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List of works by Ariela Benigni

A novel interpretation of the role of von Willebrand factor in thrombotic microangiopathies based on platelet adhesion studies at high shear rate flow

scientific article

A novel strategy to enhance mesenchymal stem cell migration capacity and promote tissue repair in an injury specific fashion

scientific article published on 10 August 2012

A previously unrecognized role of C3a in proteinuric progressive nephropathy

scientific article published on 27 June 2016

AAV9-mediated engineering of autotransplanted kidney of non-human primates

scientific article published on 27 March 2017

ACE inhibition limits chronic injury of kidney transplant even with treatment started when lesions are established

scientific article published in December 2003

ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease

scientific article published in April 2006

Abnormalities of arachidonate metabolism in experimental ciclosporin nephrotoxicity

scientific article

Acute cyclosporine A nephrotoxicity in rats: which role for renin-angiotensin system and glomerular prostaglandins?

article

Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat.

scientific article

Adding a statin to a combination of ACE inhibitor and ARB normalizes proteinuria in experimental diabetes, which translates into full renoprotection

scientific article published on 18 August 2010

Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection

scientific article published on 26 April 2006

Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice

scientific article

Aging and the kidney

scientific article published on May 2011

Aging and the renin-angiotensin system

scientific article published on 27 August 2012

Allograft rejection: acute and chronic studies

scientific article published on January 2008

An unanticipated role for survivin in organ transplant damage

scientific article published on 14 April 2014

Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects

scientific article published on 7 November 2012

Angiotensin II blockade limits tubular protein overreabsorption and the consequent upregulation of endothelin 1 gene in experimental membranous nephropathy

article

Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via Notch1/Snail pathway

scientific article published on 23 May 2013

Angiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney

scientific article published on 01 May 1996

Angiotensin II revisited: new roles in inflammation, immunology and aging

scientific article

Angiotensin receptors as determinants of life span

scientific article

Angiotensin-converting enzyme inhibition prevents glomerular-tubule disconnection and atrophy in passive Heymann nephritis, an effect not observed with a calcium antagonist

scientific article

Another Piece of the Puzzle of Podocyte B7-1 Expression: Lupus Nephritis.

scientific article

Anti-Phospholipase A2 Receptor Antibody Titer Predicts Post-Rituximab Outcome of Membranous Nephropathy

scientific article

Any value of podocyte B7-1 as a biomarker in human MCD and FSGS?

scientific article published on 23 December 2015

Atrial natriuretic peptide and prostacyclin synergistically mediate hyperfiltration and hyperperfusion of diabetic rats

scientific article published on April 1992

B7-1 Is Not Induced in Podocytes of Human and Experimental Diabetic Nephropathy

scientific article published on 28 August 2015

BRAF Signaling Pathway Inhibition, Podocyte Injury, and Nephrotic Syndrome

scientific article published on 24 February 2017

Beneficial effect of TGFbeta antagonism in treating diabetic nephropathy depends on when treatment is started

Biomarkers of Fabry disease nephropathy

scientific article published on 5 November 2009

Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney

scientific article published on March 1996

Bone marrow-derived mesenchymal stem cells improve islet graft function in diabetic rats.

scientific article published in June 2009

Cells for treating organ damage: how long will we need them?

scientific article

Cellular responses to protein overload: key event in renal disease progression

scientific article published on January 2004

Changes in glomerular perm-selectivity induced by angiotensin II imply podocyte dysfunction and slit diaphragm protein rearrangement

scientific article published on March 2004

Combining lisinopril and l-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis

scientific article published in September 2003

Complement Alternative Pathway Deficiency in Recipients Protects Kidney Allograft From Ischemia/Reperfusion Injury and Alloreactive T Cell Response

scientific article

Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus

scholarly article by Carla Zoja et al published 2007 in Arthritis and Rheumatism

Dendritic cells genetically engineered with adenoviral vector encoding dnIKK2 induce the formation of potent CD4+ T-regulatory cells

scientific article published in May 2005

Direct reprogramming of human bone marrow stromal cells into functional renal cells using cell-free extracts

scientific article

Disruption of the Ang II type 1 receptor promotes longevity in mice

scientific article

Distinct cardiac and renal effects of ETA receptor antagonist and ACE inhibitor in experimental type 2 diabetes

scientific article published on 3 August 2011

DnIKK2-Transfected Dendritic Cells Induce a Novel Population of Inducible Nitric Oxide Synthase???Expressing CD4+CD25??? Cells with Tolerogenic Properties

