 March 2007

Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8+ T Cells

scientific article published on 7 January 2016

Individual- and trial-level surrogacy in colorectal cancer

scientific article published on 19 February 2008

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

scientific article published on 10 December 2020

Integrating biomarkers in clinical trials

scientific article published on March 2011

International study on inter-reader variability for circulating tumor cells in breast cancer

scientific article

Interpretation of microarray data in cancer

scientific article

Investigating trial and treatment heterogeneity in an individual patient data meta-analysis of survival data by means of the penalized maximum likelihood approach.

scientific article

Joint model for left-censored longitudinal data, recurrent events and terminal event: Predictive abilities of tumor burden for cancer evolution with application to the FFCD 2000-05 trial

scientific article

Joint model imputation to estimate the treatment effect on long-term survival using auxiliary events

scientific article published on 16 February 2017

Leukemia-free survival as a surrogate end point for overall survival in the evaluation of maintenance therapy for patients with acute myeloid leukemia in complete remission.

scientific article published on 5 May 2011

Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression

scientific article published on 6 September 2012

Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer.

scientific article published on 14 November 2011

Meta-analysis when only the median survival times are known: a comparison with individual patient data results

scientific article published in January 2005

Mining the coding and non-coding genome for cancer drivers

scientific article published on 30 September 2015

Modulation of Rb phosphorylation and antiproliferative response to palbociclib: the preoperative-palbociclib (POP) randomized clinical trial

scientific article published on 01 August 2018

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis

scientific article published in September 2004

Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial

scientific article

Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array.

scientific article

Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement.

scientific article published on December 2012

Multidimensionality of microarrays: statistical challenges and (im)possible solutions

scientific article published on 03 February 2011

Multifactorial approach to predicting resistance to anthracyclines

scientific article published on 21 March 2011

Multiple testing of treatment-effect-modifying biomarkers in a randomized clinical trial with a survival endpoint.

scientific article

Multivariate joint frailty model for the analysis of nonlinear tumor kinetics and dynamic predictions of death.

scientific article published on 26 March 2018

Mutation-Independent Activation of the Anaplastic Lymphoma Kinase in Neuroblastoma

scientific article published on 11 December 2015

Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients

scientific article

Neoadjuvant buparlisib plus trastuzumab and paclitaxel for women with HER2+ primary breast cancer: A randomised, double-blind, placebo-controlled phase II trial (NeoPHOEBE).

scientific article published on 15 September 2017

Network meta-analyses: Interest and limits in oncology

scientific article published on 23 February 2016

New insights into the evaluation of randomized controlled trials for rare diseases over a long-term research horizon: a simulation study

scientific article

Omics-based clinical trial designs

scientific article published on May 2013

Overestimated treatment effects in randomised phase II trials: What's up doctor?

scientific article published on 01 November 2019

PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer

scientific article

Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

scientific article

Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers

scientific article

Precision medicine for metastatic breast cancer--limitations and solutions.

scientific article published on 21 July 2015

Precision medicine for patients with advanced biliary tract cancers: An effective strategy within the prospective MOSCATO-01 trial

scientific article published on 13 November 2017

Prediction of cancer outcome with microarrays

Prediction of cancer outcome with microarrays: a multiple random validation strategy

scientific article published on 01 February 2005

Prediction of treatment benefit in high-dimensional cox models via gene signatures in randomized clinical trials.

scientific article published on 16 November 2015

Predictors of responses to immune checkpoint blockade in advanced melanoma

scientific article published on 19 September 2017

Preface

Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98

scientific article

Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple negative breast cancer patients after neo-adjuvant chemotherapy

scientific article published on 01 February 2019

Prognostic value of tumor-infiltrating lymphocytes in patients with early-stage triple-negative breast cancers (TNBC) who did not receive adjuvant chemotherapy

scientific article published on 01 December 2019

Progression-Free Survival as a Surrogate for Overall Survival in Clinical Trials of Targeted Therapy in Advanced Solid Tumors

scientific article published on 23 March 2017

Progression-free survival as a surrogate for overall survival in advanced/recurrent gastric cancer trials: a meta-analysis

scientific article published on 09 October 2013

Progression-free survival as surrogate end point for overall survival in clinical trials of HER2-targeted agents in HER2-positive metastatic breast cancer

scientific article published on 8 March 2016

Progression-free survival is a surrogate for survival in advanced colorectal cancer

scientific article published in November 2007

Quelles exigences pour qu'un biomarqueur puisse être un critère de substitution acceptable ?

