List of works - Rey-Ting Guo

"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

scientific article published on 7 December 2017

A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products

scientific article

Antibacterial drug leads: DNA and enzyme multitargeting

scientific article published on 22 January 2015

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.

scientific article published on 31 August 2016

Binding mode of the oxidized α-anomer of NAD+ to RSP, a Rex-family repressor

scientific article

Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum.

scientific article

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

scientific article

Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-β-endoglucanase from Thielavia terrestris.

scientific article

Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination ⬇️

scientific article published on November 15, 2003

Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase fromSaccharomyces cerevisiaeand the Mechanism of Product Chain Length Determination

scientific article published in Journal of Biological Chemistry

Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50.

scientific article

Crystal structure and substrate-binding mode of a novel pectate lyase from alkaliphilic Bacillus sp. N16-5

scientific article

Crystal structure and substrate-binding mode of cellulase 12A from Thermotoga maritima

scientific article

Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis

scientific article published on 01 February 2019

Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein

scientific article

Crystal structures of Bacillus alkaline phytase in complex with divalent metal ions and inositol hexasulfate

scientific article

Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima

scientific article

Crystal structures of d-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars

scientific article

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase fromEscherichia colireveal the catalytic and chain-length determining mechanisms ⬇️

scientific article

Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis

scientific article published on 23 March 2005

Crystallization and preliminary X-ray diffraction analysis of (R)-carbonyl reductase from Candida parapsilosis

scientific article

Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168.

scientific article published on 25 December 2012

Crystallization and preliminary X-ray diffraction analysis of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485

scientific article

Crystallization and preliminary X-ray diffraction analysis of a novel β-L-arabinofuranosidase (HypBA1) from Bifidobacterium longum.

scientific article

Crystallization and preliminary X-ray diffraction analysis of an endo-1,4-β-D-glucanase from Aspergillus aculeatus F-50.

scientific article

Distinct structural features of Rex-family repressors to sense redox levels in anaerobes and aerobes

scientific article published on 13 November 2014

Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose

scientific article

Enhanced activity of Thermotoga maritima cellulase 12A by mutating a unique surface loop

scientific article

Expression in Pichia pastoris and characterization by circular dichroism and NMR of rhodostomin

scientific article published on 01 June 2001

Functional and structural analyses of a 1,4-β-endoglucanase from Ganoderma lucidum

scientific article

Functional and structural analysis of Pichia pastoris-expressed Aspergillus niger 1,4-β-endoglucanase.

scientific article published on 3 May 2016

Functional and structural studies of pullulanase from Anoxybacillus sp. LM18-11.

scientific article published on 22 April 2014

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

scientific article published on 24 March 2017

Immobilization of Clostridium cellulolyticum d-Psicose 3-Epimerase on Artificial Oil Bodies

scientific article published on 08 July 2014

Improving specific activity and thermostability of Escherichia coli phytase by structure-based rational design.

scientific article

Improving the catalytic performance of a GH11 xylanase by rational protein engineering.

scientific article published on 19 June 2015

Improving the specific activity of β-mannanase from Aspergillus niger BK01 by structure-based rational design

scientific article published on 28 January 2014

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †

scientific article

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB fromBacillus subtilisandStaphylococcus aureus

scientific article

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes

scientific article

KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge

scientific article published on 25 January 2022

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

scientific article

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.

scientific article

Multitarget drug discovery for tuberculosis and other infectious diseases

scientific article

Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases

scientific article published on 05 January 2021

Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli

scientific article

Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase from Escherichia coli.

scientific article published on 27 February 2013

Preliminary X-ray diffraction analysis of thermostable β-1,4-mannanase from Aspergillus niger BK01

scientific article published on 28 September 2013

Rational design to improve thermostability and specific activity of the truncated Fibrobacter succinogenes 1,3-1,4-β-d-glucanase ⬇️

scientific article published on September 30, 2011

Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis

scientific article published on 10 April 2012

Roles of tryptophan residue and disulfide bond in the variable lid region of oxidized polyvinyl alcohol hydrolase

scientific article

SQ109, a new drug lead for Chagas disease

scientific article

Squalene synthase as a target for Chagas disease therapeutics

scientific article

Structural Basis by Which the N-Terminal Polypeptide Segment of Rhizopus chinensis Lipase Regulates Its Substrate Binding Affinity

scientific article published on 11 September 2019

Structural analyses and yeast production of the β-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum

scientific article

Structural analysis of a glycoside hydrolase family 11 xylanase from Neocallimastix patriciarum: insights into the molecular basis of a thermophilic enzyme.

scientific article

Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.

scientific article published on 6 March 2015

Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485

scientific article

Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production

scientific article

Structural and mutagenetic analyses of a 1,3-1,4-β-glucanase from Paecilomyces thermophila

scientific article

Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum

scientific article

Structural insight into potential cold adaptation mechanism through a psychrophilic glycoside hydrolase family 10 endo-β-1,4-xylanase

scientific article

Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase

scientific article published on 29 May 2020

Structural perspectives of an engineered β-1,4-xylanase with enhanced thermostability

scientific article

Structural studies reveal the molecular mechanism of PETase

scientific article published on 17 August 2018

Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase.

