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List of works by Takehiko Yokomizo

12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2

scientific article

12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor

scientific article

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

scientific article

A Novel Anti-FLAG Monoclonal Antibody Is Useful to Study GPCRs

A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor

scientific article published on 29 April 2003

A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss

scientific article

A high-affinity monoclonal antibody against the FLAG tag useful for G-protein-coupled receptor study

scientific article published on 27 March 2012

A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy

scientific article published on 09 November 2020

A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders

scientific article

A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes

scientific article published on 14 September 2016

Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems

scientific article published on 30 August 2012

Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice

scientific article published on 06 February 2020

An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice

scientific article published on 8 October 2015

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

scientific article

Association of eNOS Glu298Asp polymorphism with end-stage renal disease

scientific article published in October 2002

Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1.

scientific article

Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice

scientific article

BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils

scientific article published on 11 July 2016

BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation

scientific article

Basic Techniques for Lipid Extraction from Tissues and Cells

Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1.

scientific article published on 18 September 2017

Biochemical characterization of three BLT receptors in zebrafish

scientific article published in 2015

CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis

scientific article published on 16 February 2016

CD10-bearing fibroblast inhibits matrigel invasive potency of interleukin-1α-producing squamous cell carcinoma by diminishing substance P levels in the tumor microenvironment

scientific article published on 28 September 2010

Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene

scientific article

Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes

scientific journal article

Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins

scientific article

Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution

scientific journal article

Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue

scientific article

Characterization of the leukotriene B4 receptor in porcine leukocytes. Separation and reconstitution with heterotrimeric GTP-binding proteins

scientific article

Characterization of two distinct types of leukotriene B4 receptor

Cloning and characterization of rat leukotriene B(4) receptor

scientific article

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article

Co-expression of two LTB4 receptors in human mononuclear cells

scientific article published on 01 April 2001

Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2.

scientific article

Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13-Reductase Complex Reveals the Structural Basis of Broad Spectrum Indomethacin Efficacy

scientific article published on 17 August 2006

Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes

scientific article

Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration

scientific article published on 9 May 2017

Eicosanoids in Skin Wound Healing

scientific article published on 10 November 2020

Erratum: corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article published in Nature

Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation

scientific article published on 09 October 2020

Expression, purification and characterization of leukotriene B(4) receptor, BLT1 in Pichia pastoris

scientific article published on 24 February 2010

From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.

scientific article published on 20 December 2016

G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine

scientific article

Generation and characterization of a human-mouse chimeric high-affinity antibody that detects the DYKDDDDK FLAG peptide

scientific article published on April 2017

Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells

scientific article published in September 2003

Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization

scientific article

Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum

scientific article published on 6 January 2009

Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation

scientific article published on 5 August 2003

Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2

scientific article (publication date: 13 April 2001)

IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages

scientific article

Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123

scientific journal article

Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation

scientific article published on 9 December 2006

Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase

scientific article published in December 2001

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions

scientific article

Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice

scientific article published on 29 December 2016

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

scientific journal article

Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells

scientific article published on 19 November 2015

International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions

scientific article

International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor

scientific article (publication date: March 2004)

International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors

scientific article (publication date: March 2003)

Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production

scientific article published on 9 January 2017

Leukotriene A4 hydrolase and leukotriene B4 metabolism.

scientific article published on October 1995

Leukotriene B4 Augments and Restores FcγRs-dependent Phagocytosis in Macrophages ⬇️

scientific article published on October 19, 2010

Leukotriene B4 Receptors

article from 2015

Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia

scientific article

Leukotriene B4 receptor and the function of its helix 8.

scientific article

Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins

scientific article published on 2 November 2015

Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.

scientific article published on 05 October 2016

Leukotriene B4 receptors

scientific article

Leukotriene B4 receptors: Novel roles in immunological regulations ⬇️

scientific article published on October 28, 2010

Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment

scientific article published on 29 April 2013

Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin

scientific article published in July 2008

Leukotriene B4: metabolism and signal transduction.

scientific article

Leukotriene receptors as potential therapeutic targets

Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury.

scientific article published on 15 January 2013

Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis

scientific journal article

Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma

scientific article published on 4 March 2013

Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE)

scientific article published on 26 January 2016

Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1.

scientific article published on 8 January 2018

Neuronatin is related to keratinocyte differentiation by up-regulating involucrin

scientific article published on 30 October 2013

Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2.

scientific article published on 16 October 2017

Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains

scientific article (publication date: 24 January 2003)

Preparation of 2- and 4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2 receptors

scientific article published in November 2004

Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans and their BLT1 and/or BLT2 inhibitory activities

scientific article published on 29 November 2007

Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity

scientific article published on 31 August 2007

Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells

scientific article

Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis

scientific article

ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration

scientific article published on 19 February 2015

Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling

scientific article published on 10 November 2016

Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release

scientific journal article

Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

scientific article

Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation.

scientific article

Stepwise phosphorylation of leukotriene B4receptor 1 defines cellular responses to leukotriene B4

article

Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop.

scientific article published on 8 March 2004

Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives

scientific article published on 18 January 2007

Synthesis of (S,5Z,8E,10E)-12-Hydroxyheptadeca-5,8,10-trienoic Acid (12S-HHT) and its Analogues

Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B4 receptor antagonistic activity

scientific article published on 16 May 2005

The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury

scientific article

The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders

scientific article published on 22 July 2019

The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury

scientific article

The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations

scientific article

The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes

scientific article published on 20 February 2016

The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis

scientific article published on 11 March 2010

The leukotriene receptors as therapeutic targets of inflammatory diseases

scientific article published on 01 August 2019

The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo

scientific article (publication date: September 2006)

The role of leukotrienes in allergic diseases

scientific article

Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand

scientific article

Transcriptional regulation of human G2A in monocytes/ macrophages: involvement of c/EBPs, Runx and Pu.1.

scientific article

Two distinct leukotriene B4 receptors, BLT1 and BLT2

scientific article

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

scientific article

What is the natural ligand of GPR55? ⬇️

scientific article published on February 15, 2011

[Leukotriene B4 receptors: identification and roles in inflammatory diseases]

scientific article published on 01 July 2007

cDNA cloning and characterization of guinea-pig leukotriene B4 receptor

scientific article

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