scientific article published on 01 June 2016

Random effects survival models gave a better understanding of heterogeneity in individual patient data meta-analyses.

scientific article

Relationship Between Carfilzomib Dose and Efficacy Outcomes in Patients With Relapsed and/or Refractory Multiple Myeloma

scientific article published on 25 September 2015

Reply to V.P. Retèl et al, D. Gauchan et al, and C. Rahilly-Tierney et al.

scientific article published on 6 April 2015

Reporting of time-to-event end points and tracking of failures in randomized trials of radiotherapy with or without any concomitant anticancer agent for locally advanced head and neck cancer

scientific article published on 05 October 2009

Research Highlights

scientific article published on 01 January 2011

Robotic Prophylactic Nipple-Sparing Mastectomy with Immediate Prosthetic Breast Reconstruction: A Prospective Study

scientific article published on 29 June 2018

Robust estimation of the expected survival probabilities from high-dimensional Cox models with biomarker-by-treatment interactions in randomized clinical trials

scientific article

Role of chemotherapy for advanced/recurrent gastric cancer: An individual-patient-data meta-analysis ⬇️

scientific article published on January 24, 2013

Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning

scholarly article by F Klauschen et al published October 2018 in Seminars in Cancer Biology

Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease

scientific article (publication date: 18 April 2012)

Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease

scientific article

Societal challenges of precision medicine: Bringing order to chaos

scientific article published on 30 August 2017

Sodium/Iodide Symporter (NIS) Gene Expression Is the Limiting Step for the Onset of Thyroid Function in the Human Fetus

article

Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer

scientific article published on 05 June 2013

Somatic mutation, copy number and transcriptomic profiles of primary and matched metastatic estrogen receptor-positive breast cancers.

scientific article published on October 2016

Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group

scientific article published on July 2016

Statistical controversies in clinical research: prognostic gene signatures are not (yet) useful in clinical practice

scientific article

Statistical methods applied to omics data: predicting response to neoadjuvant therapy in breast cancer

scientific article

Steps forward for cancer precision medicine

scientific article published on 24 November 2017

Surrogate End Points for Overall Survival in Loco-Regionally Advanced Nasopharyngeal Carcinoma: An Individual Patient Data Meta-analysis

scientific article

Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data ⬇️

scientific article published on May 14, 2013

Surrogate endpoints for overall survival in locally advanced head and neck cancer: meta-analyses of individual patient data

scientific article

Taking into account successive treatment lines in the analysis of a colorectal cancer randomised trial.

scientific article published on 13 March 2013

Testing the treatment effect on competing causes of death in oncology clinical trials

scientific article

The European Society for Medical Oncology (ESMO) Precision Medicine Glossary

scientific article published on 13 November 2017

The Genomic Grade Assay Compared With Ki67 to Determine Risk of Distant Breast Cancer Recurrence

scientific article published on 03 December 2015

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

scientific article published on 19 December 2018

The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.

scientific article

Time to move forward from “first-generation” prognostic gene signatures in early breast cancer

article

Towards understanding the breast cancer epigenome: a comparison of genome-wide DNA methylation and gene expression data

scientific article

Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology

scientific article

Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data

scientific article published on 22 February 2018

Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

scientific article

Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial

scientific article published on July 2015

Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers

scientific article published on 16 January 2019

Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study

scientific article published on 06 December 2016

Uncertain benefit from surgery in patients with lung metastases from breast carcinoma

scientific article published on 01 January 2004

Update of survival and cost of metastatic melanoma with new drugs: Estimations from the MelBase cohort

scientific article published on 29 October 2018

Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group o

article by Maria Vittoria Dieci et al published October 2018 in Seminars in Cancer Biology

Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement

scientific article

Validation of Microarray Data by Quantitative Reverse-Transcriptase Polymerase Chain Reaction

scientific article published on 01 December 2005

Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers

scientific article published in July 2008

[Gene expression profiling in cancer research]

scientific article published on 01 November 2007

[Individual patient data meta-analyses of randomized trials for the treatment of non-metastatic head and neck squamous cell carcinomas: Principles, results and perspectives].

scientific article

biospear: an R package for biomarker selection in penalized Cox regression

scientific article published on 12 September 2017

surrosurv: An R package for the evaluation of failure time surrogate endpoints in individual patient data meta-analyses of randomized clinical trials

scientific article published on 13 December 2017

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