List of works - Renhao Li

A General Method for Predicting Amino Acid Residues Experiencing Hydrogen Exchange

scientific article published on 01 March 2018

A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor.

scientific article

A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility

scientific article

A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia

scientific article published on January 2010

A new redox switch regulating von Willebrand factor activity

scientific article published on 30 May 2018

A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease.

scientific article published on 29 September 2016

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

scientific article published in May 2003

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

scientific article published on 21 April 2021

Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex

scientific article published on January 2014

Binding of platelet glycoprotein Ibbeta through the convex surface of leucine-rich repeats domain of glycoprotein IX.

scientific article published on 29 June 2009

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI.

scientific article published on 5 April 2018

Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.

scientific article

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy

scientific article

Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.

scientific article

Delimiting the autoinhibitory module of von Willebrand factor

scientific article published on 16 August 2018

Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance

scientific article

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.

scientific article

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.

scientific article published on December 2013

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein

scientific article (publication date: November 1997)

Expanding the binding model of DITP

scientific article

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.

scientific article

FAM-tastic phospho-regulation of von Willebrand factor activity

scientific article published on 01 June 2019

FERM domain of moesin desorbs the basic-rich cytoplasmic domain of l-selectin from the anionic membrane surface.

scientific article published on 22 June 2013

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.

scientific article published on 4 December 2017

Glycans and the platelet life cycle

scientific article published on 2 May 2016

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

scientific article published on 05 July 2016

Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex

scientific article

Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage

scientific article published on 14 July 2016

Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding

scientific article published on 2 June 2011

Juxtamembrane basic residues in glycoprotein Ibbeta cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.

scientific article

Juxtamembrane contribution to transmembrane signaling

scientific article published in July 2015

L-selectin transmembrane and cytoplasmic domains are monomeric in membranes ⬇️

scientific article published on February 18, 2011

Live-cell super-resolved PAINT imaging of piconewton cellular traction forces

scientific article published on 14 September 2020

Mechanisms of platelet clearance and translation to improve platelet storage.

scientific article published on 23 February 2018

Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10.

scientific article

Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding

scientific article published in February 2002

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction

scientific article published on 17 September 2018

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

scientific article published on 19 March 2019

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

scientific article published on 27 September 2016

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

scientific article published on 01 September 2018

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera

scientific article

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions

scientific article published in September 2005

Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs.

scientific article published on 18 November 2011

Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets.

scientific article published on 2 November 2017

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.

scientific article published on 30 April 2015

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex

scientific article published on 8 October 2007

Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.

scientific article published on December 2013

Structural basis for integrin alphaIIbbeta3 clustering.

scientific article published on June 2004

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody

scientific article published on 22 April 2016

Structure-function of platelet glycoprotein Ib-IX

scientific article published on 31 July 2020

The hydrogen exchange core and protein folding.

scientific article

The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.

scientific article published on 19 July 2008

The organizing principle of the platelet glycoprotein Ib-IX-V complex.

scientific article

The slow-exchange core and protein folding

scientific article published on 01 October 1998

The transmembrane domain of glycoprotein Ibbeta is critical to efficient expression of glycoprotein Ib-IX complex in the plasma membrane

scientific article published on 6 June 2006

Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha.

scientific article

Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.

scientific article

Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope

scientific article published on 03 August 2021

Twins actin' differently

scientific article

Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibα: implications for Bernard-Soulier syndrome

scientific article published on 22 December 2019

List of works by Renhao Li

A General Method for Predicting Amino Acid Residues Experiencing Hydrogen Exchange

A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor.

A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility

A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia

A new redox switch regulating von Willebrand factor activity

A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease.

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex

Binding of platelet glycoprotein Ibbeta through the convex surface of leucine-rich repeats domain of glycoprotein IX.

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI.

Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy

Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.

Delimiting the autoinhibitory module of von Willebrand factor

Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein

Expanding the binding model of DITP

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.

FAM-tastic phospho-regulation of von Willebrand factor activity

FERM domain of moesin desorbs the basic-rich cytoplasmic domain of l-selectin from the anionic membrane surface.

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.

Glycans and the platelet life cycle

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex

Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage

Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding

Juxtamembrane basic residues in glycoprotein Ibbeta cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.

Juxtamembrane contribution to transmembrane signaling

L-selectin transmembrane and cytoplasmic domains are monomeric in membranes ⬇️

Live-cell super-resolved PAINT imaging of piconewton cellular traction forces

Mechanisms of platelet clearance and translation to improve platelet storage.

Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10.

Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions

Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs.

Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets.

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex

Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.

Structural basis for integrin alphaIIbbeta3 clustering.

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody

Structure-function of platelet glycoprotein Ib-IX

The hydrogen exchange core and protein folding.

The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.

The organizing principle of the platelet glycoprotein Ib-IX-V complex.

The slow-exchange core and protein folding

The transmembrane domain of glycoprotein Ibbeta is critical to efficient expression of glycoprotein Ib-IX complex in the plasma membrane

Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha.

Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.

Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope

Twins actin' differently

Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibα: implications for Bernard-Soulier syndrome