scientific article published on 29 February 2016

Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis

scientific article

Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate

scientific article published on 23 October 2019

Structure of the alkalohyperthermophilic Archaeoglobus fulgidus lipase contains a unique C-terminal domain essential for long-chain substrate binding

scientific article

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.

scientific article published on 26 July 2016

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

scientific article

Structure-Based Inhibitors Exhibit Differential Activities againstHelicobacter pyloriandEscherichia coliUndecaprenyl Pyrophosphate Synthases

scientific article

Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+) , NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms.

scientific article

Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis

scientific article published in November 2004

Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets

scientific article published on 23 February 2016

Substrate binding of a GH5 endoglucanase from the ruminal fungusPiromyces rhizinflata

scientific article

Substrate binding to a GH131 β-glucanase catalytic domain from Podospora anserina

scientific article published on 20 July 2013

The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement

scientific article published on 23 October 2018

The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485

scientific article

Three-dimensional structure of an alkaline xylanase Xyn11A-LC from alkalophilic Bacillus sp. SN5 and improvement of its thermal performance by introducing arginines substitutions.

scientific article published on 30 March 2014

Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase

scientific article

List of works by Rey-Ting Guo

"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products

Antibacterial drug leads: DNA and enzyme multitargeting

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.

Binding mode of the oxidized α-anomer of NAD+ to RSP, a Rex-family repressor

Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum.

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-β-endoglucanase from Thielavia terrestris.

Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination ⬇️

Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase fromSaccharomyces cerevisiaeand the Mechanism of Product Chain Length Determination

Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50.

Crystal structure and substrate-binding mode of a novel pectate lyase from alkaliphilic Bacillus sp. N16-5

Crystal structure and substrate-binding mode of cellulase 12A from Thermotoga maritima

Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis

Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein

Crystal structures of Bacillus alkaline phytase in complex with divalent metal ions and inositol hexasulfate

Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima

Crystal structures of d-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase fromEscherichia colireveal the catalytic and chain-length determining mechanisms ⬇️

Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis

Crystallization and preliminary X-ray diffraction analysis of (R)-carbonyl reductase from Candida parapsilosis

Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168.

Crystallization and preliminary X-ray diffraction analysis of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485

Crystallization and preliminary X-ray diffraction analysis of a novel β-L-arabinofuranosidase (HypBA1) from Bifidobacterium longum.

Crystallization and preliminary X-ray diffraction analysis of an endo-1,4-β-D-glucanase from Aspergillus aculeatus F-50.

Distinct structural features of Rex-family repressors to sense redox levels in anaerobes and aerobes

Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose

Enhanced activity of Thermotoga maritima cellulase 12A by mutating a unique surface loop

Expression in Pichia pastoris and characterization by circular dichroism and NMR of rhodostomin

Functional and structural analyses of a 1,4-β-endoglucanase from Ganoderma lucidum

Functional and structural analysis of Pichia pastoris-expressed Aspergillus niger 1,4-β-endoglucanase.

Functional and structural studies of pullulanase from Anoxybacillus sp. LM18-11.

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Immobilization of Clostridium cellulolyticum d-Psicose 3-Epimerase on Artificial Oil Bodies

Improving specific activity and thermostability of Escherichia coli phytase by structure-based rational design.

Improving the catalytic performance of a GH11 xylanase by rational protein engineering.

Improving the specific activity of β-mannanase from Aspergillus niger BK01 by structure-based rational design

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB fromBacillus subtilisandStaphylococcus aureus

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes

KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.

Multitarget drug discovery for tuberculosis and other infectious diseases

Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases

Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli

Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase from Escherichia coli.

Preliminary X-ray diffraction analysis of thermostable β-1,4-mannanase from Aspergillus niger BK01

Rational design to improve thermostability and specific activity of the truncated Fibrobacter succinogenes 1,3-1,4-β-d-glucanase ⬇️

Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis

Roles of tryptophan residue and disulfide bond in the variable lid region of oxidized polyvinyl alcohol hydrolase

SQ109, a new drug lead for Chagas disease

Squalene synthase as a target for Chagas disease therapeutics

Structural Basis by Which the N-Terminal Polypeptide Segment of Rhizopus chinensis Lipase Regulates Its Substrate Binding Affinity

Structural analyses and yeast production of the β-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum

Structural analysis of a glycoside hydrolase family 11 xylanase from Neocallimastix patriciarum: insights into the molecular basis of a thermophilic enzyme.

Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.

Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485

Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production

Structural and mutagenetic analyses of a 1,3-1,4-β-glucanase from Paecilomyces thermophila

Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum

Structural insight into potential cold adaptation mechanism through a psychrophilic glycoside hydrolase family 10 endo-β-1,4-xylanase

Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase

Structural perspectives of an engineered β-1,4-xylanase with enhanced thermostability

Structural studies reveal the molecular mechanism of PETase

Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase.

Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis

Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate

Structure of the alkalohyperthermophilic Archaeoglobus fulgidus lipase contains a unique C-terminal domain essential for long-chain substrate binding

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

Structure-Based Inhibitors Exhibit Differential Activities againstHelicobacter pyloriandEscherichia coliUndecaprenyl Pyrophosphate Synthases

Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+) , NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms.

Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis

Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets

Substrate binding of a GH5 endoglucanase from the ruminal fungusPiromyces rhizinflata

Substrate binding to a GH131 β-glucanase catalytic domain from Podospora anserina

The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement

The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485