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List of works by Ryan L. Boudreau

A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER

scientific article

Applying gene silencing technology to contraception

scientific article (publication date: December 2012)

Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo

scientific article published on 7 April 2015

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

scholarly article

Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo

scientific article

Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy

scientific article

Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4

scientific article

Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP

scientific article published on 14 July 2016

Generation of hairpin-based RNAi vectors for biological and therapeutic application.

scientific article published on January 2012

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

scientific article published on 7 July 2015

Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs

scientific article published on 12 August 2008

Nonallele specific silencing of ataxin-7 improves disease phenotypes in a mouse model of SCA7.

scientific article published on 16 June 2014

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

scientific article

Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease ⬇️

scientific article published on October 25, 2011

RNA interference-based therapy for spinocerebellar ataxia type 7 retinal degeneration.

scientific article

RNAi medicine for the brain: progresses and challenges.

scientific article

RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1

scientific article

RNAi therapy for neurodegenerative diseases.

scientific article published on January 2006

Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease.

scientific article

Rhes suppression enhances disease phenotypes in Huntington's disease mice

scientific article

Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice

scientific article published on 03 July 2013

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

scientific article

Targeted gene silencing to induce permanent sterility

scientific article (publication date: August 2012)

Transcriptome-wide discovery of microRNA binding sites in human brain.

scientific article

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.

scientific article

β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

scientific article published on January 2015

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