EGF receptor-mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling

scientific article published on 01 September 2020

Early and late scanning electron microscopy findings in diabetic kidney disease.

scientific article published on 20 March 2018

Early histological changes in the kidney of people with morbid obesity.

scientific article published on 13 July 2009

Effect of Low-Dose Aspirin on Fetal and Maternal Generation of Thromboxane by Platelets in Women at Risk for Ppregnancy-Induced Hypertension

article by Ariela Benigni et al published 10 August 1989 in The New England Journal of Medicine

Effect of angiotensin II antagonism on the regression of kidney disease in the rat.

scientific article published in September 2002

Effect of aspirin and sulindac in rabbit nephrotoxic nephritis

Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat.

scientific article published in May 2008

Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate

article

Effect on blood pressure of combined inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomised, crossover, double-blind, placebo-controlled trial

scientific article published on 13 June 2013

Effects of rosuvastatin on glomerular capillary size-selectivity function in rats with renal mass ablation

scientific article published on 11 September 2007

Endothelin and eicosanoid synthesis in cultured mesangial cells

scientific article published on March 1990

Endothelin antagonists

scientific article

Endothelin antagonists and renal protection

scientific article

Endothelin in chronic proteinuric kidney disease

scientific article published on 30 August 2011

Endothelin in the progressive renal disease of glomerulopathies

scientific article

Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products

article by N Perico et al published July 1991 in Journal of the American Society of Nephrology

Endothelin: a mediator of renal disease progression

scientific article published on July 1997

Endothelins in the control of cardiovascular and renal function

scientific article published on September 1993

Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery

Enhanced glomerular thromboxane A2 mediates some pathophysiologic effect of platelet-activating factor in rabbit nephrotoxic nephritis: evidence from biochemical measurements and inhibitor trials

scientific article

Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury

Et and diabetic nephropathy: preclinical and clinical studies

scientific article published on March 2015

Evaluation of the Zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles

scientific article

Evidence against a pathogenetic role for endothelin in pre-eclampsia

article published in 1992

Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization

scientific article

FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat.

scientific article

Favorable effect of cotransfection with TGF-beta and CTLA4Ig of the donor kidney on allograft survival

scientific article

Fluid shear stress modulates von Willebrand factor release from human vascular endothelium

scientific article published on 01 August 1997

Functional implications of decreased renal cortical atrial natriuretic peptide binding in experimental diabetes

scientific article

Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporin A

article

Gene therapy to the kidney

scientific article

Gene therapy: how to target the kidney. Promises and pitfalls

scientific article published on March 2004

Generation of functional podocytes from human induced pluripotent stem cells

scientific article published on 3 June 2016

Genetics of rare diseases of the kidney: learning from mouse models

scientific article published in January 2004

Glomerular hyperfiltration and urinary prostaglandins in type 1 diabetes mellitus

article by G. C. Viberti et al published April 1989 in Diabetic Medicine

How renal cytokines and growth factors contribute to renal disease progression.

scientific article

Human Bone Marrow Mesenchymal Stem Cells Accelerate Recovery of Acute Renal Injury and Prolong Survival in Mice

scholarly article by Marina Morigi et al published August 2008 in Stem Cells

Human amniotic fluid stem cell preconditioning improves their regenerative potential

scientific article

Human mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function

scientific article

Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress.

scientific article

Imaging of the porous ultrastructure of the glomerular epithelial filtration slit

scientific article

Immunophenotypic analysis of cellular infiltrate of renal allograft biopsies in patients with acute rejection after induction with alemtuzumab (Campath-1H).

scientific article published on 5 April 2006

Impact of a Complement Factor H Gene Variant on Renal Dysfunction, Cardiovascular Events, and Response to ACE Inhibitor Therapy in Type 2 Diabetes

scientific article published on 26 July 2019

Impediments to successful gene transfer to the kidney in the context of transplantation and how to overcome them

scientific article published on January 2002

In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies

scientific article

In vivo maturation of functional renal organoids formed from embryonic cell suspensions

scientific article

Increased renal endothelin production in rats with reduced renal mass

article

Inflammation and glomerular injury

scientific article published on January 1994

Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture

scientific article

Inhibiting angiotensin-converting enzyme promotes renal repair by modulating progenitor cell activation

scientific article

Inhibition of Human Platelet Aggregation by Parathyroid Hormone

Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated?

