List of works - Dirk Werling

A prospective, randomized, blinded, placebo-controlled pilot study on the effect of Enterococcus faecium on clinical activity and intestinal gene expression in canine food-responsive chronic enteropathy.

scientific article published on 16 March 2015

A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappaB activation of Theileria parva-transformed B cells

scientific article published on 01 October 2003

Ability to differentiate between cp and ncp BVDV by microarrays: towards an application in clinical veterinary medicine?

scientific article published in October 2005

Analysis of the phenotype and phagocytic activity of monocytes/macrophages from cattle infected with the bovine leukaemia virus

scientific article published in April 1998

Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex

scientific article published on 26 March 2012

Assessment and quantification of post-weaning multi-systemic wasting syndrome severity at farm level

scientific article

Association between nucleotide oligomerisation domain two (Nod2) gene polymorphisms and canine inflammatory bowel disease

scientific article published on 26 June 2014

Association of immune responses of Zebu and Holstein-Friesian cattle and resistance to mycobacteria in a BCG challenge model

scientific article published on 29 November 2020

Bovine P-selectin mediates leukocyte adhesion and is highly polymorphic in dairy breeds

scientific article published on 24 August 2016

Bovine interleukin-12 and modulation of IFNγ production

article

Bovine macrophages sense Escherichia coli Shiga toxin 1.

scientific article

Bovine viral diarrhea virus strain- and cell type-specific inhibition of type I interferon pathways

scientific article published on 26 January 2011

Breed-independent toll-like receptor 5 polymorphisms show association with canine inflammatory bowel disease

scientific article published on 29 May 2011

CD11c+ cells are significantly decreased in the duodenum, ileum and colon of dogs with inflammatory bowel disease.

scientific article

CD23 is a glycan-binding receptor in some mammalian species

scientific article published on 05 September 2019

Calcium influx, a new potential therapeutic target in the control of neutrophil-dependent inflammatory diseases in bovines.

scientific article published on 23 June 2011

Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK.

scientific article

Caprine arthritis encephalitis virus infection changes caprine blood monocyte responsiveness to lipopolysaccharide stimulation in vitro

scientific article published on November 1994

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor

scientific article published in Scientific Reports

Caveolae and caveolin in immune cells: distribution and functions.

scientific article

Characterisation of antibodies to bovine Toll-like receptor (TLR)-2 and cross-reactivity with ovine TLR2.

scientific article

Characterisation of the acute phase response of heifers to a prolonged low dose infusion of lipopolysaccharide

article

Comparison of TNFα responses induced by Toll-like receptor ligands and probiotic Enterococcus faecium in whole blood and peripheral blood mononuclear cells of healthy dogs

article

Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes

scientific article published on 31 October 2002

Correlation of cell surface marker expression with African swine fever virus infection.

scientific article published on 14 December 2013

Cross-reactivity of mAbs to human CD antigens with cells from cattle

scientific article published on 20 June 2007

Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus.

scientific article published in August 2002

Dendritic cells in cattle: phenotype and function.

scientific article

Differential macrophage function in Brown Swiss and Holstein Friesian cattle

scientific article published on 28 February 2016

Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists.

scientific article published in January 2004

Differential responses of bovine macrophages to infection with bovine-specific and non-bovine specific mycobacteria

article

Disease resistance and immunity

scientific article published on 17 July 2007

East Coast fever, a neglected tropical disease with an outdated vaccine approach?

scientific article published in 2022

Effect of bovine leukemia virus infection on bovine peripheral blood monocyte responsiveness to lipopolysaccharide stimulation in vitro

scientific article

Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils.

scientific article

Effectiveness of porcine circovirus type 2 vaccination in reducing the severity of post-weaning multisystemic wasting syndrome in pigs.

scientific article published on 2 July 2013

Evaluation of the effect of phosphodiesterase on equine platelet activation and the effect of antigen challenge on platelet phosphodiesterase activity in horses with recurrent airway obstruction

scientific article published in May 2010

Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b

scientific article published on 20 March 2015

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus.

scientific article published on 13 October 2005

Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination?

