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List of works by Kenneth Pfarr

A niche for Wolbachia

scientific article

A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection.

scientific article published on 14 March 2006

A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro

scientific article

ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling.

scientific article

Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species).

scientific article published on 14 September 2005

Antibiotics which target the Wolbachia endosymbionts of filarial parasites: a new strategy for control of filariasis and amelioration of pathology.

scientific article

Brugia malayi: localization of nitric oxide synthase in a lymphatic filariid

scientific article published in February 2000

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

scientific article

Complete Mitochondrial Genome Sequence of Mansonella perstans

scientific article published on 23 July 2020

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo ⬇️

scientific article published on May 14, 2012

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

scientific article published on 07 December 2020

Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteria

scientific article

Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production

scientific article (publication date: November 2003)

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

scientific article

Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment

scientific article

Endo16, a large multidomain protein found on the surface and ECM of endodermal cells during sea urchin gastrulation, binds calcium

scientific article published in September 1994

Extracellular Onchocerca-derived small RNAs in host nodules and blood

scientific article

Filariasis and lymphoedema.

scientific article

Filariasis in Africa—treatment challenges and prospects ⬇️

scientific article published on July 1, 2011

Frequent detection of worm movements in onchocercal nodules by ultrasonography

scientific article

Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?

scientific article published on 28 July 2009

In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites

scientific article published on 13 October 2014

Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms

scientific article

Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives

scientific article published on 2 October 2015

Is there a risk of filarial infection during long-term missions in Haiti?

scientific article

Litomosoides sigmodontis: a jird urine metabolome study.

scientific article published on 23 October 2015

Localization of a filarial phosphate permease that is up-regulated in response to depletion of essential Wolbachia endobacteria

scientific article

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

scientific article

Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine

scientific article published in October 2009

Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti

scientific article

Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana

scientific article published on 12 November 2020

Multivariable Regression Analysis in Schistosoma mansoni-Infected Individuals in the Sudan Reveals Unique Immunoepidemiological Profiles in Uninfected, egg+ and Non-egg+ Infected Individuals

scientific article

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

scientific article published on 22 December 2016

New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria

scientific article

Nitric oxide synthase in filariae: demonstration of nitric oxide production by embryos in Brugia malayi and Acanthocheilonema viteae

scientific article

On the taxonomic status of the intracellular bacterium Wolbachia pipientis: should this species name include the intracellular bacteria of filarial nematodes?

scientific article published on August 2007

RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype.

scientific article

Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi Infections: a study in Indonesian transmigrants

scientific article

Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline.

scientific article

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

scientific article

Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes

scientific article

Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host ⬇️

scientific article published on January 11, 2012

Risk factors for epilepsy in Bas-Uélé Province, Democratic Republic of the Congo: a case-control study ⬇️

scientific article published on 19 May 2016

Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

scientific article published on 18 November 2020

The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections

scientific article

The Mbam drainage system and onchocerciasis transmission post ivermectin mass drug administration (MDA) campaign, Cameroon

scientific article published in 2021

The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia

scientific article published on 21 January 2008

The ratio of calprotectin to total protein as a diagnostic and prognostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

scientific article

Towards the sustainable discovery and development of new antibiotics

scientific article published in 2021

Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon

scientific article published in 2021

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article published in 2008

wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs

scientific article published on 25 February 2014

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