article

Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion

scientific article

Insulin-Like Growth Factor-1 Sustains Stem Cell Mediated Renal Repair

article by B. Imberti et al published 17 October 2007 in Journal of the American Society of Nephrology

Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

scientific article published on January 1993

Involvement of renal tubular Toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus

scientific article

Key fibrogenic mediators: old players. Renin–angiotensin system

scientific article

Key pathways in renal disease progression of experimental diabetes

scientific article published on August 2015

Kidney failure: aims for the next 10 years and barriers to success

scientific article published on 31 May 2013

Kidney regeneration

scientific article published on April 2010

L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species

scientific article published on 26 January 2004

Life and Death of Podocytes: Not Only a Matter of Vascular Endothelial Growth Factor

scientific article published on 2 March 2016

Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury

scientific article

MYO1E mutations and childhood familial focal segmental glomerulosclerosis

scientific article

Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review

scientific article

Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes

scientific article

Membranous Nephropathy Associated With IgG4-Related Disease

scientific article published on 12 June 2011

Mesenchymal stem cell therapy promotes renal repair by limiting glomerular podocyte and progenitor cell dysfunction in adriamycin-induced nephropathy

scientific article published on 5 September 2012

Mesenchymal stem cells and kidney repair

scientific article published on 20 December 2012

Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure

scientific article published in July 2004

Metabolism of thromboxane B2 in the isolated perfused rat kidney: mass spectrometric identification of urinary products

scientific article published in November 1989

MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy

scientific article

MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition

scientific article

MicroRNAs as Master Regulators of Glomerular Function in Health and Disease

scientific article published on 23 February 2017

MicroRNAs in kidney physiology and disease

scientific article

Mitochondrial Dynamics Is Linked to Longevity and Protects from End-Organ Injury: The Emerging Role of Sirtuin 3.

scientific article published on 14 March 2016

Mitochondrial Sirtuin 3 and Renal Diseases.

scientific article published in July 2016

Mitochondrial-dependent Autoimmunity in Membranous Nephropathy of IgG4-related Disease

scientific article published on 6 March 2015

Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis

scientific article published in August 2001

Nature and mediators of parietal epithelial cell activation in glomerulonephritides of human and rat.

scientific article

Nature and mediators of renal lesions in kidney transplant patients given cyclosporine for more than one year

article by Ariela Benigni et al published February 1999 in Kidney International

Nephrotoxicity of increased glomerular protein traffic

scientific article

New therapeutics that antagonize endothelin: promises and frustrations

scientific article

Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

article

Nonviral and Viral Gene Transfer to the Kidney in the Context of Transplantation

article

Parathyroid hormone inhibits human platelet function

scientific article

Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury

scientific article

Pharmacologic control of angiotensin II ameliorates renal disease while reducing renal TGF-beta in experimental mesangioproliferative glomerulonephritis

scientific article published on March 1998

Platelet function in patients on maintenance hemodialysis: depressed or enhanced?

scientific article

Podocyte-actin dynamics in health and disease

scientific article

Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension.

scientific article

Post-transcriptional gene regulation makes things clearer in renal fibrosis

scientific article published on 30 May 2013

Potential of mesenchymal stem cells in the repair of tubular injury

scientific article published on September 2011

Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection

scientific article published on 10 October 2008

Primer: strategies for identifying genes involved in renal disease

scientific article published on 25 March 2008

Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides

scientific article

Protein overload activates proximal tubular cells to release vasoactive and inflammatory mediators

Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB- and p38 mitogen-activated protein kinase-dependent pathways

scientific article published on October 2003

Protein traffic activates NF-kB gene signaling and promotes MCP-1–dependent interstitial inflammation

article

Proteins abnormally filtered throughout glomerular capillary have an intrinsic renal toxicity

scientific article

Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins

scientific article published on December 1995

Rabbit anti-rat thymocyte immunoglobulin preserves renal function during ischemia/reperfusion injury in rat kidney transplantation

