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List of works by Matthew P. Crump

1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide

article

A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

scientific article published on 06 February 2020

A biomimetic receptor for glucose

scientific article published on 12 November 2018

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

scientific article

A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains

scientific article

A simple and accessible synthetic lectin for glucose recognition and sensing.

scientific article

A synthetic lectin for O-linked beta-N-acetylglucosamine

scientific article

A synthetic lectin for beta-glucosyl.

scientific article published in January 2009

A threading receptor for polysaccharides.

scientific article published on 23 November 2015

Acylation of Streptomyces type II polyketide synthase acyl carrier proteins

article

Affinity enhancement by dendritic side chains in synthetic carbohydrate receptors.

scientific article published on 21 January 2015

Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.

scientific article

An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.

scientific article published on 5 April 2018

An accessible bicyclic architecture for synthetic lectins.

scientific article

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution

scientific article

Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity ⬇️

scientific article published on June 6, 2011

Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria ⬇️

scientific article published on 15 October 2015

Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

scientific article published on 31 January 2019

Assembly pathway of a designed alpha-helical protein fiber.

scientific article

Assignments of 1H and 15N resonances of the Pseudomonas aeruginosa K122-4 pilin monomer

scientific article published on 01 April 2001

Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase.

scientific article published in March 2008

Automated Protein–Ligand Interaction Screening by Mass Spectrometry

article

Backbone dynamics of the human CC chemokine eotaxin: fast motions, slow motions, and implications for receptor binding

scientific article published on October 1999

Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways

scientific article published on 27 March 2014

Carbohydrate Recognition in Water by a Tricyclic Polyamide Receptor

article

Conserved secondary structure in the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) and the fatty acid synthase acyl carrier protein from Escherichia coli.

scientific article

Constructing a man-made c-type cytochrome maquette in vivo: electron transfer, oxygen transport and conversion to a photoactive light harvesting maquette.

scientific article published on February 2014

Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme.

scientific article published on 25 August 2017

Control of β-Branching in Kalimantacin Biosynthesis: Application of 13 C NMR to Polyketide Programming

scientific article published on 07 August 2019

Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586

scientific article published in Scientific Reports

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery.

scientific article published on 22 December 2014

Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics

scientific article published on 11 July 2017

Enantioselective carbohydrate recognition by synthetic lectins in water.

scientific article published on 30 March 2017

Engineering protein stability with atomic precision in a monomeric miniprotein.

scientific article

Erratum: Corrigendum: Local and macroscopic electrostatic interactions in single α-helices

article

Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface

scientific article

Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.

scientific article published on 21 May 2004

Five atomic resolution structures of endothiapepsin inhibitor complexes: implications for the aspartic proteinase mechanism

scientific article

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

scientific article published on 02 May 2016

Glycosylated Foldamers To Probe the Carbohydrate−Carbohydrate Interaction

scientific article published on 01 August 2006

Harmane and harmalan are bioactive components of classical clonidine-displacing substance.

scientific article published in December 2004

High‐Affinity Disaccharide Binding by Tricyclic Synthetic Lectins ⬇️

scientific article published on March 29, 2012

Identification of differential protein binding affinities in an atropisomeric pharmaceutical compound by noncovalent mass spectrometry, equilibrium dialysis, and nuclear magnetic resonance.

scientific article published on 3 June 2013

In support of the BMRB.

scientific article published in September 2012

Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper

scientific article

Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor zeta chain by the protein tyrosine kinase Lck.

scientific article published in June 2003

Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues.

scientific article

Local and macroscopic electrostatic interactions in single α-helices.

scientific article published on 9 February 2015

Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression

scientific article published on 06 August 2019

Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

article

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

scientific article

NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL ⬇️

scientific article published on April 25, 2012

Overproduction of the N-terminal anticodon-binding domain of the non-discriminating aspartyl-tRNA synthetase from Helicobacter pylori for crystallization and NMR measurements

scientific article

Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water

scientific article published on 17 June 2016

Polyketide β-branching: diversity, mechanism and selectivity

scientific article published on 15 October 2020

Practical Considerations in High-Precision Compound-Specific Radiocarbon Analyses: Eliminating the Effects of Solvent and Sample Cross-Contamination on Accuracy and Precision

scientific article published on 07 September 2018

Preliminary kinetic analysis of acyl carrier protein-ketoacylsynthase interactions in the actinorhodin minimal polyketide synthase

scientific article published on 20 March 2009

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.

scientific article

Probing nascent structures in peptides using natural abundance 13C NMR relaxation and reduced spectral density mapping

scientific article published in April 2007

Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

scientific article

Proposed arrangement of proteins forming a bacterial type II polyketide synthase

scientific article published in November 2008

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.

scientific article

Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein.

scientific article published on 10 December 2015

Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis

scientific article

SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal non-reducing polyketide synthase

scientific article published on 12 October 2020

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics. ⬇️

scientific article

Solution Structure and Conformational Dynamics of a Doublet Acyl Carrier Protein from Prodigiosin Biosynthesis

scientific article published on 08 January 2021

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

scientific article

Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation

scientific article

Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

scientific article

Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer–nucleotide coacervate droplets

article

Stabilizing and Understanding a Miniprotein by Rational Redesign

scientific article published on 08 July 2019

Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC.

scientific article published on 21 November 2017

Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A.

scientific article published on 18 December 2007

Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11

scientific article

Structural resolution of switchable states of a de novo peptide assembly

scientific article published on 09 March 2021

Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth

scientific article published on 10 February 2009

Structure and malonyl CoA-ACP transacylase binding of streptomyces coelicolor fatty acid synthase acyl carrier protein

scientific article

Structure of a pilin monomer from Pseudomonas aeruginosa: implications for the assembly of pili

scientific article

Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry

scientific article published in March 2004

Structure/function of human herpesvirus-8 MIP-II (1-71) and the antagonist N-terminal segment (1-10)

scientific article

Synthesis and evaluation of a desymmetrised synthetic lectin: an approach to carbohydrate receptors with improved versatility.

scientific article

Synthetic Receptors for the High-Affinity Recognition of O-GlcNAc Derivatives

scientific article published on 28 January 2016

Temperature Dependence of Dynamics and Thermodynamics of the Regulatory Domain of Human Cardiac Troponin C†

article

The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor

scientific article published on 05 June 2019

The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase

scientific article

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

scientific article

The Malonyl Transferase Activity of Type II Polyketide Synthase Acyl Carrier Proteins

article

The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding

scientific article published on October 2004

The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity

scientific article published in Scientific Reports

The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA

scientific article published in Journal of Biological Chemistry

The role of large-scale motions in catalysis by dihydrofolate reductase.

scientific article published on 22 November 2011

The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture

scientific article published on 30 March 2020

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere ⬇️

scientific article published on 15 December 2017

The structural role of the carrier protein – active controller or passive carrier ⬇️

scientific article published on August 24, 2012

The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs

scientific article published in February 2003

Total Synthesis of Kalimantacin A

scientific article published on 10 August 2020

Use of a 700 MHz NMR Microcryoprobe for the Identification and Quantification of Exogenous Carbon in Compounds Purified by Preparative Capillary Gas Chromatography for Radiocarbon Determinations.

scientific article

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