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List of works by R. Daniel Beauchamp

A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization.

scientific article published on 8 June 2003

A network-based gene expression signature informs prognosis and treatment for colorectal cancer patients ⬇️

scientific article published on July 23, 2012

A phase I study of concurrent 9-nitro-20(s)-camptothecin (9NC/Orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas

scientific article published in July 2005

A phase I study of vitamin E, 5-fluorouracil and leucovorin for advanced malignancies

scientific article published in January 2001

A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.

scientific article

Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation.

scientific article published on 24 April 2015

Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.

scientific article published on 13 June 2013

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.

scientific article published on 7 March 2011

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis.

scientific article

Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice

scientific article published on 24 March 2021

Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors

scientific article published on 01 February 1999

Cyclin D3 is essential for intestinal epithelial cell proliferation

scientific article published on 15 April 2002

Cyclooxygenase-2 alters transforming growth factor-beta 1 response during intestinal tumorigenesis

scientific article published on August 1999

Deciphering genomic alterations in colorectal cancer through transcriptional subtype-based network analysis

scientific article

Differential effects of sodium butyrate and hexamethylene bisacetamide on growth and secretion of cultured human endocrine tumor cells

scientific article published on 01 April 1991

Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase

scientific article published on 01 November 2003

E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells

scientific journal article

Elevated ALCAM shedding in colorectal cancer correlates with poor patient outcome.

scientific article published on 28 March 2013

Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging

scientific article published in February 2004

Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.

scientific article

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction.

scientific article published on 17 February 2014

Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma

scientific article

HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability.

scientific article published on 2 November 2009

Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression

scientific article published in December 2002

Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells.

scientific article published on 9 February 2011

Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS

scientific article

Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras.

scientific article

Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway

scientific article

Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells

scientific article published on 01 October 2000

Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions.

scientific article published on May 2003

Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters

scientific article

Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness

scientific article

Lymphatic mapping and sentinel lymphadenectomy after preoperative therapy for stage II and III breast cancer

scientific article published on 01 July 2003

Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer

scientific article published in March 2006

Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer

scientific article published on 15 October 2014

Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas.

scientific article published on April 1998

Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition.

scientific article published on July 2008

Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells

scientific article

Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation.

scientific article

Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis.

scientific article published on June 2006

Over-expression of cyclin D1 regulates Cdk4 protein synthesis.

scientific article published on December 2003

Phase I trial of Orzel (UFT plus leucovorin), cisplatin, and radiotherapy in the treatment of potentially resectable esophageal cancer

scientific article published in April 2005

Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer

scientific article published on 9 November 2006

Potentiation of apomorphine and D-amphetamine effects by naloxone

scientific article published on 01 February 1981

Presidential address: evolution

scientific article published on 01 August 2000

Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer

scientific article

Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.

scientific article published on 28 July 2003

Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology.

scientific article published on 25 July 2008

Resident work hour limits and patient safety.

scientific article published in June 2005

Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation

scientific article published in August 2002

Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells.

scientific article published on 8 November 2005

Role of cholecystokinin in canine pancreatic exocrine response to bombesin stimulation

scientific article published on 01 January 1987

Short-term caloric restriction augments age-related decreases in gastrin content and release

scientific article published in May 1996

Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells

scientific article published on February 2007

Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta

scientific article published on 7 September 2006

Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.

scientific article

Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.

scientific article

Systemic alterations in ornithine decarboxylase activity caused by colon cancer in mice

scientific article published on 01 June 1991

The changing roles of a surgical department chair: adapting to a changing environment.

scientific article published in March 2005

The use of a multidisciplinary morbidity and mortality conference to incorporate ACGME general competencies ⬇️

scientific article published on March 25, 2011

Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2.

scientific article

Transforming growth factor-beta inhibits rat intestinal cell growth by regulating cell cycle specific gene expression

scientific article published on January 1994

Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells

scientific article published in June 1992

Urine PGE-M: A Metabolite of Prostaglandin E2 as a Potential Biomarker of Advanced Colorectal Neoplasia

scientific article published on 25 September 2006

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling

scientific article

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