Recellularization of well-preserved acellular kidney scaffold using embryonic stem cells

scientific article

Recombinant human erythropoietin to correct uremic bleeding

scientific article published on July 1991

Recommendations for biomarker identification and qualification in clinical proteomics

scientific article published in August 2010

Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect

scientific article

Regression of Renal Disease by Angiotensin II Antagonism Is Caused by Regeneration of Kidney Vasculature

scientific article published on 26 June 2015

Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor

scientific article

Renal metabolism and urinary excretion of thromboxane B2 in the rat

Renal primordia activate kidney regenerative events in a rat model of progressive renal disease

scientific article

Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis

scientific article

Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury

scientific article

Renal prostacyclin biosynthesis is reduced in children with hemolytic-uremic syndrome in the context of systemic platelet activation

scientific article

Renoprotection by nitric oxide donor and lisinopril in the remnant kidney model

scientific article published in April 1999

Renoprotective effect of contemporary blocking of angiotensin II and endothelin-1 in rats with membranous nephropathy

scientific article

Repairing renal lesions: Will VEGF be the builder?

article published in 2000

Report on the first combined working group and management committee meeting of EuroKUP (Urine and Kidney Proteomics cost action)

Research on renal endothelin in proteinuric nephropathies dictates novel strategies to prevent progression

scientific article

Reversible activation defect of the platelet glycoprotein IIb-IIIa complex in patients with uremia

article

Role of eicosanoids as mediators of glomerular injury in immune-mediated nephropathies

scientific article

Role of increased glomerular protein traffic in the progression of renal failure

scientific article published on November 1997

Role of renal prostaglandins in normal and nephrotic rats with diet-induced hyperfiltration

article

Role of ultrastructural determinants of glomerular permeability in ultrafiltration function loss

scientific article published on 09 July 2020

SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy

Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy

scientific article published in June 2004

Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling

scientific article published on December 2006

Sirtuin 3 in acute kidney injury

scientific article published in July 2015

Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury

scientific article

Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II

scientific article published on 19 May 2015

Targeted Downregulation of Extracellular Nephrin in Human IgA Nephropathy

Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria

scientific article published in October 2004

The Nrf2 pathway in the progression of renal disease

scientific article published on 11 June 2013

The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases

scientific article published on 11 August 2017

The acute effect of FK506 and cyclosporine on endothelial cell function and renal vascular resistance.

scientific article

The goal of intragraft gene therapy

scientific article

The potential of endothelin antagonism as a therapeutic approach

scientific article published in November 2004

The regenerative potential of stem cells in acute renal failure

scientific article published on January 2006

The renal toxicity of sustained glomerular protein traffic

scientific article published on October 1995

The renoprotective potential of endothelin receptor antagonists

The role of B7-1 in proteinuria of glomerular origin

article published in 2018

The role of vasoactive molecules of endothelial origin in the pathophysiology of normal pregnancy and pregnancy-induced hypertension

Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease

scholarly article by Cinzia Rota et al published 14 August 2018 in Stem Cell Research & Therapy

Therapy with a Selective Cannabinoid Receptor Type 2 Agonist Limits Albuminuria and Renal Injury in Mice with Type 2 Diabetic Nephropathy

article by Carlamaria Zoja et al published 9 December 2015 in Nephron

Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides

scientific article published on November 1994

Transcriptional Regulation of Nephrin Gene by Peroxisome Proliferator-Activated Receptor- Agonist: Molecular Mechanism of the Antiproteinuric Effect of Pioglitazone

article

Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells

scientific article

Treatment of Chronic Proteinuric Kidney Disease

Understanding the nature of renal disease progression

scientific article published on January 1997

Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.

scientific article

Unlike each drug alone, lisinopril if combined with avosentan promotes regression of renal lesions in experimental diabetes

scientific article published on 12 August 2009

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Untangling the Knot in Diabetic Nephropathy: The Unanticipated Role of Glycocalyx in the Antiproteinuric Effect of Endothelin Receptor Antagonists

scientific article

Urinary excretion of platelet-activating factor in haemolytic uraemic syndrome

scientific article

Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity

scientific article published on 9 May 2012

Vasopeptidase inhibitor restores the balance of vasoactive hormones in progressive nephropathy

scientific article published in November 2004

Will fish foster regenerative medicine in man?

scientific article published on 5 May 2011

Xenotransplantation in the 21st century

scientific article

alpha 1-Antitrypsin therapy in a case of thrombotic thrombocytopenic purpura

scientific article

β-arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury

scientific article published on 26 December 2013

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