scientific article

Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease.

scientific article published in December 2009

Expression of caveolin by bovine lymphocytes and antigen-presenting cells

scientific article published on 01 February 2002

Expression of trefoil factor genes in the duodenum and colon of dogs with inflammatory bowel disease and healthy dogs

article

Flagellin expression enhances Salmonella accumulation in TLR5-positive macrophages.

scientific article published on 4 March 2010

Flt-3 ligand, in combination with bovine granulocyte-macrophage colony-stimulating factor and interleukin-4, promotes the growth of bovine bone marrow derived dendritic cells

scientific article

Functional characterisation of bovine TLR5 indicates species-specific recognition of flagellin.

scientific article published on 30 December 2013

Gammadelta T cells present antigen to CD4+ alphabeta T cells

scientific article published in June 1998

Gene expression of selected signature cytokines of T cell subsets in duodenal tissues of dogs with and without inflammatory bowel disease

article

Global gene expression profiling of myeloid immune cell subsets in response to in vitro challenge with porcine circovirus 2b

scientific article

Host species-specific usage of the TLR4-LPS receptor complex.

scientific article

Identification and functional characterization of a bovine orthologue to DC-SIGN.

scientific article published on 3 March 2008

Identification and gene expression of the bovine C-type lectin Dectin-1

article

Identification of a lineage negative cell population in bovine peripheral blood with the ability to mount a strong type I interferon response

scientific article published on 31 May 2011

Induction of reactive oxygen species in bovine neutrophils is CD11b, but not dectin-1-dependent

scientific article

Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease

scientific article

Inhibition of cytosolic Phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin

scientific article

Innate immunity and vaccination

scientific article published on 01 July 2006

Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells

scientific article published in July 1999

LRRfinder2.0: a webserver for the prediction of leucine-rich repeats

scientific article published on 23 November 2012

LRRfinder: a web application for the identification of leucine-rich repeats and an integrative Toll-like receptor database.

scientific article

Lack of TNF alpha supports persistence of a plasmid encoding the bovine leukaemia virus in TNF(-/-) mice

scientific article published in March 2003

Lack of correlation between mucosal immunoglobulin A-positive plasma cell numbers and TLR5 genotypes in German shepherd dogs with idiopathic chronic enteropathy

scientific article published on 27 February 2015

Lack of genetic diversity in newly sequenced porcine circovirus type 1 strains isolated 20 years apart

scientific article published on 10 April 2014

Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells

scientific article published on 22 March 2016

Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair

scientific article (publication date: 2012)

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

scientific article published on 15 March 2021

Mammalian lectin arrays for screening host-microbe interactions

scientific article published on 24 February 2020

Molecular cloning and characterization of Toll-like receptors 1-10 in sheep

scientific article published on 08 October 2008

Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance

scientific article

Morphologic and functional changes in bovine monocytes infected in vitro with the bovine leukaemia virus

scientific article published in November 2001

Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation.

scientific article published on 20 March 2009

Non-infectious stressors and innate immune response.

scientific article published on 9 January 2018

Of Creatures Great and Small: The Advantages of Farm Animal Models in Immunology Research ⬇️

scientific article published on May 27, 2013

Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo.

scientific article published on 14 October 2015

Pattern recognition receptors in companion and farm animals - the key to unlocking the door to animal disease?

scientific article published on 29 November 2006

Peripheral blood-derived bovine dendritic cells promote IgG1-restricted B cell responses in vitro

article

Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs

scientific article (publication date: 23 December 2010)

Porcine circovirus type 2 infection before and during an outbreak of postweaning multisystemic wasting syndrome on a pig farm in the UK.

scientific article published on 29 May 2012

Potential evidence for biotype-specific chemokine profile following BVDV infection of bovine macrophages

scientific article published on September 2012

Primary bovine colonic cells: A model to study strain-specific responses to Escherichia coli

article

Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors

scientific article

Relationship of body fat stores and leptin expression in adipose tissue in African cows of different genotype

Replacement of two aminoacids in the bovine Toll-like receptor 5 TIR domain with their human counterparts partially restores functional response to flagellin

scientific article

Replication of linkage at chromosome 20p13 and identification of suggestive sex-differential risk loci for autism spectrum disorder

scientific article published on 17 February 2014

Role of bovine chemokines produced by dendritic cells in respiratory syncytial virus-induced T cell proliferation

scientific article published in September 2002

Role of sugars in surface microbe-host interactions and immune reaction modulation.

scientific article published on August 2007

Short communication: Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows

scientific article published on 17 July 2019

Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1.

scientific article published on 20 June 2013

Stimulation of duodenal biopsies and whole blood from dogs with food-responsive chronic enteropathy and healthy dogs with Toll-like receptor ligands and probiotic Enterococcus faecium

scientific article

Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals

scientific article

Summary of the third European Veterinary Immunology Workshop (EVIW), September 2009, Berlin, Germany

scientific article published on 18 June 2010

TB or not TB: a disease forgotten, but not gone

scientific article

TGF-b2 induction regulates invasiveness of Theileria-transformed leukocytes and disease susceptibility

scientific article

TLR5 risk-associated haplotype for canine inflammatory bowel disease confers hyper-responsiveness to flagellin

scientific article (publication date: 2012)

TOLL-like receptors linking innate and adaptive immune response.

scientific article

The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes.

scientific article

The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge

scientific article

The phylogeography of rabies in Grenada, West Indies, and implications for control

scientific article

Theileria apicoplast as a target for chemotherapy

scientific article published on 15 December 2008

Therapeutic targeting of the innate immune system in domestic animals

scientific article published on 16 October 2010

To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion.

scientific article published on 02 July 2013

Toll-like receptors in domestic animals ⬇️

scientific article published on 07 October 2010

Transboundary Disease Management: The Theory and the Practice - The Science and the Politics

scientific article published on 01 January 2008

Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response

scientific article

Vaccination of calves with yeast- and bacterial-expressed paramyosin from the bovine lungworm Dictyocaulus viviparus

scientific article published on 26 September 2015

Variation matters: TLR structure and species-specific pathogen recognition

scientific article published on 09 February 2009

WC1(+) gammadelta T cells indirectly regulate chemokine production during mycobacterium bovis infection in SCID-bo mice

scientific article

Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.

scientific article published on 31 October 2011

c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria

scientific article published in June 2006

c-Myc activation by Theileria parasites promotes survival of infected B-lymphocytes

scientific article

List of works by Dirk Werling

A prospective, randomized, blinded, placebo-controlled pilot study on the effect of Enterococcus faecium on clinical activity and intestinal gene expression in canine food-responsive chronic enteropathy.

A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappaB activation of Theileria parva-transformed B cells

Ability to differentiate between cp and ncp BVDV by microarrays: towards an application in clinical veterinary medicine?

Analysis of the phenotype and phagocytic activity of monocytes/macrophages from cattle infected with the bovine leukaemia virus

Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex

Assessment and quantification of post-weaning multi-systemic wasting syndrome severity at farm level

Association between nucleotide oligomerisation domain two (Nod2) gene polymorphisms and canine inflammatory bowel disease

Association of immune responses of Zebu and Holstein-Friesian cattle and resistance to mycobacteria in a BCG challenge model

Bovine P-selectin mediates leukocyte adhesion and is highly polymorphic in dairy breeds

Bovine interleukin-12 and modulation of IFNγ production

Bovine macrophages sense Escherichia coli Shiga toxin 1.

Bovine viral diarrhea virus strain- and cell type-specific inhibition of type I interferon pathways

Breed-independent toll-like receptor 5 polymorphisms show association with canine inflammatory bowel disease

CD11c+ cells are significantly decreased in the duodenum, ileum and colon of dogs with inflammatory bowel disease.

CD23 is a glycan-binding receptor in some mammalian species

Calcium influx, a new potential therapeutic target in the control of neutrophil-dependent inflammatory diseases in bovines.

Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK.

Caprine arthritis encephalitis virus infection changes caprine blood monocyte responsiveness to lipopolysaccharide stimulation in vitro

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor

Caveolae and caveolin in immune cells: distribution and functions.

Characterisation of antibodies to bovine Toll-like receptor (TLR)-2 and cross-reactivity with ovine TLR2.

Characterisation of the acute phase response of heifers to a prolonged low dose infusion of lipopolysaccharide

Comparison of TNFα responses induced by Toll-like receptor ligands and probiotic Enterococcus faecium in whole blood and peripheral blood mononuclear cells of healthy dogs

Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes

Correlation of cell surface marker expression with African swine fever virus infection.

Cross-reactivity of mAbs to human CD antigens with cells from cattle

Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus.

Dendritic cells in cattle: phenotype and function.

Differential macrophage function in Brown Swiss and Holstein Friesian cattle

Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists.

Differential responses of bovine macrophages to infection with bovine-specific and non-bovine specific mycobacteria

Disease resistance and immunity

East Coast fever, a neglected tropical disease with an outdated vaccine approach?

Effect of bovine leukemia virus infection on bovine peripheral blood monocyte responsiveness to lipopolysaccharide stimulation in vitro

Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils.

Effectiveness of porcine circovirus type 2 vaccination in reducing the severity of post-weaning multisystemic wasting syndrome in pigs.

Evaluation of the effect of phosphodiesterase on equine platelet activation and the effect of antigen challenge on platelet phosphodiesterase activity in horses with recurrent airway obstruction

Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus.

Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination?

Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease.

Expression of caveolin by bovine lymphocytes and antigen-presenting cells

Expression of trefoil factor genes in the duodenum and colon of dogs with inflammatory bowel disease and healthy dogs

Flagellin expression enhances Salmonella accumulation in TLR5-positive macrophages.

Flt-3 ligand, in combination with bovine granulocyte-macrophage colony-stimulating factor and interleukin-4, promotes the growth of bovine bone marrow derived dendritic cells

Functional characterisation of bovine TLR5 indicates species-specific recognition of flagellin.

Gammadelta T cells present antigen to CD4+ alphabeta T cells

Gene expression of selected signature cytokines of T cell subsets in duodenal tissues of dogs with and without inflammatory bowel disease

Global gene expression profiling of myeloid immune cell subsets in response to in vitro challenge with porcine circovirus 2b

Host species-specific usage of the TLR4-LPS receptor complex.

Identification and functional characterization of a bovine orthologue to DC-SIGN.

Identification and gene expression of the bovine C-type lectin Dectin-1

Identification of a lineage negative cell population in bovine peripheral blood with the ability to mount a strong type I interferon response

Induction of reactive oxygen species in bovine neutrophils is CD11b, but not dectin-1-dependent

Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease

Inhibition of cytosolic Phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin

Innate immunity and vaccination

Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells

LRRfinder2.0: a webserver for the prediction of leucine-rich repeats

LRRfinder: a web application for the identification of leucine-rich repeats and an integrative Toll-like receptor database.

Lack of TNF alpha supports persistence of a plasmid encoding the bovine leukaemia virus in TNF(-/-) mice

Lack of correlation between mucosal immunoglobulin A-positive plasma cell numbers and TLR5 genotypes in German shepherd dogs with idiopathic chronic enteropathy

Lack of genetic diversity in newly sequenced porcine circovirus type 1 strains isolated 20 years apart

Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells

Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

Mammalian lectin arrays for screening host-microbe interactions

Molecular cloning and characterization of Toll-like receptors 1-10 in sheep

Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance

Morphologic and functional changes in bovine monocytes infected in vitro with the bovine leukaemia virus

Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation.

Non-infectious stressors and innate immune response.

Of Creatures Great and Small: The Advantages of Farm Animal Models in Immunology Research ⬇️

Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo.

Pattern recognition receptors in companion and farm animals - the key to unlocking the door to animal disease?

Peripheral blood-derived bovine dendritic cells promote IgG1-restricted B cell responses in vitro

Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs

Porcine circovirus type 2 infection before and during an outbreak of postweaning multisystemic wasting syndrome on a pig farm in the UK.

Potential evidence for biotype-specific chemokine profile following BVDV infection of bovine macrophages